scholarly journals Study of the technological properties of excipients in the development of the composition of orally dispersible tablets

2021 ◽  
Vol 10 (4) ◽  
pp. 46-53
Author(s):  
I. D. Kasymov ◽  
A. V. Basevich
Keyword(s):  
Experimental Data ◽  
Bulk Density ◽  
Technological Properties ◽  
Solubility In Water ◽  
Hardness Tester ◽  
Tablet Press ◽  
Dispersible Tablets ◽  
Tablet Hardness ◽  
Multifactorial Experiment

Introduction. The article presents the results of studying the technological properties of individual excipients widely used in the compositions of existing orally dispersed tablets (ODT) for subsequent planning a multifactorial experiment. Samples of excipients were analyzed according to such pharmacopoeial indicators as description, flowability, bulk density, compressibility, fractional composition, solubility in water.Aim. The aim of the work is to create a list and study the technological properties of candidate substances for the role of auxiliary substances in the composition being developed by the ODT.Materials and methods. The technological properties of excipient samples were studied according to the methods of the State Pharmacopoeia of the XIV edition using the flowability tester GTL (ERWEKA, Germany), the bulk density tester SVM 221 (ERWEKA, Germany), the tablet press PGR-10 (LabTools, Russia) and the tablet hardness tester TBH 125 TDP (ERWEKA, Germany).Results and discussion. As a result of the study, experimental data on the technological properties of excipient samples were collected, and the selected samples were compared according to pharmaceutical and technological indicators.Conclusion. In the course of the study, a list of auxiliary substances for the development of the composition of ODT was formed and studies of their technological properties were carried out. The obtained experimental data will allow to develop an optimal matrix of a multifactorial experiment for the development of the composition of ODT and justify the choice of excipients.

РОЛЬ ФИЗИЧЕСКОЙ РАЗМИНКИ В ПОДГОТОВКЕ К ТРЕНИРОВОЧНЫМ ЗАНЯТИЯМ И СОРЕВНОВАНИЯМ ШАХМАТИСТОВ БГУ

2019 ◽  
pp. 63-65
Author(s):  
Судоргин Е.П. ◽  
Карсакова И.Н.
Keyword(s):  
Experimental Data ◽  
Sport Performance ◽  
Warm Up ◽  
Physical Exercises ◽  
Methods Of Evaluation ◽  
Mental Fitness ◽  
Physical Preparation ◽  
Tools And Methods

Аннотация: О роли разминки перед тренировкой и соревнованиями написано много научных статьей и диссертаций. Ещё больше о значимости физической подготовки спортсменов, в том числе и шахматистов. В то же время авторы считают, что вопросу физической подготовки шахматистов и в частности разминке в научной и научно-методической литературе уделяется недостаточно внимания. В своей статье авторы приводят собственные экспериментальные данные о влиянии физических упражнений (разминки) на умственную работоспособность студентов-шахматистов БГУ и как следствие на спортивные результаты команды. Ключевые слова: Шахматы, разминка, умственная работоспособность, средства и методы разминки, методы оценки результатов. Аннотация: Машыгуунун жана мелдештердин алдында даярдоонун ролу жөнүндө көптөгөн илимий макала жана диссертация жазылган. Ошондой эле илимий жана илимий-методикалык адабияттарда шахматка даярдоого көп көңүл бурулбай жатат. Макаланын авторлору шахмат ойногон студенттерге физикалык көнүгүүлөрдүн тийгизген таасири жөнүндө өздөрүнүн эксперименталдык маалыматтарын көргөзүштү. Түйүндүү сөздөр: Шахмат, акыл-дарамет, курулуштар жана ыкмалар, баа берүү жыйынтыгы боюнча кабыл алынат. Abstract: on the role of warm-up before training and competitions written many scientific articles and theses. More about the significance of the physical preparation of athletes, including players. At the same time, the authors believe that the issue of fit- ness players and in particular workout in scientific and scientific-methodical literature neglected. In his article the authors cite their own experimental data on the influence of physical exercises (warm-up) on the mental fitness of students-BSU players and as a result the sport performance team. Keywords: chess, warm-up, mental fitness, workout tools and methods, methods of evaluation results.

scholarly journals Oxidation of Terpenoids to Achieve High-Value Flavor and Fragrances—Questioning Microalgae Oxidative Capabilities in the Biotransformation of the Sesquiterpene Valencene and of Selected Natural Apocarotenoids

Chemistry ◽  
2021 ◽  
Vol 3 (3) ◽  
pp. 821-830
Author(s):  
Davide De Simeis ◽  
Stefano Serra ◽  
Alessandro Di Fonzo ◽  
Francesco Secundo
Keyword(s):  
Experimental Data ◽  
Natural Products ◽  
Aqueous Medium ◽  
Photochemical Reaction ◽  
Substrate Oxidation ◽  
Market Size ◽  
Chlorella Sp ◽  
General Opinion ◽  
Natural Way

Natural flavor and fragrance market size is expected to grow steadily due to the rising consumer demand of natural ingredients. This market request is guided by the general opinion that the production of natural compounds leads to a reduction of pollution, with inherent advantages for the environment and people’s health. The biotransformation reactions have gained high relevance in the production of natural products. In this context, few pieces of research have described the role of microalgae in the oxidation of terpenoids. In this present study, we questioned the role of microalgal based oxidation in the synthesis of high-value flavors and fragrances. This study investigated the role of three different microalgae strains, Chlorella sp. (211.8b and 211.8p) and Chlorococcum sp. (JB3), in the oxidation of different terpenoid substrates: α-ionone, β-ionone, theaspirane and valencene. Unfortunately, the experimental data showed that the microalgal strains used are not responsible for the substrate oxidation. In fact, our experiments demonstrate that the transformation of the four starting compounds is a photochemical reaction that involves the oxygen as oxidant. Even though these findings cast a shadow on the use of these microorganisms for an industrial purpose, they open a new possible strategy to easily obtain nootkatone in a natural way by just using an aqueous medium, oxygen and light.

scholarly journals Elucidating the Complex Interactions between Stress and Epileptogenic Pathways

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Aaron R. Friedman ◽  
Luisa P. Cacheaux ◽  
Sebastian Ivens ◽  
Daniela Kaufer
Keyword(s):  
Experimental Data ◽  
Blood Brain Barrier ◽  
Inflammatory Cytokine ◽  
Stress Hormones ◽  
Brain Barrier ◽  
Barrier Dysfunction ◽  
Complex Interactions ◽  
Narrow Focus ◽  
Analytical Tools

Clinical and experimental data suggest that stress contributes to the pathology of epilepsy. We review mechanisms by which stress, primarily via stress hormones, may exacerbate epilepsy, focusing on the intersection between stress-induced pathways and the progression of pathological events that occur before, during, and after the onset of epileptogenesis. In addition to this temporal nuance, we discuss other complexities in stress-epilepsy interactions, including the role of blood-brain barrier dysfunction, neuron-glia interactions, and inflammatory/cytokine pathways that may be protective or damaging depending on context. We advocate the use of global analytical tools, such as microarray, in support of a shift away from a narrow focus on seizures and towards profiling the complex, early process of epileptogenesis, in which multiple pathways may interact to dictate the ultimate onset of chronic, recurring seizures.

Contriving and Assessment of Magnesium Alloy Composites Augmented with Boron Carbide VIA Liquid Metallurgy Route

2022 ◽  
Vol 1048 ◽  
pp. 3-8
Author(s):  
J. Allen Jeffrey ◽  
S. Suresh Kumar ◽  
V. Anusha Roseline ◽  
A. Lazar Mary ◽  
D. Santhosh
Keyword(s):  
Boron Carbide ◽  
Testing Machine ◽  
High Strength ◽  
Stir Casting ◽  
Vital Role ◽  
Magnesium Metal ◽  
Hardness Tester ◽  
Universal Testing ◽  
Modern Engineering

In modern engineering low-density composites plays a vital role of which magnesium alloys are very effective due to its high strength with better corrosion resistance and neat cast ability. In this work a micron sized Boron carbide ceramic (B4C) of about 100 microns is diffused as a reinforcement with AZ91 for preparing a magnesium metal matrix composite (MMMC) through stir casting route. A modified pit furnace setup is used for doing stir casting with varying volume fractions of 0％ and 3% of boron carbide for doing the composites. Furthermore mechanical and metallurgical properties like Tensile test is made through universal testing machine, Micro-hardness through Vickers hardness tester and Micro structure through Optical Microscopy is done for investigation.

scholarly journals Permeability of Sand-Clay Mixtures

2010 ◽  
Vol 56 (4) ◽  
pp. 299-320 ◽  
Author(s):  
G. Kacprzak ◽  
C. Boutin ◽  
T. Doanh
Keyword(s):  
Experimental Data ◽  
Actual State ◽  
Load Step ◽  
Qualitative And Quantitative ◽  
Experimental Data Point ◽  
Saturated Clay ◽  
Simplifying Assumptions ◽  
Data Point ◽  
Homogenization Methods

Abstract This study deals with the behavior of composite blends constituted of rigid and impervious grains included in saturated clay paste of kaolin, considered as permeable and deformable. Permeability tests performed during standard oedometr tests (before each load step) highlight the key role of the original and actual state of the clay paste, and show the existence of a threshold of sand grain concentration above which a structuring effect influences its permeability. In the light of these experiments some usual homogenization methods (with simplifying assumptions to make the problem manageable) are considered in order to model the mixture permeability. Qualitative and quantitative comparisons with experimental data point out their respective domain of interest and limitations of such approaches

scholarly journals A Model for Predicting Cation Selectivity and Permeability in AMPA and NMDA Receptors Based on Receptor Subunit Composition

2021 ◽  
Vol 13 ◽  
Author(s):  
Sampath Kumar ◽  
Sanjay S. Kumar
Keyword(s):  
Experimental Data ◽  
Divalent Cations ◽  
Ion Selectivity ◽  
Gene Families ◽  
Subunit Composition ◽  
Receptor Subunit ◽  
Cation Selectivity ◽  
Subunit Stoichiometry ◽  
Ampa And Nmda Receptors

Glutamatergic AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) and NMDA (N-methyl-D-aspartate) receptors are implicated in diverse functions ranging from synaptic plasticity to cell death. They are heterotetrameric proteins whose subunits are derived from multiple distinct gene families. The subunit composition of these receptors determines their permeability to monovalent and/or divalent cations, but it is not entirely clear how this selectivity arises in native and recombinantly-expressed receptor populations. By analyzing the sequence of amino acids lining the selectivity filters within the pore forming membrane helices (M2) of these subunits and by correlating subunit stoichiometry of these receptors with their ability to permeate Na+ and/or Ca2+, we propose here a mathematical model for predicting cation selectivity and permeability in these receptors. The model proposed is based on principles of charge attractivity and charge neutralization within the pore forming region of these receptors; it accurately predicts and reconciles experimental data across various platforms including Ca2+ permeability of GluA2-lacking AMPARs and ion selectivity within GluN3-containing di- and tri-heteromeric NMDARs. Additionally, the model provides insights into biophysical mechanisms regulating cation selectivity and permeability of these receptors and the role of various subunits in these processes.

scholarly journals EMPIRICAL STUDY OF THE INFLUENCE OF SECONDARY OBJECT AND SPATIAL IMAGERY ON A LITERARY TEXT TRANSLATION

2021 ◽  
pp. 266-273
Author(s):  
Алексей Григорьевич Шипулин
Keyword(s):  
Experimental Data ◽  
Empirical Study ◽  
Negative Correlation ◽  
Literary Text ◽  
Mental Images ◽  
Spatial Imagery ◽  
Low Level ◽  
Different Types ◽  
Moderate Negative Correlation

Статья посвящена исследованию влияния вторичных образов различного типа на перевод художественного текста. Результаты эксперимента подтверждают ведущую роль предметных образов для нахождения адекватных решений. Также показано наличие умеренной обратной корреляции между уровнем образного мышления в целом и количеством неадекватных трансформаций в переводе. Выявлено негативное влияние на результаты перевода низкого пространственного воображения. The article aims to investigate the influence of different types of secondary mental images on literary text translation. Our experimental data confirm a stone role of object imagery for finding adequate translation solutions, as well as suggest a moderate negative correlation between individual imagery scores and the number of inadequate translation solutions. A low level of spatial imagery may negatively affect the translator’s choices.

Understanding the role of different geographical features in the hydrological response of humid mountainous areas through a stepwise clustering scheme

2021 ◽  
Author(s):  
Yaqian Yang ◽  
Jintao Liu
Keyword(s):  
Bulk Density ◽  
Optimal Parameter ◽  
Soil Bulk Density ◽  
Model Parameters ◽  
Hydrological Response ◽  
Runoff Generation ◽  
Explanatory Variables ◽  
Hydrological Responses ◽  
Rainfall Patterns

<p>In the mountainous basins with less anthropogenic influence, the hydrological function is mainly affected by climate and landscape, which makes it possible to measure hydrological similarity indirectly by geographical features. Due to the mechanisms of runoff generation can vary geographically, in this study, a simple stepwise clustering scheme was proposed to explore the role of geographical features at different spatial hierarchy in indicating hydrological response. Research methods mainly include (1) Stepwise regression was used to quantitatively show the correlation between 35 geographical features and 35 flow features and identify the important explanatory variables for hydrological response; (2) 64 basins were divided by stepwise clustering scheme, and the overall ability of the scheme to capture hydrological similarity was tested by comparing the optimal parameters; (3) The hydrological similarity of basin groups was measured by the leave-one cross validation of hydrological model parameters. The results showed that: (1) Rainfall features, elevation, slope and soil bulk density are the main explanatory variables. (2) The NSE of basin groups based on stepwise clustering is 0.64, reaches 80% of the optimal parameter sets (NSE=0.80). The NSE of 90% basins is greater than 0.5, 80% is greater than 0.6, and 49% is greater than 0.7. (3) In humid areas, the hydrological responses of the basins with more uniform monthly rainfall and more abundant summer rainfall are more similar, e.g., the NSE of Class 4 is 0.77. Under similar rainfall patterns, the hydrological responses of the basins with higher average altitude, greater slope, more convergent of shape and richer vegetation are more similar, e.g., the NSE of Class 3-2 is 0.72 and that of Class 1-2 is 0.70. In the case of similar rainfall patterns and landforms, the hydrological responses of the basins with smaller soil bulk density are more similar, e.g., the NSE of Class 3-2-2 is 0.80. In conclusion, the stepwise clustering enhances the interpretability of basin classification, and the effect of different geographical features on hydrological response can show the applicability of hydrological simulation in ungauged basins.</p>

COVID-19 Beyond the Lungs

2022 ◽  
pp. 109-126
Author(s):  
Omar El Hiba ◽  
Hicham Chatoui ◽  
Nadia Zouhairi ◽  
Lahoucine Bahi ◽  
Lhoussaine Ammouta ◽  
...  
Keyword(s):  
Experimental Data ◽  
Nervous System ◽  
Clinical Symptoms ◽  
Case Reports ◽  
The World ◽  
Acute Pneumonia ◽  
The Brain ◽  
Cardinal Feature ◽  
Shed Light

Since December 2019, the world has been shaken by the spread of a highly pathogen virus, causing severe acute respiratory syndrome (SARS-Cov2), which emerged in Wuhan, China. SARS-Cov2 is known to cause acute pneumonia: the cardinal feature of coronavirus disease 2019 (COVID-19). Clinical features of the disease include respiratory distress, loss of spontaneous breathing, and sometimes neurologic signs such as headache and nausea and anosmia, leading to suppose a possible involvement of the nervous system as a potential target of SARS-CoV2. The chapter will shed light on the recent clinical and experimental data sustaining the involvement of the nervous system in the pathophysiology of COVID-19, based on several case reports and experimental data reporting the possible transmission of SARS-CoV2 throughout the peripheral nerves to the brain cardiorespiratory centers. Thus, understanding the role of the nervous system in the course of clinical symptoms of COVID-19 is important in determining the appropriate therapeutic approach to combat the disease.

Sign in / Sign up

Export Citation Format

Share Document