Chalcone-Heterocyclic Derivatives (Synthesis, Spectral Identification, Microbial Evaluation)

Inhibitors of monoamine oxidase (MAO) have shown therapeutic values in a variety of neurodegenerative diseases such as depression, Parkinson’s disease and Alzheimer’s disease. Heterocyclic compounds exhibit a broad spectrum of biological activities and vital leading compounds for the development of chemical drugs. Herein, we focus on the synthesis and screening of novel single heterocyclic derivatives with MAO inhibitory activities during the past decade. This review covers recent pharmacological advancements of single heterocyclic moiety along with structure- activity relationship to provide better correlation among different structures and their receptor interactions.

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Structure-Bioactivity Relationship Study of Xanthene Derivatives: A Brief Review

Current Organic Synthesis ◽

10.2174/1570179416666191017094908 ◽

2020 ◽

Vol 16 (8) ◽

pp. 1071-1077

Author(s):

Aref G. Ghahsare ◽

Zahra S. Nazifi ◽

Seyed M.R. Nazifi

Keyword(s):

Biological Activities ◽

Cyclic Compound ◽

Research Field ◽

Pharmaceutical Chemistry ◽

Therapeutic Effects ◽

Main Research ◽

Research Fields ◽

Xanthene Derivatives ◽

Anti Cancer ◽

Heterocyclic Derivatives

: Over the last decades, several heterocyclic derivatives compounds have been synthesized or extracted from natural resources and have been tested for their pharmaceutical activities. Xanthene is one of these heterocyclic derivatives. These compounds consist of an oxygen-containing central heterocyclic structure with two more cyclic structures fused to the central cyclic compound. It has been shown that xanthane derivatives are bioactive compounds with diverse activities such as anti-bacterial, anti-fungal, anti-cancer, and anti-inflammatory as well as therapeutic effects on diabetes and Alzheimer. The anti-cancer activity of such compounds has been one of the main research fields in pharmaceutical chemistry. Due to this diverse biological activity, xanthene core derivatives are still an attractive research field for both academia and industry. This review addresses the current finding on the biological activities of xanthene derivatives and discussed in detail some aspects of their structure-activity relationship (SAR).

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A new heterocyclic ring closure in ferricyanide oxidation of 2,4,6-triphenylpyridinium salts

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19833307 ◽

1983 ◽

Vol 48 (11) ◽

pp. 3307-3314 ◽

Cited By ~ 6

Author(s):

Petr Nesvadba ◽

Petr Štrop ◽

Josef Kuthan

Keyword(s):

Alkaline Solution ◽

Heterocyclic Ring ◽

Potassium Ferricyanide ◽

Probable Mechanism ◽

Ring Closure ◽

Pyridinium Salts ◽

Mechanism Of Formation ◽

Pyrrole Derivatives ◽

Quaternary Pyridinium Salts ◽

Heterocyclic Derivatives

The quaternary pyridinium salts Ia-Ic react with alkaline solution of potassium ferricyanide to give the condensed heterocyclic derivatives IIIa, b, IV, whereas the salts Id-If give the pyrrole derivatives IIa-IIc under the same conditions. The diaza heterocycle IIIa reacts with methyl iodide to give methoiodide V, whereas by action of bromine it produces two monobromo derivatives VIa, b. The pyrrole derivatives IIa, b give monobromo derivatives IId, e on bromination. A probable mechanism of formation of the heterocyclic derivatives is discussed.

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