KRTAP21-1 expression associates with survival in triple negative breast cancer.
Keyword(s):
We mined published microarray data (1) to understand the most significant gene expression differences in the tumors of triple negative breast cancer patients based on survival following treatment: dead or alive. We observed significant transcriptome-wide differential expression of keratin associated protein 21-1, encoded by KRTAP21-1 when comparing the primary tumors of triple negative breast cancer patients dead or alive. Importantly, KRTAP21-1 expression was correlated with recurrence-free survival inpatients with breast cancer. KRTAP21-1 may be of relevance as a biomarker or as a molecule of interest in understanding the etiology or progression of triple negative breast cancer.
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