Accelerometer-Measured, Habitual Physical Activity and Circulating Brain-Derived Neurotrophic Factor: A Cross-Sectional Study

2021 ◽  
pp. 1-10
Author(s):  
Nicole L. Spartano ◽  
Jayandra J. Himali ◽  
Ludovic Trinquart ◽  
Qiong Yang ◽  
Galit Weinstein ◽  
...  
Keyword(s):  
Physical Activity ◽  
Neurotrophic Factor ◽  
Smoking Status ◽  
Linear Trend ◽  
Brain Derived Neurotrophic Factor ◽  
Cross Sectional Study ◽  
Activity Levels ◽  
Vigorous Activity ◽  
Middle Aged ◽  
Cross Sectional

Background: One of the mechanisms suggested to link physical activity (PA) to favorable brain health is through stimulation of neural growth factors such as brain-derived neurotrophic factor (BDNF). Acute bouts of PA stimulate circulating BDNF levels. Objective: In this investigation, we assessed whether habitual, accelerometer-measured PA levels were related to circulating BDNF levels in a middle-aged cohort. Methods: In the Framingham Heart Study Third Generation cohort, 1,769 participants provided reliable accelerometry data and were not missing BDNF measurement and platelet counts. In a cross-sectional analysis, using multivariable regression, we related PA measures to serum BDNF levels, adjusting for age, sex, smoking status, platelet count, depression status, and accelerometer wear time. Results: Our study participants (mean age 47±9 years, 50.8% women) spent an average of 22.3 mins/day moderate-to-vigorous (MV)PA. Most PA variables (steps, MVPA, light activity, and sedentary time) were not related to BDNF levels (p > 0.05). We observed a non-linear trend, where 15–50 mins/week vigorous activity was associated with lower BDNF compared to those with 0 min vigorous activity (β= –0.049±0.024, p = 0.05), but with no significant associations at lower or higher vigorous activity levels. In smokers, MVPA was also associated with lower BDNF levels (β= –0.216±0.079, p = 0.01). Conclusion: Our study reveals that circulating BDNF is not chronically elevated in individuals with higher levels of habitual PA in middle-aged adults from the community and may even be chronically suppressed with higher PA in subgroups, including current smokers. These results do not contradict previous studies demonstrating that circulating BDNF rises acutely after PA.

scholarly journals Brain-Derived Neurotrophic Factor Mitigates the Association Between Platelet Dysfunction and Cognitive Impairment

2021 ◽  
Vol 8 ◽  
Author(s):  
Jean-Christophe Bélanger ◽  
Véronique Bouchard ◽  
Jessica Le Blanc ◽  
Louisia Starnino ◽  
Mélanie Welman ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Platelet Activation ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Cross Sectional Study ◽  
Cognitive Outcomes ◽  
Activity Levels ◽  
Platelet Activity ◽  
Cross Sectional ◽  
The Relationship

Background: Platelet hyperactivity is deleterious in coronary artery disease (CAD), requiring lifelong antiplatelet therapy, and is associated with worse cognitive outcomes. Upon activation, platelets release Brain-Derived Neurotrophic Factor (BDNF), a neurotrophin protective against cognitive decline. Given these apparently opposing effects of platelet activation on cognitive health, we investigated whether BDNF levels intercede in the relationship between platelet activation and cognitive function; and whether this relationship is moderated by the presence of CAD.Methods: In this cross-sectional study, 1,280 participants with (n = 673) and without CAD (n = 607) completed the Montreal Cognitive Assessment (MoCA). Plasma BDNF and soluble P-selectin (a marker of platelet activity) levels were assessed using multiplex flow cytometry.Results: In a mediation model, platelet activity was correlated with higher plasma BDNF concentrations (b = 0.53, p < 0.0001). The relationship between sP-selectin and BDNF concentrations was stronger for individuals without CAD (b = 0.71, p < 0.0001) than for CAD participants (b = 0.43, p < 0.0001; pinteraction <0.0001). Higher BDNF concentrations were associated with higher MoCA scores (b = 0.26, p = 0.03). The overall effect of platelet activity on cognitive performance was non-significant (total effect: b = −0.12, p = 0.13), and became significant when accounting for BDNF as a mediating factor (direct effect: b = −0.26, p = 0.01). This resulted in a positive indirect effect of platelet activity (via BDNF) on MoCA scores (b = 0.14, CI 95% 0.02–0.30), that was smaller in CAD participants than in non-CAD participants [Δ −0.07 (95% CI −0.14 to −0.01)].Conclusions: BDNF released from activated platelets could be a mitigating factor in a negative association between platelet activity and cognitive function.

Association between brain-derived neurotrophic factor (BDNF) level and perceptual thresholds in middle-aged women: a cross-sectional study

Maturitas ◽  
2019 ◽  
Vol 124 ◽  
pp. 170-171
Author(s):  
Fernanda Vargas Ferreira ◽  
Charles Francisco Ferreira ◽  
Mona Lúcia Dall’Agno ◽  
Jéssica Zandoná ◽  
Joana Zanotti ◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Middle Aged ◽  
Bdnf Level ◽  
Cross Sectional

Health and nutrition literacy in adults: Links with lifestyle factors and obesity

2020 ◽  
Vol 13 (4) ◽  
pp. 361-370
Author(s):  
Maria Michou ◽  
Demosthenes B. Panagiotakos ◽  
Christos Lionis ◽  
Vassiliki Costarelli
Keyword(s):  
Physical Activity ◽  
Alcohol Consumption ◽  
Linear Regression ◽  
Smoking Status ◽  
Linear Regression Analysis ◽  
Cross Sectional Study ◽  
Lifestyle Factors ◽  
Linear Regression Models ◽  
Chi Square ◽  
Cross Sectional

BACKGROUND: Low Health Literacy (HL) and Nutrition Literacy (NL) are associated with serious negative health outcomes. OBJECTIVES: The aim of this study was to investigate certain lifestyle factors and obesity, in relation to HL and NL. METHODS: This cross-sectional study was conducted in the urban area of the Attica region, in Greece. The sample consisted of 1281 individuals, aged ≥18 years. HL, NL sociodemographic characteristics and lifestyle factors (physical activity, smoking status, alcohol consumption,) were assessed. Mann-Whitney U, the Kruskall Wallis, Pearson chi-square tests and multiple linear regression models were used. RESULTS: Linear regression analysis has shown that smoking, alcohol consumption and physical activity, were associated with HL levels (–1.573 points for ex-smokers in comparison to smokers, p = 0.035, –1.349 points for alcohol consumers in comparison to non-consumers, p = 0.006 and 1.544 points for physically active individuals to non-active, p = 0.001). With respect to NL levels, it was also not associated with any of these factors. Obesity was not associated with HL and NL levels. CONCLUSIONS: Certain lifestyle factors, including physical activity, are predicting factors of HL levels, in Greek adults. The results contribute to the understanding of the relationship between lifestyle factors and HL and should be taken into account when HL policies are designed.

Prevalence of Physical Activity Among Lebanese Adults: A Cross-Sectional Study

2009 ◽  
Vol 6 (3) ◽  
pp. 315-320 ◽  
Author(s):  
Mohamad Al-Tannir ◽  
Samer Kobrosly ◽  
Taha Itani ◽  
Mariam El-Rajab ◽  
Sawsan Tannir
Keyword(s):  
Physical Activity ◽  
Medical History ◽  
Smoking Status ◽  
Physical Activity Behavior ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
Sectional Study ◽  
Cross Sectional ◽  
Activity Behavior ◽  
The Relationship

Background:This survey aims to assess the prevalence of physical activity among adult Lebanese, and to report the relationship between sociodemographic variables and physical activity behavior, highlighting the correlates discouraging people to carry out physical activity.Methods:A cross-sectional study using an anonymous self-reported questionnaire was conducted on 346 adults from four Lebanese districts. Demographic characteristics, physical activity, smoking status, alcohol consumption, and medical history were obtained.Results:Prevalence of physical activity among Lebanese adults was 55.5% (192/346). Age, BMI, marital status, medical history, occupation, educational level, and smoking were significantly associated with physical activity (P < .05). Inactive obese participants were about three times more likely to report hypertension and diabetes than inactive normal weight participants (P = .013). BMI was significantly higher among inactive participants (P = .014).Conclusion:Physical activity among Lebanese adults was comparable to other populations. Married, non–office workers, and smokers were the main correlates of physical inactivity in Lebanese adulthood.

Effect of Confinement by COVID-19 on the Lifestyle of the University Population of Argentina: Evaluation of Physical Activity, Food and Sleep (Efecto del confinamiento por COVID-19 sobre el estilo de vida en población universitaria de Argentina: Evaluaci

Retos ◽  
2021 ◽  
Vol 43 ◽  
pp. 274-282
Author(s):  
Leonardo Intelangelo ◽  
Nacim Molina Gutiérrez ◽  
Nicolás Bevacqua ◽  
Cristian Mendoza ◽  
Iris Paola Guzmán-Guzmán ◽  
...  
Keyword(s):  
Physical Activity ◽  
Sleep Quality ◽  
Physical Activity Behavior ◽  
Cross Sectional Study ◽  
Lifestyle Changes ◽  
Poor Sleep ◽  
Activity Levels ◽  
Cross Sectional ◽  
Good Nutrition ◽  
University Population

Objective: to determine lifestyle changes, such as physical activity, nutrition, and sleep in an Argentinean university population, caused by confinement during the COVID-19 pandemic. Methods: Cross-sectional study via web survey. 1021 the Argentinean university population (women, n = 645 and men, n = 376) aged between 18–70 years old was participate. Survey was utilized to measure participant physical activity behavior, nutrition, and sleep April to May 2020. Results: the main findings revealed that 4.3% of the sample showed obesity; the highest proportion of the sample stayed more than 6 hours in a sedentary status; 21.74% reported bad sleep quality; a reduction in good feeding pattern; and an increase in subjects who do not perform physical activity. According to socio-demographic and anthropometric factors, being a student (OR 2.19, CI95% 1.18 - 4, p= .012), overweight (OR 1.71, CI95% 1.19 – 2.44, p= .003), obesity (OR 4.45, CI95% 2.27 – 8.7, p< .001), and have been confined more than 45 days was associated with bad feeding. Likewise, low physical activity levels were associated with obesity (OR 3.2 CI95% 1.66 – 6.18, p= .001), being female (OR 1.61, CI95% 1.14 –2.28, p= .006) and get married (OR 1.72, CI95% 1.14 – 2.61, p= .009). Moreover, being a student was associated with poor sleep quality (OR 43.6, CI95%5.4 – 350, p< .001). Conclusion: This study suggests that confinement decreased healthy living habits such as good nutrition and physical activity and affected the quality of sleep in young subjects.  Resumen. Objetivo: determinar los cambios en el estilo de vida, como la actividad física, la nutrición y el sueño en una población universitaria argentina, causados por el confinamiento durante la pandemia de COVID-19. Métodos: Estudio transversal mediante encuesta por Internet. Participaron 1021 personas de la población universitaria argentina (mujeres, n = 645 y hombres, n = 376) de entre 18 y 70 años de edad. La encuesta fue utilizada para medir el comportamiento de la actividad física, la nutrición y el sueño de los participantes de abril a mayo de 2020.Resultados: los principales hallazgos mostraron que el 4,3% de la muestra presentaba obesidad; la mayor proporción de la muestra permaneció más de 6 horas en estado sedentario; el 21,74% informó sobre la mala calidad del sueño; una reducción de los hábitos correctos de alimentación; y un aumento de los participantes que no realizan actividad física. De acuerdo con factores socio-demográficos y antropométricos, ser estudiante (OR 2.19, CI95% 1.18 - 4, p= .012), el sobrepeso (OR 1.71, CI95% 1.19 - 2.44, p= .003), la obesidad (OR 4.45, CI95% 2.27 - 8.7, p< .001), y haber estado confinado más de 45 días se asoció con una mala alimentación. Asimismo, los bajos niveles de actividad física se asociaron con la obesidad (OR 3,2; IC95% 1,66 - 6,18, p= .001), ser mujer (OR 1,61; IC95% 1,14 -2,28, p= .006) y estar casado (OR 1,72; IC95% 1,14 - 2,61, p= .009). Además, ser estudiante se asoció con una mala calidad de sueño (OR 43,6, CI95% 5,4 - 350, p< .001). Conclusión: Este estudio sugiere que el confinamiento disminuyó los hábitos de vida saludables como la buena nutrición, la actividad física, y afectó la calidad del sueño en sujetos jóvenes.

scholarly journals Effects of Attitude, Motivation, and Eagerness for Physical Activity among Middle-Aged and Older Adults

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Md Mizanur Rahman ◽  
Dongxiao Gu ◽  
Changyong Liang ◽  
Rao Muhammad Rashid ◽  
Monira Akter
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Positive Attitude ◽  
Sports Participation ◽  
Cost Effective ◽  
Cross Sectional Study ◽  
Middle Aged ◽  
Cross Sectional ◽  
Cost Effective Method ◽  
Global Statistics

Background. Although physical activity (PA) is a noninvasive and cost-effective method of improving the quality of health, global statistics show that only a few middle-aged and older adults engage in the recommended PAs. This is due to a lack of motivation and companionship. Objective. This study analyses the attitudes and self-determined motivation of Chinese middle-aged and older adults for PAs and their eagerness to participate in PAs such as sports, exercise, and recreational and cultural activities (RCAs), from attitudinal, eagerness, and motivational objectives of PAs perspective. Methods. A cross-sectional study was carried out on 840 middle-aged (35–54 years) and older adults (55+ years). To determine their attitude, eagerness, and self-determined motivation for PA, we used attitudinal, Eagerness for Physical Activity Scale (EPAS), and Situational Motivational Scale (SIMS). The data were analyzed with SPSS 23.0. Results. The results show that 39.1% of the participants were not satisfied with PAs. Compared with females, males reported a less positive attitude towards PAs. Moreover, a positive attitude decreases with age. Participants’ motivation and eagerness in activities such as RCAs, exercise, and sports are decreasing. Regarding self-determined motivation, there are gender differences in RCAs, but there is none for exercise and sports participation. Conclusion. The findings show the importance of RCAs and the support of family and friends enhancing the eagerness, attitude, and motivation to participate in PAs. Furthermore, the findings can help to create more effective PA programs for middle-aged and older adults. By engaging in RCAs, participants can reap the benefits of PAs. Participating in RCAs can lead to social equity in health.

scholarly journals Functional capacity of patients with chronic stroke based upon their physical activity levels

2017 ◽  
Vol 18 (4) ◽  
pp. 457
Author(s):  
Janaine Cunha Polese ◽  
Thaianne Servio ◽  
Gabriela Chaves ◽  
Luci Fuscaldi Teixeira-Salmela
Keyword(s):  
Physical Activity ◽  
Functional Capacity ◽  
Cross Sectional Study ◽  
Chronic Stroke ◽  
Activity Levels ◽  
Cross Sectional ◽  
Physical Activity Levels ◽  
Duke Activity Status Index ◽  
Activity Groups ◽  
Post Hoc

Introduction: People with stroke commonly show low levels of physical activity and reduced functional capacity, independent of the severity of the impairments. The use of simple measures that are able to produce transferable information from clinical practice to life in society is crucial within clinic contexts. Objective: To compare the functional capacity of patients with chronic stroke based upon their physical activity levels. Methods: For this cross sectional study, functional capacity and levels of physical activity were assessed by the Duke Activity Status Index (DASI) and the adjusted activity score (AAS) of the Human Activity Profile (HAP), respectively. One-way analysis of variance (ANOVA), followed by LSD post-hoc tests were employed to investigate differences between the physical activity groups regarding their DASI scores. Results: Fifty-one individuals with mean age 58.8 ± 13.5 and a mean time since the onset of stroke of 25.5 ± 13.9 months participated. According to their HAP AAS, 18 individuals were classified as impaired, 28 as moderately active, and five as active. Between-group differences were observed for the DASI scores [F(2,48)=13.72; p < 0.01]. Conclusion: Increases in functional capacity were observed with increases in physical activity levels.Key-words: stroke, motor activity, activities of daily living.

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