scholarly journals Assessment of Biochemical Changes Among Covid-19 Cases in a Tertiary Hospital of Bangladesh During Early Pandemic

2022 ◽  
Vol 40 (1) ◽  
pp. 34-42
Author(s):  
Sangita Mithun ◽  
Syed Abul Hassan Md Abdullah ◽  
SM Nurul Irfan

Background: Corona virus disease 2019 (COVID-19) involves various organs of the body causing several biochemical changes which plays an essential role in estimating the patients’ condition and prognosis, directing treatment, and even evaluating the curative effects. The present study aimed to assess the biochemical changes among the COVID-19 patients during early pandemic. Methods: This cross sectional study was conducted at Combined Military Hospital (CMH) Dhaka among purposively selected 237 confirm COVID-19 cases. Data were collected through face to face interview and review of medical records using a pre-tested semi-structured questionnaire. The study was conducted in the Combined Military Hospital Dhaka from 15 April 2020 to 31 May 2020 Results: Highest number of the respondents were in the age group of 31-40 years (37.1%) with male predominance (83.1%). About 95.6% were Muslim and 58.6% were educated up to secondary level. About 87.8% had contact with a confirmed case and having 47.7%, 37.2%, 15.1% cardiovascular, endocrine and respiratory comorbidities respectively. Fever (34.6%) was the most common presenting symptoms followed by cough (22.9%), sore throat (10.6%). Neutrophilia observed in 26.16%, lymphopenia in 20.7%, thrombocytopenia in 14.3% cases, 30.0% with positive D-dimer test, 22.4% either sepsis or systemic infection in procalcitonin estimation, 28.3% with increased ferritin, 28.7% with positive C reactive protein, 21.1% with increased LDH. Chi-square analysis revealed a statistically significant association between cardiovascular and endocrine diseases with several biochemical changes (p<0.05). Conclusion: Early identification of various biochemical changes would help the physician for appropriate assessment and management. JOPSOM 2021; 40(1): 34-42

2020 ◽  
Vol 5 (3) ◽  
pp. 1191-1195
Author(s):  
Sushmita Shrestha ◽  
Navin Agrawal ◽  
Deependra Prasad Sarraf

Introduction: Irrational or inappropriate prescribing practice is common in developing countries that can lead to ineffective treatment, prolonged hospitalization, harm to the patient, increased treatment cost and development of drug-resistant organisms. The prescription of antibiotics and other drugs in endodontics is limited to patients with progressive and diffuse swelling and with systemic infection. However, antibiotics continue to be over-prescribed by more than 66% dentists without a rational justification.Therefore, the periodic assessment of drug utilization pattern is important to know the existing pattern of drug use, decrease adverse effects and provide feedback to the prescribers. Objective: To evaluate the drug utilization pattern in endodontics using the World Health Organization prescribing indicators. Methodology: A cross-sectional prospective study was conducted among the patients visiting the outpatient department of Conservative Dentistry and Endodontics. After obtaining the informed consent, the relevant data were collected on a self-designed proforma by reviewing the health cards of the patients. The WHO prescribing indicators were calculated. Descriptive statistics were calculated using SPSS version 11.0. Results: Out of 187 patients, 101 (54%) were female. Mean age was 38.9±16.6 years. Majority of the patients suffered from acute apical periodontitis (30.5%). A total of 281 drugs were prescribed to 187 patients. Paracetamol+Ibuprofen (44.1%) was the most frequently prescribed drugs. Most of the patients were prescribed one drug (78.6%).  Average drug per prescription was 1.5. Majority of the drugs (89.0%) were prescribed from Essential drug list of Nepal. Conclusions: Analgesics were the most frequently prescribed drug. The prescription practice was rational. There is need to increase the number of medicine prescribed from National List of Essential medicines.Educational initiatives should be undertaken to further strengthen the rational prescription among dental practitioners.


2021 ◽  
Vol 2 (5) ◽  
pp. 01-08
Author(s):  
Şule Gökçe ◽  
Aslı Aslan ◽  
Feyza Koç

Background: Malnutrition is defined as deficiency and or imbalance of nutrients and energy and may produce a negative effect on the growth, maintenance, and specific functions of the body. This study purposed to determine the nutritional situation, to define the presence of malnutrition, to detect the deficiencies of micronutrients of the children admitted to a pediatric tertiary hospital. Methods: A retrospective, cross‑sectional, single unit-based study in pediatric patients admitted to the pediatric wards for differential diagnosis or treatment was conducted between November 2017 and December 2019. The anthropometric measurements were figured out on hospital admission of all pediatric patients. The pediatric patients diagnosed with malnutrition were assessed to detect their nutritional status/feeding habits and to identify any associated factors. Results: A total of 1206 children were hospitalized with an acute illness diagnosis and/or treatment during the study period. One hundred fifteen patients were noted to have malnutrition; acute malnutrition (wasting) (weight for height z-score < - 2 SDS) (n=51/115, 44.3%) and chronic malnutrition (stunted) (height-for-age < −2 SDS) was detected in 64/115 (55.7%) patients; the prevalence of wasting, and stunting was 4.2% and 5.3%, respectively. Conclusions: Our study suggests that it should be performed an assessment of nutritional status/ history and anthropometric measurements every admission to the hospital in order to provide healthy growth development in childhood, particularly under 2 of age and interventions should be strengthened for general child health.


Author(s):  
Zephania Saitabau Abraham ◽  
Onesmo Tarimo ◽  
Aveline Aloyce Kahinga ◽  
Daudi Ntunaguzi ◽  
Kassim Babu Mapondella ◽  
...  

<p class="abstract"><strong>Background:</strong> Otitis externa is among the otological diseases with significant impact on the quality of life of sufferers. Little is known in Sub Saharan countries despite being the focus of such disease. The study aimed to determine the prevalence and clinical characteristics of otitis externa at Muhimbili National Hospital, Tanzania’s largest tertiary hospital.</p><p class="abstract"><strong>Methods:</strong> This was a hospital based descriptive cross sectional study where 1200 participants were recruited from June 2016 to January 2017. Data was analyzed using SPSS program version 20.  </p><p class="abstract"><strong>Results:</strong> A total of 1200 patients were recruited in this study and majority 601(50.1%) were females. Majority 672(56%) were in age group 0–10 years. Among 1200 patients, 138 (11.5%) were diagnosed to have otitis externa and male predominance (55.1%) was found. Majority 120 (87%) had diffuse otitis externa and with 0-10 years (25.83%) being the commonly affected age group by variant. The commonest risk factor was self-ear cleansing 87(53.7%) and only 2.9% were found to have complications of otitis externa.</p><p class="abstract"><strong>Conclusions:</strong> Otitis externa was found to be prevalent and with male predominance. Self-ear cleansing was the commonest risk factor. Complications of otitis externa were found to be rare. Public awareness on otitis externa should be advocated in our country.</p>


2022 ◽  
Vol 40 (1) ◽  
pp. 1-13
Author(s):  
SM Nurul Irfan ◽  
AHM Kazi Mostofa Kamal ◽  
Taufiqul Hasan Siddiquee ◽  
Mahbubur Rahman Bhuiyan ◽  
Sangita Mithun ◽  
...  

Background: The unprecedented global pandemic caused by SARS-CoV-2 creates considerable psychological problems among the health care workers (HCW). The present study aimed to determine the predictors of psychological impact (in terms of depression, anxiety and stress) among the HCWs exposed Covid-19 cases in Combined Military Hospital (CMH) Dhaka. Methods: This cross-sectional study was conducted at CMH Dhaka among purposively selected 390 HCWs. Data were collected through face-to-face interview using a pre-tested semi-structured questionnaire with validated and reliable tools. The study was conducted in the Combined Military Hospital Dhaka from 15 July 2020 to 30 September 2020. Results: Among the 390 respondents, 21.6%, 43.1% and 24.1% had depression, anxiety and stress symptoms, respectively. Being married (OR=0.391, 95% CI=0.160-0.953), graduate (OR=2.977; 95% CI=1.181-7.509) and attending 41-80 patients per day (OR=1.996; 95% CI=0.965-4.125) was significantly associated with depressive symptoms. In respect of anxiety, being graduate (OR=2.788, 95% CI=1.228 -6.333) and HSC qualified (OR=2.714, 95% CI=1.073-6.869), staying in family accommodation (OR=2.720, 95% CI=1.136 - 6.516), with nuclear family (OR=0.459, 95% CI=0.281-0.750), smoker (OR=1.827, 95% CI=0.987 - 3.384), doctor (OR=0.362, 95% CI=0.173- 0.758), having service length <20 years (OR=2.229, 95% CI=1.158 - 4.289), service in current place of posting for <20 months (OR=0.460, 95% CI=0.241-0.880), attended 41-80 patient daily (OR=1.720, 95% CI=0.933 - 3.169) and performing overtime duty (OR=2.568, 95% CI=1.609-4.099) were significantly associated with anxiety symptoms. Being graduate (OR=2.249, 95% CI=0.866-5.844), with nuclear family type (OR=0.423, 95% CI=0.249-0.721), having duty place at emergency (OR=2.135, 95% CI=0.902-5.053), being a nurse (OR=0.364, 95% CI=0.162-0.819), having service length <10 years (OR=2.570, 95% CI=1.207-5.472) and performing overtime duty (OR=2.214, 95% CI=1.3101-3.742) were significantly associated with stress symptoms. Conclusion: Psychological problems among the HCW found very common in our study which needs psychological crisis interventions to protect the mental health of HCWs. JOPSOM 2021; 40(1): 1-13


2021 ◽  
Vol 41 (1) ◽  
pp. 8-13
Author(s):  
Nahid H. O. Wanni ◽  
Reem Al Dossary ◽  
Obeid E. Obeid ◽  
Nourah Hasan Al Qahtani ◽  
Zaheenul Islam Siddiqui ◽  
...  

BACKGROUND: Sexually transmitted infections are a serious public health problem. Syphilis, a multistage, curable chronic disease caused by the spirochete Treponema pallidum , remains a major health problem worldwide. The disease re-emerged in the era of HIV in many countries despite the accessibility of curative therapy and continuing public health efforts to eliminate it. OBJECTIVE: Analyse the seropositivity for syphilis. DESIGN: Retrospective cross-sectional. SETTING: Tertiary hospital. PATIENTS AND METHODS: We retrospectively studied individuals who underwent screening tests for syphilis between January 2014 and December 2018. The samples that were positive by both screening and confirmatory tests were considered as confirmed positive for syphilis. MAIN OUTCOME MEASURES: Syphilis positivity identified by chemiluminescence immunoassay, the rapid plasma reagin test, and specific antibodies against Treponema pallidum . SAMPLE SIZE: 11 832. RESULTS: Of the 11 832, 54 (0.45%) were confirmed as seropositive for syphilis. Thirty-three (61.1%) were non-Saudi; 21 (38.9%) were Saudis. Thirty (55.6%) cases were males. Twenty-two (40.74%) were married and 29 (53.70%) were unmarried. Of the 54 diagnosed as syphilis positive, 28 (51.9%) were expatriate workers screened for pre-employment. The percentage of syphilis among Saudis was 0.36%. In an overall chi-square analysis, a P <.0001 indicated a difference among nationalities in the frequency of syphilis. A post-hoc analysis showed that Somalians ( P =.004) and Sudanese ( P =.005) differed significantly from other nationalities. CONCLUSION: The study showed that syphilis was low among the screened population. More than half of the syphilis positive cases in this study were household employees. Screening for syphilis assists in planning complementary services for target populations and improves syphilis control. LIMITATIONS: Retrospective design. Hospital-based findings may not be representative of the seroprevalence of syphilis in the general population. CONFLICT OF INTEREST: None.


2021 ◽  
Author(s):  
UGONMA Dozie ◽  
Sally Ibe ◽  
Chidozie Nwaokoro ◽  
Uchechukwu Chukwuocha ◽  
Obinna Udujih ◽  
...  

Abstract Background A Non-pharmaceutical public health measures are being promoted for mitigating the risk and impact of epidemic and pandemic covid-19 influenza and the introduction of its vaccine necessitate the assessment of individual perception regarding the vaccine. This study assessed compliance with covid-19 non-medicinal preventive protocol and intent to accept covid-19 vaccine among adults in Owerri West, Imo state Nigeria. Method Descriptive cross sectional research design was employed in recruiting four hundred and thirty six (436) participants used for the study. Using SPSS version 23, data were subjected to descriptive and Chi-square analysis. Results Results showed that almost all of them 433(99%) have heard about covid-19 especially from radio 151(35%). A vast number of them know the cause of the disease 397(92%) and when and where it was first reported 423(98%). They were aware that the disease is transmitted through respiratory droplet 351(81%) and it can enter the body through the nose 400(92%), mouth 359(83%) and eyes 362(84%). Moreover, almost all of them know that the disease has no cure 398(92%). On their perception, majority of them strongly agreed that the disease is real and is a serious disease but not in Nigeria where most of the participants disagreed that people did not die from the disease 303(69%). Most of them strongly perceived that the disease can be prevented through regular washing of hands with soap 291(67%), maintaining social distance 223(51%), wearing of nose mask 204(47%), cleaning and disinfecting the environment 231(53%). However, most of them sometimes wear nose mask wash their hands with soap 298(68%) and maintain at least one meter distance when with others 283(65%). Equally, the participants sometimes wash cloth nose mask before reuse 288(66%) but never share nose mask with any other person 200(46%). Moreover, most of them sometimes touch face with fingers 231(53%), clean and disinfect door handles 258(59%), tables and chairs 252(58%). Most of them sometimes sneeze/cough into their elbow 244(56%) and dispose tissue paper used for sneezing/coughing into a closed bin 325(75%), travel in a crowded vehicle 244(56%), attend events with more than 50 persons in attendance 189(43%) and in general sometimes follow all the recommended preventive measures 259(59%) resulting in greater proportions of them 197(45%) observing low level of compliance. Major barrier for not observing the preventive measures as reported by majority of the respondents is that hand washing with soap for up to 20 minutes is lack of time 203(47%), feel uncomfortable with wearing of nose mask 180(41%), attend crowded events because it is very crucial 167(38%) and usually touch their face when cleaning sweat 178(41%). Only few of the participants 114(26%) were willing to accept vaccine especially if it given free of charge 151(35%) in liquid form 55(48%) and its safety trusted 352(81%). Prominent reason for not taking vaccine was because of hidden agenda behind it which is not to the advantage of humanity 87(27%) whereas prominent reason for accepting it was to prevent the recipient from getting the disease 88(77%). Conclusion With the exception of religion, all the demographic characteristics had significant influence (p<0.05) on the level of compliance to covid-19 preventive measures and respondents’ intent to accept covid-19 vaccine when provided. Therefore, to increase vaccine acceptability, baseless rumors and myths against the COVID-19 vaccines must be checked and they should be reached out with scientific facts describing the safety and efficacy of the vaccines.


2019 ◽  
Vol 39 (1) ◽  
pp. 42-48
Author(s):  
Adefunke Olarinre Babatola ◽  
Oladele Simeon Olatunya ◽  
Temitope Olumuyiwa Ojo ◽  
Adekunle Bamidele Taiwo ◽  
Joseph Olusesan Fadare

Introduction: This study assessed the socio-demographic profile, outcomes of treatment and challenges encountered in the management of children admitted for Severe Acute Malnutrition at the Paediatric Unit of a State University Teaching Hospital, Ado-Ekiti, Nigeria.  Methods: A retrospective cross-sectional study was conducted. The records of twenty-five children with SAM admitted from March 2013-March 2018 were reviewed. SAM was defined according to the Wellcome Classification based on child’s weight and oedema status. Data on demographic characteristics, presenting symptoms, co-morbid conditions, duration of admission and outcome were extracted. Results: There were 13 (52.0%) males and 12 (48.0%) females. The median age of children with SAM was eight months. Eighteen children (72%) were marasmic, four (16%) had kwashiorkor while three (12%) had marasmic-kwashiorkor. Common presenting symptoms included poor weight gain (59.1%), fever (54.5%) and diarrhoea (36.4%). Majority (84.0%) of the patients had co-morbid conditions which included sepsis (66.7%), anaemia (37.5%), hypoglycaemia (16.7%) and hypothermia (16.7%). Twenty-one (84.0%) children were fully vaccinated for age, two (8.0%) had partial vaccination while two (8.0%) were never vaccinated. Only two (8.0%) had exclusive breastfeeding, 19 (76.0%) had mixed feeding from birth. Majority (60%) of the children had one or more social challenges such as teenage parents and financial constraints. Mean duration of admission was 4.56 days. Twelve (48.0%) left against medical advice, nine (36.0%) were discharged, one (4.0%) was referred to another tertiary facility and three (12.0%) deaths were recorded. Conclusions: Many of the children admitted for SAM in our study had social problems and almost half of them left the hospital against medical advice. Besides health problem, social factors may play more role in SAM.


2020 ◽  
Author(s):  
Mohammad Jahid Hasan ◽  
Md. Abdullah Saeed Khan ◽  
Monjur Rahman ◽  
Md. Shahnoor Islam ◽  
Sourav Debnath ◽  
...  

Abstract Background: The pandemic of Corona Virus Disease 2019 (COVID-19) has cost a large number of lives and is causing substantial mental stress among people. We conducted a study to identify the sociodemographic and clinical characteristics and prevalence of anxiety and depression among confirmed COVID-19 cases in Bangladesh.Methods: An online cross-sectional survey using a preformed questionnaire adapted in Google form was conducted for data collection. The form was shared along with a brief introduction and rationale via Facebook, Twitter, Facebook Messenger, Viber, and What’s App. Formal ethical clearance was taken from the Biomedical Research Foundation, Bangladesh. Informed consent was ensured before participation.Results: Seventy-four patients with COVID-19 who had an average age of 42.59±14.43 years with male predominance (77%) were included. A total of 29.7% were doing health-care related jobs, and 14.9% lost their jobs due to COVID-19. Patients had a median income of BDT 30000. Of all, 87.8% of patients were symptomatic and presented with fever (77%), cough (58.8%), breathlessness (24.3%), myalgia (24.3%), sore throat (21.6%), fatigue (17.6%), nausea and/or vomiting (12.2%), headache (12.2%), runny nose (9.5%), chest pain (9.5%), diarrhea (8.1%), ARDS (2.7%), stuffy nose (2.7%), conjunctivitis (1.4%) and oral ulcer (1.4%). Overall, the prevalence of anxiety and depression was 60% and 52.9%, respectively. Among the participants, 11.4% had only anxiety, 4.3% had only depression and 48.6% had both.Conclusion: Patients were mostly middle aged, male and healthy workers. Typical presentations were fever and cough. Nearly two-thirds of the patients had either or both anxiety and depression.


2021 ◽  
Vol 39 (4) ◽  
pp. 220-224
Author(s):  
Colonel Lubna Naznin ◽  
Susane Giti ◽  
Arif Ahmed Khan ◽  
Yasmin Akter ◽  
Mimi Parvin ◽  
...  

Introduction: Corona virus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), has become global pandemic. Proinûammatory mediator, serum ferritin is reported to be elevated significantly by different studies in COVID-19. Our study was aimed to find whether serum ferritin level can be employed as a biomarker to assess the disease severity in COVID-19 cases. Methods: This cross sectional observational study was carried out at Armed Forces Institute of Pathology (AFIP), a tertiary referral laboratory between 15 March 2020 and 15 June 2020. Total 2418 hospitalized RT-PCR confirmed COVID- 19 patients from Combined Military Hospital (CMH) were included in our study. Serum ferritin was measured by electrochemiluminescence immunoassay and was compared between the severe and non-severe groups. P-value < 0.05 was considered statistically significant. Results: Total patients were 2418, among them 337 (13.9%) from intensive care unit (ICU) and 2081 (86.1%) from non- ICU. Median age and IQR were 60.5 (51.5–68.0) years in ICU patients versus 38.0 (28-46.1) years in non-ICU patients (p <0.0001). Most (86.8%) patients were males; 82.8% in ICU and 87.5% in non-ICU. Serum ferritin was significantly higher (p<0.0001) in ICU patients; median and IQR was 952.8 (529.9 - 1520.5) ng/mL versus 254.2 (156.1 - 441.9) ng/mL (p <0.0001) in non-ICU patients. Serum ferritin, at cut off value (COV) <550 ng/mL had sensitivity 82.36% and specificity 73.59% for categorization of COVID-19 cases as non-severe. Comparison of proportions of ICU and non-ICU patients was found highly significant (p <0.0001 at 95% confidence interval) with this cut off value. Conclusions: Serum ferritin level was significantly high among COVID-19 patients requiring ICU admission than non-ICU cases. Serum ferritin may be used for categorizing COVID-19 patients. Cut off value 550 ng/mL can be meaningfully used for this categorization, above which should be considered severe and need more careful monitoring. J Bangladesh Coll Phys Surg 2021; 39: 220-224


2020 ◽  
Vol 1 (2) ◽  
pp. 125
Author(s):  
Sukma Ayu Indrianisa ◽  
Raudhotun Nisa

Introduction: Diabetes mellitus is a condition in which the body is unable to produce insulin so hyperglycemic. Uncontrolled hyperglikemi can result in several complications, one of which occurs in diabolical ulcers or leg injuries. Prevention of diasecond ulcers can be done by controlling blood sugar levels, exercising, and undergoing foot care. Knowledge of foot care needs to be known by diabetics in order to minimize the risk of diabetic ulcers. The purpose of this study is to know the level of knowledge of foot care in diabetics mellitus with the occurrence of diabetic ulcers. The design used is a scriptive correlation with the cross sectional approach. Methods: The technique of taking sambel with accidental sempling with a sample of 73 respondents. Analyze data using chi square. Results: The results of the study obtained as many as 40 reseponden (55.8%) knowledgeable and 50 respondents (68.5%) did not have a diabetikum ulcer. The results of the chi square analysis test obtained Pvalue = 0,000 which showed that there is a link between the knowledge of foot care and the incidence of diabetic ulcers in diabetics mellitus. Conclusion: From the results of this study, diabetics are expected to perform foot treatment so as to reduce the risk of diabetic ulcers.


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