scholarly journals Bacteriological profile, antibiotic susceptibility pattern and other factors related to neonatal meningitis: A cross-sectional hospital-based study from West Bengal

2022 ◽  
Vol 13 (1) ◽  
pp. 93-98
Author(s):  
Kanai Lal Barik ◽  
Projesh Biswas ◽  
Kuntal Kanti Das ◽  
Sumanta Laha ◽  
Sudipto Paul ◽  
...  
Keyword(s):  
Neonatal Sepsis ◽  
West Bengal ◽  
Antibiotic Sensitivity ◽  
Good Effect ◽  
Neonatal Meningitis ◽  
Cross Sectional ◽  
Clinical Sepsis ◽  
Bacteriological Profile ◽  
Sensitivity Pattern ◽  
Culture Sensitivity

Background: Neonatal sepsis and meningitis is an important cause of neonatal mortality and morbidity especially in the developing countries. Bacteriological profile of meningitis and antibiotic sensitivity pattern may vary from one region to another. Aims and Objectives: We have planned this study to know the etiological agent of neonatal meningitis with its antibiotic sensitivity profile and to evaluate some other associated risk factors of meningitis. Materials and Methods: This observational, cross-sectional study was done for a period of 1 year in the SNCU and NICU of a district Medical College of West Bengal in neonates presented with clinical sepsis and meningitis. Sepsis screen, blood culture, cerebrospinal fluid (CSF) study, and culture sensitivity was done and recorded along with demographic data, clinical presentation, outcome, and other associated factors. Results: We found meningitis in 55 neonates out of 250 clinical sepsis. CSF culture was positive in 42 cases with Escherichia coli (30.9%), Klebsiella (26.1%), Staphylococcus aureus (16.6%), Acinetobacter (14.2%) and Coagulase negative Staphylococcus (CoNS 11.9%) as prevalent organism. E. coli and Klebsiella were mostly sensitive to Amikacin, Levofloxacin, and Colistin whereas less sensitive to Cefotaxime, Pipercilin-tazobactam or Meropenem and Acinetobacter showed good sensitivity only to Levofloxacin. Among the gram-positive organism, S. aureus and CoNS were only sensitive to Linezolid, Vancomycin, and Teicoplanin. Conclusion: This type of study should help to make a proper antibiotic policy for an institution so that the empirical first-line antibiotic can be started with good effect in cases of neonatal sepsis and meningitis before the arrival of culture sensitivity report.

scholarly journals Bacteriological profile and sensitivity pattern of neonatal sepsis

2017 ◽  
Vol 8 (1) ◽  
pp. 174-177
Author(s):  
Rowshan Jahan Akhter ◽  
Md Mahbubul Hoque ◽  
BH Nazma Yasmeen ◽  
MAK Azad Chowdhury
Keyword(s):  
Antibiotic Resistance ◽  
Neonatal Sepsis ◽  
Antibiotic Sensitivity ◽  
Neonatal Morbidity ◽  
Diffusion Method ◽  
Bacteriological Profile ◽  
Sensitivity Pattern ◽  
Haematological Profile ◽  
Resistance Patterns ◽  
Antibiotic Resistance Patterns

Introduction : Neonatal sepsis remains an important cause of neonatal morbidity and mortality in NICU setup and a major challenge for the neonatologists. The prevalent organisms and their antibiotic resistance patterns evolve with time and with the usage of antimicrobials.Aims and Objectives : To analyze the bacteriological profile and antibiotic resistance patterns of proven neonatal sepsis cases in Dhaka Shishu Hospital.Materials and Methods : The study was Prospective observational study. All the clinically suspected cases of Neonatal Sepsis admitted to the Neonatal word from January 2015 to December 2015 were included in the study. Clinically suspected cases of neonatal sepsis further evaluated with blood cultures and antibiotic susceptibility testing using the Kirby Bauer disc diffusion method. Data was collected for the following variables: Demographic profile, haematological profile, blood culture result and antibiotic sensitivity patterns.Results : Total 96 cases clinically suspected neonatal sepsis were included in the study. Among them 29 cases (30.21%) was culture positive septicemia. Klebsiella pneumoniae was the most common isolate accounting for 31.03% cases followed by Escherichia coli 27.59%. In Klebsiella infection most common sensitivity were Imipenum and Ciprofloxacin which were 77.78 and 33.33% respectively. In E.coli common sensitive drugs were Imipenum and Amikacin. In serratia common sensitive drugs were Imipenum, Netlmicin and Ciprofloxacin.Conclusion : K. pneumoniae was the most common pathogen. Most common sensitivity was Imipenum, Amikacin, Ciprofloxacin, Gentamicin, Netlmicin, and Ceftazidime,.Northern International Medical College Journal Vol.8(1) July 2016: 174-177

scholarly journals Incidence, bacteriological profile and antibiotic sensitivity pattern of neonatal sepsis in a tertiary health facility in Abuja, North-central Nigeria.

2021 ◽  
Author(s):  
Olutunde Oluyinka ◽  
Kareem I. Airede ◽  
Kudi E. Olateju ◽  
Obaro K. Stephen ◽  
Nosakhare Izevbigie ◽  
...  
Keyword(s):  
Blood Culture ◽  
Incidence Rate ◽  
Neonatal Sepsis ◽  
White Cell Count ◽  
Antibiotic Sensitivity ◽  
Signs And Symptoms ◽  
Special Care Unit ◽  
Bacteriological Profile ◽  
Sensitivity Pattern ◽  
Pseudomonas Luteola

Abstract Background: Neonatal sepsis is commonly caused by bacteria in the first 28 days of life. Due to diagnostic limitations in developing settings, prompt laboratory identification of causative organisms is usually a challenge. To prevent mortality, clear knowledge of bacteria and their antibiotic sensitivity patterns are important for prompt empirical treatment. Methods: This prospective study enrolled 339 newborns with signs and symptoms suggestive of neonatal sepsis out of 645 that were admitted into the special care unit of the University of Teaching Hospital during the study period. Socio-demographic and clinical profiles of the newborns were obtained using a questionnaire and blood culture was done from every enrolled newborn (339 newborns) using BACTEC 9050. The bacteriological profile and antibiotic sensitivity pattern of newborns with confirmed neonatal sepsis were documented. Results: A total of 339 newborn were admitted for probable sepsis out of a total admission of 645 newborns during the study period based on clinical features and initial laboratory work-up. Forty-six of the 645 newborns (46/645) had culture proven sepsis resulting in a neonatal sepsis incidence rate of 71.3 (95%CI 50.7-91.9) per 1000 admitted newborns. Seventeen of the 46 confirmed sepsis cases were among the 1322 newborns delivered within the study facility during the study period giving an in-hospital neonatal sepsis incidence rate of 12.9 (95% CI 6.7-19.0) per 1000 live births. Amongst the 46 babies with positive blood culture, 27/46 (58.7%) had normal white cell count while the remaining 19/46 (41.3%) had abnormal results. Fifty-two (52) counts of bacteria categorized into 11 bacteria species were isolated from the 46 positive blood cultures. Enterococcus spp and streptococcus species were the commonest gram-positive while Escherichia coli and Pseudomonas luteola were the commonest gram-negative bacteria isolates. Imipenem, amoxicillin/clavulanic acid, Vancomycin, and ofloxacin had the widest coverage of bacteria isolated from newborn with sepsis. Conclusion: Neonatal sepsis is still prevalent in our environment and compared to previous documented isolates and sensitivity pattern, the bacteria causes, and their antibiotic sensitivity patterns appears to be changing.

scholarly journals Clinical and bacteriological profile of neonatal sepsis with emerging resistance patterns

2018 ◽  
Vol 5 (6) ◽  
pp. 2203 ◽  
Author(s):  
Rohitashwa Rajana ◽  
Dhan Raj Bagri ◽  
J. N. Sharma ◽  
Vijay Agrawal
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Neonatal Sepsis ◽  
Antibiotic Sensitivity ◽  
Polymyxin B ◽  
Laboratory Evaluation ◽  
Gram Positive ◽  
Gram Negative ◽  
Bacteriological Profile ◽  
Sensitivity Pattern

Background: The present study was designed to evaluate the clinical spectrum, bacteriological profile, antibiotic sensitivity pattern and mortality due to neonatal septicemia in neonates admitted in neonatal units attached to the SMS Medical College, Jaipur.Methods: In born and out born babies of postnatal age up to 28 days who were bacteriological proven cases of septicemia were subjected to history, clinical examination and laboratory evaluation and data were analyzed statistically.Results: Out of 150 cases 67.33% neonates were preterm and 77.33% were low birth weight neonates. Gram negative organisms were most common cause of septicemia (66.6%), Both the Gram negative and Gram positive organisms were sensitive to piperacillin-tazobactam, linezolid, fosfomycin, teicoplanin, polymyxin B, colistin, ofloxacin. Both the Gram negative and Gram positive organisms were resistant against cephalosporins, ampicillin, Amoxyclav, cotrimoxazole. Gram negative isolates were most sensitive to Polymyxin B (70%) and had the highest resistance to cefepime (36%). Gram-positive organisms were most sensitive to vancomycin (84%) and linezolid (82%). Highest resistance was noted from Amoxyclav (52%).Conclusions: Preterm (<37 week) and low birth weight (<2500gm) neonates are considered as major susceptible causes of neonatal sepsis. Proper hygiene and hand washing, early detection of sepsis and judicial use of antibiotics to prevent multidrug resistance is needful in our setup.

scholarly journals Epidemiological and Bacteriological Profile of Urinary Tract Infection and the Antibiotic Sensitivity Pattern of Causative Organisms in National Medical College and Teaching Hospital - A Retrospective Cross-Sectional Study

Med Phoenix ◽  
2020 ◽  
Vol 5 (1) ◽  
pp. 40-45
Author(s):  
Sagar Ghimire ◽  
Sanjay Paudel ◽  
Shahrukh KC ◽  
Pragya Gautam ◽  
Vikash Paudel
Keyword(s):  
Escherichia Coli ◽  
Urinary Tract ◽  
Teaching Hospital ◽  
Antibiotic Sensitivity ◽  
Cross Sectional ◽  
National Medical College ◽  
Medical College ◽  
National Medical ◽  
Bacteriological Profile ◽  
Sensitivity Pattern

Background: Urinary tract infections (UTIs) are one of the most common infectious conditions seeking treatment. There are varieties of microorganisms associated. The bacteriological investigations are incomplete without antibiotic sensitivity test of the isolate. Our aim is to determine age and sex distribution of UTI, bacteriological profile, and antibiotic sensitivity pattern of the organisms. Materials and Methods: A retrospective cross-sectional observational study of records of patients with clinically suspected UTI from Kartik 2076 to Magh 2076 was conducted at National Medical College and Teaching Hospital (NMCTH). It included both inpatient and OPD visit patients who submitted their clean-catch midstream urine sample for culture and antibiotic sensitivity at Microbiology lab of NMCTH. Result: Out of 385 patients, 103 (26.75%) showed bacterial growth. Escherichia coli (47.58 %) was the most common organism followed by Staphylococcus sps. (18.45%) and Klebsiella sps.(17.47%) respectively. There was female dominance (62.13%) but male were predominantly affected in children and older population. The most common age group for UTI was 21-30 years (mean age 25 years) and females were more affected than males. The most common pathogen was Escherichia coli, followed by Staphylococcal sps. and Klebsiella. All the organisms showed best sensitivity to tigecycline (100%). Conclusion: This study highlights the common pathogens causing UTI and their antibiotic sensitivity patterns which could help clinicians in starting rational empirical antibiotic therapy for such patients while awaiting urine culture reports.   

Neonatal Sepsis in a Tertiary Care Hospital in South India: Bacteriological Profile and Antibiotic Sensitivity Pattern

2010 ◽  
Vol 78 (4) ◽  
pp. 413-417 ◽  
Author(s):  
Bambala Puthattayil Zakariya ◽  
Vishnu Bhat ◽  
Belgode Narasimha Harish ◽  
Thirunavukkarasu Arun Babu ◽  
Noyal Mariya Joseph
Keyword(s):  
Neonatal Sepsis ◽  
South India ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Antibiotic Sensitivity ◽  
Care Hospital ◽  
Bacteriological Profile ◽  
Sensitivity Pattern

scholarly journals Study of bacteriological profile in chronic suppurative otitis media and their pattern of antibiotic sensitivity

2021 ◽  
Vol 7 (4) ◽  
pp. 663
Author(s):  
Kiran J. Shinde ◽  
Netra A. Pathak ◽  
Namrata J. Katake
Keyword(s):  
Otitis Media ◽  
Antibiotic Sensitivity ◽  
Empirical Therapy ◽  
Chronic Suppurative Otitis Media ◽  
Suppurative Otitis Media ◽  
Bacteriological Profile ◽  
Sensitivity Pattern ◽  
Culture Sensitivity ◽  
High Degree ◽  
Middle Ear Cleft

<p class="abstract"><strong>Background: </strong>Chronic suppurative otitis media is a long-standing infection of the middle ear cleft which is characterized by recurrent and persistent ear discharge and persistent non healing perforation of tympanic membrane. It can lead to severe complications if not treated appropriately. Due to emerging antibiotic resistance, it is necessary to understand the antimicrobial pattern and their sensitivity to antibiotics which will help clinicians to select antibiotic which is sensitive to their corresponding microorganism. The aim of the study is to isolate the prevalent microorganism and study their antibiotic sensitivity pattern in patients of chronic suppurative otitis media (CSOM).</p><p class="abstract"> <strong>Methods:</strong> Total 100 patients were examined, ear swab were collected by sterile ear swab and sent for microscopy and culture sensitivity examination to microbiology department. Results were documented and analyzed.</p><p class="abstract"><strong>Results: </strong>Pseudomonas aeruginosa was the most common isolate (41%) followed by Staphylococci (28.2%). Gram negative cocci showed high degree of sensitivity to Cotrimoxazole (100%), Amikacin (79%) and Piperacillin - tazobactum (75%). Gram positive cocci showed high degree of sensitivity to Linezolid.</p><p class="abstract"><strong>Conclusions: </strong>Study of bacteriological profile and their sensitivity pattern helps in empirical therapy and reduces the risk of complications.</p>

scholarly journals Bacteriological Profile and Antibiotic Sensitivity Pattern of Pus Samples in a Tertiary Care Hospital

2020 ◽  
Vol 24 (1) ◽  
pp. 18-22
Author(s):  
Ahsan Tameez-ud-Din ◽  
Abdullah Sadiq ◽  
Noman Ahmed Chaudhary ◽  
Awais Ahmed Bhatti ◽  
Raja Saeed Lehrasab ◽  
...  
Keyword(s):  
Bacterial Isolate ◽  
Tertiary Care ◽  
Antibiotic Sensitivity ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Cross Sectional ◽  
Bacteriological Profile ◽  
Sensitivity Pattern ◽  
Prolonged Hospital ◽  
Hospital Acquired

Background: Wound infection is one of the most common causes of mortality and prolonged hospital stay worldwide. The emergence of resistant strains of bacteria poses a serious threat to the eradication of hospital-acquired infections. The objective of this study is to find the most common bacterial isolates in the pus samples and to assess their antibiotic sensitivity patterns.Material and Methods: This descriptive cross-sectional study was conducted in the Department of Pathology and Microbiology, Holy Family Hospital, Rawalpindi from August 2017 to December 2017 by using convenient sampling. The pus samples of all the patients, tested in the department, were included in the study. Sampling was done using blood and MacConkey agar and antibiotic sensitivity were done on Muller Hinton agar. Data was analyzed using SPSS v-23.0.Results: The most common bacterial isolate was Staphylococcus aureus (29.6%) followed by Escherichia coli (23.8%) and Pseudomonas aeruginosa (14.7%). S. aureus was most sensitive to vancomycin (100%) whereas E. coli and P. aeruginosa showed the highest sensitivity to imipenem (90.7%) and tazocin (80%), respectively.Conclusion: The most common bacterial isolate in pus cultures is S. aureus. Vancomycin is highly effective against S. aureus.

scholarly journals Incidence and Antibiogram of Acinetobacter Causing Neonatal Sepsis Among Hospitalised Patients

2020 ◽  
Vol 19 (1) ◽  
pp. 20-23
Author(s):  
Syeda Shahnoor Hasina Mamtaz ◽  
Abu Hena Md Saiful Karim Chowdhury ◽  
Gulshan Ara Begum ◽  
Asma Ferdousi ◽  
Mohammad Shahab Uddin
Keyword(s):  
Neonatal Sepsis ◽  
Antibiotic Sensitivity ◽  
Testing Time ◽  
Sensitivity Testing ◽  
Klebsiella Species ◽  
Acinetobacter Species ◽  
Bacteriological Profile ◽  
Hospitalised Patients ◽  
Sensitivity Pattern ◽  
Acinetobacter Spp

Background: Acinetobacter species are typical nosocomial pathogens causinginfections and high mortality, almost exclusively in compromised hospitalizedpatients. Multidrug-resistant Acinetobacter spp. blood infection in the neonatalintensive care unit patients create a great problem in hospital settings. The studywas done to detect prevalence of acinetobacter spp. as the causative agent ofneonatal sepsis with its antibiogram Materials and methods: A total of 100 clinically suspected neonatal sepsis caseswas enrolled in the study. Bacteriological profile and antibiotic sensitivity pattern ofacinetobacter spp. were done accordingly. Results: Among the 100 suspected neonatal sepsis cases, 28% were culture positiveand 72% were culture negative. Klebsiella species was the predominant isolatedbacteria which was 53.58% followed by Acinetobacter spp. (14.28%) E. coli(10.72%)Pseudomonas spp. (7.14%) S. aureus (7.14%) & Candida (7.14%). Acinetobacter spp.showed 100% resistant to ampicillin, ciprofloxacin, gentamycin, amikacin,ceftazidime, cefotaxime & cefepime, 75% resistant to meropenem & 50% sensitiveto levofloxacin. Conclusion: It is essential to conduct periodic bacteriological profile along withroutine antimicrobial sensitivity testing time to time for effective management ofneonatal sepsis. Chatt Maa Shi Hosp Med Coll J; Vol.19 (1); January 2020; Page 20-23

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