scholarly journals Impact of Repeated Lidocaine Injections, Exercise, and Mindfulness on Fibromyalgia Symptoms in a Clinical Population

2021 ◽  
Vol 23 ◽  
Author(s):  
Grace Miranda Hansen
Keyword(s):  
Pain Intensity ◽  
Single Mode ◽  
Treatment Method ◽  
Clinical Population ◽  
Depression And Anxiety ◽  
Randomized Controlled Studies ◽  
Combined Use ◽  
Lidocaine Hcl ◽  
Accompanying Symptoms ◽  
Nonpharmacological Treatments

Fibromyalgia (FM) patients usually are resistant to conventional single mode therapy. Therefore, the efficacy of combined pharmacological and nonpharmacological treatments for the management of FM symptoms in a clinical population was assessed. Participants were injected with 4x5 mL 1% lidocaine HCl solution and given education materials and support on increasing their daily steps walked and to engage in mindfulness techniques to reduce their overall pain and accompanying symptoms of their condition. Participants self-reported pain intensity, unpleasantness, anxiety, fatigue, and depression three days prior to and after each injection. Overall ratings of pain intensity and unpleasantness showed statistically significant reductions of 34.7 and 47.2 percent respectively with the combined use of treatments. Additionally, fatigue levels had a significant decrease but depression and anxiety ratings were not significantly modified by this treatment modality. Patients who had a greater adherence to their protocol had an improved pain relief when compared to others. These results suggest that the use of a combination treatment method for FM in a clinical setting and when used in combination is effective. This pilot study can be used as a model for future randomized controlled studies on comprehensive treatments for FM. 

Investigation of the role of anxiety and depression on the formation of phantom vibration and ringing syndrome induced by working stress during medical internship (Preprint)

2019 ◽  
Author(s):  
Yu-Hsuan Lin ◽  
Kuan-I Lin ◽  
Yuan-Chien Pan ◽  
Sheng-Hsuan Lin
Keyword(s):  
Anxiety And Depression ◽  
Depression And Anxiety ◽  
Prospective Longitudinal Study ◽  
Work Related ◽  
Working Stress ◽  
Causal Mediation Analysis ◽  
Accompanying Symptoms ◽  
Prospective Longitudinal ◽  
The Relationship

BACKGROUND Phantom vibrations syndrome (PVS) and phantom ringing syndrome (PRS) are prevalent hallucinations during medical internship. Depression and anxiety are probably understudied risk factors of PVS and PRS. OBJECTIVE The aim of this study was to investigate the role of anxiety and depression on the relationship between working stress during medical internship and PVS and PRS. METHODS A prospective longitudinal study of 74 medical interns was carried out using repeated investigations of the severity of phantom vibrations and ringing, as well as accompanying symptoms of anxiety and depression as measured by Beck Anxiety Inventory and the Beck Depression Inventory before, at the 3rd, 6th, and 12th month during internship, and 2 weeks after internship. We conducted a causal mediation analysis to investigate the role of depression and anxiety in the mechanism of working stress during medical internship inducing PVS and PRS. RESULTS The results showed that depression explained 21.9% and 8.4% for stress-induced PRS and PVS, respectively. In addition, anxiety explained 15.0% and 7.8% for stress-induced PRS and PVS, respectively. CONCLUSIONS Our findings showed both depression and anxiety can explain a portion of stress-induced PVS and PRS during medical internship and might be more important in clinical practice and benefit to prevention of work-related burnout.

Effect of 5% Lidocaine Medicated Plaster on Pain Intensity and Paroxysms in Classical Trigeminal Neuralgia

2014 ◽  
Vol 48 (11) ◽  
pp. 1521-1524 ◽  
Author(s):  
Stefano Tamburin ◽  
Vittorio Schweiger ◽  
Francesca Magrinelli ◽  
Maria Paola Brugnoli ◽  
Giampietro Zanette ◽  
...  
Keyword(s):  
Trigeminal Neuralgia ◽  
Pain Intensity ◽  
Trigeminal Nerve ◽  
Signs And Symptoms ◽  
C Fibers ◽  
Randomized Controlled Studies ◽  
Reduction Of Pain ◽  
Peripheral Afferents ◽  
Systemic Side Effects ◽  
Third Line

Objective: Trigeminal neuralgia (TN) is a neuropathic pain condition affecting one or more branches of the trigeminal nerve. It is characterized by unilateral, sudden, shock-like, and brief painful attacks, which follow the distribution of trigeminal nerve branches, and with no other accompanying sensorimotor or autonomic signs and symptoms. Current guidelines stipulate which therapies represent first-, second-, and third-line treatments for TN, but there is a consistent mismatch between the therapeutic guidelines and the patient’s preferences and expectations. Case Summary: We report on 2 patients with classical TN in whom conventional drugs for TN were not tolerated. In these patients, treatment with 5% lidocaine medicated plaster (LMP) resulted in reduction of pain intensity and the number of pain paroxysms. Discussion: LMP is known to block the sodium channels on peripheral nerves and may cause a selective and partial block of Aδ and C fibers. According to the TN ignition hypothesis, blockage of peripheral afferents by LMP may reduce pain paroxysms. The effect of LMP may outlast the pharmacokinetics of the drug by reducing pain amplification mechanisms in the central nervous system. LMP has limited or no systemic side effects. Conclusions: LMP may be an effective and well-tolerated treatment option for TN in those patients who do not tolerate or who refuse other therapies. Future randomized controlled studies should better address this issue.

scholarly journals Investigation of the role of anxiety and depression on the formation of phantom vibration and ringing syndrome caused by working stress during medical internship (Preprint)

2020 ◽  
Author(s):  
Yu-Hsuan Lin ◽  
Kuan-I Lin ◽  
Yuan-Chien Pan ◽  
Sheng-Hsuan Lin
Keyword(s):  
Anxiety And Depression ◽  
Depression And Anxiety ◽  
Prospective Longitudinal Study ◽  
Work Related ◽  
Working Stress ◽  
Causal Mediation Analysis ◽  
Accompanying Symptoms ◽  
Prospective Longitudinal ◽  
The Relationship

BACKGROUND Phantom vibrations syndrome (PVS) and phantom ringing syndrome (PRS) are prevalent hallucinations during medical internship. Depression and anxiety are probably understudied risk factors of PVS and PRS. OBJECTIVE The aim of this study was to investigate the role of anxiety and depression on the relationship between working stress during medical internship and PVS and PRS. METHODS A prospective longitudinal study of 74 medical interns was carried out using repeated investigations of the severity of phantom vibrations and ringing, as well as accompanying symptoms of anxiety and depression as measured by Beck Anxiety Inventory and the Beck Depression Inventory before, at the 3rd, 6th, and 12th month during internship, and 2 weeks after internship. We conducted a causal mediation analysis to investigate the role of depression and anxiety in the mechanism of working stress during medical internship inducing PVS and PRS. RESULTS The results showed that depression explained 21.9% and 8.4% for stress-induced PRS and PVS, respectively. In addition, anxiety explained 15.0% and 7.8% for stress-induced PRS and PVS, respectively. CONCLUSIONS Our findings showed both depression and anxiety can explain a portion of stress-induced PVS and PRS during medical internship and might be more important in clinical practice and benefit to prevention of work-related burnout.

scholarly journals Alexithymia in individuals with chronic pain and its relation to pain intensity, physical interference, depression, and anxiety

Pain ◽  
2019 ◽  
Vol 160 (5) ◽  
pp. 994-1006 ◽  
Author(s):  
Rachel V. Aaron ◽  
Emma A. Fisher ◽  
Rocio de la Vega ◽  
Mark A. Lumley ◽  
Tonya M. Palermo
Keyword(s):  
Chronic Pain ◽  
Pain Intensity ◽  
Depression And Anxiety ◽  
Physical Interference

Nonlinear Dynamics of a NEMS Carbon Nanotube Resonator

2012 ◽  
Author(s):  
Laura Ruzziconi ◽  
Mohammad I. Younis ◽  
Stefano Lenci
Keyword(s):  
Nonlinear Response ◽  
Ritz Method ◽  
Single Mode ◽  
Reduced Order Model ◽  
Phase Portraits ◽  
Order Model ◽  
Reduced Order ◽  
Combined Use ◽  
Dynamic Voltage ◽  
Carbon Nanotube Resonator

In this study we consider a slacked CNT and analyze the nonlinear response under electrostatic and electrodynamic actuation. We introduce a reduced-order model, which takes into account the single-mode dynamics and is derived via the Ritz method and the Padé approximation. The overall scenario of the device behavior is investigated when both the frequency and the electrodynamic voltage are varying. Extensive numerical simulations are performed by the combined use of frequency response diagrams, attractor-basins phase portraits, and frequency-dynamic voltage behavior chart. Our aim is that of illustrating the richness of the nonlinear events that may undergo in the device due to the coupling of mechanical and electrical nonlinearities. We observe that the CNT exhibits coexisting competing attractors, which lead to a versatile behavior. We examine the multistability in detail. The response is explored not only at low electrodynamic voltages, where the safe jump between attractors is ensured, but also at large electrodynamic excitation, where the inevitable escape (dynamic pull-in) becomes impending. We detect the theoretical boundaries of appearance and disappearance of the main attractors, which provide a complete description of the response.

scholarly journals Does human serotonin-1A receptor polymorphism (rs6295) code for pain and associated symptoms in fibromyalgia syndrome?

Reumatismo ◽  
2021 ◽  
Vol 73 (1) ◽  
pp. 24-31
Author(s):  
S. Tanwar ◽  
B. Mattoo ◽  
U. Kumar ◽  
R. Dada ◽  
R. Bhatia
Keyword(s):  
Gene Polymorphism ◽  
Pain Intensity ◽  
Healthy Subjects ◽  
Fibromyalgia Syndrome ◽  
Rating Scale ◽  
Research Work ◽  
Pain Modulation ◽  
Mcgill Pain Questionnaire ◽  
Depression And Anxiety ◽  
Serotonin 1A Receptor

Genetic predisposition may play an important role in the development of fibromyalgia syndrome (FMS). Serotonin is known to be involved in pain modulation and serotonin-1A receptor plays a considerable role in determining the central 5-HT tone. Consequently, variation in 5-HT1A receptor gene (HTR1A) may be responsible for inter-individual variability in pain sensitivity and other clinical symptoms of FMS. Therefore, the objectives of this research work were to study the gene polymorphism of 5-HTR1A gene and to explore the correlation between rs6295 genotype (−1019C/G HTR1A) and duration of pain, pain intensity and pain related depression and anxiety, if any, in FMS. 5-HTR1A genotype for the C(-1019)G polymorphism was typed in 62 patients with FMS and 42 healthy subjects. Present pain intensity, components of pain and pain related depression and anxiety were assessed using the numerical pain rating scale, McGill pain questionnaire and Hamilton depression and anxiety rating scale respectively. 5-HTR1A gene was represented by three different genotypes, homozygous C/C, heterozygous C/G and homozygous G/G. Analysis of the 5-HTR1A gene showed a frequency of 58%, 31% and 11% for the C/C, C/G and G/G genotypes, respectively in FMS group. This proportion was 69%, 23% and 8% in healthy subjects. No significant correlation was observed between 5-HTR1A gene polymorphism and pain and related symptoms in FMS patients. To the best of our knowledge this is the first study which investigated the correlation between the 5-HTR1A gene polymorphism and pain intensity, the affective component of pain, pain related depression and anxiety in FMS.

scholarly journals iAWARE: Um modelo para Cuidado ubíquo de Pacientes com Transtornos de Ansiedade, Depressão e Estresse utilizando Gamificação e Biodata

2019 ◽  
Author(s):  
Lucas Pfeiff er Salomão Dias ◽  
Jorge Luis Victória Barbosa
Keyword(s):  
Mental Disorders ◽  
Technology Acceptance ◽  
Technology Acceptance Model ◽  
Stress Disorders ◽  
Clinical Population ◽  
Depression And Anxiety ◽  
Related Factors ◽  
Anxiety Treatment ◽  
Acceptance Model ◽  
Patient’S History

Depression and anxiety are the most prevalent mental disorders, reaching million people worldwide. As they share many characteristics these two disorders can manifest themselves together. In addition, stress is one of the related factors with both depression and anxiety, being relevant in the analysis of these disorders. This paper proposes a model for ubiquitous care of patients with depression, anxiety and stress disorders (DASD) using gamification and biodata, called iAware. A/B tests evaluated with a clinical population the interaction engagement of the patient to the treatment provided by gamification. Based on the patient’s history, the iAware monitors and applies interventions for the patient at the most appropriate time. Six patients used a prototype with a smartband for two weeks to evaluate iAware. Interactions with intervention stages were greater in patients who used iAware gamified. A more detailed analysis is still required. The evaluated patients got more occurrences of anxiety at home. The patients also filled out a survey based on the Technology Acceptance Model (TAM). TAM results show that patients have found the iAware useful in their anxiety treatment routines.

scholarly journals Jaw Exercise Therapy and Psychoeducation to Reduce Oral Parafunctional Activities for the Management of Persistent Dentoalveolar Pain

2018 ◽  
Vol 2018 ◽  
pp. 1-7
Author(s):  
Izumi Makino ◽  
Young-Chang Arai ◽  
Shuichi Aono ◽  
Masayuki Inoue ◽  
Hiroki Sakurai ◽  
...  
Keyword(s):  
Standard Deviation ◽  
Combination Therapy ◽  
Pain Intensity ◽  
Rating Scale ◽  
Numerical Rating Scale ◽  
End Of Treatment ◽  
Before And After ◽  
Numerical Rating ◽  
Therapy Treatment ◽  
Nonpharmacological Treatments

Objective. To retrospectively analyze the effects of our original combination therapy treatment on patients with nonodontogenic persistent dentoalveolar pain. Methods. Twenty-one patients suffering from persistent dentoalveolar pain (nineteen females and two males; mean age ± standard deviation: 55.7 ± 19.6 years) participated in this study. They were treated with a therapy combination of jaw exercise and psychoeducation to reduce oral parafunctional activities every month. The intensity of pain in these subjects was evaluated using a numerical rating scale (NRS) before and after treatment. Results. The NRSs at the baseline ranged from 5 to 10 (median, 8), from 0 to 10 (median, 2) at one month after treatment, from 0 to 10 (median, 1) at three months after treatment, and from 0 to 10 (median, 0) at the end of treatment. Pain intensity after treatment improved significantly. Conclusion. There was a significant reduction in pain after our combination of therapies as nonpharmacological treatments, and therefore this treatment could be useful in the management of NPDP patients.

scholarly journals The Efficacy of Acupuncture for the Treatment of Sciatica: A Systematic Review and Meta-Analysis

2015 ◽  
Vol 2015 ◽  
pp. 1-12 ◽  
Author(s):  
Mei Ji ◽  
Xiaoxia Wang ◽  
Meijuan Chen ◽  
Yan Shen ◽  
Xu Zhang ◽  
...  
Keyword(s):  
Acupuncture Therapy ◽  
Pain Intensity ◽  
Fixed Effects ◽  
Pain Threshold ◽  
Clinical Symptoms ◽  
Meta Analysis ◽  
Treatment Method ◽  
Threshold Effect ◽  
Effect Sizes

Background. Sciatica is one of the most frequently reported complaints; it affects quality of life and reduces social and economic efficacy. Clinical studies on the efficacy of acupuncture therapy in sciatica are increasing, while systematic reviews assessing the efficacy of acupuncture therapy are still lacking.Objective. This study aims to assess the effectiveness of acupuncture therapy for sciatica.Methods. Comprehensive searches of 8 databases were conducted up until April 2015. Outcomes included effectiveness (proportion of patients who improved totally or partly in clinical symptoms), pain intensity, and pain threshold. Effect sizes were presented as risk ratio (RR) and mean difference (MD). Pooled effect sizes were calculated by fixed effects or random effects model.Results. A total of 12 studies (involving 1842 participants) were included. Results showed that acupuncture was more effective than conventional Western medicine (CWM) in outcomes effectiveness (RR 1.21, 95% CI: 1.16–1.25), pain intensity (MD −1.25, 95% CI: −1.63 to −0.86), and pain threshold (MD: 1.08, 95% CI: 0.98–1.17). Subgroup and sensitivity analysis found that the results did not change in different treatment method and drug categories substantially. The reported adverse effects were acceptable.Conclusions. Acupuncture may be effective in treating the pain associated with sciatica.

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