Administration of curcumin affects the anxiety behavior in Wistar rats after formaldehyde injected

2021 ◽  
Vol 9 (3) ◽  
pp. -----
Mouna Nouacer ◽  
Amira Bakeche ◽  
Ibtissem Chouba ◽  
Abdelkrim Tahraoui
2020 ◽  
pp. 95-104
Samanta Cristina-Siebel-de-Moraes ◽  
Victória Branca Moron ◽  
Aline Belem-Machado ◽  
Paula Schmitt ◽  
Daniela Montanari-Migliavacca-Osorio ◽  

El Material Particulado (MP) puede alterar los procesos cognitivos, el comportamiento depresivo y hematológico en el modelo animal. El objetivo fue evaluar los efectos causados por MP en los parámetros conductuales, hematológicos y bioquímicos en un modelo animal. Se observaron alteraciones en la actividad locomotora de las ratas, donde hubo una disminución significativa en la locomoción del Grupo 3 (MP10) en comparación con los Grupo 1 (Control) y Grupo 2 (MP2,5). Con respecto al comportamiento de ansiedad, el Grupo 3 pasó significativamente más tiempo en brazos abiertos en comparación con el control y MP2,5. No se observaron cambios hematológicos y bioquímicos. En este estudio, se concluye que, la exposición a la MP puede causar daño neurológico y, en consecuencia, afectar a otros sistemas. Particulate matter (PM) can alter the cognitive processes, the depressive behavior, and the hematological profile in animals. This study aimed to evaluate the effects on behavioral, hematological, and biochemical parameters caused by PM in an animal model. A significant decrease in the locomotion activity of Group 3 (PM10) in relation to Group 1 (Control) and Group 2 (PM2.5) was observed. Regarding the anxiety behavior, Group 3 remained significantly the most part of the time in the open arms when compared to the control and PM2.5 groups. No hematological or biochemical alterations were observed among groups. In this study, we concluded that the exposure to particulate matter can cause neurological damages, and consequently, affect other systems.

2020 ◽  
Deepika Patel ◽  
Ioannis Koutlas ◽  
Sebastiaan H. de Waard ◽  
Bauke Buwalda

ABSTRACTSuppression of hippocampal neurogenesis is a readout for stress-induced alterations in neuroplasticity. In this study, we hypothesized that a single episode of severe social or non-social stress would differentially suppress neurogenesis in the dentate gyrus (DG) 10 days later in two rat strains. We anticipated that the suppression following social stress would be less severe in wildtype Groningen (WTG) rats, a rat strain considered relatively resilient to social stressors. Male Wistar and WTG were subjected to either social defeat or to immobilization stress. Behavioral response to social defeat and acute corticosterone response to both stressors was measured as well as anxiety behavior 10 days later on the elevated plus maze. Subsequently, brains were collected following cardiac aldehyde perfusion. The behavioral freezing response to defeat was much stronger in Wistar rats as compared to WTG rats. Acute corticosteroid response was similar in both strains although Wistar rats more rapidly resumed baseline values. There was no significant effect of both stressors on hippocampal DG cell proliferation and differentiation as well as on anxiety behavior. However, a striking strain difference appeared in anxiety behavior and both markers of neurogenesis. The WTG strain exhibiting much lower anxiety as well as reduced rate of hippocampal neurogenesis under all treatments. The results in this study suggest that both short-lasting acute stressors failed to induce lasting anxiety or decreased neurogenesis in the DG. Future studies could explore if and how rate of hippocampal neurogenesis is related with behavioral coping with stress.

2012 ◽  
Vol 32 (11) ◽  
pp. 920-928 ◽  
K. Dziendzikowska ◽  
J. Gromadzka-Ostrowska ◽  
A. Lankoff ◽  
M. Oczkowski ◽  
A. Krawczyńska ◽  

2009 ◽  
Vol 42 (02) ◽  
pp. 110-114 ◽  
T. T. Yang ◽  
S-M. Ling ◽  
C-W. Tsao ◽  
J-T. Cheng

2011 ◽  
Vol 57 (06) ◽  
pp. 339-346
Amaya Azqueta ◽  
Ana Gil ◽  
Alba García-Rodríguez ◽  
Jose García-Jalón ◽  
Felipe Cia ◽  

2011 ◽  
Vol 32 (6) ◽  
pp. 436-445 ◽  
P. V. Prabhakar ◽  
Utkarsh A. Reddy ◽  
S. P. Singh ◽  
A. Balasubramanyam ◽  
M. F. Rahman ◽  

2011 ◽  
Vol 33 (1) ◽  
pp. 24-31 ◽  
Simone de Siqueira Bringel ◽  
Adelmar Afonso de Amorim Júnior ◽  
Marleyne José Afonso Accioly Lins Amorim ◽  
Lorena Tavares Brito ◽  
Rosana Nogueira Morais ◽  

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