scholarly journals Effects of quercetin and low-level laser on oxidative and inflammatory factors among patients with type 2 diabetes mellitus and mild cognitive impairment

2022 ◽  
Vol 5 (1) ◽  
pp. 1
Author(s):  
Danik M. Martirosyan ◽  
Mohammad Reza Ashoori ◽  
Alireza Rezaeinezhad ◽  
Fahimeh Jahanbakhshi ◽  
Shaghayegh Pezeshki ◽  
...  

Background: Unmanaged type 2 diabetes mellitus has dangerous consequences, such as neuropathy. Oxidative stress and inflammatory factors play an important role in the development of diabetic neuropathy. Diabetics are prone to mild cognitive impairment, which is a neurological disease. The aim of this study was to investigate the effects of quercetin as a functional food and oxidative agents and inflammatory factors of low-level laser.Methods: In this study, 60 elderly volunteers were selected: 30 normal as a control group and 30 with type 2 diabetes mellitus and mild cognitive impairment. The average age was 75 years old. Groups of diabetic patients were examined for changes in glucose levels, oxidants, antioxidants and inflammatory factors before and after treatment with quercetin and low-level laser therapy–green laser diode with a wavelength of 532 nm at 100 mw and compared with the control group. Changes in the levels of biochemical parameters were performed according to the instructions of the relevant kits. Results: The results of the obtained data analysis showed that there was a significant difference (P value < 0.05) in the levels of glucose, hydrogen peroxide, advanced glycation end-products, malondialdehyde, oxidized-low density lipoprotein, paraoxonase, lipoprotein lipase, and inflammatory factors including TNF-α, interleukin-1 alpha and interleukin-1 beta between diabetic samples before and after treatment with quercetin and laser from control subject samples. There was no significant difference (P value > 0.05) in inflammatory factors between quercetin-treated, laser-treated and both quercetin and laser treated groups. The synergistic effect of quercetin and laser between the quercetin and laser treated group and the untreated group on changes in the levels of biochemical parameters was observed significantly only in advanced glycation end-products, malondialdehyde, oxidized-low density lipoprotein, and paraoxonase.Conclusion: The results showed that quercetin, laser, and their synergistic effect can play a role in reducing some oxidant factors.Keywords: Quercetin, Low-level laser, Inflammatory factors, Oxidative factors, Diabetes mellitus

2020 ◽  
Vol 3 (5) ◽  
pp. 82
Author(s):  
Danik Martirosyan ◽  
Mohammad Reza Ashoori ◽  
Hossein Mirmiranpour

Background: The control and management of type 2 diabetes mellitus is the most important way to prevent health consequences of the disease. Oxidative stress derived from diabetes mellitus is an important cause of these symptoms in uncontrolled diabetic patients. The consumption of functional foods containing antioxidants and trace minerals can help prevent these consequences and control diabetes mellitus.Objective: In this study, we examined whether low-level laser therapy could have an effect on levels of antioxidant enzymes and minerals in the serum of patients with type 2 diabetes mellitus.Methods: Thirty individuals with type 2 diabetes and thirty healthy individuals, as controls, were selected as participants for this study. The levels of antioxidant enzymes glutathione peroxidase, catalase, superoxide dismutase; biochemical parameters, such as glucose and hydrogen peroxide; minerals iron, zinc, magnesium, copper; and selenium binding protein 1 (as an indicator of selenium) were studied before and after low level-laser therapy.Results: The levels of antioxidant enzymes and some minerals significantly increased in control and diabetic patients after low level-laser therapy. The levels of glucose, hydrogen peroxide, and selenium binding protein 1, however, were unchanged after low-level laser therapy.Conclusions: Low level-laser therapy may be an important tool for reducing oxidative stress caused by type 2 diabetes mellitus due to its ability to increase levels of antioxidant enzymes and mineral content.Keywords: Laser Irradiation; Antioxidant; Functional Foods/Bioactive Compounds; Diabetes Mellitus.


2019 ◽  
Vol Volume 15 ◽  
pp. 167-175 ◽  
Author(s):  
Oana Albai ◽  
Mirela Frandes ◽  
Romulus Timar ◽  
Deiana Roman ◽  
Bogdan Timar

Author(s):  
Noritaka Machii ◽  
Akihiro Kudo ◽  
Haruka Saito ◽  
Hayato Tanabe ◽  
Mariko Iwasaki ◽  
...  

Diabetes is a risk factor for mild cognitive impairment (MCI) and dementia. However, how the clinical characteristics of type 2 diabetic patients with MCI are linked to sarcopenia and/or its criterion remain to be elucidated. Japanese patients with type 2 diabetes mellitus were categorized into the MCI group for MoCA-J (the Japanese version of the Montreal cognitive assessment) score &lt;26, and into the non-MCI group for MoCA-J &ge;26. Sarcopenia was defined by a low skeletal mass index along with low muscle strength (handgrip strength) or low physical performance (walking speed &lt;1.0 m/s). Univariate and multivariate-adjusted odds ratio models were used to determine the independent contributors for MoCA-J &lt;26. Among 438 participants, 221 (50.5%) and 217 (49.5%) comprised the non-MCI and MCI groups, respectively. In the MCI group, age (61 &plusmn; 12 vs. 71 &plusmn; 10 years, p &lt; 0.01) and duration of diabetes (14 &plusmn; 9 vs. 17 &plusmn; 9 years, p &lt; 0.01) were higher than those in the non-MCI group. Patients in the MCI group exhibited lower hand grip strength, walking speed, and skeletal mass index, but higher prevalence of sarcopenia. Only walking speed (rather than muscle loss or muscle weakness) was found to be an independent determinant of MCI after adjusting for multiple factors, such as age, gender, BMI, duration of diabetes, hypertension, dyslipidemia, smoking, drinking, eGFR, HbA1c, and history of coronary heart diseases and stroke. In subgroup analysis, a group consisting of male patients aged &ge;65 years, with BMI &lt;25, showed a significant OR for walking speed. This is the first study to show that slow walking speed is a sole determinant for the presence of MCI in patients with type 2 diabetes. It was suggested that walking speed is an important factor in the prediction and prevention of MCI development in patients with diabetes mellitus.


2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Dan Guo ◽  
Yang Yuan ◽  
Rong Huang ◽  
Sai Tian ◽  
Jiaqi Wang ◽  
...  

Abstract Background The adipokine adipsin contributes to insulin resistance (IR), inflammation, and obesity, which are all regarded as high-risk factors for mild cognitive impairment (MCI) in patients with type 2 diabetes mellitus. This research aimed to uncover the role of adipsin in Chinese type 2 diabetes mellitus (T2DM) population with early cognitive dysfunction and determine whether adipsin contributes to diabetic MCI caused by IR. Methods In our study, 126 patients with T2DM were enrolled. The Montreal Cognitive Assessment (MoCA) was used to assess cognitive impairment. Demographic data and neuropsychological test results were evaluated. Plasma adipsin level was measured by enzyme-linked immunosorbent assay. Results The MCI group (n = 57) presented higher plasma adipsin levels compared with the healthy controls (p = 0.018). After adjustment for educational attainment, and age, begative correlations were found between plasma adipsin levels and MoCA, Mini Mental State Exam, and Verbal Fluency Test scores(r = − 0.640, p < 0.001; r = − 0.612, p < 0.001; r = − 0.288, p = 0.035; respectively). Correlation analysis demonstrated that adipsin levels were significantly positively correlated with fasting C-peptide; homeostasis model of assessment for insulin resistance (HOMA-IR) (r = 0.368, p < 0.001; r = 0.494, p < 0.001; respectively). Multivariable regression analysis further indicated that high plasma adipsin level was a significant independent determinant of MCI in the Chinese population withT2DM (p = 0.017). Conclusions Elevated plasma adipsin level was associated with MCI in Chinese T2DM patients. Further large-scale studies should be designed to determine whether adipsin is linked to IR-associated susceptibility to early cognitive decline in T2DM patients.


PLoS ONE ◽  
2020 ◽  
Vol 15 (7) ◽  
pp. e0236453
Author(s):  
Iman I. Salama ◽  
Samia M. Sami ◽  
Ghada A. Abdellatif ◽  
Amira Mohsen ◽  
Hanaa Rasmy ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document