Early discontinuation of antiseizure medication in neonatal seizures - Proceed with caution

2021 ◽  
pp. 1-4
Author(s):  
H.C. Glass ◽  
R.A. Shellhaas
Keyword(s):  
Neonatal Seizures ◽  
Early Discontinuation

Provider Practices of Phenobarbital Discontinuation in Neonatal Seizures

2017 ◽  
Vol 33 (2) ◽  
pp. 153-157 ◽  
Author(s):  
Niranjana Natarajan ◽  
Christopher W. Beatty ◽  
Juliane Gust ◽  
Lorie Hamiwka
Keyword(s):  
Seizure Control ◽  
Prolonged Treatment ◽  
Published Data ◽  
Neonatal Seizures ◽  
Early Discontinuation ◽  
Treatment Length ◽  
Provider Practices ◽  
Factors Influencing ◽  
Symptomatic Seizures ◽  
Infectious Etiology

Neonatal seizures are treated with phenobarbital and prolonged treatment does not prevent postneonatal epilepsy. The authors documented factors influencing phenobarbital use and determined whether published data changed practice. A total of 83 neonates with symptomatic seizures, clinical or electrographic, were evaluated for treatment, incidence of postneonatal epilepsy, and associated factors. Median phenobarbital treatment was 81 days. Nineteen children (23%) developed postneonatal epilepsy. Longer duration of seizures and an infectious etiology were associated with postneonatal epilepsy suggesting no impact on duration of phenobarbital treatment. Treatment duration was associated with duration of seizures and use of a second antiseizure medication. This study supports early discontinuation of phenobarbital and suggests providers utilize factors such as use of a second antiseizure medication and time to seizure control to determine phenobarbital duration, despite prior studies suggesting no impact of treatment length.

Early Discontinuation of Anticonvulsants After Neonatal Seizures

1982 ◽  
Vol 75 (3) ◽  
pp. 298-300 ◽  
Author(s):  
PETER GAL ◽  
HENRY R. BOER
Keyword(s):  
Neonatal Seizures ◽  
Early Discontinuation

scholarly journals Safety of Early Discontinuation of Antiseizure Medication After Acute Symptomatic Neonatal Seizures

2021 ◽  
Author(s):  
Hannah C. Glass ◽  
Janet S. Soul ◽  
Taeun Chang ◽  
Courtney J. Wusthoff ◽  
Catherine J. Chu ◽  
...  
Keyword(s):  
Neonatal Seizures ◽  
Early Discontinuation

A Randomized Controlled Trial of Levetiracetam Compared with Phenobarbital in the Treatment of Neonatal Seizures

2019 ◽  
Author(s):  
Cynthia Sharpe ◽  
Gail E. Reiner ◽  
Suzanne L. Davis ◽  
Mark Nespeca ◽  
Jeffrey J. Gold ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Neonatal Seizures ◽  
Randomized Controlled

Neonatal seizures

2020 ◽  
Vol 543 (50-51) ◽  
pp. 45-50
Author(s):  
Vinko Vrdoljak ◽  
Edi Paleka-Bosak ◽  
Rebeka Ribičić ◽  
Snježana Gverić-Ahmetašević
Keyword(s):  
Neonatal Seizures

scholarly journals Temperature and pharmacological rescue of a folding-defective, dominantl-negative KV7.2 mutation associated with neonatal seizures

2011 ◽  
Vol 32 (10) ◽  
pp. E2283-E2293 ◽  
Author(s):  
Snezana Maljevic ◽  
Georgios Naros ◽  
Özlem Yalçin ◽  
Dragica Blazevic ◽  
Heidi Loeffler ◽  
...  
Keyword(s):  
Neonatal Seizures
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