scholarly journals Synthesis and Biological Evaluation of N-Heterocyclic Substituted Fluoro-Benzothiazole Sulphonamido Analogs as a Potential Therapeutic Agents

2022 ◽  
Vol 11 (1) ◽  
Author(s):  
Sri Ranga. T ◽  
Neelesh Chaubey
Keyword(s):  
Biological Evaluation ◽  
Therapeutic Agents ◽  
Synthesis And Biological Evaluation

The present investigation is aimed to synthesize fluorobenzothiazole comprising sulphonamido pyrazole analogs starting from fluoro-chloroaniline  to get 2-amino-6-fluoro-7-chloro (1,3) benzothiazole (I), this was treated with anilino-s-methyl ethylene cyanoacetamide  in the presence of ethanol to get desired molecules. The synthesized targeted molecules are characterized, docked and screened  for their invitro antidiabetic properties. Keywords: Fluorobenzothiazole, Docking, antidiabetic

scholarly journals Novel Synthesis and Biological Evaluation of Enigmols as Therapeutic Agents for Treating Prostate Cancer

2011 ◽  
Vol 2 (6) ◽  
pp. 438-443 ◽  
Author(s):  
Ethel C. Garnier-Amblard ◽  
Suzanne G. Mays ◽  
Richard F. Arrendale ◽  
Mark T. Baillie ◽  
Anatoliy S. Bushnev ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Biological Evaluation ◽  
Therapeutic Agents ◽  
Novel Synthesis ◽  
Synthesis And Biological Evaluation

Synthesis and biological evaluation of pentacyclo[5.4.0.02,6.03,10.05,9]undecane derivatives as potential therapeutic agents in Parkinson's disease

2004 ◽  
Vol 12 (7) ◽  
pp. 1799-1806 ◽  
Author(s):  
Werner J Geldenhuys ◽  
Sarel F Malan ◽  
Thangaraju Murugesan ◽  
Cornelis J Van der Schyf ◽  
Jeffrey R Bloomquist
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Biological Evaluation ◽  
Therapeutic Agents ◽  
Synthesis And Biological Evaluation

scholarly journals Features of the synthesis and biological evaluation of 3-(carboxyphenyl)chromones

2020 ◽  
Vol 15 (2) ◽  
pp. 3-12
Author(s):  
Olga Shablykina ◽  
Viktoriia Moskvina ◽  
Volodymyr Khilya
Keyword(s):  
Biological Activity ◽  
Biological Evaluation ◽  
Therapeutic Agents ◽  
New Drugs ◽  
Pharmacological Activities ◽  
Chromone Derivatives ◽  
Methods Of Synthesis ◽  
Patent Literature ◽  
Synthetic Routes ◽  
Synthesis And Biological Evaluation

Flavonoids and their derivatives have historically been a source of therapeutic agents. Every year, more and more data is published on new flavonoid compounds, both synthetic and isolated from natural sources, and their innumerable physiological and pharmacological activities. This review presents synthetic routes towards 3-(carboxyphenyl)chromones and evaluation of their biological activity as published in both journal and patent literature. We have focused specifically on the 3-(carboxyphenyl)chromones, because while methods of synthesis and biological activity of 2(3)-substituted and 2,3-disubstituted chromones are well studied, literature data on isoflavones containing a carboxyl, ester, or amide group in ring B is scarce and fragmentary. The presented generalization of synthetic strategies and biological activity of 3-(carboxyphenyl)chromone derivatives demonstrates that this class of compounds can be targeted for discovery of new drugs and can be readily prepared owing to recent advances in synthetic organic and medicinal chemistry.

Arylsulfonamide inhibitors of aggrecanases as potential therapeutic agents for osteoarthritis: Synthesis and biological evaluation

2013 ◽  
Vol 62 ◽  
pp. 379-394 ◽  
Author(s):  
Elisa Nuti ◽  
Salvatore Santamaria ◽  
Francesca Casalini ◽  
Kazuhiro Yamamoto ◽  
Luciana Marinelli ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Therapeutic Agents ◽  
Synthesis And Biological Evaluation
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