scholarly journals PHARMACOTHERAPY OF SYSTEMIC AUTOIMMUNE DISEASES IN CONDITIONS OF THE COVID-19 PANDEMIC: INNOVATIVE EXPERIMENTAL STUDY

2021 ◽  
Author(s):  
Ihor Hayduchok
Keyword(s):  
Experimental Study ◽  
Content Analysis ◽  
Autoimmune Diseases ◽  
Discrete Series ◽  
Supply And Demand ◽  
Postgraduate Education ◽  
Dosage Forms ◽  
Systemic Autoimmune Diseases ◽  
Medical Academy ◽  
Coronavirus Infection

The article presents the results of an innovative experimental study of pharmacotherapy of systemic autoimmune diseases in a pandemic of coronavirus infection is a timely and socially oriented way. The methodology of conducting a content analysis based on the theoretical principles of pharmaceutical and medical law and its components. Author used the method of drug selection developed by the Department of Medical and Pharmaceutical Law, General and Clinical Pharmacy of the Kharkiv Medical Academy of Postgraduate Education. Content analysis was performed by dosage forms by grouping them using the Sturgess formula, followed by the construction of discrete series of variations and distribution polygon. Received data made possible to state, that in some circumstances, doctors have a choice of both drugs and dosage forms. However, the data obtained show a lack of balance between supply and demand for patients and physicians. The analysis allows to obtain a complete description of the balance of "supply and demand" between the range and types of dosage forms of drugs INN Silymarin ATC code A05BA03, that approved for use.

scholarly journals INNOVATIVE APPROACHES TO PHARMACOTHERAPY OF SYSTEMIC AUTOIMMUNE DISEASES IN THE CONDITIONS OF THE COVID-19 PANDEMIC

2020 ◽  
pp. 64-74
Author(s):  
I. G. Hayduchok
Keyword(s):  
Content Analysis ◽  
Autoimmune Diseases ◽  
Drug Distribution ◽  
Postgraduate Education ◽  
Health Care Facilities ◽  
Discrete Variation ◽  
Systemic Autoimmune Diseases ◽  
State Register ◽  
Retail Prices ◽  
Innovative Approaches

Introduction. In the current context of the spread of the coronavirus pandemic, the role of pharmacotherapy in the maintenance of immunopathological syndromes among patients with systemic diseases and patients with dual health disorders is growing. The need to adjust the pharmacotherapy regimens of systemic autoimmune diseases arises when addressing issues of quality, economic and physical availability of drugs in accordance with wholesale and retail prices. In continuation of the research, the aim of the work was to study and implement innovative approaches in the pharmacotherapy of systemic autoimmune diseases by content analysis on the example of antiviral drugs for international nonproprietary name (INN) Acyclovir. Materials and methods. The information base of the study consisted of scientific works of foreign and domestic scientists on the topic of the article. The review of scientific sources of literature was carried out taking into account the recommendations of the Cochrane Society for PICO. The names of drugs were systematized by INN, trade names, the number of drugs, dosage forms. For the content analysis, the method of drug selection developed by the Department of Medical and Pharmaceutical Law, General and Clinical Pharmacy of the Kharkiv Medical Academy of Postgraduate Education was used, which included seven criteria. Discussion. At the first stage of the study, a marketing analysis of the range of drugs for INN Acyclovir was performed. Medicines were selected, which according to the State Register of Medicines of Ukraine as of November 2020 were registered and allowed for circulation in health care facilities. After summarizing the processed data, a marketing list of drugs was compiled under the ATC code J05AB01 in accordance with the INN Acyclovir, which has 36 names of drugs. During the study, a discrete variation series of drug distribution was compiled, which indicates that the studied quantitative indicator of drug manufacturers fluctuates within the first group with the highest frequency (fi = 8). A graphic discrete variation in the form of a distribution polygon was created. Conclusions. Innovative approaches to the pharmacotherapy of systemic autoimmune diseases are the use of content analysis as an additional method in the study of pharmacotherapy of drugs. The study is based on the formalized method of qualitative and quantitative analysis of documents, which allows you to get a detailed picture of the selected clinical and pharmacological group of drugs – drugs by INN Aciclovir PBX code J05AB01. The analysis allows obtaining a complete description of the range and manufacturers of drugs approved for use.

scholarly journals ASSESSMENT OF THE STATE OF THE ORGANIZATION OF CIRCULATION AND THE AVAILABILITY OF MEDICINES FOR DIFFERENT CATEGORIES OF PATIENTS AT THE LEVEL OF OBSTETRIC UNITS

2021 ◽  
pp. 62-69
Author(s):  
С. И. Зброжек
Keyword(s):  
Health Care ◽  
Content Analysis ◽  
Primary Health Care ◽  
Discrete Series ◽  
The State ◽  
Primary Health ◽  
Primary Network ◽  
Health Care Unit ◽  
Medium Level ◽  
Coronavirus Infection

Introduction. In the context of the coronavirus infection pandemic, the relevance of increasing the level of availability of medicines for various categories of patients in primary care is becoming crucial. The aim of the work was to process the state of the organization of circulation and the availability of medicines for various clinical and pharmacological groups of patients at the level of obstetric points. Materials and methods. To assess the organization of circulation and the availability of medicines of various clinical-pharmacological, nomenclature-legal and classification-legal groups, a conditional indicator was used – the conditional availability of medicines, calculated using content analysis. To conduct a content analysis, the organization of the regional primary network of medical care was studied; a list of obstetric points was compiled according to a quantitative indicator by grouping using the Sturges formula, followed by the construction of discrete series of variations and a distribution polygon. Results and discussion. Noted that obstetric centers perform socially oriented tasks to increase the level of organization of circulation and the availability of medicines for all contingents of the population on the principles of medical and pharmaceutical law, as the basis of state policy to minimize risks in the organization of pharmaceutical business. According to our own developed methods using content analysis, the structuring of the primary health care with a network of obstetric points at the regional level was carried out and it was established for the overwhelming majority of districts a low, above low and medium level of conditional availability of drugs for patients. Conclusions. The organization of circulation and the availability of drugs for various contingents of the population in the studied regional primary health care network is at the following level: unsatisfactory (for three districts); low (for five districts); higher than low (twelve districts); medium (for five districts); above average (for one district) satisfactory (for one district). Based on the results obtained, it can be concluded that the insufficient number of obstetric points in the regional primary health care unit is an obstacle to the timely provision of the population with high quality, effective and affordable drugs.

Role of Positron Emission Tomography for Central Nervous System Involvement in Systemic Autoimmune Diseases: Status and Perspectives

2018 ◽  
Vol 25 (26) ◽  
pp. 3096-3104 ◽  
Author(s):  
Daniele Mauro ◽  
Gaetano Barbagallo ◽  
Salvatore D`Angelo ◽  
Pasqualina Sannino ◽  
Saverio Naty ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Central Nervous System ◽  
Nervous System ◽  
Autoimmune Diseases ◽  
Pet Imaging ◽  
Emission Tomography ◽  
Cns Involvement ◽  
Systemic Autoimmune Diseases ◽  
Positron Emission

In the last years, an increasing interest in molecular imaging has been raised by the extending potential of positron emission tomography [PET]. The role of PET imaging, originally confined to the oncology setting, is continuously extending thanks to the development of novel radiopharmaceutical and to the implementation of hybrid imaging techniques, where PET scans are combined with computed tomography [CT] or magnetic resonance imaging[MRI] in order to improve spatial resolution. Early preclinical studies suggested that 18F–FDG PET can detect neuroinflammation; new developing radiopharmaceuticals targeting more specifically inflammation-related molecules are moving in this direction. Neurological involvement is a distinct feature of various systemic autoimmune diseases, i.e. Systemic Lupus Erythematosus [SLE] or Behcet’s disease [BD]. Although MRI is largely considered the gold-standard imaging technique for the detection of Central Nervous System [CNS] involvement in these disorders. Several patients complain of neuropsychiatric symptoms [headache, epilepsy, anxiety or depression] in the absence of any significant MRI finding; in such patients the diagnosis relies mainly on clinical examination and often the role of the disease process versus iatrogenic or reactive forms is doubtful. The aim of this review is to explore the state-of-the-art for the role of PET imaging in CNS involvement in systemic rheumatic diseases. In addition, we explore the potential role of emerging radiopharmaceutical and their possible application in aiding the diagnosis of CNS involvement in systemic autoimmune diseases.

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