scholarly journals Neurobehavioral and hepatic complications induced by acute inhalation exposure to abamectin in female rats of the Wistar strain treated with ginger (Zingiber officinale)

2021 ◽  
Vol 9 (1) ◽  
pp. -----
Author(s):  
Ines Refes ◽  
Abdelkrim Tahraoui ◽  
Samir Djemli ◽  
Mabrouk Boussena ◽  
Faiza Rouag ◽  
...  
Keyword(s):  
Inhalation Exposure ◽  
Zingiber Officinale ◽  
Female Rats ◽  
Wistar Strain

Placental Grafts in Rats

Development ◽  
1961 ◽  
Vol 9 (1) ◽  
pp. 106-116
Author(s):  
J. M. Payne ◽  
Sylvia Payne
Keyword(s):  
Yolk Sac ◽  
Female Rats ◽  
Male Rats ◽  
Epidermoid Cysts ◽  
Wistar Strain ◽  
Albino Mice ◽  
Bulk Breeding ◽  
And Cartilage

We have previously reported that certain parts of the rat placenta are capable of growth and differentiation when transferred from the uterus to the mother's omentum (Payne & Payne, 1960). Yolk-sac membrane, transplanted on the 15th day of pregnancy, produced grafts containing a variety of tissues which included epidermoid cysts, mucus-secreting epithelium, muscle, bone, and cartilage. The purpose of this paper is to describe the work in detail and to report the results of further experiments. Methods Stock female rats (Albino Wistar strain) were used throughout except in 2 experiments where male rats of the same strain or stock albino mice were employed. The rats came from a colony at Compton which was not inbred although the population had been ‘closed’ for many years and bulk breeding had been practised. All animals were mature when incorporated in the experiments, rats weighing 200–250 g. and mice 20–25 g.

Protection Of Endotoxin Induced Disseminated Intravascular Coagulation In Rats By Gabexate Mesilate

1981 ◽  
Author(s):  
T Yoshikawa ◽  
Y Furukawa ◽  
M Murakami ◽  
S Takemura ◽  
M Kondo
Keyword(s):  
Disseminated Intravascular Coagulation ◽  
Femoral Vein ◽  
Inhibitory Effect ◽  
Female Rats ◽  
Gabexate Mesilate ◽  
Intravascular Coagulation ◽  
Wistar Strain ◽  
Potent Inhibitory Effect ◽  
Strong Inhibitory Effect ◽  
Hemorrhagic Tendency

Gabexate mesilate[ methane sulfonic acid salt of ethyl-p- (6-guanidino hexanoyloxy) benzoate : FOY ] has recently been developed in Japan, and has been known to have potent inhibitory effects on trypsin, kallikrein, plasmin, thrombin and C1-esterase. Advantage of clinical use of this agent is that FOY has smaller molecular weight than aproti- nin so that production of antibody against FOY is hardly observed. In the present investigation, effect of FOY on disseminated intravascular coagulation (DIC) was examined using experimental animal models, in comparison with that of heparin.Female rats of Wistar strain (8-weeks) were infused with l00mg/kg of bacterial endotoxin (Lipopolysaccharide B; E. coli; 055, Difco) continuously for 4 hours through femoral vein. Blood samples were serially taken from abdominal artery using catheter and examined for plasma fibrinogen, FDP, platelet counts, prothrombin time and partial thromboplastin time. After the experiment, kidneys were removed to examine the deposition of fibrin to glomeruli.Different concentrations of FOY were intraperitoneally injected to the rats prior to the infusion of endotoxin, and it was found that the administration of 10 mg/kg of FOY showed the most potent inhibitory effect on the development of DIC, either hematologically or histologically. In comparison, heparin showed a strong inhibitory effect on DIC over a dosage of 5 U/kg.It is concluded that, although inhibitory effect of FOY was less significant than heparin, FOY might be valuable agent for the treatment of DIC especially when heparin is difficult to use in such cases as severe hemorrhagic tendency.

Inhalation Toxicology of Octamethylcyclotetrasiloxane (D4) Following a 3-Month Nose-Only Exposure in Fischer 344 Rats

2002 ◽  
Vol 21 (1) ◽  
pp. 39-53 ◽  
Author(s):  
Leigh Ann Burns-Naas ◽  
Robert G. Meeks ◽  
Gary B. Kolesar ◽  
Richard W. Mast ◽  
Michael R. Elwell ◽  
...  
Keyword(s):  
Reproductive Tract ◽  
Inhalation Exposure ◽  
Female Reproductive Tract ◽  
Female Rats ◽  
Serum Chemistry ◽  
Fischer 344 Rats ◽  
Histopathological Changes ◽  
Male And Female ◽  
Fischer 344 ◽  
Toxicological Significance

Octamethylcyclotetrasiloxane (D4) is a low-molecular-weight cyclic siloxane used primarily in the synthesis of silicone polymers. The objective of the present study was to evaluate the subchronic toxicity of D4 following a 3-month nose-only inhalation exposure. Male and female Fischer 344 rats (20/sex/group) were exposed 6 h/day, 5 days/week for 3 months to vapor concentrations of 0, 35, 122, 488, and 898 ppm D4. Also, an additional 10 per sex in the control and high-exposure groups were allowed a 4-week recovery period to observe reversibility, persistence, or delayed occurrence of any potential adverse effects. Body weights and food consumption were monitored at least twice weekly over the course of exposures. Approximately 18 hours preceding euthanasia, animals were transferred into metabolism cages for urine collection, and were fasted. At necropsy, rats were anesthetized with pentobarbital and euthanized by exsanguination. Blood was collected for hematological and clinical biochemical analyses. Selected organ weights were measured and a complete set of tissues was taken for histopathological examination. A concentration-dependent increase in absolute and relative liver weight (488 to 898 ppm) and a significant decrease in ovarian weight (898 ppm) were observed in female rats. Exposure to D4 via nose-only inhalation (35 to 898 ppm) produced minor alterations in hematological and serum chemistry parameters that were considered either incidental and of little toxicological significance (hematology) or suggestive of metabolic adaptation/alteration (serum chemistry) in response to exposure-related hepatomegaly. There were no histopathological findings noted in the liver. Histopathological evidence indicated the primary target organs following D4 inhalation exposure to be components of the female reproductive tract. Reversible histopathological changes were observed in the ovary (hypoactivity) and vagina (mucification) of female rats in the high-dose group only (898 ppm). Although an increase in the incidence and severity of both macrophage accumulation, interstitial inflammation, and eosinophil infiltration was observed in the lungs of male and female rats exposed to D4, the toxicological significance is uncertain as other inhalation studies at similar concentrations failed to show these effects. In summary, nose-only inhalation of a high concentration of D4 resulted in reversible histopathological changes in the female rat reproductive tract. Lower concentrations did not elicit these same effects.

scholarly journals The effect of calcium intake on bone composition and bone resorption in the young growing rat

2001 ◽  
Vol 86 (4) ◽  
pp. 453-459 ◽  
Author(s):  
Annette Creedon ◽  
Kevin D. Cashman
Keyword(s):  
Bone Resorption ◽  
Bone Mineral ◽  
Dry Weight ◽  
Female Rats ◽  
Wistar Strain ◽  
Restricted Group ◽  
Growing Rat ◽  
Old Rats ◽  
Bone Mineral Accrual ◽  
Recommended Level

A low Ca intake by both rats and man increases bone resorption, decreases bone mass and increases the risk of osteoporosis. The skeletal effect of high Ca intakes is less clear, particularly during periods of bone mineral accrual. Twenty-four female 5-week-old rats, Wistar strain, were randomized by weight into three groups of eight rats each and fedad libituma semi-purified diet containing 2 (Ca-restricted), 5 (normal) or 20 (Ca-supplemented) g Ca/kg for 3 weeks. When compared with the normal Ca diet, urinary Ca excretion was unaffected by the dietary restriction of Ca for 3 weeks, but was greater (P<0·001) in Ca-supplemented rats. Urinary pyridinoline (Pyr) and deoxypyridinoline (Dpyr) levels were significantly greater during weeks 2 (PyrP<0·05, DpyrP<0·001) and 3 (PyrP<0·01, Dpyr,P<0·001) of dietary Ca restriction, but were unaffected by Ca supplementation. Femoral dry weight and the concentration of Mg and P in femora were unaffected by dietary Ca concentration. Femoral Ca concentration was reduced (P<0·05) in the Ca-restricted group compared with the other two groups. In conclusion, these results suggest that increasing dietary Ca intake, well above the recommended level, had no effect on bone mineral composition or bone resorption (as assessed with urinary pyridinium crosslinks) in young growing female rats. In addition, these results confirm the findings of previous studies which have shown that bone Ca content in young growing rats was reduced by dietary Ca restriction and that this reduction results, at least in part, from an increased rate of bone resorption.

Effects of a 13-Week Chloropentafluorobenzene Inhalation Exposure of Fischer 344 Rats and B6C3F1 Mice

1991 ◽  
Vol 7 (4) ◽  
pp. 309-318 ◽  
Author(s):  
Edwin R. Kinkead ◽  
Susan K. Bunger ◽  
Edgar C. Kimmel ◽  
Carlyle D. Flemming ◽  
Henry G. Wall ◽  
...  
Keyword(s):  
Inhalation Exposure ◽  
Chemical Warfare Agents ◽  
Female Rats ◽  
Laboratory Animals ◽  
High Concentration ◽  
Inhalation Study ◽  
Male And Female ◽  
Male And Female Rats ◽  
Warfare Agents ◽  
Rats And Mice

Chloropentafluorobenzene (CPFB) has been identified as a can didate simulant for nonpersistent chemical warfare agents. Acute toxicity studies have shown that CPFB has limited adverse ef fects on laboratory animals. A 21-day inhalation study of rats and mice to 2.5, 0.8, and 0.25 mg CPFB/liter resulted in re duced weight gain in male and female rats exposed at the high concentration only and identified the liver as a potential target organ. This multiconcentration inhalation study was designed to detect a no-observable-effect level associated with repeated expo sure to CPFB. Male and female rats and mice were exposed to 250, 50, or 10 mg CPFB/m3 (0.25, 0.05, or 0.01 mg CPFB/li ter) for 13 weeks. No treatment-related effects on body weight, clinical chemistries, mortality, absolute or relative organ weight or histopathology were noted.

scholarly journals Effect of per oral sipermetrin exposure on serum 17 estradiol and uterine malondialdehyde (MDA) levels in female Wistar strain rats (Rattus norvegicus)

2018 ◽  
Vol 26 (1) ◽  
pp. 20
Author(s):  
Hesty Widowati ◽  
Hidayat Sujuti ◽  
Karyono Mintaroem
Keyword(s):  
Rattus Norvegicus ◽  
Serum Levels ◽  
Female Rats ◽  
Control Group ◽  
Serum Estradiol ◽  
Opposite Pattern ◽  
Wistar Strain ◽  
Significant Difference ◽  
Post Test

Objective: This study aimed to verify the effect of oral siper-metrin exposure to decrease serum estradiol 17b levels and increased malondialdehyde (MDA) in the uterus level of female Wistar strain rats (Rattus norvegicus).Materials and Methods: The method of this study was true experimental post test only control group in vivo using 24 female rats, divided into 3 groups treated by administering a dose of 5, 10 and 20 mg/kg sipermetrin for 28 days and one control group. Then blood samples were taken from the heart for measurement of serum estradiol 17b levels by ELISA and uterine organs were taken for measurement of Malondialdehyde (MDA) with spectro-photometry method.Results: The results of the measurement of serum estradiol 17b and uterus malondialdehyde (MDA) levels of female Wistar strain rats (Rattus norvegicus) showed an opposite pattern, where there was a decline in serum estradiol 17b levels and an increase in uterus malondialdehyde (MDA) level. There was a significant difference (p=0.000<alpha) in 17b estradiol serum and uterus Malondialdehyde (MDA) levels of female rats between control group and group exposed to sipermetrin treatment for 28 days.Conclusions: Oral sipermetrin exposure can decrease serum levels of estradiol 17b and increase uterine levels of malondi-aldehyde (MDA) of female Wistar strain rats (Rattus norvegicus).

scholarly journals A SUBCHRONIC TOXICITY TEST OF ETHANOL EXTRACT FROM TUNJUK LANGIT RHIZOME (HELMINTHOSTACHYS ZEYLANICA) ON ALBINO RATS, RATTUS NOVERTICUS (WISTAR STRAIN)

2017 ◽  
Vol 10 (2) ◽  
pp. 270
Author(s):  
Fitrya Fitrya ◽  
Najma Annuria Fithry
Keyword(s):  
Ethanol Extract ◽  
Biochemical Properties ◽  
Female Rats ◽  
Albino Rats ◽  
Subchronic Toxicity ◽  
Group V ◽  
Toxic Symptom ◽  
Male And Female Rats ◽  
Wistar Strain ◽  
Ethanol Extracts

Objective: Traditionally, Tunjuk langit (Helmynthostachis zaylanica) rhizome has been used as anticancer and anti-inflammation drugs; however, it may have toxic effects on major organs for a long-term continuously consecutive consumption. Therefore, this study was carried out to test sub- chronic toxicity of the ethanol extract of the rhizome on Albino rats, Rattus noverticus (Wistar strain). Methods: A total of 100 male and female rats were divided into five groups. Groups I, II, III, and IV were orally administered with ethanol extracts of 68, 136, 272, and 554 mg/kg body weight (BW), respectively. Meanwhile, Group V used as a control was no treatment with the extract. A toxic symptom has been observed by analyzing several parameters, namely BW, hematologic and biochemical properties, macroscopic organs, and relative organ weight.Results: In general, the results show that there is no any toxic symptom and statistically insignificant differences in these parameters between treated and control groups. Conclusion: We conclude that the ethanol extract of Tunjuk Langit rhizome does not have effects of subchronic toxicity.Keywords: Tunjuk langit rhizome, Ethanol extract, Subchronic toxicity.

DEVELOPMENT OF A STRAIN OF RATS WITH GREATER THAN NORMAL SUSCEPTIBILITY TO OXYGEN POISONING

1966 ◽  
Vol 44 (2) ◽  
pp. 259-265 ◽  
Author(s):  
J. D. Wood
Keyword(s):  
High Pressure ◽  
Second Generation ◽  
Female Rats ◽  
Third Generation ◽  
Male And Female ◽  
Male And Female Rats ◽  
Wistar Strain ◽  
Oxygen Poisoning ◽  
Parent Generation

Male and female rats of the Wistar strain were exposed to oxygen at high pressure (OHP) once per week for 3 weeks. Based on the incidence and severity of the convulsions observed, animals were selected which were considered the most susceptible and the most resistant to oxygen poisoning. The animals were mated and the offspring exposed to OHP. The rats from susceptible parents were more than normally susceptible to oxygen poisoning as gauged by time until onset of convulsions, incidence and severity of convulsions, and mortality. The animals from resistant parents were no more tolerant of OHP than were the randomly selected rats of the parent generation. Similar results were observed with a third generation of rats obtained by mating second generation susceptible and resistant animals respectively.

scholarly journals Effects of Stimulation and Blockade of Receptor on Depression-Like Behavior in Ovariectomized Female Rats

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Julia Fedotova
Keyword(s):  
Receptor Antagonist ◽  
Receptor Agonist ◽  
Low Dose ◽  
Forced Swimming Test ◽  
Forced Swimming ◽  
Female Rats ◽  
Ovx Rats ◽  
Wistar Strain ◽  
Immobility Time ◽  
Swimming Test

The aim of the present study was to explore the hedonic effects of D2 receptor agonist, quinpirole and D2 receptor antagonist, and sulpiride alone or in combination with a low dose of 17β-E2-estradiol (17β-E2) in the adult ovariectomized female rats (OVX). OVX rats of Wistar strain were used in all experiments. Two weeks after surgery rats were chronically treated with vehicle, a low dose of 17β-E2 (5.0 μg/rat), quinpirole (0.1 mg/kg), sulpiride (10.0 mg/kg), quinpirole plus 17β-E2, or sulpiride plus 17β-E2 for 14 days before the forced swimming test. We found that sulpiride significantly decreased immobility time in the OVX females. A combination of sulpiride with a low dose of 17β-E2 induced more profound decrease of immobility time in the OVX rats compared to the rats treated with sulpiride alone. On the contrary, quinpirole failed to modify depression-like behavior in the OVX rats. In addition, quinpirole significantly blocked the antidepressant-like effect of 17β-E2 in OVX rats. Thus, the D2 receptor antagonist sulpiride alone or in combination with a low dose of 17β-E2 exerted antidepressant-like effect in OVX female rats, while the D2 receptor agonist quinpirole produced depressant-like profile on OVX rats.

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