scholarly journals ANALYSIS OF CHANGES IN HOMOCYSTEIN USED AS A MARKER OF METABOLIC SYNDROME IN PATIENTS WITH INCREASED BODY MASS INDEX WHO HAVE MULTIPLE TRAUMA

Author(s):  
V. V. Kucheryavchenko

In recent years, the concept of "metabolic syndrome" has become more spreading, and in parallel with disorders of carbohydrate and lipid metabolism, endothelial dysfunction is no less significant. The aim of our work was to analyze changes in homocysteine (HC) as a marker of metabolic syndrome in patients with an increased body mass index (IBMI) in polytrauma. The study involved 224 patients with polytrauma, who had different initial values of body mass index (BMI) and were treated at the polytrauma department and the intensive care unit for patients with combined injuries for a period from 1 day to 1 year since the moment of injury. All the patients were subjected to identifying the level of serum HC. The patients had the same severity according to the APACHE II scale, 14 ± 5.8, at the admission to the hospital, and were divided into 3 stratified clinical groups depending on the initial values of anthropometric parameters and BMI. The study was conducted on the 1, 3, 7, 14, 30 and 360 days from the date of polytrauma. Assessment of blood serum HC was performed by ELISA. It was found that the overweight patients with BMI ≤ 29.9 demonstrated an increase in the mean values of blood HC on the 7th and 14th days of the treatment, with a further decrease on the 15th day since the date of injury. For the patients with BMI within the range of 30.0 - 39.9, the persistence of the HC index during the first month of the treatment at baseline with an increase on the 360th day was found out. The patients with BMI ˃ 40.0 showed an increase in the level of blood HC through the year since the date of polytrauma. It was revealed that the level of HС directly affects the course of traumatic disease in patients with increased BMI, its severity in terms of uniformity of injuries received and the same range of severity according to the APACHE II scale depends on BMI at the admission to the hospital.

2021 ◽  
Vol 15 (11) ◽  
pp. 3247-3251
Author(s):  
Yar Muhammad Tunio ◽  
Ruqayya Farhad ◽  
Abdul Rashid ◽  
Najeeb Ullah Ansari ◽  
Sadia Chaudhary ◽  
...  

Objectives: To evaluate the frequency of different risk profiles and associated clinical parameters in patients with nonalcoholic fatty liver disease (NAFLD). Methodology: This cross-sectional study was conducted at the Gambat Institute Of Medical Sciences,Gambat District, Khairpur, between March 2019 to January 2020. A total of 345 patients participated in the study. Demographics, clinical features, investigations, and causative agents of NAFLD were noted in a document. Patients with raised ALT, fatty liver on imaging, aged between 18-75 years were a part of the study. Exclusion criteria included patients with overconsumption of alcohol, positive HBsAg, positive anti-HCV, and other underlying liver diseases with known origin. Patients’ blood samples were also tested for fasting blood sugar, random blood sugar, fasting cholesterol and fasting triglyceride levels.Levels of glucose, triglycerides and cholesterol were measured with an autoanalyzer; Photometer 4010; Beohrnger Mannheim; using the enzymatic-calorimetric methods. All data was analyzed using SPSS version 24. Results: The mean age of the patient was 48.4 ± 12.2 years and a mean body mass index of 30.2 The mean cholesterol was 199.4 ± 54.3 mg/dl. The majority i.e. > 60 percent were women with only 128 (37.1%) males (Table 1). The body mass index (BMI) was significantly higher in female patients as compared to males (p<0.001). The males had a significantly greater frequency of traits for metabolic syndrome as compared to women i.e. 111 (86.7%) vs. 145 (66.8%) (p=0.02). Obesity in patients was also significantly associated with female gender. We found a significant relationship of hypercholesterolemia in patients with DMT2 (p=0.04). Similarly, the majority of the patients i.e. 55 (47%) with DMT2 also had hypertriglyceridemia (p=0.002). Conclusion: The present study indicated that female gender, obesity, and diabetes mellitus were significantly associated with NAFLD. NAFLD places a significant burden on the healthcare system and is associated with poor quality of life of patients. Metabolic syndrome is another leading association that needs to be explored in further detail. Recognition of high-risk profile patients can help establish early diagnosis and hence treatment plans can be implemented at an early stage of disease. Keywords: fatty liver, chronic liver disease, non-alcoholic liver disease, NAFLD, obesity, diabetes mellitus, dyslipidemia


2018 ◽  
Vol 9 (1) ◽  
pp. 21-26
Author(s):  
Jasim N Al-Asadi

Background: Handgrip is a predictor of physical fitness, hand functions, and nutritional status. It is affected by many factors including age, sex, body mass index, and hand dimensions.Aims and Objectives: To assess the handgrip strength among medical students and to examine its correlation with body mass index and hand dimensions.Materials and Methods: This cross-sectional study included 256 students of both sexes selected from College of Medicine, Basrah University, Iraq using non-probability purposive sampling method. Their anthropometric parameters including height, weight, and hand dimensions were assessed using routine techniques. The handgrip was measured by using a handheld dynamometer. Hand preference was determined by asking which hand was used to write.Results: The mean age of the participants was 21.1 ± 1.9 years. The mean of handgrip strength was 34.1 ± 11.9 Kg. Males had significantly (P <0.001) greater handgrip strength than females. Statistically significant correlation was detected between body mass index, hand dimensions and handgrip strength. The right-handed students scored significantly higher grip strength with their preferred hand. While among left-handed students, no significant difference in handgrip strength was noticed between left and right hands. Multivariate logistic regression analysis showed that gender, hand span, height, and body mass index were independent determinants of handgrip strength. They accounted for 70.6% of the variation in handgrip strength.Conclusion: A significant effect of body mass index and hand span on handgrip strength among medical students was observed.Asian Journal of Medical Sciences Vol.9(1) 2018 21-26


2016 ◽  
Vol 9 (16) ◽  
pp. 35-39
Author(s):  
Marius Neculăeş ◽  
Paul Lucaci

Abstract This papers aims at identifying the mean body mass index and body fat percentage among students from Physical Education and Sport Faculty in Iaşi. The study was conducted on a series of 297 students majoring in Physical Education and Sports, but also in Kinetotherapy and Special Motricity (bachelor studies and master studies). By determining the body mass index mean and body fat mean for students within five specialties, we managed to classify them into categories. The assessment of body mass index was conducted using the standard formula BMI= weight in kilograms/height in meters2 and that of body fat using the Fat Track II body fat calliper. Research findings highlighted that the body mass index mean values for each academic year range within normal parameters. As for body fat, the mean value of all academic years ranges in the “very good” and “good” categories. Whereas most mean values range within normal limits, it must not be neglected that overweight or underweight cases were also pinpointed, which should be a warning sign for the future specialists in the field of Physical Education and Sports.


2021 ◽  
pp. 158-162
Author(s):  
L. P. Martirosyan ◽  
I. A. Balandina

Introduction. Mortality from cardiovascular disease ranks first in the world. New and high requirements are required for the anatomical substantiation of emerging methods and methods of treatment. In modern literature, there are many publications on the issues of heart morphology, but data on the influence of gender, age, body weight on heart parameters are insufficient, fragmentary and often contradictory.Objective. To determine the thickness of the ventricles and interventricular septum in overweight men when performing echocardiography and to assess the presence or absence of the relationship of these parameters with age and body mass index (BMI) of the subjects. Patients and methods. The analysis of the protocols of ultrasound examination of the heart of 68 apparently healthy men of adolescence, the first and second periods of adulthood with a body mass index of 25.0–29.9 kg/m², with no pulmonary and cardiac pathology and the risk of cardiovascular diseases was carried out. Ultrasound examination was performed on an Aloka ProSound Alpha 6 ultrasound scanner. Results and discussion. When comparing the mean values of heart parameters in overweight men in three age groups according to the Kruskell – Wallis criterion, no statistically significant differences were found between the mean values (p > 0.05). Revealed a moderate strength relationship between the thickness of the anterior wall of the right ventricle with the age of the subject (r = 0.375; p = 0.020) and moderate strength relationship between the thickness of the posterior wall of the left ventricle and BMI (r = 0.352; p = 0.030).Conclusions. The  results of  the  study supplement the  information available in  the  scientific literature on the  thickness of  the  ventricles of  the  heart and the  interventricular septum in  healthy men with overweight in  three age groups. The data obtained will be useful to doctors of functional diagnostics when performing echocardiography in matters of differentiation between norm and pathology.


Author(s):  
Anupam Sharma ◽  
Savita Devi ◽  
Kamaldeep Singh ◽  
Pranav Kumar Prabhakar

Objective: The present study was investigated to determine the correlation of body mass index (BMI) with thyroid-stimulating hormones (TSH) in thyroid patient.Methods: The data which are used in this study were taken in Tagore Hospital and Heart Care Centre (Jalandhar). A total of 90 volunteers both males and females in the age group between 17 and 85 years were included in this study. The following information taken on pro forma such as age in years, height (cm), weight (kg), and history (including: Chief complaints, family thyroid history, blood pressure, temperature, and head and neck examination) from the subjects were collected. Serum T3, T4 and TSH test are performed by the use of instrument ADVIA Centaur@CP Immunoassay System (SIEMENS). The total data were divided into three groups named as: Subclinical hypothyroid (SH) (n=30), euthyroid (n=57), and hyperthyroid including only three patients, and according to age, weight (kg), height (m2), and BMI, the mean±standard deviation (S.D) values were calculated. The BMI is calculated with the formula given by the WHO.Results: For correlation analysis, according to total male and female population in euthyroid group, the mean and SD values of TSH and BMI were calculated. Maximum values of T3 (4.7) and T4 (22.1) in hyperthyroid and TSH (9.9) in SH group were found. The high mean values of T3 (2.92) and T4 (18.46) in hyperthyroid and TSH (29.1) in SH group were observed. Low mean values of T3 (0.97) and T4 (7.7) in SH and low mean TSH (0.04) in hypothyroid group were noticed.Conclusion: Based on the data analysis, it can interpreted that a poor positive correlation between TSH and BMI and poor negative correlation between TSH and BMI are associated in euthyroid subjects. It indicates that, when TSH increases, the BMI will also be increased in total and female euthyroid subjects.


2015 ◽  
Vol 7 (2) ◽  
pp. 28-33
Author(s):  
Abdulmonem Alsiddiky ◽  
Abdullatef Alrashoudi ◽  
Ahmed AL Sayed ◽  
Albaraa Aljerian ◽  
Abeer Aljomiah

Aims and Objectives: To assess the effect of Cobb angle and body mass index (BMI) on surgery recovery outcomes in Adolescent Idiopathic Scoliosis (AIS) patients.Materials and Methods: A retrospective study of 79 Adolescent Idiopathic Scoliosis patients who underwent corrective operations, at King Khaled University Hospital, Riyadh, Saudi Arabia was carried out in 2014. The patients were divided according into Cobb’s angle (mild, moderate and severe) and as per weight (healthy weight and overweight). Data of preoperative, intra-operative and postoperative information as well as measures of daily-living activities were collected.Results: The mean age of 79 patients (70females) was 16.6 years. Cobb angle assessment was mild in 41 (51.9%), moderate in 24(30.4%) and 14(17.7%) were severe. Mean surgery and recovery time of patients is statistically significantly different in relation to severity of Cobb’s angle (mild, moderate and severe). There is highly statistically significant difference in mean ranks of days taken for different measures of daily living in relation to severity of Cobb’s angle. The mean values of body mass index have significantly reduced after surgery, when compared with mean values at before surgery. The mean surgery time was statistically significantly higher in over weight patients (5.33 hours).Conclusions: The results show an effect of severity of Cobb angle on recovery measures of patients with AIS, but no effect of BMI. BMI was corrected in these patients after surgery. Prospective studies are required to assess clinical outcomes of post-operative surgery, satisfaction of patients towards their body image and quality of life.Asian Journal of Medical Sciences Vol.7(2) 2015 28-33


Author(s):  
Ghada A Elfadil ◽  
Abdelgadir Elmugadam ◽  
Rasheeda A Saied ◽  
Salah Omar Hussein

Introduction: An increased Body Mass Index (BMI) has an adverse effect on the socio-economic and healthcare sectors and may influence metabolic status. High sensitivity C-reactive Protein (hs-CRP) is an emerging biomarker. The association between dyslipidaemia and obesity is well established, and has been found to be the risk factors for CVD. Aim: To study the relationship of hs-CRP with BMI, lipid profile and magnesium among obese and overweight non-diabetic non-hypertensive Sudanese women. Materials and Methods: A cross-sectional study was conducted on 90 women in Khartoum state (Sudan), aged between 20 and 43 years, from June to November 2019. The study included three groups of women based on BMI. hs-CRP was measured by using latex immunoturbidimetric method, lipid profile was evaluated using Biosystems colourimetric methods and magnesium by a chemical method. Results were computed using Statistical Package for the Social Sciences (SPSS) version 20.Results: There was significant increase in the mean values of hs-CRP, Total Cholesterol (TC), Triglyceride (TG), Low Density Lipoprotein Cholesterol (LDL-C), and a significant decrease in the mean values of High Density Lipoprotein Cholesterol (HDL-C) and magnesium in obese and overweight women, when compared to normal body weight women. Pearson’s correlation coefficient revealed a positive correlation between hs-CRP, and BMI, Waist-To-Hip Ratio (WHR), TC, TG, and LDL-C (p-value <0.01). Conclusion: Overweight and obese women have increased hs-CRP and atherogenic lipid profile, suggesting obesity to be a state of chronic inflammation. hs-CRP can be used to assess the risk of obesity-related disorders for early intervention.


Cholesterol ◽  
2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Mojgan Gharipour ◽  
Nizal Sarrafzadegan ◽  
Masoumeh Sadeghi ◽  
Elham Andalib ◽  
Mohammad Talaie ◽  
...  

This study aimed to investigate whether body mass index (BMI), waist circumference (WC), or waist to hip ratio (WHR) could be a better predictor of metabolic syndrome and, if so, what would be the cutoff points for these surrogates to appropriately differentiate metabolic syndrome in different age and sex subgroups. Methods. The present cross-sectional study was conducted on a sample of Isfahan Cohort Study (ICS). In total, 468 individuals (194 with and 274 subjects without metabolic syndrome) according to the National Cholesterol Education Program’s Adult Treatment Panel III (ATP-III) criteria were selected. Anthropometric indices were measured and plotted using receiver-operating characteristic (ROC) curves. Results. According to ROC curve analysis, WC and WHR parameters were better indicators of metabolic syndrome compared to BMI in women, whereas in men WHR had a lower discriminating value compared to the other two parameters. Among these three anthropometric parameters, BMI had a lower sensitivity and WC and WHR both had a higher sensitivity for predicting metabolic syndrome in women compared with in men. The cut points for WC were nearly equal in men and women, 90.3 versus 90.0, respectively. Women had higher cut points for BMI (28.5 kg/m2) compared to men (26.0 kg/m2). Our results showed the highest sensitivity and specificity for WC cut points specially in women. To predict metabolic syndrome, we looked into optimal age-specific cut points for BMI, WC, and WHR. The results indicated that WC had the highest discriminating value compared to other indicators in the different age subgroups. The optimal cut points for all three parameters gradually increased with age. Conclusion. Our results demonstrated that regardless of gender and age variables, WC could be a preferred parameter for predicting metabolic syndrome compared to BMI and WHR in Iranian population.


2013 ◽  
Vol 40 (2) ◽  
pp. 133-138
Author(s):  
OA Oyinlade ◽  
AO Olowu ◽  
TA Ogunlesi

Background: Childhood growth is characterized by changes in anthropometric parameters. The location of the apex beat may besimilarly influenced by growth.Objectives: The objective of this study was to determine any relationshipbetween the location of the apex beat and anthropometric parameters.Subjects and Methods: This crosssectional survey was carried out inSagamu, Nigeria. Apparently healthy children were randomly selected for the study. Apex beat location in the intercostal space was determined and distance from the midline was recorded. Weight and length/height were also recorded while Body Mass Index (BMI) and Body Surface Area (BSA) were calculated.Results: A total of 237 children aged 12 hours to 10 years were surveyed.The mean distance of the apex beat from the midline from birth to 10 years ranged from 2.3cm to 6.4cm. The mean distance of apex beat from the midline increased progressively with weight, height, chest circumference and BSA but not with BMI. Strong correlations were observed betweendistance of apex beat from the midline and weight (r = 0.850, p .0.001); height (r = 0.867, p .0.001); chest circumference (r = 0.833, p . 0.001); BSA (r = 0.862, p . 0.001) but not with Body Mass Index (r = 0.019, p = 0.774).Conclusion: The location of the apex beat in children was stronglyinfluenced by growth as suggested by anthropometric parameters.Key words: Anthropometry, apex beat, children, mid-clavicular line,nipple line


Sign in / Sign up

Export Citation Format

Share Document