Two Year Outcomes, Cognitive and Behavioral Markers of Decline in Healthy, Cognitively Normal Older Persons with Global Deterioration Scale Stage 2 (Subjective Cognitive Decline with Impairment)

2019 ◽  
Vol 67 (2) ◽  
pp. 685-705 ◽  
Author(s):  
Barry Reisberg ◽  
Carol Torossian ◽  
Melanie B. Shulman ◽  
Isabel Monteiro ◽  
Istvan Boksay ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Older Persons ◽  
Subjective Cognitive Decline ◽  
Global Deterioration Scale ◽  
Cognitively Normal ◽  
Behavioral Markers

scholarly journals Subjective cognitive decline in cognitively normal elders from the community or from a memory clinic: Differential affective and imaging correlates

2016 ◽  
Vol 13 (5) ◽  
pp. 550-560 ◽  
Author(s):  
Audrey Perrotin ◽  
Renaud La Joie ◽  
Vincent de La Sayette ◽  
Louisa Barré ◽  
Florence Mézenge ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Subjective Cognitive Decline ◽  
Memory Clinic ◽  
Cognitively Normal ◽  
Community Or

P4-381: DISCLOSURE OF AMYLOID STATUS FOR RISK OF ALZHEIMER'S DISEASE TO COGNITIVELY NORMAL PERSONS WITH SUBJECTIVE COGNITIVE DECLINE

2006 ◽  
Vol 14 (7S_Part_31) ◽  
pp. P1620-P1620
Author(s):  
Taisei Wake ◽  
Hajime Tabuchi ◽  
Kei Funaki ◽  
Daisuke Ito ◽  
Bun Yamagata ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Decline ◽  
Subjective Cognitive Decline ◽  
Cognitively Normal

scholarly journals P3-447: MINOR NEUROPSYCHOLOGICAL DEFICITS IN COGNITIVELY NORMAL OLDER INDIVIDUALS WITH SUBJECTIVE COGNITIVE DECLINE: RESULTS FROM THE DELCODE STUDY

2019 ◽  
Vol 15 ◽  
pp. P1133-P1134
Author(s):  
Steffen Wolfsgruber ◽  
Luca Kleineidam ◽  
Oliver Peters ◽  
Katharina Buerger ◽  
Michael Ewers ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Neuropsychological Deficits ◽  
Subjective Cognitive Decline ◽  
Older Individuals ◽  
Cognitively Normal

scholarly journals Validation of a 4‐item subjective cognitive decline screening questionnaire in cognitively normal older adults

2021 ◽  
Vol 17 (S6) ◽  
Author(s):  
Jennifer Strenger ◽  
Jessica Alber ◽  
Edmund Arthur ◽  
Peter J Snyder ◽  
Stuart Sinoff ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Decline ◽  
Subjective Cognitive Decline ◽  
Cognitively Normal ◽  
Screening Questionnaire

scholarly journals Subjective Cognitive Decline Modifies the Relationship Between Cerebral Blood Flow and Memory Function in Cognitively Normal Older Adults

2017 ◽  
Vol 24 (3) ◽  
pp. 213-223 ◽  
Author(s):  
Chelsea C. Hays ◽  
Zvinka Z. Zlatar ◽  
Laura Campbell ◽  
M.J. Meloy ◽  
Christina E. Wierenga
Keyword(s):  
Cognitive Decline ◽  
Verbal Memory ◽  
Memory Performance ◽  
Inferior Frontal Gyrus ◽  
Memory Function ◽  
Posterior Cingulate Cortex ◽  
Middle Temporal Gyrus ◽  
Subjective Cognitive Decline ◽  
Cognitively Normal ◽  
Middle Temporal

AbstractObjectives: Subjective cognitive decline (SCD), or self-reported cognitive decline despite normal neuropsychological test performance, is a risk factor for objective cognitive decline and Alzheimer’s disease (AD). While brain mechanisms contributing to SCD are not well defined, studies show associations with vascular risk factors and altered cerebral blood flow (CBF), raising the hypothesis that those with SCD might be experiencing vascular dysregulation, or a disruption in the normal relationship between CBF and cognition. We examined whether the association between CBF and verbal memory performance differs between those with SCD (SCD+) and those without SCD (SCD-). Methods: Linear mixed-effects models were used to investigate whether the voxel-wise relationship between arterial spin labeling (ASL) MRI-measured CBF and verbal memory performance was modified by SCD among a group of 70 cognitively normal older adults (35 SCD+, 35 SCD-; mean age=72) matched on age, gender, and symptoms of depression. Results: Results indicated that the SCD- group exhibited positive associations between verbal memory and CBF within the posterior cingulate cortex, middle temporal gyrus, and inferior frontal gyrus, whereas the SCD+ group displayed negative associations between verbal memory and CBF within the posterior cingulate cortex, middle temporal gyrus, hippocampus, fusiform gyrus, and inferior frontal gyrus. Conclusions: Findings suggest that, while higher CBF is supportive of memory function in those without SCD, higher CBF may no longer support memory function in those presenting with SCD, perhaps reflecting neurovascular dysregulation. (JINS, 2018, 24, 213–223)

Subjective cognitive decline predicts future deterioration in cognitively normal patients with Parkinson's disease

2014 ◽  
Vol 35 (7) ◽  
pp. 1739-1743 ◽  
Author(s):  
Jin Yong Hong ◽  
Mun Kyung Sunwoo ◽  
Seok Jong Chung ◽  
Jee Hyun Ham ◽  
Ji E. Lee ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Decline ◽  
Subjective Cognitive Decline ◽  
Cognitively Normal

P1-232: Subjective cognitive decline and Aβ status are associated with longitudinal episodic memory decline in cognitively normal older adults

2015 ◽  
Vol 11 (7S_Part_9) ◽  
pp. P441-P441
Author(s):  
Rachel F. Buckley ◽  
Paul Maruff ◽  
Kathryn A. Ellis ◽  
Lance Macaulay ◽  
Ralph N. Martins ◽  
...  
Keyword(s):  
Older Adults ◽  
Episodic Memory ◽  
Cognitive Decline ◽  
Subjective Cognitive Decline ◽  
Memory Decline ◽  
Cognitively Normal

scholarly journals White Matter Integrity Underlies the Physical-Cognitive Correlations in Subjective Cognitive Decline

2021 ◽  
Vol 13 ◽  
Author(s):  
Yi-Chia Wei ◽  
Chih-Chin Heather Hsu ◽  
Wen-Yi Huang ◽  
Yao-Liang Chen ◽  
Chemin Lin ◽  
...  
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
White Matter ◽  
Cognitive Decline ◽  
Cognitive Performance ◽  
Physical Inactivity ◽  
Subjective Cognitive Decline ◽  
Cognitively Normal ◽  
Corona Radiata ◽  
Moca Score

Objective: Although previous studies postulated that physical and cognitive decline codeveloped in preclinical dementia, the interconnected relationship among subjective cognitive complaints (SCCs), objective cognitive performance, and physical activity remained hazy. We investigated the mediating roles of physical activity between subjective and objective cognition. Diffusion tensor imaging (DTI) was utilized to test our hypothesis that brain white matter microstructural changes underlie the physical-cognitive decline in subjective cognitive decline (SCD).Methods: We enrolled cognitively normal older adults aged > 50 years in the Community Medicine Research Center of Keelung Chang Gung Memorial Hospital during 2017–2020. Regression models analyzed mediation effects of physical activity between subjective and objective cognition. The self-reported AD8 questionnaire assessed SCCs. The SCD group, defined by AD8 score ≥ 2, further underwent diffusion MRI scans. Those who agreed to record actigraphy also wore the SOMNOwatch™ for 72 h. Spearman's correlation coefficients evaluated the associations of diffusion indices with physical activity and cognitive performance.Results: In 95 cognitively normal older adults, the AD8 score and the Montreal Cognitive Assessment (MoCA) score were mediated partially by the metabolic equivalent of the International Physical Activity Questionnaire-Short Form (IPAQ-SF MET) and fully by the sarcopenia score SARC-F. That is, the relation between SCCs and poorer cognitive performance was mediated by physical inactivity. The DTI analysis of 31 SCD participants found that the MoCA score correlated with mean diffusivity at bilateral inferior cerebellar peduncles and the pyramids segment of right corticospinal tract [p < 0.05, false discovery rate (FDR) corrected]. The IPAQ-SF MET was associated with fractional anisotropy (FA) at the right posterior corona radiata (PCR) (p < 0.05, FDR corrected). In 15 SCD participants who completed actigraphy recording, the patterns of physical activity in terms of intradaily variability and interdaily stability highly correlated with FA of bilateral PCR and left superior corona radiata (p < 0.05, FDR corrected).Conclusions: This study addressed the role of physical activity in preclinical dementia. Physical inactivity mediated the relation between higher SCCs and poorer cognitive performance. The degeneration of specific white matter tracts underlay the co-development process of physical-cognitive decline in SCD.

scholarly journals Regional atrophy and cognitive decline depend on definition of subjective cognitive decline

2021 ◽  
Author(s):  
Cassandra Morrison ◽  
Mahsa Dadar ◽  
Neda Shafiee ◽  
Sylvia Villeneuve ◽  
D. Louis Collins ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Cognitive Decline ◽  
Cognitive Change ◽  
Disease Assessment ◽  
Subjective Cognitive Decline ◽  
Cognitively Normal ◽  
Increased Risk ◽  
Definition Of

AbstractBackgroundPeople with subjective cognitive decline (SCD) may be at increased risk for Alzheimer’s disease (AD). However, not all studies have observed this increased risk. Inconsistencies may be related to different methods used to define SCD. The current project examined whether four methods of defining SCD (applied to the same sample) results in different patterns of atrophy and future cognitive decline between cognitively normal older adults with (SCD+) and without SCD (SCD-).MethodsMRI scans and questionnaire data for 273 cognitively normal older adults from Alzheimer’s Disease Neuroimaging Initiative were examined. To operationalize SCD we used four common methods: Cognitive Change Index (CCI), Everyday Cognition Scale (ECog), ECog + Worry, and Worry only. A previously validated MRI analysis method (SNIPE) was used to measure hippocampal volume and grading. Deformation-based morphometry was performed to examine volume at regions known to be vulnerable to AD. Logistic regressions were completed to determine whether diagnostic method was associated with volume differences between SCD- and SCD+. Linear mixed effects models were performed to examine the relationship between the definitions of SCD and future cognitive decline.ResultsResults varied between the four methods of defining SCD. Left hippocampal grading was lower in SCD+ than SCD-when using the CCI (p=.041) and Worry (p=.021) definitions. The right (p=.008) and left (p=.003) superior temporal regions were smaller in SCD+ than SCD-, but only with the ECog. SCD+ was associated with greater future cognitive decline measured by Alzheimer’s Disease Assessment Scale, but only with the CCI definition. In contrast, only the ECog definition of SCD was associated with future decline on the Montreal Cognitive Assessment.ConclusionThe current findings suggest that the various methods used to differentiate between SCD- and SCD+ influence whether volume differences and findings of cognitive decline are observed between groups in this retrospective analysis.

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