Role of Sildenafil in the Treatment of Persistent Pulmonary Hypertension of Newborn (PPHN) - Should it Be Withdrawn from Market of Bangladesh due to Threat of being Misuses

2020 ◽  
Vol 35 (2) ◽  
pp. 100-104
Author(s):  
Maksudur Rahman ◽  
Mohammad Abdullah Al Mamun ◽  
MAK Azad Chowdhury ◽  
Abu Sayeed Munsi
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Neonatal Intensive Care ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cardiac Intensive Care Unit ◽  
Cross Sectional ◽  
Cardiac Intensive Care ◽  
Hospital Protocol

Background: Recently it has been apprehended that sildenafil, a drug which has been successfully using in the treatment of PPHN and erectile dysfunction in adult, is going to be withdrawn from the market of Bangladesh due to threat of its misuses. Objective: The aim of this study was to see the extent of uses of sildenafil in the treatment of PPHN and importance of availability of this drugs in the market inspite of its probable misuses. Methods: This cross sectional study was conducted in neonatal intensive care unit (NICU), special baby care unit (SCABU) and cardiac intensive care unit (CICU) of Dhaka Shishu (Children) Hospital from June, 2017 to May 2018. Neonates with PPHN were enrolled in the study. All cases were treated with oral sildenefil for PPHN along with others management according to hospital protocol. Data along with other parameters were collected and analyzed. Results: Total 320 patients with suspected PPHN were admitted during the study period. Among them 92 (29%) cases had PPHN. Male were 49(53 %) cases and female were 43(47%) cases. Mean age at hospital admission was 29.7±13.4 hours. Based on echocardiography,13(14%) cases had mild, 38 (41%) cases moderate and 41(45%) cases severe PPHN. Mean duration of sildenafil therapy was 11.9±7.1 days. Improved from PPHN were 83 (90%) cases. Mortality was 10% (9). Conclusion: In this study it was found that the incidence of PPHN is 29% among the suspected newborns. Sildenafil is successfull in improving the oxygenation of PPHN and to decrease the mortality of neonates. DS (Child) H J 2019; 35(2) : 100-104

Nosocomial Sepsis and its Risk Factors: A Cross-Sectional Study in a Neonatal Intensive Care Unit

2019 ◽  
Vol 2 (1) ◽  
pp. 52-59
Author(s):  
Sunil Kumar Yadav ◽  
SP Yadav ◽  
P Kanodia ◽  
N K Bhatta ◽  
R R Singh ◽  
...  
Keyword(s):  
Risk Factors ◽  
Intensive Care Unit ◽  
Mechanical Ventilation ◽  
Intensive Care ◽  
Neonatal Intensive Care Unit ◽  
Neonatal Intensive Care ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Nosocomial Sepsis

Introduction: Nosocomial sepsis is a common and serious infection of neonates who are admitted in intensive care unit. They lead to significant morbidity and mortality in both developed and resource limited countries. The neonatal intensive care unit (NICU) is a suitable environment for disseminating the infections and, hence, needs preventive intervention. The study was carried out to determine the risk factors for nosocomial sepsis in neonatal intensive care unit. Material and Methods: This was a cross-sectional study conducted in a seven bedded teaching and referral hospital NICU. All neonates in NICU who did not have any sign of infection at admission and remained hospitalized for at least 48 hours were observed. Nosocomial sepsis was diagnosed according to the CDC criteria. Risk factors for nosocomial sepsis were analyzed with Chi-square test and Logistic regression model. P-value of <0.05 was considered significant. Results: Low birth weight (both preterm and IUGR) and mechanical ventilation were found to be related with nosocomial sepsis. Conclusions: Low birth weight and mechanical ventilation were the most important risk factors fornosocomial sepsis.

Ventilation Practices in the Neonatal Intensive Care Unit: A Cross-Sectional Study

2010 ◽  
Vol 157 (5) ◽  
pp. 767-771.e3 ◽  
Author(s):  
Anton H. van Kaam ◽  
Peter C. Rimensberger ◽  
Dorine Borensztajn ◽  
Anne P. De Jaegere
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Neonatal Intensive Care Unit ◽  
Neonatal Intensive Care ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Prevalence and risk factors of dysnatremia in sick newborns admitted in neonatal intensive care unit: a cross-sectional study

2020 ◽  
Vol 7 (12) ◽  
pp. 2369
Author(s):  
Farogh Hassan ◽  
Vasanth N. Kumar ◽  
Imran Asghar ◽  
Lata Jha ◽  
Indranil Choudhury
Keyword(s):  
Risk Factors ◽  
Intensive Care Unit ◽  
Intensive Care ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Serum Sodium ◽  
Neonatal Intensive Care ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

Background: The objective of the study was to study the prevalence and various risk factors of dysnatremia in sick newborns admitted in neonatal intensive care unit (NICU).Methods: Cross sectional study conducted in Paediatric Department of tertiary care hospital from February 2016 to October 2016 which includes 384 neonates admitted to NICU during the study period. After informed consent, detailed history was taken and clinical examination carried out in both cases and controls. Blood investigations were done to diagnose sodium levels in sick neonates. Based on the corrected sodium values, the subjects were classified as having hyponatremia (serum sodium <135 meq/l), hypernatremia (serum sodium >145 meq/l) or normonatremia (serum sodium 135 to 145 meq/l).Results: The mean (SD) (range) serum sodium in sick newborns measured was 136.72 (6.7) (115-165) meq/l at a median (range) age of 56.97 (1-545) hours. Out of 384 sodium values obtained, 285 (74.2%) were sent on ≤3 days, 64 (16.7%) between 4th to the 6th day and 35 (9.1%) were sent on ≥7 days. The overall frequency of dysnatremia in 384 sodium values from 384 patients was 142 (37%). Hyponatremia was observed in 117 (30.5%) and hypernatremia in 25 (6.5%) of sodium values. Hyponatremia observed in term, low birth weight, very low birth weight and extremely low birth weight neonates were 16.4%, 25.2%, 67.2% and 100% respectively whereas hypernatremia were 10.1%, 4.6%, 3.4% and 0% respectively. Various risk factors for hyponatremia namely; prematurity, necrotizing enterocolitis, renal failure, birth asphyxia, sepsis, meningitis, vomiting/ nasogastric drainage.Conclusions: Hyponatremia are common in sick newborns in NICU.

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