scholarly journals Genetic principles of the philosophy of perfect education

2021 ◽  
Vol 27 (1) ◽  
pp. 179-192
Author(s):  
Valentyn Pomohaibo ◽  
Andrii Pomohaibo
Keyword(s):  
Large Scale ◽  
Core Curriculum ◽  
Behavioral Genetics ◽  
School Education ◽  
Basic Knowledge ◽  
Pedagogical Practice ◽  
Knowledge And Skills ◽  
Educational Challenges ◽  
The Impact

Based on the analysis of the content of the book of famous British behavioral geneticists K. Asbury and R. Plomin «G means genes: the impact of genetics on education and achievement» shows the way to create a perfect school education, based on the latest numerous large-scale and long-term researches in different countries and prove that the role of genetic factors in human learning and life success is not absolute and that the impact of the environment is no less important than genes. This thesis is a base of the personalized child education idea. Based on an analysis of the research results, the authors of the book assert that school education should be personalized. It is the personalization of learning that will ensure to develop the thinking ability, acquire knowledge and skills at a pace and direction that is appropriate for each child. Personalized learning should be based on the following principles: a minimization of the core curriculum and test basic knowledge and skills; a maximizing of options to all pupils alongside the compulsory basic knowledge and skills; a stopping of labeling ability of children; an individual education of each pupil; a teaching of children to achieve success; a promotion of equal opportunities for children from an early age; an availability of out-of-school education for all children; a two-stage physical education program; wide choice of future life ways; a training of new teachers in genetics and a giving them the methods to put it into pedagogical practice; the scale of schools in directions and levels of education. Finally, the authors of the book offer their vision of a school that will be based on the laws of behavioral genetics. Possible publication of the book by K. Asbury and R. Plomin, «G is for genes: The impact of genetics on education and achievement» in Ukrainian will be an interesting and useful handbook for policymakers, educators and parents with its constructive recommendations on one of the most important educational challenges – how to prepare each and every child for a successful life in today's ever-changing world.

A Perspective On The Impact of COVID-19 Pandemic in Basic Science Research and its Future implications

Coronaviruses ◽  
2020 ◽  
Vol 01 ◽  
Author(s):  
Yam Nath Paudel ◽  
Efthalia Angelopoulou ◽  
Bhupendra Raj Giri ◽  
Christina Piperi ◽  
Iekhsan Othman ◽  
...  
Keyword(s):  
Basic Science ◽  
Large Scale ◽  
Preventive Measure ◽  
Science Research ◽  
Research Institutes ◽  
Basic Science Research ◽  
Long Term Consequences ◽  
Long Term Impact ◽  
The Impact

: COVID-19 has emerged as a devastating pandemic of the century that the current generations have ever experienced. The COVID-19 pandemic has infected more than 12 million people around the globe and 0.5 million people have succumbed to death. Due to the lack of effective vaccines against the COVID-19, several nations throughout the globe has imposed a lock-down as a preventive measure to lower the spread of COVID-19 infection. As a result of lock-down most of the universities and research institutes has witnessed a long pause in basic science research ever. Much has been talked about the long-term impact of COVID-19 in economy, tourism, public health, small and large-scale business of several kind. However, the long-term implication of these research lab shutdown and its impact in the basic science research has not been much focused. Herein, we provide a perspective that portrays a common problem of all the basic science researchers throughout the globe and its long-term consequences.

scholarly journals Anti-meningococcal B vaccination in Italian adolescents: a cost-effective health opportunity

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
D Panatto ◽  
P Landa ◽  
D Amicizia ◽  
P L Lai ◽  
E Lecini ◽  
...  
Keyword(s):  
Large Scale ◽  
Public Health Problem ◽  
Vaccination Strategy ◽  
Cost Effective ◽  
Dose Schedule ◽  
Developed Countries ◽  
Invasive Disease ◽  
International Setting ◽  
The Impact

Abstract Background Invasive disease due to Neisseria meningitidis (Nm) is a serious public health problem even in developed countries, owing to its high lethality rate (8-15%) and the invalidating sequelae suffered by many (up to 60%) survivors. As the microorganism is transmitted via the airborne route, the only available weapon in the fight against Nm invasive disease is vaccination. Our aim was to carry out an HTA to evaluate the costs and benefits of anti-meningococcal B (MenB) vaccination with Trumenba® in adolescents in Italy, while also considering the impact of this new vaccination strategy on organizational and ethics aspects. Methods A lifetime Markov model was developed. MenB vaccination with the two-dose schedule of Trumenba® in adolescents was compared with 'non-vaccination'. Two perspectives were considered: the National Health Service (NHS) and society. Three disease phases were defined: acute, post-acute and long-term. Epidemiological, economic and health utilities data were taken from Italian and international literature. The analysis was conducted by means of Microsoft Excel 2010®. Results Our study indicated that vaccinating adolescents (11th year of life) with Trumenba® was cost-effective with an ICER = € 7,912/QALY from the NHS perspective and € 7,758/QALY from the perspective of society. Vaccinating adolescents reduces the number of cases of disease due to meningococcus B in one of the periods of highest incidence of the disease, resulting in significant economic and health savings. Conclusions This is the first study to evaluate the overall impact of free MenB vaccination in adolescents both in Italy and in the international setting. Although cases of invasive disease due to meningococcus B are few, if the overall impact of the disease is adequately considered, it becomes clear that including anti-meningococcal B vaccination into the immunization program for adolescents is strongly recommended from the health and economic standpoints. Key messages Free, large-scale MenB vaccination is key to strengthening the global fight against invasive meningococcal disease. Anti-meningococcal B vaccination in adolescents is a cost-effective health opportunity.

Numerical Modelling of a District Scale Groundwater Heat Pump Operation: Case Study from Colchester, UK

2021 ◽  
Author(s):  
Taha Sezer ◽  
Abubakar Kawuwa Sani ◽  
Rao Martand Singh ◽  
David P. Boon
Keyword(s):  
Large Scale ◽  
District Level ◽  
Thermal Plume ◽  
Injection Wells ◽  
Term Operation ◽  
Heating And Cooling ◽  
Groundwater Heat Pump ◽  
The Impact

<p>Groundwater heat pumps (GWHP) are an environmentally friendly and highly efficient low carbon heating technology that can benefit from low-temperature groundwater sources lying in the shallow depths to provide heating and cooling to buildings. However, the utilisation of groundwater for heating and cooling, especially in large scale (district level), can create a thermal plume around injection wells. If a plume reaches the production well this may result in a decrease in the system performance or even failure in the long-term operation. This research aims to investigate the impact of GWHP usage in district-level heating by using a numerical approach and considering a GWHP system being constructed in Colchester, UK as a case study, which will be the largest GWHP system in the UK. Transient 3D simulations have been performed pre-construction to investigate the long-term effect of injecting water at 5°C, into a chalk bedrock aquifer. Modelling suggests a thermal plume develops but does not reach the production wells after 10 years of operation. The model result can be attributed to the low hydraulic gradient, assumed lack of interconnecting fractures, and large (>500m) spacing between the production and injection wells. Model validation may be possible after a period operational monitoring.</p>

scholarly journals Nonlinear Creep Model of Deep Gangue Backfilling Material and Time-Dependent Characteristics of Roof Deformation in Backfilling Mining

Geofluids ◽  
2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Peng Huang ◽  
Jixiong Zhang ◽  
Qi Zhang ◽  
Ntigurirwa Jean Damascene ◽  
Yuming Guo
Keyword(s):  
Large Scale ◽  
High Stress ◽  
Viscoelastic Model ◽  
Creep Model ◽  
Mine Pressure ◽  
Nonlinear Creep ◽  
Viscoelastic Foundation ◽  
The Impact ◽  
Roof Deformation

With the gradual increase in mining depth of coal resource exploitation, deep backfilling mining has effectively solved the impact of strong deep mine pressure and strong mining disturbances. However, after deep backfilling mining, the backfilling material is subjected to high stress for a long time, and its viscoelasticity has a significant impact on the roof control effect. This paper uses a large-scale bulk confinement test device to analyze the viscoelastic properties of gangue, establishes a high-precision fractional viscoelastic creep model, and identifies the gangue parameters. The established fractional viscoelastic model was used as the foundation model of the beam, and the roof model based on the fractional viscoelastic foundation was solved. The top deformation characteristics of elastic foundation and fractional foundation were compared and analyzed, and the time effect, viscoelastic effect, and order effect of the fractional order viscoelastic foundation beam were discussed. The results show that the viscosity of gangue increased under the action of deep high stress. As time increased, the roof deformation also increased. In order to more effectively control the long-term deformation of the roof, the viscosity coefficient of the backfilling material should be greater than 20 MPa. This research provides relevant guidance for the requirements of backfilling materials for deep backfilling mining and the prediction of long-term dynamic deformation of the roof in underground excavations.

Replicative Senescence-Associated Gene Expression Changes In Human MSPCs Independent of Genomic Variations

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 4775-4775
Author(s):  
Katharina Schallmoser ◽  
Christina Bartmann ◽  
Eva Rohde ◽  
Simone Bork ◽  
Christian Guelly ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Culture ◽  
Bone Marrow ◽  
Large Scale ◽  
Replicative Senescence ◽  
Genomic Stability ◽  
The State ◽  
Efficient Treatment ◽  
The Impact

Abstract Abstract 4775 Background: Based on promising experimental studies with mesenchymal stem and progenitor cells (MSPCs) multiple clinical trials have been initiated. In previous studies we have observed genomic stability of MSPCs after efficient short-term expansion in a humanized GMP compliant system with pooled human platelet lysate (pHPL) replacing fetal bovine serum (FBS) as the cell culture supplement (Schallmoser K. and Strunk D., Journal of Visualized Experiments (32) DOI: 10.3791/1523, 2009). Notably, depending on culture protocols, an extensive propagation with highly variable cell culture duration may be necessary to yield enough MSPCs for therapy. The decline in proliferation rates of MSPCs in the course of the different long-term expansion procedures may indicate a propensity for replicative senescence which may hamper long term functionality in vivo. We have therefore initiated a molecular profiling of senescence-associated regulated genes to determine the state of senescence before MSPC transplantation. Methods: Human bone marrow-derived MSPCs were cultured following a highly efficient two-passage protocol (primary culture of unseparated bone marrow and subsequent large scale expansion; Schallmoser K. et al., Tissue Engineering 14:185-196, 2008) compared to conventional serial passaging in three different growth conditions with regularly more then four passages to obtain comparable final cell numbers. Culture media were either supplemented with FBS in different concentrations or pHPL. Gene expression changes were tested by microarray analysis and selected targets were reanalyzed by quantitative real-time PCR. The genomic stability of MSPCs after long-term culture was determined by array comparative genomic hybridization (CGH). Results: Despite high proliferation rate large scale expanded MSPCs showed genomic stability in array CGH. Long-term MSPC growth induced similar gene expression changes in MSPCs irrespective of isolation and expansion conditions. In particular, genes involved in cell differentiation, apoptosis and cell death were up-regulated, whereas genes involved in mitosis and proliferation were down-regulated. Furthermore, overlapping senescence-associated gene expression changes were found in all MSPC preparations. The genomic copy number variations detected in MSPCs of early and late passages in all culture conditions did not coincide with differentially expressed genes. Conclusion: Our data indicate that MSPC expansion can induce gene expression changes independent of isolation and FBS-supplemented as well as FBS-free expansion conditions. A panel of genes will be presented that might offer a practicable approach to assess MSPC quality with regard to the state of replicative senescence in advance of therapeutic application. Determining the impact of senescence acquired during cell expansion on the therapeutic potential of MSCPs for both immune modulation and organ regeneration may help to develop more efficient treatment strategies. Disclosures: No relevant conflicts of interest to declare.

scholarly journals The impact of equitization on financial and operating performance of state-owned enterprises (SOEs) in Vietnam: An approach using propensity score matching

2020 ◽  
Vol 4 (2) ◽  
pp. First
Author(s):  
Nguyen Van Tan
Keyword(s):  
Large Scale ◽  
Operating Performance ◽  
Comparison Method ◽  
Average Treatment Effect ◽  
Operating Efficiency ◽  
Investment Strategies ◽  
Industry Group ◽  
Using Data ◽  
The Impact

This paper examines the impact of equitization on financial and operating performance of state-owned enterprises (SOEs) in Vietnam. Previous related privatization theories have not explained whether there is an improvement in financial and operating performance of equitized SOEs compared to non-equitized SOEs or not. This study proposes to use with-without comparison method through the average treatment effect measuring the impact of equitization on financial and operating performance of SOEs. By using data of 114 SOEs equitized in the period from 2012 to 2014, the author finds that equitized SOEs can not improve profitability, operating efficiency, and output when considering non-equitized SOEs. There is also no evidence for a reduction in the number of employees of equitized SOEs after equitization. These findings are in contrast to previous studies in Vietnam, but there are similarities with the results of studies in China. This is because equitized SOEs in the early post-equitization period in Vietnam are still monitored by the Vietnamese government, as well as the equitized enterprises in the period 2012-2014 are mainly large-scale ones with slow change of operating objectives, monitoring mechanism and weak competitiveness after equitization. However, equitization can help equitized SOEs operate more efficiently than non–equitized SOEs when considering non-listing status or industry group. This research provides implications for the Vietnamese government to encourage non-equitized enterprises to participate in the equitization program actively. The research results also help investors to have appropriate long-term investment strategies in equitized SOEs. This paper also has some limitations for further research.

scholarly journals Yet another lockdown? A large-scale study on people's unwillingness to be confined during the first 5 months of the COVID-19 pandemic in Spain

2021 ◽  
Author(s):  
Marina Martinez-Garcia ◽  
Alejandro Rabasa ◽  
Xavier Barber ◽  
Kristina Polotskaya ◽  
Kristof Roomp ◽  
...  
Keyword(s):  
Large Scale ◽  
Psychological Impact ◽  
Important Variable ◽  
Decision Makers ◽  
Policy Makers ◽  
Time Period ◽  
Economic Support ◽  
Gender And Age ◽  
The Impact

Population confinements have been one of the most widely adopted non-pharmaceutical interventions (NPIs) implemented by governments across the globe to help contain the spread of the SARS-CoV-2 virus. While confinement measures have been proven to be effective to reduce the number of infections, they entail significant economic and social costs. Thus, different policy makers and social groups have exhibited varying levels of acceptance of this type of measures. In this context, understanding the factors that determine the willingness of individuals to be confined during a pandemic is of paramount importance, particularly, to policy and decision-makers. In this paper, we study the factors that influence the unwillingness to be confined during the COVID-19 pandemic by means of a large-scale, online population survey deployed in Spain. We apply both quantitative (logistic regression) and qualitative (automatic pattern discovery) methods and consider socio-demographic, economic and psychological factors, together with the 14-day cumulative incidence per 100,000 inhabitants. Our analysis of 109,515 answers to the survey covers data spanning over a 5-month time period to shed light on the impact of the passage of time. We find evidence of pandemic fatigue as the percentage of those who report an unwillingness to be in confinement increases over time; we identify significant gender differences, with women being generally less likely than men to be able to sustain long-term confinement of at least 6 months; we uncover that the psychological impact was the most important factor to determine the willingness to be in confinement at the beginning of the pandemic, to be replaced by the economic impact as the most important variable towards the end of our period of study. Our results highlight the need to design gender and age specific public policies, to implement psychological and economic support programs and to address the evident pandemic fatigue as the success of potential future confinements will depend on the population's willingness to comply with them.

scholarly journals Core curriculum guidelines for a required clinical neurology experience

Neurology ◽  
2019 ◽  
Vol 92 (13) ◽  
pp. 619-626 ◽  
Author(s):  
Joseph E. Safdieh ◽  
Raghav Govindarajan ◽  
Douglas J. Gelb ◽  
Yazmin Odia ◽  
Madhu Soni
Keyword(s):  
Medical School ◽  
Core Curriculum ◽  
Diagnostic Errors ◽  
Health Impact ◽  
Basic Knowledge ◽  
Clinical Neurology ◽  
Self Directed Learning ◽  
Diverse Patient Population ◽  
The Impact ◽  
School Curricula

Physicians in most specialties frequently encounter patients with neurologic conditions. For most non-neurologists, postgraduate neurologic education is variable and often limited, so every medical school's curriculum must include clinical learning experiences to ensure that all graduating medical students have the basic knowledge and skills required to care for patients with common neurologic symptoms and neurologic emergencies. In the nearly 20 years that have elapsed since the development of the initial American Academy of Neurology (AAN)–endorsed core curriculum for neurology clerkships, many medical school curricula have evolved to include self-directed learning, shortened foundational coursework, earlier clinical experiences, and increased utilization of longitudinal clerkships. A workgroup of both the Undergraduate Education Subcommittee and Consortium of Neurology Clerkship Directors of the AAN was formed to update the prior curriculum to ensure that the content is current and the format is consistent with evolving medical school curricula. The updated curriculum document replaces the term clerkship with experience, to allow for its use in nontraditional curricular structures. Other changes include a more streamlined list of symptom complexes, provision of a list of recommended clinical encounters, and incorporation of midrotation feedback. The hope is that these additions will provide a helpful resource to curriculum leaders in meeting national accreditation standards. The curriculum also includes new learning objectives related to cognitive bias, diagnostic errors, implicit bias, care for a diverse patient population, public health impact of neurologic disorders, and the impact of socioeconomic and regulatory factors on access to diagnostic and therapeutic resources.

The Effect of Private Customer-Manager Social Engagement Upon Online Booking Behavior

2020 ◽  
pp. 193896552097533
Author(s):  
Saram Han ◽  
Christopher K. Anderson
Keyword(s):  
Social Engagement ◽  
Large Scale ◽  
Term Effect ◽  
Third Party ◽  
Travel Agency ◽  
Long Term Effects ◽  
Individual Level ◽  
Customer Manager ◽  
The Impact

Owing to the impact of third-party commissions upon hotel profitability, many hotel brands have actively engaged in book direct campaigns, but to date, no large-scale longitudinal effort has been conducted to systematically evaluate direct booking behavior (i.e., direct versus online travel agency [OTA]). In this study, we use three years of transactional data from a large hotel brand to evaluate booking channel choices. To address the dynamic nature of the longitudinal individual-level data, we use a hidden Markov model (HMM), allowing us to evaluate both short- and long-term effects. Using the HMM, we evaluate the latent loyalty status of customers through their observed online booking channel behavior (i.e., direct versus OTA). As a result, we find that customer–manager engagement through guest satisfaction surveys (and managerial responses to those surveys) has a long-term effect on consumer propensities to book direct, gradually increasing customer loyalty to the brand. Specifically, we find that positive customer feedback signals a greater willingness to book direct in subsequent purchases. Moreover, managerial responses to the satisfied customer result in greater tendency to remain loyal and book direct. Second, the membership program tier of the customer has a significant short-term effect on the consumer’s propensity to book direct. Low-loyalty customers’ direct booking tendency increases as soon as they join the membership program. These findings not only illustrate the impact of membership status upon channel choice but also indicate the effect of the customer’s voice and the resulting managerial response upon booking behaviors over time.

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