scholarly journals New Perspective on Addiction: The Hypothesis of Rebound Effect

2021 ◽  
Vol 5 (2) ◽  
Author(s):  
Domina Petric

Addiction alters the levels of all happy brain hormones. My hypothesis is that addictive stimuli cause high amplitude changes in happy brain hormones with initially very high levels followed by very low levels (rebound effect). On the other hand, non-addictive stimuli such as creative work, moderate physical activity, healthy diet, healthy relationships and socialization, cause moderate amplitude changes in happy brain hormones with stable levels of dopamine, serotonin, endorphins and oxytocin without rebound effect. Therefore, all of these non-addictive stimuli might be very helpful in the treatment of addiction.

2019 ◽  
Vol 7 (3) ◽  
pp. 354-373 ◽  
Author(s):  
Christina Duff ◽  
Johann Issartel ◽  
Wesley O’ Brien ◽  
Sarahjane Belton

The aim of this study was to quantify levels of physical activity (PA) and fundamental movement skills (FMS) of children aged 3 to 5 years in Irish preschool services during care hours, and investigate the relationship between these two variables. Data were collected from 141 children (50.3% boys, age M = 3.9 ± 0.5 years) across 9 preschool services. Measurements included PA via accelerometry, and proficiency in four FMS (run, vertical jump, throw and catch). The recommended guideline of 15 minutes of PA per hour (min PA/hour) was met by 35% of children (M = 13.6 min PA/hour). Significant differences in mean PA per hour were found by gender, with boys (14.2 min PA/hour) more active than girls (13.0 min PA/ hour), and age, with younger children (14.2 min PA/hour) more active than older (12.6 minutes PA/hour). Percentage of children proficient in the run was high (88.4%), but low across the other skills (4.9%–18.5%). Significant differences were identified by gender for vertical jump with girls scoring higher than boys. No significant relationship was found between FMS and total PA. Low levels of PA and FMS proficiency highlight need for intervention in early years settings to ensure children develop skills to participate in PA.


1988 ◽  
Vol 60 (3) ◽  
pp. 487-497 ◽  
Author(s):  
C. J. Bates ◽  
T. D. Cowen ◽  
Harumi Tsuchiya

1. Guinea-pig dams were fed on purified diets containing high (5 g/kg diet plus 1 g/l drinking water) or moderate (0.5 g/kg diet) levels of ascorbic acid, in combination with high (1 g/kg diet) or moderate (0.043 g/kg diet) levels of iron, during pregnancy and suckling. Their offsprings' diets contained 0.1 g ascorbic acid/kg and 0.04 g Fe/kg.2. High ascorbic acid intake clearly enhanced both tissue ascorbate and Fe storage in the dams, and high Fe intake increased both the dams' and the pups' tissue Fe stores.3. In the animals receiving high Fe intake, a co-existing high ascorbate intake by the dams reduced the growth rate of the offspring, but only during the early stages of development, not during the later stages of post-weaning growth. All the pups' tissue ascorbate levels fell after weaning, but those born of the dams receiving the high ascorbic acid diets did not fall to levels lower than those of the other pups.4. Thus, although certain disadvantages to the offspring resulting from very-high ascorbic acid intake by pregnant guinea-pig dams were detected, these did not include permanently increased ascorbate requirements, and hence a progression to scurvy as the pups grew and matured.


Neofilolog ◽  
2019 ◽  
Vol 2 (42/2) ◽  
pp. 241-254
Author(s):  
Ewa Piechurska-Kuciel

Reflection is understood as an activity which enables the reproduction of past experiences, reflection and meditation about them and their evaluation. One of the most significant features shaping learner reflection may be willingness to communicate in a foreign language – one’s volitional readiness to enter a communicative event in this language. In spite of a wealth of research conducted in this area, it is still unclear why some students are willing to start communication in a foreign language, while others are adamant to avoid it. For the purpose of this paper a qualitative-quantitative study was performed, focusing on four students with very low levels of willingness to communicate in English, and four with very high levels. The research results demonstrate that high willingness is connected with feelings of safety, a tendency to achieve high proficiency and learning satisfaction. On the other hand, low willingness to communicate in English coexists with feelings of threat and unavoidable necessity to surrender to the demands of the educational system.


Nativa ◽  
2019 ◽  
Vol 7 (3) ◽  
pp. 274
Author(s):  
Fabrício Assis Leal ◽  
Francisca Fabricia Bezerra de Souza ◽  
Glória Da Silva Almeida Leal

O presente estudo teve como objetivo realizar um zoneamento de riscos de incêndios florestais para a região Hot Spot de focos de calor no estado do Acre em 2016. Para identificar os municípios que fariam parte desta abordagem foi realizada análise de agrupamento Hot Spot. Após seleção dos municípios foram consideradas as seguintes variáveis para o zoneamento: declividade, orientação das encostas, altitude, rede viária, zonas urbanas, núcleos populacionais e uso do solo. Essas variáveis foram integradas por uma somatória em que todas elas receberam o mesmo peso. Os riscos foram classificados em cinco níveis, sendo: baixo, moderado, alto, muito alto e extremo. Ao todo, quatro municípios foram considerados Hot Spot e tiveram seu zoneamento de risco realizado. Entre as classes destacaram-se as de riscos Alto (24%), Moderado (25,5%) e Baixo (23,9%). Por outro lado, os riscos mais preocupantes tiveram porcentagem modestas, em relação as outras classes de risco, sendo risco Muito Alto com 14,1% da área total e risco Extremo com apenas 12,5% da área. Os resultados qualificados e quantificados do zoneamento de risco de incêndios foram de grande relevância, pois mostraram aquelas classes de riscos mais preocupantes por terem maior abrangência e maior alcance nas regiões Hot Spot de focos de calor.Palavras-chave: análise espacial, geoprocessamento, mapeamento geoespacial.MAPPING OF FORESTRY FIRE RISKS IN THE HOT SPOT REGION OF HEAT FOCUS, ACRE ABSTRACT:The objective of this study was to carry out a risk zoning of forest fires in a region. To reach the outbreaks of heat and state of Acre in 2016. After the distribution of the answers, the altitude varied for zoning: slope, slope orientation, altitude, road network, urban areas, population centers and land use. These variables were integrated by a summation in all the same ones that received the weight. The touches were classified in low levels, being: low, moderate, high, very high and extreme. In all, four nations were Hot Spot stocks and had their risk zoning done. Among the classes, the highlights were High (24%), Moderate (25.5%) and Low (23.9%). On the other hand, the most worrisome risks were modest rates, in relation to the other risk classes, and the risk of capital loss was greater than 14.1% of the total area and Extreme risk with only 12.5% of the area. The indexes and quantification of fuel risk zoning were of great relevance, since they were found as more worrying risk classes due to a greater and greater extent in the regions.Keywords: geospatial analysis, geoprocessing, geospatial mapping.


1973 ◽  
Vol 72 (1) ◽  
pp. 137-155 ◽  
Author(s):  
R. Welschen

ABSTRACT Rats were hypophysectomized at oestrus, at days 1, 2 and 3 of dioestrus or at pro-oestrus. They were injected with various doses of PMS only, or with combinations of PMS and HCG, in such a way that fairly constant blood levels could be expected, and killed 24 h later. It was found that the minimal doses of substitutional gonadotrophins, required to maintain normal follicular growth, were considerably higher during the period from pro-oestrus to oestrus (when a new generation of follicles begin to develop) than during all the other periods investigated. This peak requirement primarily concerned PMS. The minimal requirements during other periods showed only minor variations. The maximal doses which still caused normal follicular growth were higher during the period from dioestrus −1 to −3 than during the period from oestrus to dioestrus −1 and the period from dioestrus −3 to pro-oestrus. The data suggest that during pro-oestrus very high amounts of FSH are required to recruite a new crop of follicles, whereas during the other phases, low levels of both FSH and LH are generally needed for normal follicular growth.


1994 ◽  
Vol 72 (01) ◽  
pp. 058-064 ◽  
Author(s):  
Goya Wannamethee ◽  
A Gerald Shaper

SummaryThe relationship between haematocrit and cardiovascular risk factors, particularly blood pressure and blood lipids, has been examined in detail in a large prospective study of 7735 middle-aged men drawn from general practices in 24 British towns. The analyses are restricted to the 5494 men free of any evidence of ischaemic heart disease at screening.Smoking, body mass index, physical activity, alcohol intake and lung function (FEV1) were factors strongly associated with haematocrit levels independent of each other. Age showed a significant but small independent association with haematocrit. Non-manual workers had slightly higher haematocrit levels than manual workers; this difference increased considerably and became significant after adjustment for the other risk factors. Diabetics showed significantly lower levels of haematocrit than non-diabetics. In the univariate analysis, haematocrit was significantly associated with total serum protein (r = 0*18), cholesterol (r = 0.16), triglyceride (r = 0.15), diastolic blood pressure (r = 0.17) and heart rate (r = 0.14); all at p <0.0001. A weaker but significant association was seen with systolic blood pressure (r = 0.09, p <0.001). These relationships remained significant even after adjustment for age, smoking, body mass index, physical activity, alcohol intake, lung function, presence of diabetes, social class and for each of the other biological variables; the relationship with systolic blood pressure was considerably weakened. No association was seen with blood glucose and HDL-cholesterol. This study has shown significant associations between several lifestyle characteristics and the haematocrit and supports the findings of a significant relationship between the haematocrit and blood lipids and blood pressure. It emphasises the role of the haematocrit in assessing the risk of ischaemic heart disease and stroke in individuals, and the need to take haematocrit levels into account in determining the importance of other cardiovascular risk factors.


1979 ◽  
Author(s):  
J. G. Kelton ◽  
P. B. Neame ◽  
I. Walker ◽  
A. G. Turpie ◽  
J. McBride ◽  
...  

Thrombotic thrombocytopenic purpura (TTP) is a rare but serious illness of unknown etiology. Treatment by plasmapheresis has been reported to be effective but the mechanism for benefit is unknown. We have investigated the effect of plasmapheresis in 2 patients with TTP by quantitating platelet associated IgG (PAIgG) levels prior to and following plasmapheresis. Both patients had very high levels of PAIgG at presentation (90 and A8 fg IgG/platelet respectively, normal 0-5). in both, the PAIgG levels progressively fell to within the normal range and the platelet count rose following plasmapheresis. One patient remained in remission with normal platelet counts and PAIgG levels. The other relapsed after plasmapheresis and the PAIgG level rose prior to the fall in platelet count. Plasmapheresis was repeated and resulted in normalization of both the platelet count and PAIgG level. It is suggested that plasmapheresis removes antiplatelet antibody or immune complexes which may be of etiological importance in this illness.


Author(s):  
Milen Dimov

The present study traces the dynamics of personal characteristics in youth and the manifested neurotic symptoms in the training process. These facts are the reason for the low levels of school results in the context of the existing theoretical statements of the problem and the empirical research conducted among the trained teenagers. We suggest that the indicators of neurotic symptomatology in youth – aggression, anxiety, and neuroticism, are the most demonstrated, compared to the other studied indicators of neurotic symptomatology. Studies have proved that there is a difference in the act of neurotic symptoms when tested in different situations, both in terms of expression and content. At the beginning of the school year, neurotic symptoms, more demonstrated in some aspects of aggressiveness, while at the end of school year, psychotism is more demonstrated. The presented summarized results indicate that at the beginning of the school year, neurotic symptoms are strongly associated with aggression. There is a tendency towards a lower level of social responsiveness, both in the self-assessment of real behavior and in the ideal “I”-image of students in the last year of their studies. The neurotic symptomatology, more demonstrated due to specific conditions in the life of young people and in relation to the characteristics of age.


2020 ◽  
Vol 11 (SPL1) ◽  
pp. 934-937
Author(s):  
Tasneem M. Lakkadsha ◽  
Kiran Kumar ◽  
Waqar M. Naqvi ◽  
Pratik Phansopkar

In January 2020, we met with COVID-19 (aka SARS-Co-V-2 and/or Corona virus) on our news channels all the way from china. Little did we know that it would shake up our lives in such a manner that we had heard only in a movie or read in history books. Currently we are all in some sort of lockdown, be it in hospital/home or in our minds. Being there, most of us are facing certain kind of misery, be it emotional, mental, physical or social. To be expansive the most common stresses that have been addressed by people on mass media platform are feeling of depression and isolation caused by being away from family and friends, some are complaining of losing their enthusiasm, some of gaining weight, some of losing it and many more. Going through a pandemic is also helping people in some or the other way, one of which is being concerned about their health and habits to keep themselves fit and away from serious comorbidities which can stem out from physical inactivity and heightened stress levels. There are many ways to stay fit at home without any complex gym equipment, but far less is known about it. Thus, an understanding of methods through which one can become physically active with least complexity, easy availability, and appropriate utilization is need of the hour.


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