scholarly journals Vanishing Bile Duct Syndrome: A Paraneoplastic Phenomenon Secondary to Occult Hodgkin's Lymphoma

2020 ◽  
Vol 2 (1) ◽  
Keyword(s):  
Bile Duct ◽  
Hodgkin’S Lymphoma ◽  
Hodgkin's Lymphoma ◽  
Vanishing Bile Duct Syndrome ◽  
Vanishing Bile Duct ◽  
Duct Syndrome

scholarly journals Brentuximab vedotin in combination with sequential procarbazine, cyclophosphamide and prednisolone for the management of Hodgkin’s lymphoma-associated vanishing bile duct syndrome (VBDS) with severe obstructive liver failure

2019 ◽  
Vol 12 (2) ◽  
pp. bcr-2018-227676 ◽  
Author(s):  
Min Fong ◽  
Stephen Boyle ◽  
Naadir Gutta
Keyword(s):  
Bile Duct ◽  
Liver Failure ◽  
Hodgkin’S Lymphoma ◽  
Treatment Protocol ◽  
Brentuximab Vedotin ◽  
Hodgkin's Lymphoma ◽  
Vanishing Bile Duct Syndrome ◽  
Novel Treatment ◽  
Vanishing Bile Duct ◽  
Duct Syndrome

We present a novel treatment protocol that was successful in the management of Hodgkin’s-associated vanishing bile duct syndrome, a rare but serious complication of Hodgkin’s lymphoma. We believe that publication of this treatment protocol and the rationale for its development will be of interest to anyone faced with treating this challenging condition.

scholarly journals Vanishing Bile Duct Syndrome in Hodgkin’s Lymphoma

2016 ◽  
Vol 50 (8) ◽  
pp. 688 ◽  
Author(s):  
Mena Bakhit ◽  
Thomas R. McCarty ◽  
Sunhee Park ◽  
Basile Njei ◽  
Margaret Cho ◽  
...  
Keyword(s):  
Bile Duct ◽  
Hodgkin’S Lymphoma ◽  
Hodgkin's Lymphoma ◽  
Vanishing Bile Duct Syndrome ◽  
Vanishing Bile Duct ◽  
Duct Syndrome

scholarly journals Hodgkin’s lymphoma as a rare cause of vanishing bile duct syndrome: a case report

2018 ◽  
pp. 37-40
Author(s):  
Erdem Sunger ◽  
Elif Yorulmaz ◽  
Ahmet Engin Atay ◽  
Burcak Karadeniz ◽  
Husniye Esra Pasaoglu ◽  
...  
Keyword(s):  
Case Report ◽  
Bile Duct ◽  
Hodgkin’S Lymphoma ◽  
Hodgkin's Lymphoma ◽  
Vanishing Bile Duct Syndrome ◽  
Vanishing Bile Duct ◽  
Duct Syndrome

scholarly journals Vanishing bile duct syndrome in Hodgkin’s lymphoma: A case report and literature review

2017 ◽  
Vol 23 (2) ◽  
pp. 366 ◽  
Author(s):  
Mena Bakhit ◽  
Thomas R McCarty ◽  
Sunhee Park ◽  
Basile Njei ◽  
Margaret Cho ◽  
...  
Keyword(s):  
Case Report ◽  
Bile Duct ◽  
Literature Review ◽  
Hodgkin’S Lymphoma ◽  
Hodgkin's Lymphoma ◽  
Vanishing Bile Duct Syndrome ◽  
Vanishing Bile Duct ◽  
Duct Syndrome

scholarly journals Vanishing Bile Duct Syndrome and Hodgkin’s Lymphoma: Case Report and Thorough Review of the Literature

2021 ◽  
Vol 8 (9) ◽  
Author(s):  
Keramidas V ◽  
◽  
Tastanis C ◽  
Tsirogianni K ◽  
Hytiroglou P ◽  
...  
Keyword(s):  
Bile Duct ◽  
Liver Biopsy ◽  
Bile Ducts ◽  
Hodgkin’S Lymphoma ◽  
Clinical Manifestations ◽  
Cervical Lymphadenopathy ◽  
Hodgkin's Lymphoma ◽  
Vanishing Bile Duct Syndrome ◽  
Vanishing Bile Duct ◽  
Duct Syndrome

Vanishing Bile Duct Syndrome (VBDS) is a rare, acquired disorder, characterized by progressive destruction and loss of intrahepatic bile ducts. The main clinical manifestations are jaundice and pruritus, caused by intralobular cholestasis. Although the pathogenic mechanism is poorly understood, VBDS has been associated with numerous etiologies such as medications, malignancies, infections and autoimmune diseases. This syndrome can appear as a paraneoplastic phenomenon in patients with Hodgkin’s Lymphoma (HL). Diagnosis is based on clinical evaluation and confirmed via liver biopsy, while treating the underlying cause is the main therapeutic target. If bile duct regeneration does not occur, possible outcomes include cirrhosis, hepatic failure and death, with liver transplantation being the only curative option. In this paper, we describe a case of HL-related VBDS in a 31-year-old female patient, who presented with jaundice, pruritus and cervical lymphadenopathy. The stage of HL was determined as IIA and a liver biopsy was performed, which confirmed the degeneration of bile ducts. The patient was treated with the ABVD regimen and dexamethasone. Follow-up tests were normal and supported the full remission hypothesis. We conducted an analytical literature review and collected the available data from 38 confirmed cases, regarding the epidemiology, viral infections, clinical findings, therapeutic options and outcome.

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