The effects of various surgical manipulations on the function of the separate kidneys was studied in the dog. The application of a clamp to one renal artery produced vasoconstriction of varying severity in the contralateral kidney. The introduction of a venous catheter into the renal vein by passage upward from the femoral vein similarly caused renal vasoconstriction. The combination of manipulations involved in preparing the renal pedicle for later renal artery clamping with the passing of renal venous and ureteral catheters frequently produced oliguria or complete anuria. Since such nociceptive stimuli can cause renal vasoconstriction and, if sufficiently severe, antidiuresis, it is inferred that these mechanisms bear directly on the problem of traumatic anuria.
