CEREBRAL VENOUS THROMBOSIS SECONDARY TO SARS-COV-2 INFECTION

Cerebral venous thrombosis (CVT) is a relatively rare form of neurovascular emergency, and may present as headache, seizure, or focal neurological deficit. It typically has a higher occurrence in younger women. Recently, there are increasingly cases of CVTreported in association with COVID-19, which fall outside the typical demographics, suggesting a hyper-coagulable state attributable to COVID-19. Here, we present a case of CVTin a young gentleman with concomitant COVID-19, who presented with first-onset seizure.

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Prognosis of fasting in patients with cerebral venous thrombosis using oral contraceptives

Iranian Journal of Neurology ◽

10.18502/ijnl.v18i2.1293 ◽

2019 ◽

Author(s):

Masoud Ghiasian ◽

Maryam Mansour ◽

Nasrin Moradian

Keyword(s):

Risk Factors ◽

Risk Factor ◽

Venous Thrombosis ◽

Oral Contraceptives ◽

Neurological Deficit ◽

Cerebral Venous Thrombosis ◽

Clinical Presentation ◽

Modified Rankin Scale ◽

Focal Neurological Deficit ◽

Muslim Countries

Background: There have been studies that showed a higher incidence of cerebral venous thrombosis (CVT) in Ramadan, a month in which people fast in Muslim countries, which was associated with increasing use of oral contraceptives (OCPs) in women. We aimed to evaluate the effect and prognosis of fasting in patients with CVT using OCPs. Methods: Consecutive patients with diagnosis of CVT in Sina hospital, Hamadan, West of Iran, from May of 2009 to June of 2016 were evaluated, and women using OCPs were included. Other risk factors except fasting were excluded. Clinical presentation and outcomes of CVT was assessed. Patients were followed up for 12 months. Results: 58 patients were included in this study. 31 of these patients had fasting simultaneously. Fasting in patients using OCPs caused significantly higher focal neurological deficit (64.5%, P = 0.018), and higher hemorrhage (66.7%, P = 0.042). At discharge, 51.6% and after three months, 25.8% of patients with fasting had disability [6 > modified Rankin Scale (mRS) >1]. In patients who used OCPs as sole risk factor, 25.9% at discharge and 11.1% after three months had disability. Conclusion: Fasting in patients with CVT using OCPs causes significant increase in focal neurological deficit and hemorrhage, which also increases the hospital stay and lengthens recovery. However, longterm prognosis and mortality of CVT is similar between the two groups.

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Effect of Silencing Information Regulator on Rat Cerebral Venous Thrombosis Through Regulating Vascular Endothelial Growth Factor

Journal of Biomaterials and Tissue Engineering ◽

10.1166/jbt.2019.2175 ◽

2019 ◽

Vol 9 (11) ◽

pp. 1607-1613

Author(s):

Yan-Qing Liu ◽

Yang Zhao ◽

Yi-Jun Wu ◽

Bo-Feng Liu ◽

Hui-Ping Zhang ◽

...

Keyword(s):

Venous Thrombosis ◽

Water Content ◽

Real Time ◽

Brain Tissue ◽

Neurological Deficit ◽

Real Time Pcr ◽

Cerebral Venous Thrombosis ◽

Vegf Expression ◽

Tissue Water ◽

Sirt1 Expression

Cerebral venous thrombosis (CVST) can cause severe dysfunction and even death. Silencing information regulator (SIRT1) involves in neurodegenerative diseases. However, whether SIRT1 participates in CVST is unclear. SD rats were divided into 3 groups, control group; CVST group and SIRT1 group (transfected with AAV-SIRT1 plasmid) followed by analysis of brain tissue SIRT1 and VEGF expression by Real time PCR, neurological deficit scores and brain tissue water content. Brain vascular endothelial cells (bVECs) were cultured and divided into NC group, SIRT1 group and si-SIRT1 group followed by analysis of cell proliferation by MTT assay, Caspase 3 activity, SIRT1 expression by Real time PCR and Western blot and VEGF expression and secretion by Real time PCR and ELISA. SIRT1 expression was decreased and VEGF expression was increased, along with increased score of neurological deficit and water content of brain tissue in CVST rats. Transfection of AAV-SIRT1 plasmid up-regulated SIRT1 expression in CVST rats, inhibited VEGF expression, improved neurological deficit score and brain tissue water content (P < 0.05). Overexpression of SIRT1 in bVECs significantly decreased cell proliferation, elevated Caspase 3 activity, and decreased VEGF expression and secretion, compared to NC group (P < 0.05). Knockdown of SIRT1 expression in bVECs reversed the above changes (P < 0.05). SIRT1 expression is decreased in CVST rats and up-regulation of SIRT1 can inhibit VEGF expression and improve neurological function. SIRT1 can inhibit the proliferation of bVECs and regulate cerebral venous thrombosis by regulating VEGF.

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Clinical profile of cerebral venous thrombosis in pregnancy and puerperium in South India

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20172946 ◽

2017 ◽

Vol 6 (7) ◽

pp. 3124

Author(s):

Ramasamy Sasikala ◽

Jagan Aishwarya ◽

Syed Dilshath

Keyword(s):

Venous Thrombosis ◽

Cerebral Venous Thrombosis ◽

South India ◽

Total Mortality ◽

Acute Onset ◽

Clinical Profile ◽

Focal Neurological Deficit ◽

Presenting Symptoms ◽

Laboratory Investigations ◽

In Pregnancy

Background: Cerebral venous thrombosis (CVT) is any thrombosis occurring in intracranial veins and sinuses, which is a rare disorder affecting 5 persons per million per year with huge regional variation. Pregnancy and puerperium are the most prevalent prothrombotic states leading to cerebral venous thrombosis. The objective of this study was to analysis the clinical profile of CVT in pregnancy and puerperium.Methods: In this prospective study, we analysed 52 consecutive patients admitted with impairment of consciousness, seizures or focal neurological deficit at our hospital. The diagnosis of CVT was confirmed by neuroimaging. Detailed history, clinical examination and laboratory investigations were carried out in all the cases and analysed.Results: The incidence of CVT associated with pregnancy and puerperium at our Hospital was 3.9 per 1000 obstetric admissions. The age of the patients varied from 18-35 years with a maximum age incidence (77%) in the III decade (21-30 years). The maximum incidence was during the first two weeks of puerperium (61.8%). The most common presenting symptoms were focal or generalised seizures (88.4%) followed by headache (65.3%). In spite of the alarming clinical picture, recovery was rapid and remarkable. Total mortality was 15.5% (8 cases).Conclusions: CVT is more common during the puerperium than in the antenatal period. Obstetric CVT has a more acute onset with excellent recovery when promptly diagnosed and treated.

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ANTICOAGULATION COMPLICATIONS IN A PATIENT WITH PRIOR CEREBRAL VENOUS THROMBOSIS

Romanian Journal of Neurology ◽

10.37897/rjn.2015.2.8 ◽

2015 ◽

Vol 14 (2) ◽

pp. 101-104

Author(s):

Ioana Cociasu ◽

◽

Irene Davidescu ◽

Ioan Buraga ◽

Bogdan Ovidiu Popescu ◽

...

Keyword(s):

Venous Thrombosis ◽

Acute Phase ◽

Cerebral Venous Thrombosis ◽

Rare Form

Cerebral venous thrombosis is a rare form of stroke treated with anticoagulant compounds both in the acute phase as well as in long term. We present the case of a 56 year old female that suffered two different forms of stroke in 2 years.

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Transverse sinus thrombosis - a case report

Morecambe Bay Medical Journal ◽

10.48037/mbmj.v5i1.349 ◽

2006 ◽

Vol 5 (1) ◽

pp. 23-24

Author(s):

M Veerasamy ◽

G Cook

Keyword(s):

Venous Thrombosis ◽

Cerebral Venous Thrombosis ◽

Sinus Thrombosis ◽

Transverse Sinus ◽

University Hospitals ◽

Cranial Nerve Involvement ◽

Medical Problems ◽

Focal Neurological Deficit ◽

Uncommon Presentation ◽

Consultant Physician

Cerebral venous thrombosis is an uncommon presentation of stroke and subarachnoid haemorrhage. Cerebral venous thrombosis may present with headache, seizures, cranial nerve involvement or focal neurological deficit. Venous thrombosis may also be associated with pre-existing medical problems, which need to be diagnosed and treated. Gill Cook is a consultant physician with University Hospitals of Morecambe Bay NHS Trust.

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