scholarly journals A study on outcome of controlled ovarian hyperstimulation and intrauterine insemination (husband) in a medical college in Kolkata

2022 ◽  
Vol 13 (1) ◽  
pp. 136-141
Author(s):  
Rajib Roy ◽  
Agniv Sarkar ◽  
Bibhas Saha Dalal
Keyword(s):  
Success Rate ◽  
Ovulation Induction ◽  
Positive Impact ◽  
Endometrial Thickness ◽  
Intrauterine Insemination ◽  
Controlled Ovarian Hyperstimulation ◽  
Infertile Couple ◽  
P Value ◽  
Ovarian Hyperstimulation ◽  
Resource Setting

Background: A combination of controlled ovarian hyperstimulation and intrauterine insemination (IUI) remains an important treatment option for couple having infertility. Success rate of IUI with ovulation induction ranges from 8-20% depending on many factors. Aims and Objectives: To assess the factors affecting the success rate of IUI and to evaluate the success of ovulation Induction by different methods of controlled stimulation protocol. Materials and Methods: It is a duration-based prospective cross-sectional study where total of 67 couples were included by inclusion and exclusion criteria. They underwent 90 cycles of IUI with each couple having a maximum of three cycles. Ovulation induction was done by clomiphene citrate or letrozole or gonadotrophins. Semen preparation was done by density gradient method. The outcomewas measured by positive urine pregnancy test. Range, percentage, confidence interval, mean with standard deviation, median, range, and P-value were calculated. P<0.05 was taken as statistically significant. Results: Out of 90 IUI cycles 8 were successful resulting in a success rate of 8.8% per cycle and 11.9% per couple. Factors that had a positive impact were follicle size >21 sqmm, endometrial thickness >9 mm, post wash count >15 million/ml, >2 cycles of IUI and on the number of follicles 2 or more on the day of trigger. Conclusion: The study concluded that IUI after ovulation induction can be a simple and safe cost-effective procedure in selected group of infertile couple. Clinical significance IUI following ovulation induction can be a successful approach for specific indications in a low-resource setting where options for other ART interventions are absent or limited.

scholarly journals Study on demographic variables of controlled ovarian Hyperstimulation and Intrauterine Insemination (husband) in a tertiary medical college and hospital in Kolkata

2021 ◽  
Vol 12 (2) ◽  
pp. 1-5
Author(s):  
Agniv Sarkar ◽  
Rajib Roy ◽  
Joydeb Roy Chowdhury ◽  
Bibhas Saha Dalal
Keyword(s):  
Success Rate ◽  
Ovulation Induction ◽  
Positive Impact ◽  
Intrauterine Insemination ◽  
Controlled Ovarian Hyperstimulation ◽  
Favourable Outcome ◽  
Unexplained Infertility ◽  
Safe Procedure ◽  
Medical College ◽  
Outcome Type

Background: Intrauterine Insemination (IUI) is anage old reliable and safe procedure for couples having infertility. Success rate of IUI with ovulation induction ranges from 8-20% depending on many factors. Aims and Objectives: The current study was to assess the factors which are responsible for favourable outcome of IUI after ovulation induction. Materials and Methods: Total 67 couples were included fulfilling inclusion and exclusion criteria. They underwent 90 cycles of IUI with each couple having maximum of 3 cycles. Ovulation induction was done byeitherclomiphene citrate or letrozole or gonadotrophins. Semen preparation was done by density gradient method. The participant’s demographic parameters were analyzed. Results: Out of 90 IUI, 8 were successful resulting in a success rate of 8.8% per cycle and 11.9% per couple. Factors which had positive impact were age less than 35 years, less than 10 years of infertility, normal and overweight BMI. Anovulation and unexplained infertility had better outcome. Type of infertility did not have any impact on the outcome. Conclusion: The study concluded that IUI after ovulation induction is more useful in cases like unexplained infertility and anovulation in a patient aged less than 35 years with less than 10 years of infertility and normal or overweight BMI.

scholarly journals The Use of High Dose Letrozole in Ovulation Induction and Controlled Ovarian Hyperstimulation

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Elizabeth A. Pritts ◽  
Alexander K. Yuen ◽  
Shefaali Sharma ◽  
Robert Genisot ◽  
David L. Olive
Keyword(s):  
Ovulation Induction ◽  
Detrimental Effect ◽  
Endometrial Thickness ◽  
Controlled Ovarian Hyperstimulation ◽  
High Dose ◽  
Ovarian Hyperstimulation ◽  
Dose Administration ◽  
Treatment Groups ◽  
Starting Dose ◽  
Higher Doses

Letrozole, an aromatase inhibitor, has been demonstrated to be effective as an ovulation induction and controlled ovarian hyperstimulation agent. However, dose administration has generally been limited to 5 days at 2.5 to 7.5 mg daily. We undertook a retrospective review of over 900 treatment cycles using letrozole in doses as high as 12.5 mg per day. Results indicate that such doses do indeed offer benefit to patients; in that there is increased follicular growth and a higher number of predicted ovulations with higher doses of the drug. However, increasing doses does not produce a detrimental effect upon endometrial thickness. High-dose letrozole may be of value in women who fail to respond adequately to lower doses. Furthermore, randomized trials are needed to determine whether high-dose letrozole might actually be optimal as a starting dose for certain treatment groups.

Comparison of letrozole and clomiphene citrate efficacy in terms of ovulation induction and pregnancy rate.

2021 ◽  
Vol 28 (05) ◽  
pp. 749-754
Author(s):  
Nadia Sharif ◽  
Uzma Manzoor ◽  
Saadia Bano ◽  
Uzma Shahzaad
Keyword(s):  
Pregnancy Rate ◽  
Ovulation Induction ◽  
Endometrial Thickness ◽  
Controlled Trial ◽  
Clomiphene Citrate ◽  
Epidemiological Data ◽  
P Value ◽  
Group A ◽  
The Mean ◽  
Group B

Objective: To compare the efficacy of Letrozole and clomiphene citrate in Patients of Anovulation polycystic ovarian syndrome with Infertility. Study Design: Randomized Controlled Trial Setting: Department of Obstetrics and Gynecology Independent Medical College Faisalabad. Period: 30-09-2019 to 29-6-2020. Material & Methods: This study included 100 patients with 50 patients in each group. Group A received 2.5 to 5mg letrozole in each cycle from day 3 to 7. Group B received clomiphene citrate 50 to 100 mg incremental dose depending on ovarian response. Both Drugs were given for consecutive 3 to 6 cycles to see response. Main outcome Measure included optimal follicle size (> 18mm), endometrial thickness, and pregnancy rate. Epidemiological data and efficacy outcome measures were recorded on a Performa. Statistical analysis was done using SPSS version 13. Chi-square test applied and p-value <o.o5 was considered significant. Both group included primary infertility patients. Results: The mean age of patients was 28.03+ 3.02 years. Mean age of group A patients was 29.04+3.44 and 28.47+3.90 group B patients. Mono ovulation in group A patients (88.9%) and 27 in group b patients (60.0%). The mean endometrial thickness was 9.6mm + 1.6 in letrozole group and 6.9mm + 1.2 in clomiphene citrate group A. In group A 18% got pregnant from Letrozole group and 1.1% from the group B. Conclusion: Efficacy was significantly higher in group A Patients received letrozole as compared to patients echo received clomiphene citrate. The effects of Letrozole showed better outcome in terms of Ovulation Induction Endometrial Thickness and Pregnancy rate.

scholarly journals Comparison of intrauterine insemination and timed intercourse following controlled ovarian hyperstimulation in unexplained infertility: a randomized controlled trial

2019 ◽  
Vol 8 (3) ◽  
pp. 1035
Author(s):  
Sayanti Paul ◽  
Saumen Mandal ◽  
Arghya Pal ◽  
Sumit Ranjan Pramanik
Keyword(s):  
Randomized Controlled Trial ◽  
Intrauterine Insemination ◽  
Controlled Trial ◽  
Controlled Ovarian Hyperstimulation ◽  
Unexplained Infertility ◽  
Clinical Pregnancy ◽  
Ovarian Hyperstimulation ◽  
Randomized Controlled ◽  
Group 2 ◽  
Group 1

Background: Being a diagnosis of exclusion the treatment options of unexplained infertility are often empiric. There is significant dilemma regarding the superiority of one over another. Despite increasing use of intrauterine insemination (IUI) in adjunct to controlled ovarian hyperstimulation (COH) there is scarcity of randomized controlled trials (RCT) from developing countries. Objective was to compare IUI and timed intercourse (TI) in super ovulated cycles among couples with unexplained infertility over one year.Methods: In this prospective randomized controlled trial total 85 patients were randomly assigned into group 1 (COH with IUI, N= 44) and group 2 (COH with TI, N=41). Patients underwent COH using sequential Clomiphene Citrate and injection human menopausal gonadotrophin followed by IUI in group 1 and timed intercourse in group 2. Either protocol was repeated for three consecutive cycles. Finally, both groups were compared for clinical pregnancy rate, adverse effects and acceptability of the treatment process and outcome. Comparison was done by Student’s unpaired t test for continuous and 2-tailed chi square test for categorical variables.Results: Clinical pregnancy rates following COH/IUI and COH/TI were 13.64% and 19.51% respectively. There was observable difference in the acceptability of the outcome (38.64% in IUI and 56.09% in TI group). All the results including complications and side effect rates were statistically insignificant.Conclusions: Present study failed to show any improvement of pregnancy rates following addition of IUI over TI and it raised the probability that the outcome of the procedure may not be well accepted.

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