scholarly journals ONTOGENETIC, BREED, AND SEASONAL FEATURES OF THE SYNTHESIS OF THYROXIN AND CORTISOL IN DOGS AND CATS

Author(s):  
N. V. Efanova ◽  
S. V. Batalova ◽  
L. M. Osina ◽  
Е. D. Naumova

   The article presents data on the breed and seasonal characteristics of the synthesis of thyroxine and cortisol in dogs of different breeds and cats that do not have a breed. It has been shown that the synthesis of thyroxine in dogs and cats depends on the breed, age and season. The functional activity of the thyroid gland in dogs decreases by 10-12, and in cats by 9-13 years of age. The highest level of thyroxine production throughout the entire research period belongs to the Griffon Petit-Brabancons. The synthesis of cortisol in dogs and cats is stable and does not undergo statistically significant changes. Seasonal dynamics of thyroxine is observed in dogs, but absent in cats. No sea-sonal dependence of cortisol synthesis has been reported in dogs and cats.

2017 ◽  
Vol 13 (2) ◽  
pp. 39-44 ◽  
Author(s):  
Andrey Yu. Olkhovik ◽  
Pavel S. Sadovnikov ◽  
Anton V. Vasiliev ◽  
Dmitriy G. Denisov ◽  
Vladimir L. Emanuel

Обоснование. В клинической практике регулярно встречаются ситуации, при которых невозможно взять кровь из периферических вен для проведения лабораторных анализов. При этом проблема сравнительной оценки показателей венозной и капиллярной крови остается недостаточно изученной. Цель. Провести сравнительную оценку 5 лабораторных показателей функции щитовидной железы – свободного Т3 (св.Т3), свободного Т4 (св.Т4), антител к тиреоглобулину (АТ-ТГ), антител к тиреопероксидазе (АТ-ТПО), тиреотропного гормона (ТТГ) – для выявления характера отклонений рассматриваемых параметров капиллярной крови от аналогичных показателей венозной. Методы. В исследование были включены 22 клинически здоровых добровольца обоих полов, единовременно сдавших для обследования образцы капиллярной и венозной крови с соблюдением правил преаналитики. Выполнение исследований производили в течение трех часов после взятия биоматериала на анализаторе Roche Cobas e601. Для всех показателей рассчитывали средние значения с 95% доверительным интервалом (ДИ), вычисленным процедурой бутстрепа. В парах значений показателей венозной и капиллярной крови рассчитывали их разность, которую выражали в относительных (в %) единицах. Для сравнения зависимых выборок также использовали критерий Уилкоксона для разностей пар и корреляционный анализ. Результаты. Для св.Т3 (среднее отклонение 3,11%; p < 0,001), св.Т4 (3,89%; p < 0,001), АТ-ТГ (2,73%; p = 0,041) и АТ-ТПО (6,75%; p < 0,001) продемонстрировано статистически значимое увеличение, а для ТТГ (-4,3%; p < 0,001) – снижение значений для образцов капиллярной крови по сравнению с аналогичными показателями венозной. Отклонение в пределах 5% в подавляющем большинстве случаев не имеет клинического значения при постановке диагноза и выборе терапии для пациента. Все рассмотренные показатели капиллярной крови обладают сильной корреляцией (r > 0,75) с аналогичными показателями венозной крови: для св.Т3 r = 0,971; св.Т4 – r = 0,993; АТ-ТГ – r = 0,958; АТ-ТПО – r = 0,836; ТТГ – r = 0,995. Заключение. Таким образом, показатели св.Т3, св.Т4 и ТТГ можно определять в капиллярной крови без какого-либо ущерба для точности клинической оценки при строгом соблюдении преаналитических правил, при этом для таких показателей как АТ-ТГ, АТ-ТПО данные отклонения могут иметь значение только при результатах, находящихся на верхней границе референсных интервалов.


Author(s):  
A. H. H. Kononenko ◽  
V. M. Kravchenko

The influence of aqueous extract from Lemna minor frond on morphological status of the thyroid gland in the experimental conditions of hypothyroidism in rats induced by administration of merkazolilum solution instead of drinking water for 30 days was studied. Thyreostatic merkazolilum resulted in changes of morphological structure of the thyroid gland, accompanied by manifestations of hyperplastic tissue proliferation and corresponds with hypofunctional state.The introduction of aqueous extract from Lemna minor frond resulted in positive influence on the restructuring of the thyroid gland in rats with hypothyroidism, increasing its functional activity. There was a decrease of proliferative processes of the epithelium and extrafollicular thyrocytes in follicles. The outer diameter of the follicles are not different from intact control, height follicular thyrocytes decreased compared with pathology by 41.08%. Iodomarin and L-thyroxine increased functional activity of the thyroid gland, but to a lesser degree than the aqueous extract from Lemna minor frond. L-thyroxine is not increased pharmacological effect of the studied extract. The results have practical significance for drugs development with thyroid-stimulating action.


2021 ◽  
Author(s):  
Nataliya Yaglova ◽  
◽  
Sergey Obernikhin ◽  
Ekaterina Timokhina ◽  
◽  
...  

Impact of short-term shift in deuterium body content on thyroid function was studied. In-creased functional activity of the thyroid gland, but without raise in rate of thyroxine to triiodothyronine conversion was found both after depletion and enrichment of deuterium body co


1982 ◽  
Vol 63 (4) ◽  
pp. 42-43
Author(s):  
L. Ya. Salimova ◽  
N. N. Chukanin

The paper presents the results of a study of the lipid spectrum of breast milk and blood serum in 48 women with different functional activity of the thyroid gland. A decrease in certain lipid fractions in blood serum and in breast milk in women with altered thyroid function was established. A definite regulating effect of the thyroid gland on the lipid composition of breast milk and blood serum was established.


2019 ◽  
Vol 43 (3) ◽  
pp. 3-7 ◽  
Author(s):  
E. P. Kasatkina

The main consequence of iodine deficiency in the environment is the development of goiter in people living in iodine-deficient regions (endemic goiter). In this regard, for a long time it was considered that goiter is the only manifestation of this condition. It has now been proven that, in addition to goiter, iodine deficiency also has other adverse effects on human health. In 1983, the term "endemic goiter" was replaced by the term  "iodine deficiency diseases" (IDD). These diseases are caused by a decrease in the functional activity of the thyroid gland in response to iodine deficiency.


2017 ◽  
Vol 4 (3) ◽  
Author(s):  
Tahmina Nasserie ◽  
Ashleigh R Tuite ◽  
Lindsay Whitmore ◽  
Todd Hatchette ◽  
Steven J Drews ◽  
...  

AbstractBackgroundSeasonal influenza epidemics occur frequently. Rapid characterization of seasonal dynamics and forecasting of epidemic peaks and final sizes could help support real-time decision-making related to vaccination and other control measures. Real-time forecasting remains challenging.MethodsWe used the previously described “incidence decay with exponential adjustment” (IDEA) model, a 2-parameter phenomenological model, to evaluate the characteristics of the 2015–2016 influenza season in 4 Canadian jurisdictions: the Provinces of Alberta, Nova Scotia and Ontario, and the City of Ottawa. Model fits were updated weekly with receipt of incident virologically confirmed case counts. Best-fit models were used to project seasonal influenza peaks and epidemic final sizes.ResultsThe 2015–2016 influenza season was mild and late-peaking. Parameter estimates generated through fitting were consistent in the 2 largest jurisdictions (Ontario and Alberta) and with pooled data including Nova Scotia counts (R0 approximately 1.4 for all fits). Lower R0 estimates were generated in Nova Scotia and Ottawa. Final size projections that made use of complete time series were accurate to within 6% of true final sizes, but final size was using pre-peak data. Projections of epidemic peaks stabilized before the true epidemic peak, but these were persistently early (~2 weeks) relative to the true peak.ConclusionsA simple, 2-parameter influenza model provided reasonably accurate real-time projections of influenza seasonal dynamics in an atypically late, mild influenza season. Challenges are similar to those seen with more complex forecasting methodologies. Future work includes identification of seasonal characteristics associated with variability in model performance.


2021 ◽  
Vol 26 (2(49)) ◽  
pp. 89-97
Author(s):  
R. V. Yanko

Introduction: Despite the well-studied effect of alimentary deprivation on the body, the literature data on its effect on functional activity and, in particular, on morphological changes in the thyroid gland are single and often contradictory, which does not allow unambiguous conclusions. All this requires a more detailed study of the role and mechanisms of the impact of restricted nutrition on the thyroid gland. Aim: To investigate the effect of alimentary deprivation on morphological changes in the thyroid gland of young rats. Methods: The study was conducted on 24 male Wistar rats aged 3 months. Rats of all groups were in uniform conditions, on a standard diet. Animals of the experimental group, for 28 days, received a diet reduced by 30 %. Work with rats was carried out in accordance with the principles of the Declaration of Helsinki. Histological preparations were made from the central areas of the thyroid tissue according to the standard method. Using a digital camera, the micropreparations were photographed under a Nikon Eclipse E 100 microscope (Japan). Morphometry was performed using a computer program "Image J". Results: Histological analysis of the rat's thyroid gland affected by alimentary deprivation revealed that it had an unchanged physiological structure. The follicles were mostly of oval shape and of various sizes. Colloid in the follicles of experimental animals is of moderate density and contains numerous resorption vacuoles. Thyroid cells are of prismatic and cubic shape. It was found that in the thyroid gland of experimental rats the area of ​​follicles, colloid, their inner diameter decreases, the height of thyrocytes increases, the stereological resorption index increases and the colloid accumulation index decreases, the number of interfollicular islands increases. Also in experimental animals there was a decrease in the width of the interlobar and interfollicular connective tissue. Conclusion: In rats fed on a reduced diet, morphological signs of increased functional activity of the thyroid gland were found.


2021 ◽  
Vol 7 (3(57)) ◽  
pp. 4-7
Author(s):  
СВЕТЛАНА НИКОЛАЕВНА ГАРАЕВА ◽  
АННА ИВАНОВНА ЛЕОРДА ◽  
ГАЛИНА ВАСИЛЬЕВНА ПОСТОЛАТИ

Охрану психического здоровья необходимо поставить во главу угла в усилиях каждой страны по борьбе с пандемией КОВИД-19 и последующего восстановления. В настоящий момент особую важность приобретает своевременная профилактика «коронавирусного синдрома», для прогнозирования наступления которого, можно предложить использование анализа свободных аминокислот крови, что позволяет оценить баланс тормозных и возбуждающих процессов мозга, оценку функциональной активности щитовидной железы, а также определение уровня активности антиоксидантной системы и адаптационного потенциала организма. Mental health needs to be at the forefront of every country's efforts to tackle and recover from the COVID-19 pandemic. Currently, timely prevention of the "coronavirus syndrome" is of particular importance, for predicting the onset of which, it is possible to propose the use of an analysis of free blood amino acids, which makes it possible to assess the balance of inhibitory and excitatory processes in the brain, assess the functional activity of the thyroid gland, as well as determine the level of activity of the antioxidant system adaptive potential of the organism.


Sign in / Sign up

Export Citation Format

Share Document