scholarly journals Correlation Between β2-Microglobulin, Grobulin Levels & The Number of Plasmatic Cells in Patients with Multiple Myeloma

2021 ◽  
Vol 1 (2) ◽  
Author(s):  
Rosa María Torres Hernández ◽  
Mario Alberto Martínez Ramírez ◽  
Beatriz González Jiménez ◽  
Humberto Hernández Ojeda ◽  
Fátima Izamar Medel Cabada
Keyword(s):  
Multiple Myeloma ◽  
Pearson Correlation ◽  
High Serum ◽  
Β2 Microglobulin ◽  
Predominant Type ◽  
Margin Of Error ◽  
Pearson's R ◽  
Multiple Myelomas ◽  
The One ◽  
Pearson’S R

Introduction: Multiple myeloma is multifocal neoplasia of plasmatic cells that affects the bone marrow. It is associated with the production of a urinary or serum protein. It represents approximately 1 percent of cancer cases worldwide and between 10 to 15 percent of all cases of hematological malignancy. Furthermore, it has been proposed that the β2-microglobulin levels are correlated with other factors that can predict multiple myelomas such as the number of plasmatic cells and the creatine levels. Goals: To determine the correlation between β2-microglobulin, globulin levels, and the number of plasmatic cells in patients with multiple myeloma. Methods and techniques: We conducted an observational, retrospective, transversal, and analytical study in the Hospital of the Mexican Institute of Social Security at the Veracruz port. Our population analyzed comprehended 45 patients between the ages 30 and 80 with a confirmed diagnosis of multiple myeloma. We measured the β2-microglobulin levels and globulin levels, and the number of plasmatic cells during the diagnosis of patients. Furthermore, we conducted a statistical analysis using a Pearson correlation. Results: The average age was 61 years with a margin of error of 11.48 years. The myeloma of IgG type was the one of major prevalence and represent 82.2 percent. It was followed by the IgA type and the IgM type, which represented 15.5 and 2.2 percent respectively. The Pearson correlation coefficient (Pearson's r) between the β2-microglobulin levels and globulin levels was 0.92. The Pearson's r between the number of plasmatic cells and β2-microglobulin, excluding patients with high serum creatine levels (i.e. larger than 1.2 mg/dl), was 0.371. Conclusions: The predominant type of myeloma in the analyzed population was the IgG type. Furthermore, this myeloma affected mainly men in our study. The average age was 61 years with a margin of error of 11.48 years when compared to other populations in our study.

scholarly journals Consensus recommendations for risk stratification in multiple myeloma: report of the International Myeloma Workshop Consensus Panel 2

Blood ◽  
2011 ◽  
Vol 117 (18) ◽  
pp. 4696-4700 ◽  
Author(s):  
Nikhil C. Munshi ◽  
Kenneth C. Anderson ◽  
P. Leif Bergsagel ◽  
John Shaughnessy ◽  
Antonio Palumbo ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
In Situ Hybridization ◽  
High Risk ◽  
Risk Stratification ◽  
Fluorescence In Situ Hybridization ◽  
High Serum ◽  
Β2 Microglobulin ◽  
Poor Outcome ◽  
13Q Deletion

Abstract A panel of members of the 2009 International Myeloma Workshop developed guidelines for risk stratification in multiple myeloma. The purpose of risk stratification is not to decide time of therapy but to prognosticate. There is general consensus that risk stratification is applicable to newly diagnosed patients; however, some genetic abnormalities characteristic of poor outcome at diagnosis may suggest poor outcome if only detected at the time of relapse. Thus, in good-risk patients, it is necessary to evaluate for high-risk features at relapse. Although detection of any cytogenetic abnormality is considered to suggest higher-risk disease, the specific abnormalities considered as poor risk are cytogenetically detected chromosomal 13 or 13q deletion, t(4;14) and del17p, and detection by fluorescence in situ hybridization of t(4;14), t(14;16), and del17p. Detection of 13q deletion by fluorescence in situ hybridization only, in absence of other abnormalities, is not considered a high-risk feature. High serum β2-microglobulin level and International Staging System stages II and III, incorporating high β2-microglobulin and low albumin, are considered to predict higher risk disease. There was a consensus that the high-risk features will change in the future, with introduction of other new agents or possibly new combinations.

scholarly journals Trends and prediction in daily incidence and deaths of COVID-19 in the United States: a search-interest based model

2020 ◽  
Author(s):  
Xiaoling Yuan ◽  
Jie Xu ◽  
Sabiha Hussain ◽  
He Wang ◽  
Nan Gao ◽  
...  
Keyword(s):  
Prediction Models ◽  
Pearson Correlation ◽  
The United States ◽  
Population Based ◽  
Internet Search ◽  
Pearson's R ◽  
Pearson Correlation Test ◽  
Highly Correlated ◽  
The U.S ◽  
Pearson’S R

AbstractBackground and ObjectivesThe coronavirus disease 2019 (COVID-19) infected more than 586,000 patients in the U.S. However, its daily incidence and deaths in the U.S. are poorly understood. Internet search interest was found correlated with COVID-19 daily incidence in China, but not yet applied to the U.S. Therefore, we examined the association of internet search-interest with COVID-19 daily incidence and deaths in the U.S.MethodsWe extracted the COVDI-19 daily incidence and death data in the U.S. from two population-based datasets. The search interest of COVID-19 related terms was obtained using Google Trends. Pearson correlation test and general linear model were used to examine correlations and predict future trends, respectively.ResultsThere were 555,245 new cases and 22,019 deaths of COVID-19 reported in the U.S. from March 1 to April 12, 2020. The search interest of COVID, “COVID pneumonia,” and “COVID heart” were correlated with COVDI-19 daily incidence with ∼12-day of delay (Pearson’s r=0.978, 0.978 and 0.979, respectively) and deaths with 19-day of delay (Pearson’s r=0.963, 0.958 and 0.970, respectively). The COVID-19 daily incidence and deaths appeared to both peak on April 10. The 4-day follow-up with prospectively collected data showed moderate to good accuracies for predicting new cases (Pearson’s r=-0.641 to −0.833) and poor to good accuracies for daily new deaths (Pearson’s r=0.365 to 0.935).ConclusionsSearch terms related to COVID-19 are highly correlated with the trends in COVID-19 daily incidence and deaths in the U.S. The prediction-models based on the search interest trend reached moderate to good accuracies.

Comparison of Survival and Clinical Features In Different Age Cohorts of Patients with Multiple Myeloma: A Single Center Experience

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 4997-4997
Author(s):  
Jae Ho Jeong ◽  
Shinkyo Yoon ◽  
Dalyong Kim ◽  
Jeong Eun Kim ◽  
Dok Hyun Yoon ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Bone Marrow ◽  
Clinical Features ◽  
Bone Lesion ◽  
Elevated Serum ◽  
High Serum ◽  
Single Center ◽  
Age Cohorts ◽  
Β2 Microglobulin ◽  
The Impact

Abstract Abstract 4997 Purpose This analysis was aimed to compare clinical features in different age cohorts of multiple myeloma (MM) patients and to identify the impact of the clinical characteristics on survival in the patients in a single center. Patients and Methods We retrospectively analyzed data from 513 patients between Sep 1995 and Feb 2010 in the Asan Medical Center. Correlation of baseline characteristics with survival was made by the following age strata: <45, 45–54, 55–64, and ≥65 years of age. Results Median observed overall survival (OS) in the entire cohort was 3.20 years (95% confidence interval: 2.71–3.68). Observed survival decreased steadily with ages from 4.56 years in patients younger than age 45 years to 2.50 years in patients ≥65 years (P=0.003). The patients in the oldest group (age 65 years or older) were more likely to have International Staging System (ISS) stage II or III than others (P=0.007). There were no significant differences in hypercalcemia (≥10 mg/dL), elevated serum creatinine (≥2 mg/dL), anemia (Hb <10 g/dL) and osteolytic bone lesion, so called CRAB among the different age cohorts. Prognostic factors including elevated C-reactive protein (CRP) (≥ 0.8mg/dL), lactate dehydrogenase (LDH), bone marrow plasma cell infiltration also did not differ significantly among 10-year age cohorts. However, hypoalbuminemia (<3.5 g/dL) and high serum β2-microglobulin (≥3.5 mg/dL) level were more frequent in patients ≥65 years of age (P=0.001 and P=0.046, respectively). Furthermore, higher proportion of patients underwent ASCT in the younger 10-year age cohorts (71.4%, 53.7%, 43.4%, 2.5% in < 45, 45–54, 55–64, and ≥ 65 years of age, respectively, P<0.001). Conclusion No significant differences in the myeloma related organ or tissue impairment and prognostic markers including CRP, LDH and bone marrow infiltration of myeloma cells were noted among different age groups. However, survival significantly declined in the higher age group, which might be related to higher ISS stage associated with hypoalbuminemia, high serum β2-microglobulin level and lower proportion of patients receiving ASCT. Disclosures: No relevant conflicts of interest to declare.

CODEM Instrument

GeroPsych ◽  
2014 ◽  
Vol 27 (1) ◽  
pp. 23-31 ◽  
Author(s):  
Anne Kuemmel (This author contributed eq ◽  
Julia Haberstroh (This author contributed ◽  
Johannes Pantel
Keyword(s):  
Convergent Validity ◽  
Interrater Reliability ◽  
Discriminant Validity ◽  
Assessment Tool ◽  
Intraclass Correlation ◽  
Well Being ◽  
Communication Behavior ◽  
People With Dementia ◽  
Pearson's R ◽  
Pearson’S R

Communication and communication behaviors in situational contexts are essential conditions for well-being and quality of life in people with dementia. Measuring methods, however, are limited. The CODEM instrument, a standardized observational communication behavior assessment tool, was developed and evaluated on the basis of the current state of research in dementia care and social-communicative behavior. Initially, interrater reliability was examined by means of videoratings (N = 10 people with dementia). Thereupon, six caregivers in six German nursing homes observed 69 residents suffering from dementia and used CODEM to rate their communication behavior. The interrater reliability of CODEM was excellent (mean κ = .79; intraclass correlation = .91). Statistical analysis indicated that CODEM had excellent internal consistency (Cronbach’s α = .95). CODEM also showed excellent convergent validity (Pearson’s R = .88) as well as discriminant validity (Pearson’s R = .63). Confirmatory factor analysis verified the two-factor solution of verbal/content aspects and nonverbal/relationship aspects. With regard to the severity of the disease, the content and relational aspects of communication exhibited different trends. CODEM proved to be a reliable, valid, and sensitive assessment tool for examining communication behavior in the field of dementia. CODEM also provides researchers a feasible examination tool for measuring effects of psychosocial intervention studies that strive to improve communication behavior and well-being in dementia.

scholarly journals Pre-Planned and Non-Planned Agility in Patients Ongoing Rehabilitation after Knee Surgery: Design, Reliability and Validity of the Newly Developed Testing Protocols

Diagnostics ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 146
Author(s):  
Ivan Peric ◽  
Miodrag Spasic ◽  
Dario Novak ◽  
Sergej Ostojic ◽  
Damir Sekulic
Keyword(s):  
Total Knee Arthroplasty ◽  
Body Mass ◽  
Knee Arthroplasty ◽  
Arthroscopic Surgery ◽  
The Body ◽  
Clinical Population ◽  
Pearson's R ◽  
Total Knee ◽  
Type Of Surgery ◽  
Pearson’S R

Background: Due to its association with the risk of falling and consequent injury, the importance of agility is widely recognized, but no study so far has examined the different facets of agility in an untrained/clinical population. The aim of this study was to evaluate the reliability, validity, and correlates of newly developed tests of non-planned agility (NPA) and pre-planned agility (PPA) in an untrained/clinical sample. Methods: The sample comprised 38 participants older than 40 years (22 females, age: 56.1 ± 17.3 years, height: 170.4 ± 10.8 cm, mass: 82.54 ± 14.79 kg) who were involved in a rehabilitation program following total knee arthroplasty and knee arthroscopy. Variables included age, gender, type of surgery, history of fall, anthropometrics/body composition, and newly developed tests of NPA and PPA. Results: The results showed the high inter-testing- (ICC > 0.95, CV < 9%), and intra-testing-reliability (ICC > 0.96, CV < 9) of the newly developed tests. PPA and NPA were found to be valid in differentiation between age groups (>50 yrs. vs. <50 yrs.), and genders, with better performance in younger participants and males. Only NPA differentiated participants according to type of surgery, with better performance in those who had arthroscopic surgery, than those who had total knee arthroplasty. No differences in NPA and PPA were established between groups based on fall-history. In females, the body mass (Pearson’s r = 0.58 and 0.59, p < 0.001) and body fatness (Pearson’s r = 0.64 and 0.66, p < 0.001) were negatively correlated, while the lean body mass (Pearson’s r = 0.70 and 0.68, p < 0.001) was positively correlated with PPA and NPA. The NPA and PPA were highly correlated (Pearson’s r = 0.98, p < 0.001). Conclusions: We found that the proposed tests are reliable when evaluating agility characteristics in an untrained/clinical population after knee arthroplasty/arthroscopy. Further evaluation of the specific validity of the proposed tests in other specific subsamples is warranted.

scholarly journals Calcium Identification and Scoring Based on Echocardiography. An Exploratory Study on Aortic Valve Stenosis

2021 ◽  
Vol 11 (7) ◽  
pp. 598
Author(s):  
Luis B. Elvas ◽  
Ana G. Almeida ◽  
Luís Rosario ◽  
Miguel Sales Dias ◽  
João C. Ferreira
Keyword(s):  
Aortic Valve ◽  
Ct Scan ◽  
Pearson Correlation ◽  
Region Of Interest ◽  
Expert Assessment ◽  
Image Binarization ◽  
Real Patient ◽  
Margin Of Error ◽  
Pixel Value ◽  
Echocardiographic Images

Currently, an echocardiography expert is needed to identify calcium in the aortic valve, and a cardiac CT-Scan image is needed for calcium quantification. When performing a CT-scan, the patient is subject to radiation, and therefore the number of CT-scans that can be performed should be limited, restricting the patient’s monitoring. Computer Vision (CV) has opened new opportunities for improved efficiency when extracting knowledge from an image. Applying CV techniques on echocardiography imaging may reduce the medical workload for identifying the calcium and quantifying it, helping doctors to maintain a better tracking of their patients. In our approach, a simple technique to identify and extract the calcium pixel count from echocardiography imaging, was developed by using CV. Based on anonymized real patient echocardiographic images, this approach enables semi-automatic calcium identification. As the brightness of echocardiography images (with the highest intensity corresponding to calcium) vary depending on the acquisition settings, echocardiographic adaptive image binarization has been performed. Given that blood maintains the same intensity on echocardiographic images—being always the darker region—blood areas in the image were used to create an adaptive threshold for binarization. After binarization, the region of interest (ROI) with calcium, was interactively selected by an echocardiography expert and extracted, allowing us to compute a calcium pixel count, corresponding to the spatial amount of calcium. The results obtained from these experiments are encouraging. With this technique, from echocardiographic images collected for the same patient with different acquisition settings and different brightness, obtaining a calcium pixel count, where pixel values show an absolute pixel value margin of error of 3 (on a scale from 0 to 255), achieving a Pearson Correlation of 0.92 indicating a strong correlation with the human expert assessment of calcium area for the same images.

Serum β2-Microglobulin for Staging and Monitoring of Multiple Myelomas and Other Non-Hodgkin Lymphomas

1994 ◽  
Vol 17 (4) ◽  
pp. 428-432 ◽  
Author(s):  
S. Poley ◽  
A. Fateh-Moghadam ◽  
V. Nüssler ◽  
H. Pahl
Keyword(s):  
Β2 Microglobulin ◽  
Multiple Myelomas

scholarly journals Tingkat Pengetahuan Ibu Bekerja dalam Pemberian ASI berhubungan dengan Kejadian ISPA pada Bayi Usia 1 Tahun di Desa Bedewang Kecamatan Songgon Banyuwangi Tahun 2017

2019 ◽  
Vol 2 (2) ◽  
pp. 55-60
Author(s):  
Ayuk Naimah
Keyword(s):  
Pearson's R ◽  
Pearson’S R

Beberapa faktor risiko yang dapat menyebabkan ISPA adalah menyelimuti berlebihan, pemberian makanan tambahan terlalu dini, kurangnya pemberian ASI, imunisasi, polusi udara, tempat tinggal yang padat, kurangnya ventilasi dan sosial ekonomi. Desain penelitian ini adalah analitik survey sampai peneliti memenuhi target yang diinginkan dalam waktu satu bulan secara bertahap dengan menyebarkan kuesioner pada 35 responden. Subyek yang diteliti ditarik dari populasi dengan cara Teknik pengambilan sampel dalam penelitian menggunakan total sampling. Penelitian ini dilakukan pada bulan September 2017 yang ditabulasi silang diperoleh hasil hampir seluruhnya responden tingkat pengetahuan kurang sejumlah 32 responden (91.4%) terjadi ISPA, dan sebagian kecil responden tingkat pengetahuan cukup sejumlah 3 responden (8.6%) tidak terjadi ISPA. Analisis data dengan menggunakan uji Krusskal Wallis didapatkan interprestasi hasil Pearson's R = 1.000, sehingga dibanding dengan Krusskal-Wallis Correlation = 1.000. Dari hasil data tersebut dikatakan ada hubungan jika Pearson's R = Kruskal-Wallis Correlation maka H1 diterima. Setelah dilakukan perhitungan menggunakan SPSS maka didapatkan hubungan koefisien korelasi 0,80 – 1,000 korelasi sangat kuat. Kesimpulan dari penelitian ini bahwa tingkat pengetahuan ibu bekerja dalam pemberian ASI dengan kejadian ISPA pada bayi usia ? 1 tahun berhubung sangat kuat. Pada ibu bekerja tingkat pengetahuan dalam pemberian ASI kurang maka akan terjadi ISPA. Dalam pemberian ASI pada waktu ibu bekerja tidak dapat dijadikan alasan untuk tidak memberikan ASI pada bayinya, banyak upaya yang dapat dilakukan oleh ibu dan yang terpenting adalah perubahan pikiran serta komitmen sebagai orang tua untuk mengutamakan kesehatan dan tumbuh kembang pada bayinya.Kata Kunci : Kejadian ISPA, Pengetahuan Ibu Bekerja, Pemberian ASI

scholarly journals HUBUNGAN EFIKASI DIRI DENGAN KEPATUHAN MINUM OBAT PADA PASIEN TBC DI WILAYAH KERJA PUSKESMAS PARONGPONG KECAMATAN PARONGPONG KABUPATEN BANDUNG BARAT

2020 ◽  
Vol 5 (2) ◽  
pp. 186-193
Author(s):  
Mella Yusef Fintiya ◽  
Imanuel Sri Mei Wulandari
Keyword(s):  
Mycobacterium Tuberculosis ◽  
P Value ◽  
Cross Sectional ◽  
Purposive Sampling ◽  
Pearson's R ◽  
Pearson’S R

Tuberkulosis adalah penyakit infeksi paru yang disebabkan oleh Mycobacterium Tuberculosis. Di Indonesia kasus tuberkulosis setiap tahunnya semakin meningkat. Indonesia menepati urutan ke-6 penderita tuberkulosis tertinggi di dunia, sedangkan Jawa Barat menepati urutan pertama. Tujuan penelitian ini adalah untuk melihat adanya hubungan anatar efikasi diri dengan kepatuhan minum obat OAT. Metode penelitian menggunakan desain deskriptif korelasional dengan pendekatan cross sectional dengan melibatkan 23 responden yang sedang menjalani pengobatan di puskesmas parongpong, responden dipilih dengan menggunakan Purposive sampling. Variabel independen adalah efikasi diri, variabel dependent adalah kepatuhan minum obat. Instrumen dalam penelitian ini adalah kuesioner yang dianalisis menggunakan pearson’s r . Hasil dan analisis Efikasi Diri dengan Kepatuhan Minum obat mempunyai hubungan  dengan nilai  p-value 0,030 atau (p ≤ 0,05) dengan tingkat hubungan sedang (0,454). Efikasi merupakan salah satu faktor yang mempengaruhi kepatuhan minum obat pasien tuberkulosis di wilayah kerja Puskesmas Parongpong. Saran untuk penelitian selanjutnya perlu mengetahui peran kader kesehatan dalam kepatuhan minum obat.

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