Lesion with blue bone-a case report

Bizzare parosteal osteochondromatous proliferation, or Nora‘s lesion is a unique bone lesion that most often arises in the small bones of hands and feet. It is characterised by proliferation of chondroid, bony and fibrous tissue, and is occasionally misdiagnosed as a malignant process. Our case was a 31 yr old lady, who presented with a painless swelling near the 5th metacarpal bone of right hand. X-ray showed well marginated mineralised mass arising from the cortical surface of the metacarpal bone. Histopathological examination revealed bizarre parosteal osteochondromatous proliferation composed of varying amounts of cartilage, bone and spindle cells. Cartilage was hypercellular and chondrocytes were enlarged. Ossification was irregular and had a peculiar blue tinctorial quality.

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Bizarre Parosteal Osteochondromatous Proliferation (Nora's Lesion) in the Medial Sesamoid of the First Toe

Journal of the American Podiatric Medical Association ◽

10.7547/19-195 ◽

2020 ◽

Vol 110 (6) ◽

Author(s):

Onur Tetik ◽

Lercan Aslan ◽

Kadir Buyukdogan ◽

Mehmet Chodza ◽

Onder Kilicoglu

Keyword(s):

Young Adults ◽

Bizarre Parosteal Osteochondromatous Proliferation ◽

En Bloc ◽

Nora’S Lesion ◽

Bony Lesion ◽

En Bloc Excision ◽

Small Bones ◽

Bloc Excision ◽

Hands And Feet

Bizarre parosteal osteochondromatous proliferation, or Nora's lesion, is a unique bony lesion that generally originates from the small bones of the hands and feet in young adults. We report a case of a bizarre parosteal osteochondromatous proliferation originating from the medial sesamoid of the first toe that was managed surgically by en bloc excision. At 5-year follow-up, there was no evidence of recurrence.

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Bizarre Parosteal Osteochondromatous Proliferation

Journal of the American Podiatric Medical Association ◽

10.7547/8750-7315-105.1.80 ◽

2015 ◽

Vol 105 (1) ◽

pp. 80-84 ◽

Cited By ~ 2

Author(s):

Crystal Holmes ◽

Palak Choksi ◽

James S. Wrobel

Keyword(s):

Young Adults ◽

Case Report ◽

Bizarre Parosteal Osteochondromatous Proliferation ◽

Management Options ◽

Current Case ◽

Recurrent Lesion ◽

Microscopic Features ◽

Small Bones ◽

Hands And Feet

Bizarre parosteal osteochondromatous proliferation (BPOP) is an uncommon reactive mesenchymal lesion mainly affecting the small bones of the hands and feet. They frequently occur in young adults. It is important to understand and differentiate BPOP from other lesions, especially because of its atypical microscopic features and tendency to recur. We present a case of a recurrent lesion involving the toe and discuss management options. To our knowledge, our current case report is the first in the literature to report a recurring BPOP lesion of the toe.

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Nora's Lesion: Bizarre Parosteal Osteochondromatous Proliferation Causing Splay Foot Deformity: A Case Report

Journal of the American Podiatric Medical Association ◽

10.7547/17-009 ◽

2019 ◽

Vol 109 (6) ◽

pp. 463-466 ◽

Cited By ~ 1

Author(s):

Anthony J. Mollica ◽

Benjamin Getz ◽

Chinenye Ezike ◽

Blake Brannick ◽

Albert J. Mollica

Keyword(s):

Benign Lesion ◽

Foot Deformity ◽

Bizarre Parosteal Osteochondromatous Proliferation ◽

Nora’S Lesion ◽

Spindle Cells ◽

Common Diagnosis ◽

Hands And Feet ◽

Splay Foot ◽

Tubular Bones

Nora's lesion, or bizarre parosteal osteochondromatous proliferation (BPOP), is a rare benign lesion that is made up of varying degrees of cartilage, bone, and spindle cells. Most notably, calcification of the cartilage or “blue bone,” is a feature of the disorder. The condition principally affects long tubular bones of the hands and feet, and is generally seen in patients in their second and third decades of life. We present a case of BPOP occurring in the second interspace with symptoms that would be consistent with a more common diagnosis of predislocation syndrome, or a second interspace neuroma. This case study may help the clinician in considering a more subtle cause of a splay deformity in the second interspace, and walk through the diagnostic and treatment course for BPOP.

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Different characteristics of infants diagnosed with congenital choledochal malformation prenatally or postnatally

Scientific Reports ◽

10.1038/s41598-020-79569-4 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Wei Chen ◽

Jia Geng ◽

Ya-lan Tan ◽

Lian Zhao ◽

Hui-hui Jia ◽

...

Keyword(s):

Histopathological Examination ◽

Fibrous Tissue ◽

Operation Time ◽

Normal Diet ◽

Treatment Regimens ◽

Total Length ◽

Time Required ◽

Different Characteristics ◽

Length Of Hospitalization ◽

Choledochal Malformation

AbstractThe general condition, clinical and pathological characteristics, and treatment regimens of patients prenatally and postnatally diagnosed with congenital choledochal malformation (CM) were analyzed in order to investigate the clinical significance of early diagnosis, treatment, and intervention in CM. We retrospectively analyzed 33 children who were admitted to the Children’s Hospital of Soochow University between 1 March 2010 and 31 May 2019, and their diagnosis of CM was confirmed by radiological, surgical and pathological findings. All the patients were under 36 months of age. The patients were divided into prenatally diagnosed and postnatally diagnosed groups. There were 16 and 17 CM patients in the prenatally and postnatally diagnosed groups, respectively, with a preponderance of females in both groups. Compared with the prenatally diagnosed group, the postnatally diagnosed group had a higher incidence of abdominal pain and vomiting (p < 0.05) and higher AST, GGT, and TB levels (p < 0.05). Although postoperative histopathological examination showed inflammation in both groups, congestion in the cyst walls and fibrous tissue hyperplasia were more significant in the postnatally diagnosed group (p < 0.05). In addition, operation time, length of time required to resume a normal diet after surgery, and total length of hospitalization differed between the 2 groups (p < 0.05), with the prenatally diagnosed group having a relatively longer operation time and taking longer to resume a normal diet after surgery. However, the total length of hospitalization in the prenatally diagnosed group was shorter than that in the postnatally diagnosed group. Compared with prenatally diagnosed CM patients, more symptoms, greater severity of symptoms, and more time to recovery after surgery were observed in postnatally diagnosed CM patients.

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Pulmonary silicosis in 2 rock hyraxes, and literature review

Journal of Veterinary Diagnostic Investigation ◽

10.1177/10406387211057524 ◽

2021 ◽

pp. 104063872110575

Author(s):

Bianca R. Pfisterer ◽

Anthony L. Ashley ◽

Robert L. Donnell ◽

John R. Dunlap ◽

Kim M. Newkirk

Keyword(s):

Electron Microscopy ◽

Transmission Electron Microscopy ◽

Medical Center ◽

Fibrous Tissue ◽

Crystalline Silica ◽

Energy Dispersive ◽

Intact Male ◽

Crystal Deposition ◽

X Ray ◽

Transmission Electron

Two rock hyraxes ( Procavia capensis), from the Chattanooga Zoo, were submitted separately for autopsy at the University of Tennessee Veterinary Medical Center. The first was a 4-y-old intact female that died without premonitory signs and the second was a 10-y-old intact male that was euthanized because of severe renal disease. Microscopically, the lungs of both hyraxes had multifocal-to-coalescing, <1-mm diameter aggregates of epithelioid macrophages separated by streams of fibrous tissue. Macrophages contained intracytoplasmic, clear, acicular, birefringent crystals. Transmission electron microscopy and energy-dispersive x-ray spectroscopy findings on the lung samples were consistent with silica crystal deposition. The hyraxes had been housed together on commercially sourced play sand composed of 99–99.5% quartz, a crystalline silica polymorph. The microscopic findings, transmission electron microscopy, and energy-dispersive x-ray spectroscopy of the intrahistiocytic crystals, in addition to the history of exposure to crystalline silica, were consistent with pulmonary silicosis. Pulmonary silicosis has not been reported previously in rock hyraxes, to our knowledge.

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Seminoma and sertolioma in non-cryptorchid dog – case report

Acta Veterinaria Brasilica ◽

10.21708/avb.2021.15.4.10155 ◽

2021 ◽

Vol 15 (4) ◽

pp. 281-286

Author(s):

Guilherme Mantuani Silva ◽

Isabela Cristina de Oliveira ◽

Rodrigo Samuel de Toledo ◽

Juliana Evangelista Bezerril ◽

Gabriela Maria Benedetti Vasques ◽

...

Keyword(s):

Physical Examination ◽

Ultrasound Examination ◽

Histopathological Examination ◽

Seminiferous Tubules ◽

Biochemical Tests ◽

Predisposing Factor ◽

Left Testicle ◽

Spindle Cells ◽

Mixed Breed ◽

The Right

The most common testicular neoplasms in dogs are seminoma, leydigocytoma and sertolioma, affecting middle--aged and elderly dogs, where cryptorchidism is a predisposing factor, as well as some breeds. It can occur alone or, less fren-quently, concurrently, generally affecting the same testicle. This study aimed to report the case of a non-cryptorchid 14-year--old mixed breed dog diagnosed with seminoma and sertolioma, each in a testicle. The animal showed an increase in scrotal volume, with no changes in other clinical parameters on physical examination. On ultrasound examination, it was possible to observe alterations suggestive of neoplasia in both testicles and prostatic alteration suggestive of benign prostatic hyperplasia. Complementary blood count and biochemical tests were performed and, as treatment, orchiectomy was performed. Fragments were collected from both testicles and sent for histopathological examination. Microscopy of the left testicle showed the presence of round cells, multiple and evident nucleoli, cells in different phases of mitosis and binucleation, these changes being compa-tible with seminoma. In contrast, in the right testicle, spindle and elongated cells (pseudo-lobular) were observed, presence of long cytoplasmic projections with rounded ovoid nucleus, spindle cells and degeneration of seminiferous tubules, compatible with sertolioma. It was observed that physical examination associated with ultrasound was efficient to detect the presence of neoplasms, being validated by histopathological examination. Orchiectomy was an assertive treatment indicated for this case.

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Lucio Phenomenon: A Rare Manifestation of Leprosy in Selangor, Malaysia

International Journal of Human and Health Sciences (IJHHS) ◽

10.31344/ijhhs.v5i0-2.338 ◽

2021 ◽

Vol 5 (0-2) ◽

pp. 20

Author(s):

Shahrizan Majid Binti Allapitchai

Keyword(s):

Peripheral Nerves ◽

Histopathological Examination ◽

Skin Condition ◽

Lepromatous Leprosy ◽

Lower Limbs ◽

Who Guidelines ◽

Rare Manifestation ◽

Hands And Feet ◽

Multiple Ulcers ◽

Made In

Leprosy is a chronic infectious disease caused by Mycobacterium leprae, predominantly affecting the skin and peripheral nerves. Lucio phenomenon is a rare reactional state presenting in patient with lepromatous leprosy and described as acute cutaneous necrotising vasculitis. We discussed the case of a 38-year-old male patient presenting with oedematous and dusky discolouration of bilateral hands and feet associated with diffuse facial involvement. His skin condition gradually worsened to form multiple ulcers with bizarre shaped purpuric lesion over bilateral upper and lower limbs, trunk, and face. Histopathological examination of the skin biopsy showed multiple acid-fast bacilli and diagnosis of Lucio’s phenomenon was made in the background of lepromatous leprosy. He was treated with multi drug therapy (MDT) as recommended by the WHO guidelines. A better understanding of rarer manifestation of this illness is important for early diagnosis and to prevent significant morbidity associated with it.International Journal of Human and Health Sciences Supplementary Issue-2: 2021 Page: S20

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Chondrosarcoma of the Small Bones of the Hands and Feet

High-Yield Bone and Soft Tissue Pathology ◽

10.1016/b978-1-4377-2520-9.10043-6 ◽

2012 ◽

pp. 96-98

Keyword(s):

Small Bones ◽

Hands And Feet

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A Rare Case of Fibrous Hamartoma of Infancy: A Clinicopathological Diagnosis at a Tertiary Hospital, Eastern Nepal

Case Reports in Pathology ◽

10.1155/2019/9410415 ◽

2019 ◽

Vol 2019 ◽

pp. 1-3

Author(s):

G. Lama ◽

P. Upadhyaya ◽

B. Adhikari ◽

M. Adhikari ◽

S. Dhakal

Keyword(s):

Histopathological Examination ◽

Stellate Cell ◽

Fibrous Tissue ◽

Female Child ◽

Tertiary Hospital ◽

Fibrous Hamartoma Of Infancy ◽

Myxoid Matrix ◽

Proper Diagnosis ◽

Gross Examination ◽

Infants And Young Children

Background. Fibrous hamartoma of infancy is a rare soft tissue lesion of infants and young children with characteristic triphasic morphology. Case Description. An 18-month-old female child was presented with complaints of swelling over right leg shin since birth. On examination, a lump of size 7x3 cm was identified which was mobile and nontender. Local excision was performed and tissue sent for histopathological examination. On gross examination, a globular, capsulated, firm to hard tissue had cut section revealing solid grey-white to grey-brown lesion with myxoid areas identified. Microscopic examination revealed a poorly circumscribed lesion comprising intersecting trabeculae of fibrous tissue, areas of immature oval and stellate cell within myxoid matrix, and varying amounts of interspersed mature fat cells. Conclusion. Even though fibrous hamartoma of infancy is a rare benign entity with limited clinical knowledge, proper diagnosis is mandatory as its prognosis is excellent.

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