scholarly journals KRTAP21-1 expression associates with survival in triple negative breast cancer.

2021 ◽  
Author(s):  
Shahan Mamoor

We mined published microarray data (1) to understand the most significant gene expression differences in the tumors of triple negative breast cancer patients based on survival following treatment: dead or alive. We observed significant transcriptome-wide differential expression of keratin associated protein 21-1, encoded by KRTAP21-1 when comparing the primary tumors of triple negative breast cancer patients dead or alive. Importantly, KRTAP21-1 expression was correlated with recurrence-free survival inpatients with breast cancer. KRTAP21-1 may be of relevance as a biomarker or as a molecule of interest in understanding the etiology or progression of triple negative breast cancer.

2021 ◽  
Author(s):  
Shahan Mamoor

We mined published microarray data (1) to understand the most significant gene expression differences in the tumors of triple negative breast cancer patients based on survival following treatment: dead or alive. We observed significant transcriptome-wide differential expression of transmembrane protease, serine 7, encoded by TMPRSS7 when comparing the primary tumors of triple negative breast cancer patients dead or alive. Importantly, TMPRSS7 expression was correlated with recurrence-free survival in patients with breast cancer. TMPRSS7 may be of relevance as a biomarker or as a molecule of interest in understanding the etiology or progression of triple negative breast cancer.


2021 ◽  
Author(s):  
Shahan Mamoor

We mined published microarray data (1) to understand the most significant gene expression differences in the tumors of triple negative breast cancer patients based on survival following treatment: dead or alive. We observed significant transcriptome-wide differential expression of catenin, delta 2, encoded by CTNND2 when comparing the primary tumors of triple negative breast cancer patients dead or alive. Importantly, CTNND2 expression was significantly correlated with recurrence-free survival in basal subtype breast cancer, a molecular subtype sharing significant overlap with triple negative breast cancer. CTNND2 may be of relevance as a biomarker or as a molecule of interest in understanding the etiology or progression of triple negative breast cancer.


2021 ◽  
Author(s):  
Shahan Mamoor

We mined published microarray data (1) to understand the most significant gene expression differences in the tumors of triple negative breast cancer patients based on survival following treatment: dead or alive. We observed significant transcriptome-wide differential expression of host cell factor C1 regulator 1, encoded by HCFC1R1 when comparing the primary tumors of triple negative breast cancer patients dead or alive. Importantly, HCFC1R1 expression was significantly correlated with recurrence-free survival in basal subtype breast cancer, a molecular subtype sharing significant overlap with triple negative breast cancer. HCFC1R1 may be of relevance as a biomarker or as a molecule of interest in understanding the etiology or progression of triple negative breast cancer.


2021 ◽  
Author(s):  
Shahan Mamoor

We mined published microarray data (1) to understand the most significant gene expression differences in the tumors of triple negative breast cancer patients based on survival following treatment: dead or alive. We observed significant transcriptome-wide differential expression of amylase, alpha 1A (salivary), encoded by AMY1A when comparing the primary tumors of triple negative breast cancer patients dead or alive. Importantly, AMY1A expression was correlated with recurrence-free survival in basal subtype breast cancer, a molecular subtype sharing significant overlap with triple negative breast cancer. AMY1A may be of relevance as a biomarker or as a molecule of interest in understanding the etiology or progression of triple negative breast cancer.


2021 ◽  
Author(s):  
Shahan Mamoor

We mined published microarray data (1) to understand the most significant gene expression differences in the tumors of triple negative breast cancer patients based on survival following treatment: dead or alive. We observed significant transcriptome-wide differential expression of ataxin 7-like 3, encoded by ATXN7L3 when comparing the primary tumors of triple negative breast cancer patients dead or alive. Importantly, ATXN7L3 expression was correlated with recurrence-free survival in basal subtype breast cancer, a molecular subtype sharing significant overlap with triple negative breast cancer. ATXN7L3 may be of relevance as a biomarker or as a molecule of interest in understanding the etiology or progression of triple negative breast cancer.


2021 ◽  
Author(s):  
Shahan Mamoor

We mined published microarray data (1) to understand the most significant gene expression differences in the tumors of triple negative breast cancer patients based on survival following treatment: dead or alive. We observed significant transcriptome-wide differential expression of sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2, encoded by SULT1A2 when comparing the primary tumors of triple negative breast cancer patients dead or alive. Importantly, SULT1A2 expression was correlated with recurrence-free survival in basal subtype breast cancer, a molecular subtype sharing significant overlap with triple negative breast cancer. SULT1A2 may be of relevance as a biomarker or as a molecule of interest in understanding the etiology or progression of triple negative breast cancer.


2021 ◽  
Author(s):  
Shahan Mamoor

We mined published microarray data (1) to understand the most significant gene expression differences in the tumors of triple negative breast cancer patients based on survival following treatment: dead or alive. We observed significant transcriptome-wide differential expression of interleukin 17D, encoded by IL17D when comparing the primary tumors of triple negative breast cancer patients dead or alive. Importantly, IL17D expression was correlated with recurrence-free survival in p53 mutant patients in basal subtype breast cancer, a molecular subtype sharing significant overlap with triple negative breast cancer. IL17D may be of relevance as a biomarker or as a molecule of interest in understanding the etiology or progression of triple negative breast cancer.


2021 ◽  
Author(s):  
Shahan Mamoor

We mined published microarray data (1) to understand the most significant gene expression differences in the tumors of triple negative breast cancer patients based on survival following treatment: dead or alive. We observed significant transcriptome-wide differential expression of ADAM metallopeptidase domain 6 (pseudogene), encoded by ADAM6 when comparing the primary tumors of triple negative breast cancer patients dead or alive. Importantly, ADAM6 expression was significantly correlated with recurrence-free survival in basal subtype breast cancer, a molecular subtype sharing significant overlap with triple negative breast cancer. ADAM6 may be of relevance as a biomarker or as a molecule of interest in understanding the etiology or progression of triple negative breast cancer.


2021 ◽  
Author(s):  
Shahan Mamoor

We mined published microarray data (1) to understand the most significant gene expression differences in the tumors of triple negative breast cancer patients based on survival following treatment: dead or alive. We observed significant transcriptome-wide differential expression of thymocyte-expressed, positive selection-associated 1, encoded by TESPA1 when comparing the primary tumors of triple negative breast cancer patients dead or alive. Importantly, TESPA1 expression was correlated with recurrence-free survival in basal subtype breast cancer, a molecular subtype sharing significant overlap with triple negative breast cancer. TESPA1 may be of relevance as a biomarker or as a molecule of interest in understanding the etiology or progression of triple negative breast cancer.


2021 ◽  
Author(s):  
Shahan Mamoor

We mined published microarray data (1) to understand the most significant gene expression differences in the tumors of triple negative breast cancer patients based on survival at time of analysis: dead or alive. We observed transcriptome-wide differential expression of TET3 when comparing the primary tumors of triple negative breast cancer patients dead or alive. TET3 mRNA was present at significantly lower quantities in the tumors of TNBC patients alive. Importantly, TET3 expression was significantly correlated with recurrence-free survival in basal subtype breast cancer, a molecular subtype sharing significant overlap with triple negative breast cancer. TET3 may be of relevance as a biomarker or as a molecule of interest in understanding the etiology or progression of triple negative breast cancer.


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