scholarly journals Stressful Life Events In First Episode Psychosis

2021 ◽  
Vol 10 (1) ◽  
pp. 38-42
Author(s):  
B.D. Karki ◽  
D. Joshi ◽  
A.P. Adhikari
Keyword(s):  
Life Events ◽  
Perceived Stress ◽  
Stressful Life Events ◽  
First Episode Psychosis ◽  
Stressful Life ◽  
Psychotic Symptoms ◽  
First Episode ◽  
Psychotic Episode ◽  
Episode Psychosis

Introduction: First episode psychosis refers to the first time someone experiences psychotic symptoms or a psychotic episode. There are evidences related to the role of major life events and childhood trauma in the development of first episode psychosis. There are few studies regarding the environmental exposure to stressful life events and how these events might influence the onset of a psychotic disorder, and role of perceived stress. This study aimed to identify the relationship between stressful life events and first episode psychosis in Nepalese context. Material And Method: It was a hospital based cross-sectional, descriptive study. A total of 50 cases of first episode psychosis were included and the diagnosis was made according to ICD 10- Diagnostic Criteria for Research and verified by two consultant psychiatrists. Semi Structured Performa was designed to collect the information about the socio demographic data and perceived stress was assessed with Presumptive Stressful Life Events Scale (PSLES). Results: There were 62% female and 38% male patients with first episode psychosis with mean age 26.32 years. Majority of the participants were from rural areas (94%), married (58%), educated up to primary level (38%) and housewife (40%). 60.7% of ATPD had stressful life events (P =0. 000)which was higher than the stressful life events in patient with Schizophrenia (P =0. 005). There was a positive correlation between stressful life events and gender, setting, socioeconomic status and Diagnosis (P <0.05). Conclusion: Results show the relevance of presence of stressful life events as a potent source of perceived stress in first episode psychosis sample. Therefore this study highlights the importance of psychosocial intervention in this vulnerable group for management of illness and might be an important strategy for prevention.

scholarly journals T1. STRESSFUL LIFE EVENTS AND PERCEIVED STRESS IN THE SAMPLE OF PATIENTS WITH FIRST-EPISODE PSYCHOSIS AND HEALTHY CONTROLS: PRELIMINARY RESULTS

2018 ◽  
Vol 44 (suppl_1) ◽  
pp. S113-S113
Author(s):  
Anna Butjosa ◽  
Regina Vila-Badia ◽  
Núria Del Cacho ◽  
Itziar Riera-López de Aguileta ◽  
Mar Álvarez ◽  
...  
Keyword(s):  
Life Events ◽  
Perceived Stress ◽  
Stressful Life Events ◽  
First Episode Psychosis ◽  
Stressful Life ◽  
First Episode ◽  
Healthy Controls ◽  
Preliminary Results ◽  
Episode Psychosis

Incidence of stressful life events and influence of sociodemographic and clinical variables on the onset of first-episode psychosis

2016 ◽  
Vol 245 ◽  
pp. 108-115 ◽  
Author(s):  
Anna Butjosa ◽  
Juana Gómez-Benito ◽  
Elena Huerta-Ramos ◽  
Núria Del cacho ◽  
Ana Barajas ◽  
...  
Keyword(s):  
Life Events ◽  
Stressful Life Events ◽  
First Episode Psychosis ◽  
Stressful Life ◽  
First Episode ◽  
Clinical Variables ◽  
Episode Psychosis

Visual working memory deterioration preceding relapse in psychosis

2016 ◽  
Vol 46 (11) ◽  
pp. 2435-2444 ◽  
Author(s):  
C. L. M. Hui ◽  
Y. K. Li ◽  
A. W. Y. Li ◽  
E. H. M. Lee ◽  
W. C. Chang ◽  
...  
Keyword(s):  
Working Memory ◽  
Visual Working Memory ◽  
Life Events ◽  
Stressful Life Events ◽  
First Episode Psychosis ◽  
Stressful Life ◽  
First Episode ◽  
Medication Discontinuation ◽  
Episode Psychosis ◽  
Memory Deterioration

BackgroundRelapse is distressingly common after the first episode of psychosis, yet it is poorly understood and difficult to predict. Investigating changes in cognitive function preceding relapse may provide new insights into the underlying mechanism of relapse in psychosis. We hypothesized that relapse in fully remitted first-episode psychosis patients was preceded by working memory deterioration.MethodVisual memory and verbal working memory were monitored prospectively in a 1-year randomized controlled trial of remitted first-episode psychosis patients assigned to medication continuation (quetiapine 400 mg/day) or discontinuation (placebo). Relapse (recurrence of positive symptoms of psychosis), visual (Visual Patterns Test) and verbal (Letter–Number span test) working memory and stressful life events were assessed monthly.ResultsRemitted first-episode patients (n = 102) participated in the study. Relapsers (n = 53) and non-relapsers (n = 49) had similar baseline demographic and clinical profiles. Logistic regression analyses indicated relapse was associated with visual working memory deterioration 2 months before relapse [odds ratio (OR) 3.07, 95% confidence interval (CI) 1.19–7.92, P = 0.02], more stressful life events 1 month before relapse (OR 2.11, 95% CI 1.20–3.72, P = 0.01) and medication discontinuation (OR 5.52, 95% CI 2.08–14.62, P = 0.001).ConclusionsVisual working memory deterioration beginning 2 months before relapse in remitted first-episode psychosis patients (not baseline predictor) may reflect early brain dysfunction that heralds a psychotic relapse. The deterioration was found to be unrelated to a worsening of psychotic symptoms preceding relapse. Testable predictors offer insight into the brain processes underlying relapse in psychosis.

scholarly journals Aggressive incidents in first-episode psychosis

2001 ◽  
Vol 178 (5) ◽  
pp. 433-440 ◽  
Author(s):  
John Milton ◽  
Shazad Amin ◽  
Swaran P. Singh ◽  
Glynn Harrison ◽  
Peter Jones ◽  
...  
Keyword(s):  
First Episode Psychosis ◽  
Psychotic Symptoms ◽  
First Episode ◽  
Psychotic Episode ◽  
Increased Risk ◽  
Episode Psychosis ◽  
Clinical Associations ◽  
Independent Effects ◽  
One Act ◽  
Service Contact

BackgroundRecent research has reported increased risk of aggressive incidents by individuals with psychotic illness.AimsTo examine acts of aggression in first-episode psychosis.MethodSubjects with a first-episode psychosis were ascertained from a defined catchment area (Nottingham, UK) and reassessed at 3 years (n=166) using clinical interview, informants, health care and forensic records.ResultsOf the subjects, 9.6% demonstrated at least one act of serious aggression (defined as weapon use, sexual assault or victim injury) during at least one psychotic episode and 23.5% demonstrated lesser acts of aggression (defined as all other acts of aggression). For all aggressive subjects (33.1%), unemployment (OR=3.6, 95%CI 1.6–8.0), comorbid substance misuse (OR=3.1, CI 1.1–8.8) and symptoms of overactivity at service contact (OR=6.9, CI 2.7–17.8) had independent effects on risk of aggression.ConclusionsWe confirmed some previously reported demographic and clinical associations with aggression in first-episode psychosis but no relationship with specific psychotic symptoms or diagnostic groups was observed.

Trauma and Migration in First Episode Psychosis

2017 ◽  
Vol 41 (S1) ◽  
pp. S66-S66
Author(s):  
S. Tosato ◽  
C. Bonetto ◽  
I. Tarricone ◽  
M. Ruggeri ◽  
S. Tomassi ◽  
...  
Keyword(s):  
Life Events ◽  
Stressful Life Event ◽  
First Episode Psychosis ◽  
Stressful Life ◽  
First Episode ◽  
Targeted Prevention ◽  
Biological Stress ◽  
Increased Risk ◽  
Episode Psychosis ◽  
And Migration

IntroductionResearches show that the period of migration, or the migration process itself, may confer an increased risk for psychosis. Some studies have addressed whether the high rates of psychosis found in migrants could be due to higher genetic or environmental risk factors. Facing severe or chronic stress such as trauma, social isolation, low socio-economic status, late-life social adversity may result in long term, sometimes permanent, alterations of the biological stress response system, leading to the onset of psychosis.ObjectivesThis study aims to examine, in a large sample of first episode psychosis patients, whether negative social experiences like stressful life events and difficulties, trauma and isolation have significantly higher frequencies in migrants with respect to natives.MethodsThe present study is conducted within the framework of the EUGEI (European Network of National Schizophrenia Networks Studying Gene Environment Interactions) study, a Europe-wide incidence and case–control study of psychosis conducted in 12 centers chosen to include areas with large first and subsequent generation migrant populations.Data about age, gender, migration history, trauma, life events, ethnicity, social class and family history of mental disorders have been collected.ResultsPreliminary data on the relationship between trauma and migration in first episode psychosis will be presented.ConclusionsSince migration is an important stressful life event, and difficulties in integration in host countries may remain chronic, it is important to identify in each context the most vulnerable minority groups in order to implement targeted prevention interventions.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Stressful and intrusive life events preceding first episode psychosis

2009 ◽  
Vol 18 (3) ◽  
pp. 221-228 ◽  
Author(s):  
David Raune ◽  
Elizabeth Kuipers ◽  
Paul Bebbington
Keyword(s):  
Life Events ◽  
Patient Group ◽  
Stressful Life Events ◽  
Conflicts Of Interest ◽  
Statistical Significance ◽  
First Episode Psychosis ◽  
First Episode ◽  
Episode Psychosis ◽  
Comparison Groups ◽  
First Onset

SUMMARYAim – To test the hypothesis that stressful life events, in particular intrusive events, would cluster before the first onset of psychosis. Method – Forty-one patients with first episode psychosis were interviewed with the Life Events and Difficulties Schedule to assess events in the year before the onset of illness. Events were rated contextually on timing, independence, threat, and intrusiveness. Within-patient group clustering was evaluated, and the patient group was compared with two general population surveys from London. Results – Events were very frequent in the year before the onset of psychosis. Stressful and intrusive events were more common in the three months before onset compared with the previous nine months, although few analyses reached conventional statistical significance. Threatening and intrusive events were much more frequent in patients than in the comparison groups. First episode psychosis patients were strikingly more likely to report an intrusive event in the three months before onset (OR=17.1, 34% v 3%), and also showed an excess between three months and one year before onset (OR=8.1, 11% v 3%). Conclusions – Events may trigger many cases of first episode psychosis. The effect emerges several months before onset, particularly if the events are intrusive. This has both theoretical and clinical implications.Declaration of Interest: DR was supported by a UK Medical Research Council studentship. The authors have no conflicts of interest in writing this paper.

scholarly journals Substance use in a population-based clinic sample of people with first-episode psychosis

2007 ◽  
Vol 190 (6) ◽  
pp. 515-520 ◽  
Author(s):  
Jennifer H. Barnett ◽  
Ursula Werners ◽  
Sandra M. Secher ◽  
Katherine E. Hill ◽  
Rossa Brazil ◽  
...  
Keyword(s):  
Substance Use ◽  
General Population ◽  
Population Based ◽  
First Episode Psychosis ◽  
Psychotic Symptoms ◽  
First Episode ◽  
Psychotic Episode ◽  
Intervention Service ◽  
Episode Psychosis ◽  
British Crime Survey

BackgroundSubstance use is implicated in the cause and course of psychosis.AimsTo characterise substance and alcohol use in an epidemiologically representative treatment sample of people experiencing a first psychotic episode in south Cambridgeshire.MethodCurrent and lifetime substance use was recorded for 123 consecutive referrals to a specialist early intervention service. Substance use was compared with general population prevalence estimates from the British Crime Survey.ResultsSubstance use among people with first-episode psychosis was twice that of the general population and was more common in men than women. Cannabis abuse was reported in 51% of patients (n=62) and alcohol abuse in 43% (n=53). More than half (n=68, 55%) had used Class A drugs, and 38% (n=43) reported polysubstance abuse. Age at first use of cannabis, cocaine, ecstasy and amphetamine was significantly associated with age at first psychotic symptom.ConclusionsSubstance misuse is present in the majority of people with first-episode psychosis and has major implications for management. The association between age at first substance use and first psychotic symptoms has public health implications.

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