scholarly journals A comparative study on echocardiographic evaluation of left ventricular mass and function in normotensive diabetic and non-diabetic patient

2021 ◽  
Vol 12 (12) ◽  
pp. 96-102
Author(s):  
Tanmay Mukhopadhyay ◽  
Pankaj Sarkar ◽  
Somnath Naskar ◽  
Uttam Biswas ◽  
SK Saidul Islam

Background: Cardiovascular complications account for the highest mortality in diabetic patients, mainly due to coronary artery disease and congestive heart failure. Left ventricular hypertrophy (LVH) is an ominous prognostic sign and an independent risk factor for cardiac events which is frequently present in patients living with diabetes. Aims and Objectives: The aim of the study was to evaluate the LV mass and function in normotensive diabetes patients without antihypertensive medication. Materials and Methods: 100 normotensive diabetic patients were in study group and 100 control patients were studied. Hypertension and other known causes of LVH were excluded from the study. Data were analyzed using proper statistical method. Results: Left ventricular mass index (LVMI) is significantly higher in diabetic patients as compared to control population (P<0.001). It was also observed that the means of the left ventricular posterior wall thickness, interventricular septal thickness, and the left ventricular internal diameter during diastole (in all cases P<0.001) were statistically significantly high in diabetic patients in comparison to healthy control subjects. We have found that a significant systolic dysfunction in diabetic group and diastolic dysfunction also very common in diabetic group than the control group. The LVMI also increased in patients who have longer duration of diabetes and poor glycemic control. Conclusion: LVM is significantly higher in patients of type 2 diabetic without having hypertension, albuminuria, and apparent ischemic heart disease as compared to healthy controls. LVM in diabetic patients increases with duration of diabetes and is positively correlated with HbA1c and blood sugar level.

2017 ◽  
Vol 31 (10) ◽  
pp. 1533-1537 ◽  
Author(s):  
Maria Maiello ◽  
Annapaola Zito ◽  
Santa Carbonara ◽  
Marco Matteo Ciccone ◽  
Pasquale Palmiero

Diagnostics ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. 477
Author(s):  
Wojciech Król ◽  
Szymon Price ◽  
Daniel Śliż ◽  
Damian Parol ◽  
Marcin Konopka ◽  
...  

Plant-based diets are a growing trend, including among athletes. This study compares the differences in physical performance and heart morphology and function between vegan and omnivorous amateur runners. A study group and a matched control group were recruited comprising N = 30 participants each. Eight members of the study group were excluded, leaving N = 22 participants. Members of both groups were of similar age and trained with similar frequency and intensity. Vegans displayed a higher VO2max (54.08 vs. 50.10 mL/kg/min, p < 0.05), which correlated positively with carbohydrate intake (ρ = 0.52) and negatively with MUFA (monounsaturated fatty acids) intake (ρ = −0.43). The vegans presented a more eccentric form of remodelling with greater left ventricular end diastolic diameter (LVEDd, 2.93 vs. 2.81 cm/m2, p = 0.04) and a lower relative wall thickness (RWT, 0.39 vs. 0.42, p = 0.04) and left ventricular mass (LVM, 190 vs. 210 g, p = 0.01). The left ventricular mass index (LVMI) was similar (108 vs. 115 g/m2, p = NS). Longitudinal strain was higher in the vegan group (−20.5 vs. −19.6%, p = 0.04), suggesting better systolic function. Higher E-wave velocities (87 vs. 78 cm/s, p = 0.001) and E/e′ ratios (6.32 vs. 5.6, p = 0.03) may suggest better diastolic function in the vegan group. The results demonstrate that following a plant-based diet does not impair amateur athletes’ performance and influences both morphological and functional heart remodelling. The lower RWT and better LV systolic and diastolic function are most likely positive echocardiographic findings.


2018 ◽  
Vol 4 (2) ◽  
pp. 227-232 ◽  
Author(s):  
Muayad A Merza ◽  
Abdul Aziz Sulaiman Savo ◽  
Muhammad Jaafer

Diabetes can be linked with impaired host immunity that subsequently increases the rate of various infections including tuberculosis (TB), particularly in developing countries where TB is endemic. The objectives of this case control study were to determine the prevalence and the risk of LTBI among diabetic patients. It is a prospective case control study conducted in Azadi Teaching Hospital from September 2017 until May 2018. The diabetic patients included in this study were randomly selected. The diagnosis of diabetes mellitus (DM) was made according to the American Diabetes Association (ADA). Diabetes mellitus patients and the control participants were offered a voluntary tuberculin skin test (TST). The TST ≥10 mm was considered positive. The results were analyzed by entering the data in SPSS (statistical package for the social sciences, version 16; SPSS Inc., Chicago, Illinois, USA). Two hundred DM patients and 208 control individuals participated in this study. Collectively, 28 patients had positive TST results. Based on the sputum smear microscopy and CXR, none of these patients showed active TB disease. The differences between the DM patients and the control group had no statistical significance apart from previous hospitalization. The prevalence of LTBI was 23.53% in the diabetic group, whereas, it was 9.62% in the control group. The frequency of LTBI in diabetic patients was significantly higher than the control group. When the diabetic group was compared with the control group in terms of diabetic control and the duration of diabetes disease, there was a statistically significant association of diabetes duration ≥ 10 years and TST positivity. In conclusion, the previous hospitalization was a significant risk factor for diabetic patients to acquire TB bacilli. Latent TB infection was more common in diabetics than non diabetics and there was an increased likelihood of having LTBI with the duration of diabetes ≥ 10 years. To avoid the threatening of TB control program, prophylactic treatment of LTBI in diabetic patients is paramount.Asian J. Med. Biol. Res. June 2018, 4(2): 227-232


2000 ◽  
Vol 64 (12) ◽  
pp. 921-924 ◽  
Author(s):  
Hiroyoshi Hirayama ◽  
Masahiro Sugano ◽  
Nobuyuki Abe ◽  
Hidetoshi Yonemochi ◽  
Naoki Makino

1970 ◽  
Vol 6 (1) ◽  
pp. 18-28
Author(s):  
MP Gautam ◽  
U Ghimire Gautam ◽  
S Dwivedi ◽  
S Rijal

Background: Alcohol drinking is cardio-protective; however its beneficial and harmful effects depend on the amount consumed. This work is designed to assess the impact of prolonged non-moderate drinking in left ventricular mass index and left ventricular ejection fraction and the correlation of their severity with total lifetime intake amount. Materials and methods: Fifty non-moderate drinkers (>25 g/day) for last 10 years and 50 non-drinker-volunteers were selected. Detail echocardiographic assessment was done and findings were compared and severity was correlated with lifetime amount. Results: Mean daily intake, duration and lifetime intake amount of alcohol were 64.1 g, 21.9 years and 501.9 Kg respectively. The mean ejection fraction and left ventricular mass index were 47.2% and 105.3 g/m2. There was significant difference when compared with controls. Eighty-two percent drinking subjects had abnormal echo, most common were regurgitations (52%), diastolic dysfunction (46%), raised ventricular mass (44%), systolic dysfunction (40%), and dilated left atrium and ventricle (38%). Thirty-four percent of subjects had echo features consistent with dilated cardiomyopathy. Palpitation and dyspnea in combination were the only symptoms associated with severity of echo changes. There was strong negative correlation of lifetime intake amount with ejection fraction (r = -0.91, p<0.001); however its relationship with ventricular mass index was not statistically significant (r = 0.23, p>0.05). Conclusions: Prolonged non-moderate drinking causes significant echocardiographic abnormalities mainly systolic dysfunction and increased left ventricular mass index. The total lifetime and daily amount of alcohol are well correlated with systolic dysfunction; however their relationships with the left ventricular mass index were non-conclusive. Key words: Alcohol; left ventricular mass; cardiomyopathy DOI: 10.3126/jcmsn.v6i1.3598 Journal of College of Medical Sciences-Nepal, 2010, Vol. 6, No. 1, 18-28


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