Metal complexes with heteroscorpionate ligand founded on the pyridinamine group: cyclin-dependent kinase 2 inhibitor antimicrobial, antioxidant, and in vitro cytotoxicity, notional studies

2021 ◽  
Vol 13 (01) ◽  
Keyword(s):  
Metal Complexes ◽  
In Vitro Cytotoxicity ◽  
Cyclin Dependent Kinase

In vitro Cytotoxicity of Half-Sandwich Platinum Group Metal Complexes of a Cationic Alkylated Phosphaadamantane Ligand

2016 ◽  
Vol 2016 (8) ◽  
pp. 1267-1273 ◽  
Author(s):  
Andrew R. Burgoyne ◽  
Catherine H. Kaschula ◽  
M. Iqbal Parker ◽  
Gregory S. Smith
Keyword(s):  
Metal Complexes ◽  
Platinum Group Metal ◽  
In Vitro Cytotoxicity ◽  
Group Metal ◽  
Platinum Group ◽  
Half Sandwich

The in vitro cytotoxicity of metal-complexes of porphyrin sensitizer intended for photodynamic therapy

2016 ◽  
Vol 34 ◽  
pp. 246-256 ◽  
Author(s):  
L. Malina ◽  
K. Barton Tomankova ◽  
J. Malohlava ◽  
J. Jiravova ◽  
B. Manisova ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Metal Complexes ◽  
In Vitro Cytotoxicity

scholarly journals Synthesis and Biological Activities of 2-Substituted Benzimidazole-Metal Complexes

1970 ◽  
Vol 8 (2) ◽  
pp. 131-140 ◽  
Author(s):  
Md Afzal Azam ◽  
BRP Kumar ◽  
R Mazumdar ◽  
B Suresh
Keyword(s):  
Antitumor Activity ◽  
Metal Complexes ◽  
Biological Activities ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
In Vitro Cytotoxicity ◽  
Bidentate Ligands ◽  
Vis Spectroscopy ◽  
Mcf 7

A series of copper(II) and cobalt(II) coordination compounds with 2-substituted benzimidazole derived monodentate and bidentate ligands have been prepared and characterized by microanalysis, IR and UV-Vis spectroscopy. Synthesized metal complexes have been screened for their in vitro antioxidant and antitumor activity. The complex 4a showed significant nitric oxide free radical scavenging activity (IC50 65μg/ml), while 3i and 3g showed potent superoxide dismutase activity with IC50 of 0.26 and 0.28 μM respectively. In vitro cytotoxicity study with human breast MCF-7 and CNS SF 268 cancer cell lines showed that the most active 2-benzyl-1H-benzimidazole Cu(II) complex 3a inhibited the growth of cancer cells at 20 μM concentration. Keywords: Cu(II) complexes; Co(II) complexes; Benzimidazoles; Antitumor activity. DOI: 10.3329/dujps.v8i2.6027 Dhaka Univ. J. Pharm. Sci. 8(2): 131-140, 2009 (December)

scholarly journals Molecular Docking, DFT Calculations, Effect of High Energetic Ionizing Radiation, and Biological Evaluation of Some Novel Metal (II) Heteroleptic Complexes Bearing the Thiosemicarbazone Ligand

Molecules ◽  
2021 ◽  
Vol 26 (19) ◽  
pp. 5851
Author(s):  
Ehab M. Abdalla ◽  
Safaa S. Hassan ◽  
Hussein H. Elganzory ◽  
Samar A. Aly ◽  
Heba Alshater
Keyword(s):  
Molecular Docking ◽  
Metal Complexes ◽  
Density Functional ◽  
Thermal Studies ◽  
Antimicrobial Activities ◽  
Biological Evaluation ◽  
In Vitro Cytotoxicity ◽  
Γ Irradiation ◽  
Before And After

New Pb(II), Mn(II), Hg(II), and Zn(II) complexes, derived from 4-(4-chlorophenyl)-1-(2-(phenylamino)acetyl)thiosemicarbazone, were synthesized. The compounds with general formulas, [Pb(H2L)2(OAc)2]ETOH.H2O, [Mn(H2L)(HL)]Cl, [Hg2(H2L)(OH)SO4], and [Zn(H2L)(HL)]Cl, were characterized by physicochemical and theoretical studies. X-ray diffraction studies showed a decrease in the crystalline size of compounds that were exposed to gamma irradiation (γ-irradiation). Thermal studies of the synthesized complexes showed thermal stability of the Mn(II) and Pb(II) complexes after γ-irradiation compared to those before γ–irradiation, while no changes in the Zn(II) and Hg(II) complexes were observed. The optimized geometric structures of the ligand and metal complexes are discussed regarding density functional theory calculations (DFT). The antimicrobial activities of the ligand and metal complexes against several bacterial and fungal stains were screened before and after irradiation. The Hg(II) complex has shown excellent antibacterial activity before and after γ-irradiation. In vitro cytotoxicity screening of the ligand and the Mn(II) and Zn(II) complexes before and after γ-irradiation disclosed that both the ligand and Mn(II) complex exhibited higher activity against human liver (Hep-G2) than Zn(II). Molecular docking was performed on the active site of MK-2 and showed good results.

Exposing “Bright” Metals: Promising Advances in Photoactivated Anticancer Transition Metal Complexes

2018 ◽  
Vol 25 (4) ◽  
pp. 478-492 ◽  
Author(s):  
Aleksandra Bjelosevic ◽  
Benjamin J. Pages ◽  
Lawson K. Spare ◽  
Krishant M. Deo ◽  
Dale L. Ang ◽  
...  
Keyword(s):  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Molecular Geometry ◽  
In Vitro Cytotoxicity ◽  
Selective Treatment ◽  
Chemotherapy Drugs ◽  
Recent Advances

Background: Photodynamic therapy (PDT) is an increasingly prominent field in anticancer research. PDT agents are typically nontoxic in the absence of light and can be stimulated with nonionising irradiation to “activate” their cytotoxic effect. Photosensitzers are not classified as chemotherapy drugs although it is advantageous to control the toxicity of a drug through localised irradiation allowing for selective treatment. Transition metals are an extremely versatile class of compounds with various unique properties such as oxidation state, coordination number, redox potential and molecular geometry that can be tailored for specific uses. This makes them excellent PDT candidates as their properties can be manipulated to absorb a specific range of light wavelengths, cross cellular membranes or target specific sites in vitro. This article reviews recent advances in transition metal PDT agents, with a focus on structural scaffolds from which several metal complexes in a series are synthesised, as well as their in vitro cytotoxicity in the presence or absence of irradiation. Conclusion: The success of clinical photoactive agents such as Photofrin® has inspired the development of thousands of potential PDT agents. Transition metal complexes in particular have demonstrated excellent versatility and diversity when it comes to PDT for treatment of invasive cancers. This review has highlighted some of the many recent advances of transition metal PDT agents with high in vitro and in vivo phototoxic activity. Photoactive transition metal complexes have proven their potential due to their inherent physicochemical variety, allowing them to fill a niche in the PDT world.

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