scholarly journals Clinical Outcome of Autologous Serum Therapy in Chronic Idiopathic Urticaria

2017 ◽  
Vol 15 (1) ◽  
pp. 71-74 ◽  
Author(s):  
Dharmendra Karn ◽  
Shekhar KC
Keyword(s):  
Skin Prick Test ◽  
Chronic Urticaria ◽  
Statistical Significance ◽  
Cost Effective ◽  
Chronic Idiopathic Urticaria ◽  
Autologous Serum ◽  
P Value ◽  
Prick Test ◽  
H1 Antihistamines ◽  
Serum Therapy

Background: Quality of life in chronic idiopathic urticaria is hampered as efficacy of H1-antihistamines is limited. Autologous serum containing tolerance-generating anti-idiotype antibodies is a novel and cost-effective therapy. This study was conducted to evaluate the efficacy of autologous serum therapy (AST) among chronic urticaria patients with autologous skin prick test positive and negative status.Methods: Untreated 102 patients of chronic urticaria were enrolled in a non-randomized interventional study. Patients were categorized into two groups based on autologous serum skin prick test as test positive (ASST +) and test negative (ASST -). Patients were then treated with intramuscular injection of 0.05ml per kg body weight of autologous serum weekly for 10 weeks. Urticaria activity scoring (UAS) tool was used for quantification of the symptoms. Weekly recording of UAS (range: 0-42) was made before the therapy (baseline) and during the therapy for 10 weeks.Results: Significant improvement with AST in the mean UAS was noted from baseline to 10 weeks in both the group of patients (14.6 ± 6.3 and 10.2 ± 5.1 for ASST+ group; 16.9 ± 7.8 and 8.6 ± 4.8 for ASST- group; at baseline and 10 weeks, respectively (p-value for both <0.05)). However no statistical significance was found while comparing the efficacy of the therapy against ASST + and ASST - Groups (p-value > 0.05).Conclusions: Irrespective of autologous skin prick test results, autologous serum therapy showed significant improvement in patients with chornic idiopathic urticaria. AST can, thus, be an effective treatment modality for it.

scholarly journals Autologous Serum Skin Test for Initial Identification of Auto- Antibodies in Chronic Urticaria

2018 ◽  
Vol 19 (2) ◽  
pp. 100-103
Author(s):  
Mohammad Nura Alam ◽  
Mohammad Ali ◽  
Mohammad Moniruzzaman Khan ◽  
Keya Tarafder ◽  
Goutam Kumar Acherjya ◽  
...  
Keyword(s):  
Skin Test ◽  
Chronic Urticaria ◽  
Cost Effective ◽  
Autologous Serum ◽  
P Value ◽  
Effective Measure ◽  
Autologous Serum Skin Test ◽  
Physical Urticaria ◽  
Retrospective Data Analysis ◽  
Initial Identification

Background: Autologous serum skin test (ASST) is easy to perform, cost effective measure for initial identification of auto-antibody in patients suffering from chronic urticaria which may occur due to autoimmune trigger by spontaneously developed auto-antibodies against FcμRI receptor of skin mast cells.Objective: This review is designed to see the positivity of ASST in patients suffering from chronic urticaria.Materials & Methods: This a retrospective data analysis conducted from the records of patients suffered from at least two episodes of urticaria or more in a week for 6 weeks and who did ASST aged more than 10 years between July 2015 to June 2017. These subjects were not pregnant or lactating mother, did not had urticarial vasculitis, predominant co-existing physical urticaria and had negative Hepatitis B antigen and anti-nuclear antibody reports.Results: Total 53 were included in this study of them 33 were female. Mean age was 32 years with a standard deviation (SD) of 11 years. Among study patients 16 (30.2% of total) had a positive ASST result. No age or sex difference was observed in positive ASST cases. In positive cases significant (p-value:<0.001) mean induration difference of 2.75mm with a SD of 1.00 mm observed than induration produced by negative control.Conclusion: ASST is easy and effective tool for initial identification of auto-reactive urticaria.J MEDICINE JUL 2018; 19 (2) : 100-103

scholarly journals Autologous serum skin test and skin prick test in patients with chronic urticaria: a cross sectional study

2017 ◽  
Vol 3 (1) ◽  
pp. 46
Author(s):  
Mounika K. ◽  
Shivaswamy K. N.
Keyword(s):  
Skin Prick Test ◽  
Skin Test ◽  
Cross Sectional Study ◽  
Chronic Idiopathic Urticaria ◽  
Autologous Serum ◽  
Chi Square ◽  
Cross Sectional ◽  
Autologous Serum Skin Test ◽  
Prick Test ◽  
History Of

<p class="abstract"><strong>Background:</strong> <span lang="EN-IN">Urticaria is an allergic skin disorder characterized by wheals. Though the diagnosis is easy, it is difficult to identify the cause for the episodes. Autologous serum skin test (ASST) and skin prick test (SPT) help in the identification of the cause. The objective of the study was to determine the frequency of ASST and SPT positivity in patients with chronic idiopathic urticaria (CIU).</span></p><p class="abstract"><strong>Methods:</strong> Fifty-six patients attending the dermatology OPD with chronic idiopathic urticaria were evaluated and taken up for the study. ASST and SPT were performed on all the patients and the obtained results were documented. Data was analyzed using Chi square test.<strong></strong></p><p class="abstract"><strong>Results:</strong> Among the 56 patients studied, males (53.57%) outnumbered females and the majority was in the age group 21 to 30 years (33.9%). One third of the study patients gave history of known food allergy and 10.7% gave history of dust allergy. ASST positivity was seen in 30.3% and SPT positivity was seen in 64.3%. Ten of our patients (17.8%) were positive to both ASST and SPT. Amongst the SPT positives 33.3% showed positivity to food allergens, 19.4% showed positivity to aeroallergens and 47.2% showed positivity to both<span lang="EN-IN">. </span></p><p class="abstract"><strong>Conclusions:</strong> ASST and SPT are two reliable tools in identifying the cause for urticaria and this in turn helps in avoidance of possible causes and providing proper treatment<span lang="EN-IN">.</span></p>

scholarly journals Bioremediation of Some Reactive Dyes Commonly used in Fabric Re-dyeing by Chlorella vulgaris

2021 ◽  
pp. 10-19
Author(s):  
Zainab M. Sani ◽  
Aisha S. Dalhatu ◽  
Baha’uddeen S. Adam ◽  
Kasim Mohammed ◽  
Yusuf Y. Muhammad ◽  
...  
Keyword(s):  
Chlorella Vulgaris ◽  
Dye Removal ◽  
Statistical Significance ◽  
Reactive Dyes ◽  
Basal Medium ◽  
Textile Wastewater ◽  
Cost Effective ◽  
P Value ◽  
Wastewater Samples ◽  
Reactive Green 19

Aim: The work was aimed at assessing the potential of Chlorella vulgaris in remediation of reactive dyes. Place and Duration of Study: Department of Biological Sciences, Department of Plant Biology and Department of Biochemistry, Bayero University, Kano, Nigeria, between January 2019 and December 2019. Methodology: Wastewater containing individual reactive dyes: reactive red 198 (RR198), reactive yellow 176 (RY176), reactive green 19 (RG19), reactive orange 122 (RO122), reactive red 195 (RR195) and reactive violet 1 (RV1) were collected from a local fabric re-dyeing pit at Kofar Na’isa, Kano, Nigeria. The green microalga C. vulgaris was cultured in Bold Basal medium (BBM) at 30 ± 2°C and subjected to adsorption and decolourization assays of the dyes. Results: The highest dye removal efficiency by enzymatic action was recorded after 48 hours, while that for the biomass adsorption was at day 14, at pH 11.3 and temperature of 30°C. The percentage dye removal by adsorption and decolourization were within the ranges of 68.1-97.8% and 69.8-99.9% respectively. Dye removal decreased with increase in contact time until saturation is attained. Freundlich’s isotherm model was best fitted for the adsorption of the dyes with a strong linear correlation coefficient, R2 ranging from 0.954-0.811. There was a strong linear relationship and high statistical significance among the dyes for both decolourization and adsorption (P value; .01). Conclusion: Chlorella vulgaris was found to be effective in the removal of reactive dyes from textile wastewater samples. The results revealed C. vulgaris to be a cost-effective and eco-friendly biosorbent that can be used for the treatment of wastewaters containing toxic dyes.

scholarly journals EFFECTIVENESS OF AUTOLOGOUS SERUM THERAPY IN CHRONIC URTICARIA: A PROSPECTIVE OBSERVATIONAL STUDY IN TERTIARY CARE HOSPITAL

2016 ◽  
Vol 5 (17) ◽  
pp. 822-827
Author(s):  
Rakesh Kumar Patel ◽  
Anil Kumar Gupta ◽  
Santosh Kumar Singh ◽  
Harleen Chhachhi ◽  
Pawan Kumar Patel ◽  
...  
Keyword(s):  
Observational Study ◽  
Chronic Urticaria ◽  
Prospective Observational Study ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Autologous Serum ◽  
Care Hospital ◽  
Serum Therapy

scholarly journals Autologous serum therapy in chronic urticaria: Old wine in a new bottle

2008 ◽  
Vol 74 (2) ◽  
pp. 109 ◽  
Author(s):  
AK Bajaj ◽  
Abir Saraswat ◽  
Amitabh Upadhyay ◽  
Rajetha Damisetty ◽  
Sandipan Dhar
Keyword(s):  
Chronic Urticaria ◽  
Autologous Serum ◽  
Serum Therapy

scholarly journals Food allergies in children: a comparison of parental reports and skin prick test results

2018 ◽  
Vol 58 (2) ◽  
pp. 59-65
Author(s):  
Camilia Metadea Aji Savitri ◽  
Azwin Mengindra Putera Lubis ◽  
Gatot Soegiarto
Keyword(s):  
Skin Prick Test ◽  
Skin Prick Testing ◽  
Food Allergies ◽  
P Value ◽  
Positive Skin Prick Test ◽  
Test Results ◽  
Cross Sectional ◽  
Positive Skin ◽  
Prick Test ◽  
Parental Reports

Background Food allergy is common in children and its prevalence is generally on the rise. Imprecise parental reports about reactions to particular foods can lead to unnecessary restrictions. Since children have specific growth requirements, such nutritional restrictions may have disturbing effects on children’s growth and development.Objective To compare parental reports on food reactions to skin prick test results in their children.Method Retrospective, cross sectional study using patient’s medical record data during one-year study period. Data were analyzed manually and statistically, to assess the degree of agreement (Kappa’s coefficient) and significance (P).Results We collected data from 154 subjects aged 0-18 years. For every allergen assessed, parents reported more food reactions than positive skin prick test results. Allergy incidence were caused, in order, by cow’s milk and chicken (25.3%), eggs (22.1%), chocolate (20.1%), fruits (14.3%), seafood (13%), and saltwater fish (1.9%). Kappa coefficient are all poor (<0.2) and P value are all >0.05 except for chicken (P=0.02).Conclusion Most parents tend to overestimate which food cause reactions in their children, as reactions reported were not necessarily allergenic. Therefore, every patient experiencing allergy reactions should undergo skin prick testing to confirm the possibility of allergy.

scholarly journals Autologous serum therapy in chronic urticaria

2019 ◽  
Vol 5 (4) ◽  
pp. 275-279
Author(s):  
Surendran K A K ◽  
◽  
Nanjundaswamy B L ◽  
Sathish S ◽  
Bangaru H ◽  
...  
Keyword(s):  
Chronic Urticaria ◽  
Autologous Serum ◽  
Serum Therapy

scholarly journals Autologous serum therapy in chronic urticaria: A promising complement to antihistamines

2014 ◽  
Vol 59 (4) ◽  
pp. 375 ◽  
Author(s):  
NilayKanti Das ◽  
Panchami Debbarman ◽  
Amrita Sil ◽  
PiyushKanti Datta ◽  
Debabrata Bandyopadhyay
Keyword(s):  
Chronic Urticaria ◽  
Autologous Serum ◽  
Serum Therapy

scholarly journals Autologous serum therapy: a viable option for chronic spontaneous urticaria

2020 ◽  
Vol 7 (1) ◽  
pp. 69
Author(s):  
Darshana Sundaresh ◽  
S. Kumaravel ◽  
M. Anbumalar
Keyword(s):  
Chronic Urticaria ◽  
Adjunctive Treatment ◽  
Autologous Serum ◽  
Viable Option ◽  
Positive Skin ◽  
Female Predominance ◽  
Quasi Experimental ◽  
Study Population ◽  
Serum Therapy

<p class="abstract"><strong>Background:</strong> Chronic urticaria (CU) is a common disorder causing decrease in quality of life of patients with associated morbidity, chronic dependence on medications and a huge pill burden. CU is multifactorial and a subset of patients have an autoimmune background for their condition which is confirmed by a positive skin reaction to ASST. This study compared the efficacy of Autologous serum therapy in both ASST positive and ASST negative patients by evaluating total severity score (TSS).</p><p class="abstract"><strong>Methods: </strong>This quasi experimental study was conducted on fifty patients were selected randomly and withdrawn from antihistaminic use. ASST was done for all patients and AST was administered to all patients in both groups for 9 weeks. The patients were followed up at 4 weeks and 12 weeks after completion of AST. TSS measurements were used as baseline and recorded weekly after each injections till 9 weeks then 4th and 12th week after completion of therapy.</p><p class="abstract"><strong>Results:</strong> 50 patients were the study population. The median age was 34.7 years with a female predominance. 23 patients were ASST positive and the rest were negative. Following treatment, ASST positive group had 69% improvement in TSS and ASST negative group had 61.5% improvement in TSS. There was statistically significant differences following treatment compared to baseline and between the two groups.</p><p><strong>Conclusions:</strong> AST as an adjunctive treatment for chronic urticaria shows promise for patients irrespective of ASST positivity and is more effective for ASST positive patients.</p>

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