scholarly journals Serum Ferritin Concentration in Corona Virus Disease 19

2021 ◽  
Vol 1 (2) ◽  
pp. 34-37
Author(s):  
Samir Singh ◽  
Sujit Kumar Darnal ◽  
Arun Bahadur Chand
Keyword(s):  
Serum Ferritin ◽  
Complex Disease ◽  
Virus Disease ◽  
Inflammatory Marker ◽  
Ferritin Level ◽  
Multiorgan Failure ◽  
Cytokine Storm ◽  
Cross Sectional ◽  
Ferritin Concentration ◽  
The Mean

Introduction: Coronavirus disease 19 (COVID-19) is a complex disease responsible for the development of exacerbated inflammatory response (cytokine storm) that ultimately leads to multiorgan failure and death. Serum ferritin has been recently identified as one of the inflammatory markers responsible for the pro-inflammatory effects. Small amount of ferritin is present in plasma (15-150 ng/mL) which might increase with the severity of COVID-19. Therefore, measurement of ferritin is essential in identifying disease severity and predict disease prognosis. Objective: This study aims to assess the ferritin level in COVID-19 patients. Methods: A cross-sectional study was carried out on 259 COVID-19 patients visiting KIST Medical College and Teaching Hospital (KISTMCTH), Lalitpur, Nepal from November 2020 to April 2021. Serum ferritin was estimated in the automated Siemens ADVIA Centaur CP Chemiluminescence Immunoassay system. All the patients visiting KISTMCTH referred by clinician for ferritin assessment were included in this study. Data collected using the proforma tool was tabulated in SPSS 21 and statistical analysis was done by inferential statistical test. Results: Out of total 259 COVID-19 patients, 58.7% were male and the majority of patients (82.6%) were below 70 years of age. The mean age for all participants was 52.11±16.59 years. Hyperferritinemia was seen in 218 (84.16%) COVID -19 patients. The mean value of serum ferritin was 767.1±789.86 (IQR: 12.8-4590) ng/mL and was significantly higher in males (p<0.001). Comparing the mean values of ferritin between the patients below and above 70 years, no statistical difference was observed (p=0.872). Conclusions: In our study, serum ferritin levels were greatly increased in patients with COVID-19 infection. Keywords: Coronavirus disease 19; cytokine storm; inflammatory marker; serum ferritin.

scholarly journals Red meat and egg intake and serum ferritin concentrations in Colombian children: results of a population survey, ENSIN-2015

2020 ◽  
Vol 9 ◽  
Author(s):  
Oscar F. Herran ◽  
Jhael N. Bermúdez ◽  
María Del Pilar Zea
Keyword(s):  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
Red Meat ◽  
Cross Sectional ◽  
Egg Consumption ◽  
Dietary Consumption ◽  
The Mean ◽  
The Relationship ◽  
Meat And Eggs

Abstract The present study aimed to (a) establish the frequency of consumption of red meat and eggs; (b) determine serum ferritin levels (μg/l); and (c) establish the relationship between serum ferritin and the consumption of red meat and eggs. In Colombia during 2014–2018, an analytical study was conducted in 13 243 Colombian children between the ages of 5 and 17 years, based on cross-sectional data compiled by ENSIN-2015 (Encuesta Nacional de la Situación Nutricional en Colombia-2015) on serum ferritin levels and dietary consumption based on a questionnaire of the frequency of consumption. Using simple and multiple linear regression, with the serum ferritin level as the dependent variable and the frequency of consumption as the main explanatory variable, the crude and adjusted partial regression coefficients (β) between serum ferritin levels and consumption were calculated. The frequency of habitual consumption of red meat was 0⋅49 (95 % CI 0⋅47, 0⋅51) times/d. The frequency of habitual egg consumption was 0⋅76 (95 % CI 0⋅74, 0⋅78) times per d. The mean serum ferritin level in men was 41⋅9 (95 % CI 40⋅6, 43⋅1) μg/l and in women, 35⋅7 (95 % CI 34⋅3, 37⋅7) μg/l (P < 0⋅0001). The adjusted β between the consumption of red meat and eggs and serum ferritin levels were β = 3⋅0 (95 % CI 1⋅2, 4⋅7) and β = 2⋅5 (95 % CI 1⋅0, 3⋅9) for red meat and eggs, respectively. In conclusion, red meat and eggs are determinants of serum ferritin levels in Colombia and, therefore, could be considered public policy options to reduce anaemia and Fe deficiency.

scholarly journals The correlation between serum ferritin levels and impaired heart function in children with transfusion dependent thalassemia

2021 ◽  
Vol 16 (2) ◽  
pp. 190-195
Author(s):  
Carrina Nenggar Dewanti ◽  
I Ketut Alit Utamayasa ◽  
IDG Ugrasena
Keyword(s):  
Ejection Fraction ◽  
Serum Ferritin ◽  
Heart Function ◽  
Ferritin Level ◽  
Cross Sectional Study ◽  
Mean Value ◽  
Blood Transfusions ◽  
Cross Sectional ◽  
Paediatric Patients ◽  
The Mean

Background: Paediatric patients with transfusion dependent thalassemia require regular lifelong red cell transfusions. Blood transfusions increase the risk of iron overload, which can lead to cardiac hemosiderosis. Serum ferritin can be a parameter for evaluating systemic hemosiderosis. Objective: To evaluate the correlation between serum ferritin levels and impaired heart function in children with transfusion dependent thalassemia Methods: A cross sectional study was conducted with transfusion-dependent thalassemia who attended a cardiology and hemato-oncology outpatient clinic from January to December 2018 and had undergone more than 10 transfusion periods. Serum ferritin levels were taken from the mean of 3 measurements before echocardiography. Echocardiography examination was performed by a cardiologist using a 3D Doppler tool to evaluate ejection fraction (EF), tricuspid annular plane systolic excursion (TAPSE) and E / A ratio by calculating the initial diastole (E wave) and atrial contraction (wave A). Data analysis used the Spearman correlation with p <0.05. Results: There were 45 children with a median age of 10 (2-17) years and had received a median of 18 (10-51) blood transfusions. The mean serum ferritin level was 4,321 (1,168-15,233) ng / mL. Blood transfusion frequency was associated with an increase in serum ferritin (rho 0.74, P <0.005). From echocardiography examination, approximately 3/45 children had a feature of dilated cardiomyopathy. The mean value of EF 70 (SD 14.32), TAPSE 1.97 (SD 0.57) cm and an E / A ratio 1.68 (SD 0.46). Serum ferritin was negatively correlated with the ejection fraction (rho = -0.78, P <0.001), TAPSE (rho = -0.65, P <0.001) but positively correlated with the E / A ratio (rho = 0.67, P <0.001). Conclusion: Paediatric patients with TDT have decreased cardiac systolic and diastolic function, and serum ferritin correlates with the decreased cardiac function.

scholarly journals Evaluation of Serum Ferritin in Hospitalized Patients with COVID-19 as A Potential Biomarker for Assessing COVID-19 Severity

2021 ◽  
Vol 39 (4) ◽  
pp. 220-224
Author(s):  
Colonel Lubna Naznin ◽  
Susane Giti ◽  
Arif Ahmed Khan ◽  
Yasmin Akter ◽  
Mimi Parvin ◽  
...  
Keyword(s):  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Virus Disease ◽  
Ferritin Level ◽  
Armed Forces ◽  
Military Hospital ◽  
P Value ◽  
Cross Sectional ◽  
Icu Patients ◽  
Potential Biomarker

Introduction: Corona virus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), has become global pandemic. Proinûammatory mediator, serum ferritin is reported to be elevated significantly by different studies in COVID-19. Our study was aimed to find whether serum ferritin level can be employed as a biomarker to assess the disease severity in COVID-19 cases. Methods: This cross sectional observational study was carried out at Armed Forces Institute of Pathology (AFIP), a tertiary referral laboratory between 15 March 2020 and 15 June 2020. Total 2418 hospitalized RT-PCR confirmed COVID- 19 patients from Combined Military Hospital (CMH) were included in our study. Serum ferritin was measured by electrochemiluminescence immunoassay and was compared between the severe and non-severe groups. P-value < 0.05 was considered statistically significant. Results: Total patients were 2418, among them 337 (13.9%) from intensive care unit (ICU) and 2081 (86.1%) from non- ICU. Median age and IQR were 60.5 (51.5–68.0) years in ICU patients versus 38.0 (28-46.1) years in non-ICU patients (p <0.0001). Most (86.8%) patients were males; 82.8% in ICU and 87.5% in non-ICU. Serum ferritin was significantly higher (p<0.0001) in ICU patients; median and IQR was 952.8 (529.9 - 1520.5) ng/mL versus 254.2 (156.1 - 441.9) ng/mL (p <0.0001) in non-ICU patients. Serum ferritin, at cut off value (COV) <550 ng/mL had sensitivity 82.36% and specificity 73.59% for categorization of COVID-19 cases as non-severe. Comparison of proportions of ICU and non-ICU patients was found highly significant (p <0.0001 at 95% confidence interval) with this cut off value. Conclusions: Serum ferritin level was significantly high among COVID-19 patients requiring ICU admission than non-ICU cases. Serum ferritin may be used for categorizing COVID-19 patients. Cut off value 550 ng/mL can be meaningfully used for this categorization, above which should be considered severe and need more careful monitoring. J Bangladesh Coll Phys Surg 2021; 39: 220-224

scholarly journals Evaluating iron deficiency anaemia in the third trimester of pregnancy with haematological parameters and serum ferritin concentration

2019 ◽  
Vol 8 (9) ◽  
pp. 3744
Author(s):  
Niranjani Selva Muthukumaran ◽  
Radha B. P. Thangappah ◽  
Amrin Azad ◽  
Kesari Sravaniy
Keyword(s):  
Iron Deficiency ◽  
Serum Ferritin ◽  
Iron Deficiency Anaemia ◽  
Ferritin Level ◽  
Haematological Parameters ◽  
Third Trimester ◽  
Ferritin Concentration ◽  
Deficiency Anaemia ◽  
The Third ◽  
The Mean

Background: Iron deficiency is the commonest cause of anaemia and at least half of anaemia cases will have causes other than iron deficiency. The objective of this study was to determine the prevalence of iron deficiency anaemia among antenatal mothers based on haematological parameters and serum ferritin levels.Methods: This was a hospital based cross sectional study, conducted at Meenakshi Medical College and Research Institute, Kancheepuram from January 2017 to June 2018. Two hundred antenatal mothers who were diagnosed with anaemia in the third trimester of pregnancy were evaluated by haematological parameters and serum ferritin assay.Results: 38% of women had mild anaemia, 50% had moderate anaemia and 12% had severe anaemia. On peripheral smear, 60% had microcytic hypochromic anaemia indicating iron deficiency, and 12% had megaloblastic anaemia. In 41% of cases, the mean corpuscular volume was <82fL indicative of iron deficiency. Among the 120 women diagnosed with iron deficiency anaemia on smear, the mean ferritin level was 16.62±73.42 (less than 30µg/l). There was a statistically significant low levels of serum ferritin levels in those diagnosed with iron deficiency anaemia (P < 0.05). The serum ferritin level was >160µg/lit in 19% of cases.Conclusions: Based on the haematological parameters and serum ferritin estimation, in 60% of cases, anaemia was due to iron deficiency. Before initiating treatment, it is important to differentiate various types of anaemia, so that appropriate treatment can be given.

Serum ferritin level of transfusion dependent thalassaemia patients- A Single Centre Study

2021 ◽  
Vol 5 (02) ◽  
pp. 47-49
Author(s):  
Khaza Amirul Islam ◽  
Saqi Md. Abdul Baqi ◽  
Md. Arif-Ur- Rahman ◽  
Md. Shafiul Azam ◽  
Mahbuba Sharmin ◽  
...  
Keyword(s):  
Serum Ferritin ◽  
Selection Criteria ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
Cross Sectional Study ◽  
Single Centre ◽  
Cross Sectional ◽  
Iron Load ◽  
Single Centre Study ◽  
The Mean

The aim of the study was to determine serum ferritin level in transfusion dependent thalassaemia patients. A total of 64 transfusion dependent thalassaemia (TDT) patients was included in this cross sectional study from April, 2018 to September, 2019 according to selection criteria. Body iron load was estimated by serum ferritin level.  The study sample consisted of 43 male and 21 female TDT patients, with a mean age of 25.5 years. Most of the patients (43.8%) patients had serum ferritin level in between 1000-2500 ng/ml. 12 patients (18.7%) had serum ferritin level >5000 ng/ml and 3 patients (4.7%) had serum ferritin in between 2501-5000 ng/ml. The mean serum ferritin was found 2462.6 ± 2792.7ng/ml with range from 207.0 -11891.2ng/m.

Prevalence of iron deficiency in cancer patients: The French prospective CARENFER study.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e15617-e15617
Author(s):  
Elisabeth Luporsi ◽  
Aurelien Carnot ◽  
Vincent Massard ◽  
Sophie Morin ◽  
Bruno Chauffert ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Cancer Patients ◽  
Iron Deficiency Anemia ◽  
Serum Ferritin ◽  
Malignant Tumors ◽  
Ferritin Level ◽  
Deficiency Anemia ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Ferritin Concentration

e15617 Background: Despite the potential deleterious consequences of iron deficiency (ID) in patients with cancer, under-diagnosis is frequent and existence of ID based on both serum ferritin concentration and transferrin coefficient saturation (TSAT) index is rarely determined. The CARENFER Study aimed to assess prospectively the prevalence of ID, anemia and iron deficiency anemia (IDA) in cancer patients. Methods: The study was conducted in France from May to July 2019, as a prospective cross-sectional survey carried out in 15 oncology units. The analysis focused on 1221 patients with different types of solid malignant tumors. Serum ferritin and iron concentrations, TSAT index and hemoglobin (Hb) level were determined. Based on ESMO 2018 Guidelines, ID was defined as ferritin < 100 μg/L or TSAT < 20%, and then categorized as either absolute ID (ferritin < 100 μg/L) or functional ID (ferritin ≥ 100μg/L and TSAT < 20%). Anemia was defined as Hb level ≤ 11 g/dL. Iron deficiency anemia (IDA) was defined according to ESMO 2018 Guidelines. The prevalence of ID, anemia and IDA was estimated using Agresti-Coull 95% confidence interval. Results: Patient’s median age was 63 years (55% women and 45% men). 89.4% of patients were currently under treatment for their cancer, mainly by chemotherapy (75.4%). The proportion of cancer patients with ferritin level < 100 μg/L was 20.5% [18.3-22.9] and 50.6% [47.8-53.4] of patients had a TSAT index < 20%. Overall, ID was found in 57.9% [55.1-60.6] of patients, with absolute ID accounting for 36% of all ID cases. 36.0% of patients were anemic and among them, IDA was reported in 21.8% [19.6-24.2] of patients. The type of cancer treatment did not influence the ID status as ID was also present in 57.4% of untreated cancer patient. Conclusions: This study highlights the high prevalence of ID in cancer patients, whether or not concomitantly associated with anemia or treatment. These results emphasize the need to better management of ID in cancer thereby optimizing overall patient care. Clinical trial information: NCT03924271.

scholarly journals To Correlate Serum Ferritin Levels with Clinical Outcome in Covid-19 Patients

2021 ◽  
Vol 12 (5) ◽  
pp. 25-29
Author(s):  
Avinash Hanbe Rajanna ◽  
Ravi Krishnegowda ◽  
Rohith Maraludevanapura Govindaiah
Keyword(s):  
Serum Ferritin ◽  
Cytokine Storm ◽  
Single Center ◽  
Rt Pcr ◽  
Chain Reaction ◽  
Cross Sectional ◽  
Male Preponderance ◽  
The Mean ◽  
Polymerase Chain

Background: COVID-19 a pandemic, affecting worldwide causing significant morbidity and to some extent mortality needs to be evaluated and urgently identify reliable predictors of disease severity and outcome. The fatal outcomes by COVID-19 are accompanied by cytokine storm syndrome. The cytokine storm is determined by serum ferritin. Aims and Objective: To determine the role of Serum ferritin in assessing the severity and outcome of COVID-19. Materials and Methods: A single-center, cross-sectional, observational study was conducted among SARS-CoV-2 infected patients from March 2020 to May 2020. The diagnosis was confirmed by real-time polymerase chain reaction (RT-PCR). Serum ferritin levels were compared with the treatment outcomes of COVID-19 positive patients. Results: A total of 1977 COVID-19 patients were studied. The mean age was 43.89±15.58 years and had male preponderance of 61.56% of the total subjects. The mean serum ferritin levels among recovered and expired patients were 1225.6 ± 2502.91 ng/ml and 285.71 ± 391.99 ng/ml, respectively. Conclusion: Serum ferritin was markedly increased in COVID-19 patients who could not survive as compared to the patients who finally recovered from the infection, proving it as a useful marker for assessing the severity of COVID-19.

scholarly journals Iron status in women using oral contraceptives

2014 ◽  
Vol 26 (1-2) ◽  
pp. 25-29 ◽  
Author(s):  
Tahmina Yeasmin ◽  
Md. Shahidul Haque ◽  
Shahanara Yeasmin ◽  
Md. Ruhul Amin
Keyword(s):  
Serum Ferritin ◽  
Iron Status ◽  
Ferritin Level ◽  
Oral Contraceptive Pill ◽  
The Body ◽  
Cross Sectional ◽  
Medical College ◽  
Beneficial Effects ◽  
The Mean ◽  
The Difference

Objectives: To assess the iron status of women using oral contraceptive pill (OCP) and compare this status with that of women of non-OCP users. Methods: This prospective cross-sectional comparative study was done in Dhaka Medical College from January 2006 to December 2006. Total 61 apparently healthy women of low socioeconomic class, age ranged 20-40 years were selected from different areas of Dhaka city. Of them 41 women were OCP users (Study group) and 20 women were non-OCP users (for comparison). OCP users again subdivided into subgroups according to duration of OCP use. Serum ferritin and haemoglobin level were taken as parameters of iron status in both groups. Statistical analysis was done by the SPSS 12.0 programme. Results: The mean (±SD) of serum ferritin level were 59.45±24.79ng/ml and 77.36±35.16 ng/ml in non-OCP & OCP users respectively. The difference of mean (±SD) of serum ferritin levels were significant (p:<0.05) between two groups. The mean (±SD) of haemoglobin levels were 11.54±0.76gm/dl and 12.04±0.79gm/dl in non-OCP user and OCP users respectively. The difference of mean (±SD) were significant (p:<0.05) between two groups. Levels of serum ferritin & haemoglobin were 19ng/ml and 10.95gm/dl respectively in women using OCP for 1 year. But their levels became 144 ng/ml and 13.95gm/dl respectively in women using OCP for 12 years. Conclusion: This study suggests that OCP use raises serum ferritin and haemoglobin levels and thus has beneficial effects on iron status of the body. http://dx.doi.org/10.3329/bjpp.v26i1-2.19963 Bangladesh J Physiol Pharmacol 2010; 26(1&2) : 25-29

scholarly journals The Iron Status of Sickle Cell Anaemia Patients in Ilorin, North Central Nigeria

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Musa A. Sani ◽  
James O. Adewuyi ◽  
Abiola S. Babatunde ◽  
Hannah O. Olawumi ◽  
Rasaki O. Shittu
Keyword(s):  
Sickle Cell ◽  
Serum Ferritin ◽  
Transferrin Receptor ◽  
Sickle Cell Anaemia ◽  
Iron Status ◽  
Serum Transferrin ◽  
Cross Sectional ◽  
Serum Transferrin Receptor ◽  
Iron Deficient ◽  
The Mean

Objectives. Sickle cell anaemia (SCA) is one of the commonest genetic disorders in the world. It is characterized by anaemia, periodic attacks of thrombotic pain, and chronic systemic organ damage. Recent studies have suggested that individuals with SCA especially from developing countries are more likely to be iron deficient rather than have iron overload. The study aims to determine the iron status of SCA patients in Ilorin, Nigeria.Methods. A cross-sectional study of 45 SCA patients in steady state and 45 non-SCA controls was undertaken. FBC, blood film, sFC, sTfR, and sTfR/log sFC index were done on all subjects.Results. The mean patients’ serum ferritin (589.33 ± 427.61 ng/mL) was significantly higher than the mean serum ferritin of the controls (184.53 ± 119.74 ng/mL). The mean serum transferrin receptor of the patients (4.24 ± 0.17 μg/mL) was higher than that of the controls (3.96 ± 0.17 μg/mL) (p=0.290). The mean serum transferrin receptor (sTfR)/log serum ferritin index of the patients (1.65 ± 0.27 μg/mL) was significantly lower than that of the control (1.82 ± 0.18 μg/mL) (p=0.031).Conclusion. Iron deficiency is uncommon in SCA patients and periodic monitoring of the haematological, biochemical, and clinical features for iron status in SCA patients is advised.

Iron Chelation Treatment with Oral Solution of Deferiprone in Young Children with Hemoglobinopathies,

Blood ◽  
2011 ◽  
Vol 118 (21) ◽  
pp. 3204-3204
Author(s):  
Alexandros Makis ◽  
Nikolaos Chaliasos ◽  
Antigone Siamopoulou
Keyword(s):  
Young Children ◽  
Serum Ferritin ◽  
Iron Chelation ◽  
Oral Solution ◽  
Beta Thalassemia ◽  
Ferritin Concentration ◽  
Safety And Efficacy ◽  
Serum Ferritin Concentration ◽  
Daily Dose ◽  
The Mean

Abstract Abstract 3204 Background - Aim. Children with transfusion dependent hemoglobinopathies rapidly develop iron overload in vital organs and iron removal with chelating agents is required early in life and in some cases after the age of 2. The oral administration of iron chelation is most welcome by thalassemic children and their parents who have problems with the discomfort and side effects of deferoxamine injections. Deferiprone, previously only in tablet form, was not suitable for young children under the age of 5 years. Recently the solution form of deferiprone has been introduced. There are limited clinical data on the safety and efficacy of deferiprone at a very young age. The aim of our study was the presentation of data regarding the safety and efficacy of liquid oral solution of deferiprone in young children with hemoglobinopathies less than 10 years old. Patients and methods. Nine young children (5 boys, 4 girls) receiving oral solution of deferiprone (Ferriprox® 100 mg/mL) were studied. The mean age at the beginning of the treatment was 6.5 (range 2–10). Six children had beta-thalassemia major, 1 thalassemia intermedia and 2 sickle cell/beta thalassemia. The mean number of red blood cell transfusions during the previous year was 10.6 (range 8–15). All the children had chronic iron overload requiring chelation therapy, as defined by serum ferritin concentration [mean ± standard error (SE): 2440±1275 μg/L]. All children were naïve to iron chelation therapy before this study, except for 2 patients who were on deferoxamine (mean dose=35 mg/kg/day; mean duration of use=1.5 years). One child was splenectomized. All children had negative anti-hepatitis C antibody status at baseline. Treatment was initiated at a daily dose of 50 mg/kg, divided into 3 doses, for the first 2 weeks. The dose was increased to 75 mg/kg, for another 2 weeks. If serum ferritin concentration at baseline was greater than 2500 μg/L, the dose was further increased to a total daily dose of 100 mg/kg after 4 weeks therapy. After initiation of the treatment, full blood count was assessed weekly, serum ferritin monthly, and liver and renal function bimonthly. The mean duration of treatment was 9.5 months (range 2–15 months). To evaluate the efficacy and safety of oral deferiprone treatment, biochemical parameters such as serum ferritin and liver enzymes were analyzed using the Student t-test. All parameters are presented as mean± SE. P-values less than 0.05 were considered statistically significant. Results. All children received the oral deferiprone without any problems of compliance. The hematological and biochemical markers during treatment are shown in Table 1. Adverse reactions to deferiprone were mild and transient: abdominal discomfort and diarrhea at initiation of therapy (1 child) and mild neutropenia (1 child) resolved within 8 days with no need of discontinuation of treatment. Deferiprone oral solution was effective in reducing serum ferritin (mean±SD) (initial 2440±1275 μg/L vs final 2030±915 μg/L, p<0.005) (Figure 1). Five children of the study were <6 years old. The baseline serum ferritin of these children was significantly lower than older children (2250 μg/L±880 vs 2950 μg/L±1550, p<0.005). The differences in changes in serum ferritin did not reach statistical significance. Conclusions. This small study shows that oral solution of deferiprone was well tolerated by young children and its use was not associated with major safety concerns. Furthermore, it was effective in decreasing serum ferritin. Further studies with large number of patients and longer follow-up, are needed to confirm the safety and efficacy profile of deferiprone in childhood. Disclosures: No relevant conflicts of interest to declare.

Sign in / Sign up

Export Citation Format

Share Document