The article covers clinical trials as a type of clinical research in American medical colleges that develop innovation activity. Predominantly such clinical trials deal with oncology, neurology, ophthalmology, traumatology, pediatrics, pulmonology, and so on. To reach the aim of the article, there are the following methods as content-analysis of information concerning clinical trials from U.S. state websites and official ones of American medical colleges and a descriptive method – to give clear and accessible data on the mentioned problem. Moreover, the authors focus on clinical trials at Yale University, Johns Hopkins University School of Medicine, Stanford University School of Medicine, University of California Irvine School of Medicine, Keck School of Medicine of the University of Southern California, etc. These educational establishments attempt to find out effective and safe ways to preserve and restore health using the latest developments in science and technology. Besides, today they strive to meet effectively modern social challenges among which there is COVID-19.