scholarly journals Applying Nanotechnology in the Synthesis of Benzimidazole Derivatives: A Pharmacological Approach

2021 ◽  
Vol 12 (1) ◽  
pp. 992-1005
Keyword(s):  
Cardiovascular Disease ◽  
Structural Feature ◽  
Heterocyclic Compounds ◽  
Benzimidazole Derivatives ◽  
Organic Polymers ◽  
Strong Inhibitor ◽  
Pharmacological Approach

Benzimidazoles are classified as a category of heterocyclic compounds. They possess an essential structural feature of 6-membered benzene fused to 5-membered imidazole moiety. Molecules having benzimidazole motifs confirmed promising utility in organic and scientific studies. Various pharmacological residences were explored with a strong inhibitor of numerous enzymes. They are concerned with being efficient antidiabetic, anticancer, antimicrobial, antiparasitic, analgesics, antiviral and antihistaminic agents. Moreover, they can be utilized in cardiovascular disease, neurology, endocrinology, and ophthalmology. The multiple activities for benzimidazole compounds have emerged due to their stability, bioavailability, and good-sized organic activity. Modifications of some organic polymers were carried out by utilizing different azole moieties. This review is devoted to mention some of the various current techniques for the synthesis of benzimidazole derivatives and their pharmacological residences with representing numerous derivatives.

scholarly journals Biological Potential and Chemical Properties of Pyridine and Piperidine Fused Pyridazine Compounds: Pyridopyridazine a Versatile Nucleus

2016 ◽  
Vol 1 (1) ◽  
pp. 29 ◽  
Author(s):  
Mohammad Asif
Keyword(s):  
Nitrogen Atom ◽  
Structural Feature ◽  
Heterocyclic Compounds ◽  
Biological Activities ◽  
Chemical Properties ◽  
Pharmacological Properties ◽  
Drug Molecules ◽  
Biological Potential ◽  
Different Types ◽  
And Chemical Properties

Pyridopyridazine compounds are important nitrogen atom containing heterocyclic compounds due to their pharmacological versatility. This heterocycle system characterized a structural feature for different types of bioactive compounds that exhibiting various types of biological activities which make it an attractive scaffold for the design and development of new drug molecules. This article provided information about the pharmacological properties of pyridopyridazines derivatives.

scholarly journals New benzimidazole derivatives with potential cytotoxic activity--study of their stability by RP-HPLC.

2012 ◽  
Vol 59 (2) ◽  
Author(s):  
Katarzyna Błaszczak-Świątkiewicz ◽  
Marek Mirowski ◽  
Katarzyna Kaplińska ◽  
Rafał Kruszyński ◽  
Agata Trzęsowska-Kruszyńska ◽  
...  
Keyword(s):  
Heterocyclic Compounds ◽  
Hplc Analysis ◽  
Benzimidazole Derivatives ◽  
Chromatographic System ◽  
Uv Detector ◽  
Statistical Validation ◽  
Human Malignant Melanoma ◽  
Anticancer Properties ◽  
Rp Hplc ◽  
The Stability

Obtained benzimidazole derivatives, our next synthesized heterocyclic compounds, belong to a new group of chemical bondings with potential anticancer properties (Błaszczak-Świątkiewicz & Mikiciuk-Olasik, 2006, J Liguid Chrom Rel Tech 29: 2367-2385; Błaszczak-Świątkiewicz & Mikiciuk-Olasik, 2008, Wiad Chem 62: 11-12, in Polish; Błaszczak-Świątkiewicz & Mikiciuk-Olasik, 2011, J Liguid Chrom Rel Tech 34: 1901-1912). We used HPLC analysis to determine stability of these compounds in 0.2% DMSO (dimethyl sulfoxide). Optimisation of the chromatographic system and validation of the established analytical method were performed. Reversed phases (RP-18) and a 1:1 mixture of acetate buffer (pH 4.5) and acetonitrile as a mobile phase were used for all the analysed compounds at a flow rate 1.0 mL/min. The eluted compounds were monitored using a UV detector, the wavelength was specific for compounds 6 and 9 and compounds 7 and 10. The retention time was specific for all four compounds. The used method was found to have linearity in the concentration range of (0.1 mg/mL-0.1 μg/mL) with a correlation coefficient not less than r(2)=0.9995. Statistical validation of the method proved it to be a simple, highly precise and accurate way to determine the stability of benzimidazole derivatives in 0.2% DMSO. The recoveries of all four compounds examined were in the range 99.24-100.00%. The developed HPLC analysis revealed that the compounds studied remain homogeneous in 0.2% DMSO for up to 96 h and that the analysed N-oxide benzimidazole derivatives do not disintegrate into their analogues - benzimidazole derivatives. Compounds 8, 6 and 9 exhibit the best cytotoxic properties under normoxic conditions when tested against cells of human malignant melanoma WM 115.

Absorption Spectra of Heterocyclic Compounds. III. Some Benzimidazole Derivatives

1948 ◽  
Vol 70 (10) ◽  
pp. 3406-3410 ◽  
Author(s):  
Edgar A. Steck ◽  
Frederick C. Nachod ◽  
Galen W. Ewing ◽  
Nancy H. Gorman
Keyword(s):  
Absorption Spectra ◽  
Heterocyclic Compounds ◽  
Benzimidazole Derivatives

CO2 adsorption and catalytic application of imidazole ionic liquid functionalized porous organic polymers

2017 ◽  
Vol 8 (11) ◽  
pp. 1833-1839 ◽  
Author(s):  
Shuang Hao ◽  
Yuchuan Liu ◽  
Chuning Shang ◽  
Zhiqiang Liang ◽  
Jihong Yu
Keyword(s):  
Ionic Liquid ◽  
Catalytic Activity ◽  
Co2 Adsorption ◽  
Benzimidazole Derivatives ◽  
Alkylation Reaction ◽  
Organic Polymers ◽  
Porous Organic Polymers ◽  
Catalytic Application

A class of imidazole ionic liquid functionalized porous organic polymers has been synthesized by the Friedel–Crafts alkylation reaction. The resulting materials show high CO2 uptake and catalytic activity in the syntheses of benzimidazole derivatives.

Intramolecular cyclization reaction — Palladium(0)-catalyzed cyclization is more effective than tin hydride mediated reaction

2008 ◽  
Vol 86 (4) ◽  
pp. 325-332 ◽  
Author(s):  
Krishna C Majumdar ◽  
Pradip Debnath ◽  
Abu Taher ◽  
Amarta K Pal
Keyword(s):  
Intramolecular Cyclization ◽  
Heterocyclic Compounds ◽  
Radical Cyclization ◽  
Cyclization Reaction ◽  
Benzimidazole Derivatives ◽  
Pd Catalyst ◽  
Aryl Radical

Intramolecular CH arylation of pyrone, pyridone, uracil, imidazole, and benzimidazole derivatives are carried out in the presence of a Pd catalyst to form potentially bioactive fused heterocyclic compounds, whereas the n-Bu3SnH-mediated aryl radical cyclization of the precursors 3 afforded mainly halogen-reduced uncyclized products.Key words: Pd(0) catalyst, CH arylation, intramolecular cyclization, regioselectivity.

Synthesis, pharmacological activity evaluation and molecular modeling of new polynuclear heterocyclic compounds containing benzimidazole derivatives

2012 ◽  
Vol 35 (12) ◽  
pp. 2063-2075 ◽  
Author(s):  
Fatma A. Bassyouni ◽  
Tamer S. Saleh ◽  
Mahmoud M. ElHefnawi ◽  
Sherein I. Abd El-Moez ◽  
Waled M. El-Senousy ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Pharmacological Activity ◽  
Heterocyclic Compounds ◽  
Benzimidazole Derivatives ◽  
Activity Evaluation
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