scholarly journals Thyroid Function in Molar Pregnancies

2022 ◽  
Vol 19 (1) ◽  
pp. 22-25
Author(s):  
Kavita Sinha ◽  
Ram Das ◽  
Homnath Adhikari
Keyword(s):  
Thyroid Function ◽  
Hydatidiform Mole ◽  
Thyroid Function Test ◽  
Cross Sectional Study ◽  
Thyroid Storm ◽  
Molar Pregnancy ◽  
Cross Sectional ◽  
Medical College ◽  
Significant Burden ◽  
Gestational Trophoblastic Diseases

Introduction: Molar pregnancies represent a significant burden of disease on the spectrum of gestational trophoblastic diseases. Vaginal bleeding being the most common occasionally, molar pregnancy is complicated by hyperthyroidism, which may require treatment. Aims: To determine thyroid function test and association of hyperthyroidism among the cases of molar pregnancy. Methods: This is a hospital-based cross-sectional study conducted in the department of Obstetrics and Gynecology, Nepalgunj Medical College and Teaching Hospital, Kohalpur. Sixty cases of molar pregnancy were included during the study period from February 2020 to January 2021.Patients having history of known thyroid disorders were excluded. Results: Prevalence of molar pregnancy in our study was 5.4 per thousand pregnancies in our hospital. Molar pregnancy and hyperthyroidism, both were common in the age group of 21-35 years. Hyperthyroidism was present in 10% patients. Enlarged thyroid was seen in 3.3%, tremor was present in 3.3%, and palpitation in 21.5%. Five (8.3%) patients with hyperthyroidism were underweight. Majority of patients with hyperthyroidism, beta humanchorionic gonadotrophhin level was more than three lakhs and it was mostly associated with complete hydatidiform mole compared to partial hydatidiform mole. Thyroid storm was not experienced in any of the patients. Conclusion: The rate of molar pregnancy is high. Hyperthyroidism in molar pregnancy is not uncommon. High levels of human chorionic gonadotropin, complete hydatiform mole are directly associated with hyperthyroidism. Awareness of this condition is important for diagnosis and treatment to prevent life threatening complications.

scholarly journals Thyroid function test in nephrotic syndrome children who are admitted in emergency ward of Government Tirunelveli Medical College and Hospital, India

2018 ◽  
Vol 5 (6) ◽  
pp. 2290
Author(s):  
J. Rukmani ◽  
C. Krishanamurthy ◽  
Denny Clarin
Keyword(s):  
Nephrotic Syndrome ◽  
Thyroid Function ◽  
Genetic Diseases ◽  
Congenital Nephrotic Syndrome ◽  
Thyroid Function Test ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Medical College ◽  
Normal Limits ◽  
Function Test

Background: Nephrotic syndrome in childhood is largely primary or idiopathic, although a small proportion of cases are secondary to infectious agents and other glomerular and systemic diseases. The etiology of nephrotic syndrome is age-dependent. Most cases appearing in the first 3 months of life are referred as congenital nephrotic syndrome (CNS) and are due to genetic diseases. The objective of this study is to study the correlation between thyroid profile and different types of nephrotic syndrome.Methods: This cross-sectional study was done between March 2017 to October 2017 in the Department of Pediatrics Tirunelveli Government Medical College. 40 cases of nephrotic syndrome between 1 to12 years, which include all types of nephrotic syndrome. After history taking and clinical examination, blood samples were collected from the patients for thyroid function test and analyzed with standard techniques.Results: Serum T3, T4, TSH were found to be within normal limits. But TSH values in remission were significantly elevated compared to the first episode.Conclusions: Thyroid profiles in control were within normal range. The T4 and T3 levels in nephrotic syndrome were low and TSH was high. Hypothyroidism was more common in children less than 6 years. 

scholarly journals Screening of Thyroid Function in the First Half of Pregnancy

2016 ◽  
Vol 29 (1) ◽  
pp. 26-31
Author(s):  
Shaila Naznine Tania ◽  
Ferdousi Islam
Keyword(s):  
Pregnant Women ◽  
Thyroid Function ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Thyroid Disorder ◽  
Eligibility Criteria ◽  
Cross Sectional ◽  
Medical College ◽  
One Year ◽  
Serum Tsh

Objective: The study was conducted to find out any alterations in thyroid function status in first half of pregnancy (up to 20 weeks), with ultimate aim of deciding the usefulness of routine screening of thyroid function in pregnancy.Material and methods: A cross-sectional study was conducted in the department of Obstetrics & Gynaecology, Dhaka Medical College and Hospital, Dhaka, Bangladesh, over a period of one year from July 2011 to June 2012 on pregnant women in their 1st half of pregnancy to screen for the thyroid function. Based on predefined eligibility criteria, a total of 230 pregnant women were purposively included in the study. Thyroid function status was assessed by measuring serum levels of TSH, free thyroxine (FT4), and free tri-iodothyronine (FT3). Women with thyroid disorders were excluded.Results: The mean age of the patients being 24 years. Over 90% of the women were housewife and majority (88.7%) was educated. Over one-quarter of women was overweight with mean body mass index being 22.1 ± 4.4 kg/m2. The women were predominantly multigravida with 56% in 1st trimester 44% in the 1st half of 2nd trimester of pregnancy (13-20 weeks). Based on trimester’s specific range of serum TSH in the 1st and 1st half of 2nd trimester (13-20 weeks) of pregnancy,13% of the patients were hypothyroid and 3% were hyperthyroid thus yielding a total of 37(16%) pregnant women with abnormal thyroid function status.Conclusion: The study concluded that one in every six women may have thyroid disorder in the first half of pregnancy and subclinical hypothyroidism is four times more common than the subclinical hyperthyroidism.Bangladesh J Obstet Gynaecol, 2014; Vol. 29(1) : 26-31

scholarly journals Thyroid function status in patients with thyroid associated ophthalmopathy: a study for Nepal

2019 ◽  
Vol 3 (1) ◽  
pp. 3-9
Author(s):  
Saurav Piya ◽  
Jeena Gurung ◽  
Anadi Khatri
Keyword(s):  
Thyroid Function ◽  
Thyroid Function Test ◽  
Cross Sectional Study ◽  
Health Concern ◽  
Common Symptom ◽  
Hypothyroid Patient ◽  
Thyroid Disorder ◽  
Cross Sectional ◽  
Equal Distribution ◽  
Thyroid Associated Ophthalmopathy

Introduction: Thyroid Eye Disease (TED) is an organ-specific autoimmune inflammatory incapacitating eye disorder usually associated with Graves’ disease affecting the orbit. Objectives: To determine thyroid function status in patients with thyroid-associated Ophthalmopathy. Methods: This is a hospital-based cross-sectional study of sixty three clinically diagnosed new cases of thyroid-associated ophthalmopathy done at Nepal Eye Hospital, Kathmandu from February 2012 to January 2013. Detailed history, systemic & ocular examination with special emphasis on evaluation of extraocular movement, lid signs, exophthalmos with Hertel's exophthalmometer was done. Thyroid function test and endocrine consultation were also done in all cases. Results: There were an equal distribution of TED with hyperthyroid (34.95%) and euthyroid status (34.95%). The most common presentation of both euthyroid and hypothyroid patient was tremor (13.4%) and palpitation (13.45%). The most common symptom of TED was foreign body sensation (54 %) but in TED with euthyroid and hypothyroid status, redness (22.2 %) and diminution of vision (20.6 %) were more frequent symptoms respectively. The most common presenting sign was Von Graefe’s sign (69 %). Among TED with hyperthyroid and hypothyroid status, Dalrymple's sign (29.3%) and Mobius sign (17.4%) were most common respectively. Conclusion: Thyroid-associated ophthalmopathy is an important health concern among patients with a thyroid disorder. TED with hyperthyroid states present more severely than hypothyroid and euthyroid states. As TED occurred with a high prevalence in all thyroid states, a close collaboration between endocrinologists and ophthalmologists along with timely referrals of patients with any eye complaint is mandated.

scholarly journals Study of Thyroid Function Status in Type 2 Diabetic Patients

KYAMC Journal ◽  
2019 ◽  
Vol 10 (2) ◽  
pp. 95-98
Author(s):  
Kamrunnahar Alo ◽  
Shyamal Chandra Banik ◽  
Safayet Ahammed ◽  
Ayesha Yasmin ◽  
Tania Rahman
Keyword(s):  
Thyroid Function ◽  
Thyroid Dysfunction ◽  
Cross Sectional Study ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Cross Sectional ◽  
Medical College ◽  
The Difference ◽  
Type 2 Diabetic

Background: Thyroid dysfunction specially hypothyroidism may occur in type 2 diabetic patients. Objective: To observe thyroid function status in type 2 diabetic patients Materials and Methods: This cross sectional study was carried out in the Department of Physiology, Sir Salimullah Medical College, Dhaka from July 2016 to June 2017. Total 60 subjects including male and female, age ranged from 40 to 60 years were included in this study, among them 30 were non-diabetic subjects and 30 were type 2 diabetic patients. Results: In this study, mean serum TSH level was significantly (p<0.001) higher and serum FT4 level was significantly (p<0.01) lower in diabetic patients than that of apparently healthy non-diabetic subjects. Serum FT3 level was lower in type 2 diabetic patients in comparison to that of non-diabetic subjects but the difference was not statistically significant. However, among the diabetic patients 10% were subclinical hypothyroid and 6.67% were hypothyroid Conclusion: The present study reveals that hypothyroidism occurs in type 2 diabetic patients. So type 2 diabetic patients should measure thyroid hormone levels routinely to detect thyroid dysfunction. KYAMC Journal Vol. 10, No.-2, July 2019, Page 95-98

scholarly journals Does Postevacuation β-Human Chorionic Gonadotropin Level Predict the Persistent Gestational Trophoblastic Neoplasia?

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Azam Sadat Mousavi ◽  
Samieh Karimi ◽  
Mitra Modarres Gilani ◽  
Setareh Akhavan ◽  
Elahe Rezayof
Keyword(s):  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Predictive Factor ◽  
Hydatidiform Mole ◽  
Area Under The Curve ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Molar Pregnancy ◽  
Gestational Trophoblastic Neoplasia ◽  
Cross Sectional

β-human chorionic gonadotropin (HCG) level is not a reliable marker for early identification of persistent gestational trophoblastic neoplasia (GTN) after evacuation of hydatidiform mole. Thus, this study was conducted to evaluate β-HCG regression after evacuation as a predictive factor of malignant GTN in complete molar pregnancy. Methods. In this cross-sectional study, we evaluated a total of 260 patients with complete molar pregnancy. Sixteen of the 260 patients were excluded. Serum levels of HCG were measured in all patients before treatment and after evacuation. HCG level was measured weekly until it reached a level lower than 5 mIU/mL. Results. The only predictors of persistent GTN are HCG levels one and two weeks after evacuation. The cut-off point for the preevacuation HCG level was 6000 mIU/mL (area under the curve, AUC, 0.58; sensitivity, 38.53%; specificity, 77.4%), whereas cut-off points for HCG levels one and two weeks after evacuation were 6288 mIU/mL (AUC, 0.63; sensitivity, 50.46%; specificity, 77.0%) and 801 mIU/mL (AUC, 0.80; sensitivity, 79.82%; specificity, 71.64%), respectively. Conclusion. The rate of decrease of HCG level at two weeks after surgical evacuation is the most reliable and strongest predictive factor for the progression of molar pregnancies to persistent GTN.

scholarly journals Status of Thyroid Disorder among the Thyroid Function Test Samples Received in a Laboratory among Postmenopausal Women: A Descriptive Cross-sectional Study

2021 ◽  
Vol 59 (234) ◽  
Author(s):  
Manoranjan Shrestha ◽  
Reshmi Shrestha
Keyword(s):  
Postmenopausal Women ◽  
Thyroid Function ◽  
Subclinical Hypothyroidism ◽  
Thyroid Dysfunction ◽  
Thyroid Function Test ◽  
Cross Sectional Study ◽  
Reference Laboratory ◽  
Sectional Study ◽  
Cross Sectional ◽  
Function Test

Introduction: Thyroid dysfunction prevalence is high in females worldwide which increases with age. Postmenopausal and elderly women are particularly at risk of developing comorbidities and mortality related to thyroid dysfunction. We aimed to study the prevalence of thyroid dysfunction in postmenopausal women in the National Reference Laboratory of Nepal. Methods: A descriptive cross-sectional study was conducted in National Reference Laboratory from January 2019 to June 2019 including postmenopausal females, ≥49 years. The database of thyroid function test result was used for statistical analysis and proportion of thyroid dysfunction was calculated. The data was collected after approval from the institutional review committee. Statistical Package for Social Sciences version 21 was used to study descriptive data. Results: Out of a total of 160 postmenopausal females with thyroid function tests, 71 (44.4%) had thyroid dysfunction. Subclinical hypothyroidism was the frequently occurring thyroid dysfunction 51 (32%) followed by subclinical hyperthyroidism 13 (8%), hypothyroidism 3 (2%) and hyperthyroidism 3 (2%). In our study population, thyroid dysfunction peaked at 49 to 58 years of age interval 53 (33.1%) and subclinical hypothyroidism was the most frequent form 38 (23.7%). Conclusions: Subclinical hypothyroidism was the common thyroid dysfunction in postmenopausal age which peaked at 49 to 58 years of age group. Early postmenopausal females are predisposed to increased risk of comorbidities (cardiovascular disease, osteoporosis with high fracture, depression) which could be exacerbated with thyroid dysfunction; therefore awareness of thyroid dysfunction prevalence and thyroid screening for early management seems appropriate in Nepalese postmenopausal women.

scholarly journals Triiodothyronin, Thyroxine and Thyrotropin in Vitiligo

2012 ◽  
Vol 9 (2) ◽  
pp. 7-10
Author(s):  
K Subba ◽  
D Karn ◽  
R Khatri
Keyword(s):  
Thyroid Function ◽  
Thyroid Function Test ◽  
Cross Sectional Study ◽  
Thyroid Function Tests ◽  
Thyroid Disorder ◽  
Age Group ◽  
Cross Sectional ◽  
Function Test ◽  
High Level

BackgroundVitiligo is a common pigmentary disorder of the skin, affecting individuals globally. Not only is this ailment psychologically incapacitating, it also has a high incidence of autoimmunity, signifying that its manifestations may be the portrayal of dysfunction of immune system. ObjectiveThe aim of this study is to find out the situations of abnormal thyroid function test (TFT) in vitiligo patients. MethodsA prospective cross sectional study was conducted at the Dhulikhel Hospital, KUTH, Dhulikhel during November 2008 to January 2011 with the objective to assess the thyroid function tests in vitiligo patients. ResultsTotal 66 vitiligo patients with male 30 (45%) and female 36 (55%). Total 26 (39.39%) vitiligo patients have been found to have abnormal thyroid function test. Among them 10 had abnormal T3, seven had abnormal T4 and 12 had abnormal TSH level. Thyroid function test were normal in other vitiligo patients. Total seven vitiligo had high level of T3 than normal value, four male and three female. Two had higher level of T4 above 2.0 ng/dl and all were male, while five had abnormally low level of T4 with three male and two female. There were seven vitiligo patient with increased T3 level and three with decreased T3 level, among them six were males and four were females, the age group was ranged from seven to 68 years old. The T4 level were found abnormal in seven vitiligo patients among which five were males and two were females with the age group ranging from 7 to 51 years. ConclusionsThere has been significant association of thyroid disorder in the patient with vitiligo. Therefore, patient with vitiligo need to undergo thyroid function test to rule out the thyroid disorder and prevent from long-term complications.DOI: http://dx.doi.org/10.3126/kumj.v9i2.6279Kathmandu Univ Med J 2011;9(2):7-10 

scholarly journals Association of Age with Thyroid Hormone Status and Ischaemic Heart Disease (IHD)

2012 ◽  
Vol 2 (2) ◽  
pp. 80-84
Author(s):  
Nasreen Sultana Lovely ◽  
Rokeya Begum ◽  
Qazi Shamima Akhter ◽  
Salma Akhter ◽  
Nilufar Yasmin Mili ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Function ◽  
Healthy Subjects ◽  
Meta Analysis ◽  
Age Groups ◽  
Cross Sectional Study ◽  
College Hospital ◽  
Cross Sectional ◽  
Medical College ◽  
Cardiology Department

Background: Aging is associated with increased prevalence of thyroid function abnormalities including hypothyroidism. A meta-analysis showed an increased prevalence and incidence of cardiovascular mortality only in a relatively younger population. Objective: To compare the thyroid function status in IHD patients of different age groups. Methods: This cross sectional   study was carried out on 31 IHD subjects aged 35-59 years (Group B1) and 19 IHD subjects aged 60-85 years (Group B2) in the Department of Physiology, Dhaka Medical College, Dhaka from July 2009 to June 2010. For comparison 24 healthy subjects aged 35-59 years   (Group A1) and 26 with age 60-85 years (Group A2) were studied. The IHD subjects were   selected from coronary care unit of cardiology department and OPD of Dhaka Medical College Hospital, Dhaka. Serum FT3, FT4 and TSH of all subjects were measured by radioimmunoassay. Statistical analysis was done by unpaired Student’s ‘t’ test. Results: The mean ± SD of FT3 and FT4 were significantly lower and TSH was significantly higher in   Group B1 IHD patients than that of Group A1 healthy subjects, but no difference was found between Group A2 and Group B2 and between Group B1 and Group B2.Conclusion: Thyroid   hormone levels are significantly lower in younger IHD population (age 35-59 years) than the   age-matched normal controls. DOI: http://dx.doi.org/10.3329/jemc.v2i2.12842 J Enam Med Col 2012; 2(2): 80-84

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