Pulmonary Phaehyphomycosis in Retroviral Disease Patient

Pulmonary phaeohyphomycosis is a rare infection in the lung caused by black fungi containing a cytoplasmic melanin-like pigment. A 42-year-old man with underlying retroviral disease on HAART was investigated for having constitutional symptoms. Despite undetectable viral load and a high CD4 count, he was found to have unexplained significant loss of weight and appetite over a period of 6 months. Clinical examination revealed a cachexic man with multiple inguinal lymphadenopathies. Excisional biopsy of the inguinal lymph node revealed reactive follicular hyperplasia. CT Thorax, Abdomen and Pelvis was arranged to look for occult malignancy or infection and he was found to have multiple non-enhancing subcentimeter lung nodules mainly at the lateral segment of the right middle lobe of his lung. The largest nodule measured about 0.8 x 1.5 x 0.5 (AP x W x CC), with some nodules having an irregular margin with no extension into the adjacent bronchi. Bronchoscopy was done and demonstrated a black patch at the right intermedius, lateral segment of the middle lobe which did not disappear upon bronchial flush or wash. Histopathological examination found focal areas of blackish pigment and the bronchial alveolar lavage sent for fungal culture grew Cladosporium species. The patient was treated with oral Itraconazole with marked clinical improvement. This case highlights an unusual black fungi infection in the lung that stands out not only for its rarity and it's responsiveness to treatment, but also the susceptibility of an RVD positive patient to this infection despite having suppressed viral load and normal CD4 count.International Journal of Human and Health Sciences Supplementary Issue-2: 2021 Page: S17

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Testicular pain as an atypical presentation of sarcoidosis

Annals of The Royal College of Surgeons of England ◽

10.1308/rcsann.2019.0015 ◽

2019 ◽

Vol 101 (4) ◽

pp. e99-e101

Author(s):

F Chierigo ◽

HM Alnajjar ◽

A Haider ◽

M Walkden ◽

T Shaikh ◽

...

Keyword(s):

Small Volume ◽

Histopathological Examination ◽

Granulomatous Inflammation ◽

Middle Lobe ◽

Atypical Presentation ◽

Ultrasound Guided ◽

Testicular Pain ◽

Tract Involvement ◽

Testicular Lesions ◽

The Right

Sarcoidosis is a systemic granulomatous disease, with genitourinary tract involvement being very rare (0.2% of all sarcoidosis cases). Genitourinary sarcoidosis may present with a scrotal mass with or without testicular pain, often mimicking epididymo-orchitis or malignancy. Only 8 cases of genitourinary sarcoidosis have been reported in the literature in the last 14 years. We describe the case of a 25-year-old man who was referred with testicular pain. Scrotal ultrasonography demonstrated multiple bilateral hypoechoic testicular lesions that were of similar size and distributed unusually throughout the testicular parenchyma. Computed tomography detected a nodule in the middle lobe of the right lung, multiple small volume nodes in the retrocaval and left para-aortic regions, and enlarged bilateral external iliac and inguinal nodes, similar to those found in metastatic testicular cancer. Following ultrasound guided excision of one of the lesions, histopathological examination confirmed granulomatous inflammation consistent with sarcoidosis.

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Congenital lobar emphysema mimicking as persistent pneumonia in a newborn

Clinics and Practice ◽

10.4081/cp.2011.e101 ◽

2011 ◽

Vol 1 (4) ◽

pp. 101 ◽

Cited By ~ 2

Author(s):

Sriparna Basu ◽

Aditya Kumar Gupta ◽

Ashok Kumar

Keyword(s):

Respiratory Distress ◽

Histopathological Examination ◽

Middle Lobe ◽

Congenital Lobar Emphysema ◽

Mediastinal Shift ◽

Common Causes ◽

Lobar Emphysema ◽

Female Baby ◽

The Right ◽

High Index Of Suspicion

Congenital lobar emphysema (CLE) is an uncommon congenital malformation of the lung that can present with respiratory distress in early life. We report a full term female baby who presented with intermittent bluish discoloration of the lips and extremities during crying since birth. An initial diagnosis of left sided collapse-consolidation with right-sided compensatory emphysema was made from chest xray. When no improvement was noted after intravenous antibiotic therapy for 7 days, computerized tomographic scan of thorax was done which showed emphysema of the right middle lobe with transherniation and mediastinal shift to the left. Right middle lobectomy was done and postoperative period was uneventful. Histopathological examination of the specimen confirmed the diagnosis of CLE. CLE can mimic more common causes of respiratory distress in neonatal period and needs a high index of suspicion for diagnosis. Early diagnosis and effective surgical treatment is curative.

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CT scan shows a 9.5 mm solid nodule in the posterior segment of the right upper lobe and another 7.3 mm nodule on the lateral segment of the middle lobe

ASVIDE ◽

10.21037/asvide.2016.345 ◽

2016 ◽

Vol 3 ◽

pp. 345-345

Author(s):

Ricardo Buitrago ◽

Adriana Serna ◽

Diego González-Rivas ◽

Rafael Beltrán ◽

Carlos Mario Palacio ◽

...

Keyword(s):

Ct Scan ◽

Middle Lobe ◽

Posterior Segment ◽

Lateral Segment ◽

Solid Nodule ◽

The Right

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KASUS KROMOBLASTOMIKOSIS PADA SEORANG PEREMPUAN

JURNAL BIOMEDIK (JBM) ◽

10.35790/jbm.7.1.2015.7294 ◽

2015 ◽

Vol 7 (1) ◽

Author(s):

Mariani V. Lasut ◽

Rita S. Tanamal ◽

Grace M. Kapantow

Keyword(s):

Tissue Culture ◽

Physical Examination ◽

Histopathological Examination ◽

Fungal Culture ◽

Fonsecaea Pedrosoi ◽

Patient Will ◽

The Right ◽

Histopathology Examination ◽

Hard Consistency ◽

Test Tissue

Abstract: Chromoblatomycosis is a chronic fungal infection in the skin and subcutaneus tissue caused by pigmented fungi. It occurs most in males in tropical and subtropical countries. The causal fungi were found isolated in woods, decomposed plants, and soil. Early lesions manifest as papules that become hypertrophy plaques, and in years they develop to become hyperkeratotic masses. Chromoblastomycosis is difficult to treat. We reported a female of 37 years with lesions on the right foot for 20 years in the forms of plaques, papulonodules, multiple verrucous lesions. Lesions had hard consistency and were associated with erosion, crustae, and minimal pus. Several supporting tests were carried out. KOH 20% test resulted in sclerotic bodies; fungal culture revealed Fonsecaea pedrosoi; and histopathological examination showed chronic granulomatous inflamation. The patient was treated with itraconazole 2 x 200 mg daily, which was planned for 8-12 months. After 2 months of treatment, the lesions improved. Conclusion: Based on anamnesis, physical examination, KOH test, tissue culture, and histopathology examination, this case was diagnosed as chromoblatomycosis. Fonsecaea pedrosoi was found as the causative agent. Oral antimycotic itrakonazole 2 x 200 mg/day showed lesion improvement after 2 months of treatment. The patient will be evaluated until full treatment has been achieved. Keywords: chromoblastomycosis, Fonsecaea pedrosoi, itrakonazole Abstrak: Kromoblastomikosis merupakan infeksi jamur kronis pada kulit dan jaringan subkutan, disebabkan jamur berpigmen, umumnya pada laki-laki, banyak ditemukan di daerah tropis/subtropis, terisolasi di lingkungan dari kayu, sisa tanaman, dan tanah. Lesi awal berupa papul yang membesar membentuk plak hipertrofi dalam beberapa tahun menjadi massa hiperkeratotik. Kromoblastomikosis sukar disembuhkan. Kami melaporkan seorang perempuan 37 tahun dengan lesi pada kaki kanan sejak 20 tahun lalu berupa plak, papulonodul, verukous multipel, konsistensi keras, disertai erosi, krusta, pus yang minimal. Pada pemeriksaan KOH 20% didapatkan badan sklerotik, pemeriksaan kultur jamur ditemukan Fonsecaea pedrosoi, histopatologis menunjukkan radang kronik granulomatik. Terapi itrakonazole 2x200 mg/hari akan diberikan selama 8–12 bulan. Setelah 2 bulan pengobatan terdapat perbaikan. Simpulan: Pada kasus ini, diagnosis kromoblastomikosis ditegakkan berdasarkan anamnesis, pemeriksaan fisik, dan pemeriksaan penunjang berupa KOH, kultur jaringan, dan histopatologi. Hasil kultur menunjukkan Fonsecaea pedrosoi sebagai penyebab kromoblastomikosis. Pemberian antimikotik oral itrakonazole 2 x 200 mg/hari menunjukkan perbaikan setelah 2 bulan pengobatan. Evaluasi akan terus dilanjutkan sampai pengobatan selesai. Kata kunci: kromoblastomikosis, Fonsecaea pedrosoi, itrakonazole

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Mesenchymal Cystic Hamartoma Presenting with Spontaneous Pneumothorax

Canadian Respiratory Journal ◽

10.1155/2003/595082 ◽

2003 ◽

Vol 10 (5) ◽

pp. 280-281 ◽

Cited By ~ 7

Author(s):

J Glezos ◽

D Toppin ◽

T Cooney

Keyword(s):

Computed Tomography ◽

Spontaneous Pneumothorax ◽

Histopathological Examination ◽

Wedge Resection ◽

Middle Lobe ◽

Malignant Potential ◽

Right Middle Lobe ◽

The Right ◽

Mesenchymal Cystic Hamartoma ◽

Cystic Hamartoma

A 53-year-old woman presented with a spontaneous right-sided pneumothorax. Computed tomography chest scan demonstrated a large bulla involving the right middle lobe. Recurrence of the pneumothorax after initial closed chest tube drainage necessitated thoracotomy and wedge resection. Histopathological examination revealed features consistent with a benign mesenchymal cystic hamartoma. Pneumothorax is a recognized complication of mesenchymal cystic hamartoma, a lesion that also has malignant potential.

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Emphysematous lesions in the right cranial lung lobe and torsion of the right medial lung lobe in a British shorthair cat: a case report

Veterinární Medicína ◽

10.17221/8586-vetmed ◽

2017 ◽

Vol 60 (No. 12) ◽

pp. 706-711 ◽

Cited By ~ 1

Author(s):

Z. Dokic ◽

W. Pirog

Keyword(s):

Histopathological Examination ◽

Serum Biochemistry ◽

Postoperative Recovery ◽

Clinical Findings ◽

Acute Onset ◽

Middle Lobe ◽

Venous Flow ◽

Lung Lobe ◽

The Right ◽

Lung Lobes

A three-year-old male British shorthair cat that had exhibited progressive lethargy and intermittent dyspnoea for 14 days was referred for evaluation of acute respiratory deterioration. Clinical findings included rapid and shallow breathing, pale mucous membranes, sound suppression on the right side, and a subcutaneous haematoma in the right epigastric area. Serum biochemistry analysis showed leukocytosis and thrombocytosis. Radiographs revealed hydropneumothorax, a broken eighth right rib, atelectatic right cranial lung lobe (RCrL), and consolidation of the right middle lobe (RML). Doppler examination revealed sonographic changes in the echotexture of both lobes and venous flow was absent in the twisted RML. Furthermore, bronchoscopy showed proximal narrowing of the cat’s RML bronchus. Exploratory surgery via medial sternotomy confirmed torsion of the RML and identified deteriorated gas-containing lesions in the collapsed RCrL. Both lung lobes were removed by standard lobectomy, and postoperative recovery was without major complications. Histopathological examination diagnosed multiple bullae and blebs, with significant subpleural haemorrhages in the atelectatic RCrL, whereas tissue congestion with haemorrhages, necrosis, and thrombosis typical for lung lobe torsion were observed in the RML. No other underlying aetiology was apparent. Two months post-operatively, the cat presented with similar acute onset of dyspnoea and spontaneous pneumothorax and was euthanised at the owner’s request. The autopsy revealed identical new emphysematous changes in the contra-lateral lung lobes that had been absent at the time of surgery. Emphysematous lesions, regardless of their origin, should be considered in the etiopathology of lung lobe torsion.

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Popliteal artery thrombosis secondary to a tibial osteochondroma

VASA ◽

10.1024/0301-1526/a000101 ◽

2011 ◽

Vol 40 (3) ◽

pp. 251-255 ◽

Cited By ~ 4

Author(s):

Gruber-Szydlo ◽

Poreba ◽

Belowska-Bien ◽

Derkacz ◽

Badowski ◽

...

Keyword(s):

Case Report ◽

Magnetic Resonance Angiography ◽

Popliteal Artery ◽

Doppler Ultrasonography ◽

Histopathological Examination ◽

Previous History ◽

Plain Radiography ◽

Artery Thrombosis ◽

History Of ◽

The Right

Popliteal artery thrombosis may present as a complication of an osteochondroma located in the vicinity of the knee joint. This is a case report of a 26-year-old man with symptoms of the right lower extremity ischaemia without a previous history of vascular disease or trauma. Plain radiography, magnetic resonance angiography and Doppler ultrasonography documented the presence of an osteochondrous structure of the proximal tibial metaphysis, which displaced and compressed the popliteal artery, causing its occlusion due to intraluminal thrombosis..The patient was operated and histopathological examination confirmed the diagnosis of osteochondroma.

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Successful Control of a Co-Infection Caused by Candida albicans and Pseudomonas aeruginosa in Keratitis

Infectious Disorders - Drug Targets ◽

10.2174/1871526520666200318111957 ◽

2020 ◽

Vol 20 ◽

Author(s):

Debarati Paul ◽

Suman Saha ◽

Neelam Singh ◽

Jayansgu Sengupta ◽

Santi M. Mandal

Keyword(s):

Pseudomonas Aeruginosa ◽

Candida Albicans ◽

Histopathological Examination ◽

Specific Interaction ◽

Major Threat ◽

Effective Combination ◽

Male Farmer ◽

Successful Control ◽

The Right ◽

Corneal Button

Introduction: Nowadays, co-infection by interspecific organisms is major threat in infection control. To identify the effective combination of drugs to control the keratitis caused by Candida albicans with Pseudomonas aeruginosa are attributed in this study. Materilas and Methods: The patient of a 47 years old male farmer with infection in the right eye which showed redness and watering was treated with fortified cefazolin and fortified tobramycin before referral. No pigmentation or vascularisation was noted. The excised corneal button was also subjected to microbiological and histopathological examination. Results: A rare case of keratitis caused by co-infection of Candida albicans with Pseudomonas aeruginosa was identified. Results confirmed the inter-specific interaction of the two microorganisms. Conclusion: Cases of co-infection by Candida and Pseudomonas are not abundantly reported and difficult to treat. In this case, treatment involved Amphotercin-B and ciprofloxacin, effectively eradicated the infection. This therapy may be successfully implied for such cases of co-infection in future.

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Biochemical and Histopathological Evaluation of the Radioprotective Effects of Melatonin Against Gamma Ray-Induced Skin Damage

Current Radiopharmaceuticals ◽

10.2174/1874471012666181120163250 ◽

2019 ◽

Vol 12 (1) ◽

pp. 72-81 ◽

Cited By ~ 11

Author(s):

Dheyauldeen Shabeeb ◽

Masoud Najafi ◽

Ahmed Eleojo Musa ◽

Mansoor Keshavarz ◽

Alireza Shirazi ◽

...

Keyword(s):

Gamma Ray ◽

Histopathological Examination ◽

Radical Scavenging ◽

Limiting Factor ◽

Skin Damage ◽

Exposed Skin ◽

Male Wistar Rats ◽

Time Periods ◽

Skin Damages ◽

The Right

Background:Radiotherapy is one of the treatment methods for cancers using ionizing radiations. About 70% of cancer patients undergo radiotherapy. Radiation effect on the skin is one of the main complications of radiotherapy and dose limiting factor. To ameliorate this complication, we used melatonin as a radioprotective agent due to its antioxidant and anti-inflammatory effects, free radical scavenging, improving overall survival after irradiation as well as minimizing the degree of DNA damage and frequency of chromosomal abrasions.Methods:Sixty male Wistar rats were randomly assigned to 4 groups: control (C), melatonin (M), radiation (R) and melatonin + radiation (MR). A single dose of 30 Gy gamma radiation was exposed to the right hind legs of the rats while 40 mg/ml of melatonin was administered 30 minutes before irradiation and 2 mg/ml once daily in the afternoon for one month till the date of rat’s sacrifice. Five rats from each group were sacrificed 4, 12 and 20 weeks after irradiation. Afterwards, their exposed skin tissues were examined histologically and biochemically.Results:In biochemical analysis, we found that malondialdehyde (MDA) levels significantly increased in R group and decreased significantly in M and MR groups after 4, 12, and 20 weeks, whereas catalase (CAT) and superoxide dismutase (SOD) activities decreased in the R group and increased in M and MR groups during the same time periods compared with the C group (p<0.05). Histopathological examination found there were statistically significant differences between R group compared with the C and M groups for the three different time periods (p<0.005, p<0.004 and p<0.004) respectively, while R group differed significantly with MR group (p<0.013). No significant differences were observed between C and M compared with MR group (p>0.05) at 4 and 20 weeks except for inflammation and hair follicle atrophy, while there were significant effects at 12 weeks (p<0.05).Conclusion:Melatonin can be successfully used for the prevention and treatment of radiation-induced skin injury. We recommend the use of melatonin in optimal and safe doses. These doses should be administered over a long period of time for effective radioprotection and amelioration of skin damages as well as improving the therapeutic ratio of radiotherapy.

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Stereotactic Body Radiotherapy of a Solitary Metachronous Sphenoid Metastasis from Renal Cell Cancer: A Case Report

Case Reports in Oncology ◽

10.1159/000513743 ◽

2021 ◽

pp. 269-273

Author(s):

Charles Marchand Crety ◽

Estelle Vigneau ◽

Camille Invernizzi

Keyword(s):

Renal Cell Cancer ◽

Renal Cell ◽

Stereotactic Body Radiation Therapy ◽

Clinical Presentation ◽

Histopathological Examination ◽

Cell Cancer ◽

Papillary Renal Cell Carcinoma ◽

Complete Response ◽

Resonance Imaging ◽

The Right

Nasosinus metastases from kidney cancer are an unusual clinical presentation although some cases are reported in the literature. Among these cases, sphenoidal metastases are even rarer. Here we report a case of lone sphenoid metastasis in patients with papillary renal cell cancer. Eight months after radical nephrectomy, the patient presented with progressively worsening diplopia. Magnetic resonance imaging showed a mass in the right sphenoid sinus. Histopathological examination of the biopsy sample confirmed diagnosis of sinonasal metastasis from papillary renal cell carcinoma. The patient was declined for surgical management and received stereotactic body radiation therapy. Reassessment MRI at 4 months showed a complete response of the treated sphenoid lesion.

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