scholarly journals Acute triiodothyronine treatment and red blood cell sedimentation rate (ESR) in critically ill COVID-19 patients: A novel association?

Author(s):  
Constantinos Pantos ◽  
Vassiliki Apostolaki ◽  
Leonidas Kokkinos ◽  
Athanassios Trikas ◽  
Iordanis Mourouzis

Sepsis and septic shock result in impaired microcirculation and red blood cell rheology which lead to tissue hypoxia and multi-organ failure. Early administration of triiodothyronine prevents tissue hypoxia in experimental sepsis. In this context, a clinical trial was initiated to test the efficacy of acute triiodothyronine administration to combat tissue hypoxia in critically ill COVID19 patients. Here, we provide preliminary data from interim analysis of this study showing a novel acute effect of triiodothyronine on erythrocyte sedimentation rate which may have an important therapeutic impact on red blood cell rheology and tissue hypoxia in sepsis and particular in COVID19 critical illness. Trial registration: ClinicalTrials.gov, NCT04348513. Registered 16 April 2020, https://clinicaltrials.gov/ct2/show/NCT04348513

2005 ◽  
Vol 16 (7) ◽  
pp. 537 ◽  
Author(s):  
Michael Piagnerelli ◽  
Karim Zouaoui Boudjeltia ◽  
Michel Vanhaeverbeek

2009 ◽  
Vol 37 (12) ◽  
pp. 3041-3046 ◽  
Author(s):  
Giulia Reggiori ◽  
Giovanna Occhipinti ◽  
Andrea De Gasperi ◽  
Jean-Louis Vincent ◽  
Michael Piagnerelli

2014 ◽  
Vol 166 (4) ◽  
pp. 601-606 ◽  
Author(s):  
Régine Hierso ◽  
Xavier Waltz ◽  
Pierre Mora ◽  
Marc Romana ◽  
Nathalie Lemonne ◽  
...  

Author(s):  
M. Piagnerelli ◽  
K. Zouaoui Boudjeltia ◽  
M. Vanhaeverbeek ◽  
J. -L. Vincent

2010 ◽  
Vol 45 (2-4) ◽  
pp. 329-336 ◽  
Author(s):  
A. Seda Artis ◽  
Sami Aydogan ◽  
M. Gokhan Sahin

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