Comparison of the use of Solidago chilensis (Arnica) and low-level laser therapy for the prevention of oral mucositis in patients submitted of head and neck radiotherapy and/or high toxicity chemotherapy

The oral mucositis is an adverse event of radiotherapy and/or high toxicity chemotherapy. The Solidago chilensis (Arnica) has been used for its antiseptic, analgesic, healing and anti-inflammatory properties. Objective: The purpose of this study was to evaluate the uses of Arnica for oral mucositis prevention in patients submitted to radiotherapy for head and neck tumors treatment and/or high toxicity chemotherapy. Methodology: The determination of the cytotoxicity index of the aqueous extract was determined in vitro. The oral mucosa was evaluated in days 0, 10 and 14 of patients in the groups: treated with lasertherapy (L, n=18), treated with Arnica (A, n=24) and, treated with lasertherapy associated with Arnica (LA, n=4). It was considered significant p<0.05. Results: It was determined IC50=90,74 μg/mL of Arnica’s aqueous extract in SCC-4 cells. The development of oral mucositis was associated with the type of treatment for oral mucositis prevention: L, A, and LA (χ2 = 24,72, p<0.0001). The level of oral mucositis had significant interaction with the type of prevention treatment [F(2) = 9.545, p<0.0001] and, within 14 days [F(2) = 11.995, p<0.0001]. Conclusions: The results obtained suggest which the use of Solidago chilensis (Arnica) can be an important therapeutic option for treatment with low-level laser therapy for oral mucositis prevention in patients submitted of head and neck radiotherapy and/or high toxicity chemotherapy.

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P-52 The Effect of Prophylactic Low Level Laser Therapy on Oral Mucositis Following Chemoradiotherapy in Head and Neck Cancers: A Systematic Review

Oral Oncology ◽

10.1016/s1368-8375(21)00340-7 ◽

2021 ◽

Vol 118 ◽

pp. 8

Author(s):

Ahmed Subeh ◽

Hassan Baig ◽

Qaisar Khan ◽

Abdulaziz Alfailakawi

Keyword(s):

Systematic Review ◽

Head And Neck ◽

Laser Therapy ◽

Oral Mucositis ◽

Head And Neck Cancers ◽

Low Level Laser Therapy ◽

Low Level ◽

Low Level Laser ◽

Level Laser

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Effect of low-level laser therapy on chemoradiotherapy-induced oral mucositis and salivary inflammatory mediators in head and neck cancer patients

Lasers in Surgery and Medicine ◽

10.1002/lsm.22349 ◽

2015 ◽

Vol 47 (4) ◽

pp. 296-305 ◽

Cited By ~ 36

Author(s):

Angélica F. Oton-Leite ◽

Geisa Badauy L. Silva ◽

Marília O. Morais ◽

Tarcília A. Silva ◽

Cláudio R. Leles ◽

...

Keyword(s):

Head And Neck Cancer ◽

Head And Neck ◽

Cancer Patients ◽

Laser Therapy ◽

Neck Cancer ◽

Oral Mucositis ◽

Inflammatory Mediators ◽

Low Level Laser Therapy ◽

Low Level Laser ◽

Level Laser

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Phase III trial of low-level laser therapy to prevent induced oral mucositis in head and neck cancer patients submitted to concurrent chemoradiation.

Journal of Clinical Oncology ◽

10.1200/jco.2011.29.18_suppl.lba5524 ◽

2011 ◽

Vol 29 (18_suppl) ◽

pp. LBA5524-LBA5524 ◽

Cited By ~ 3

Author(s):

H. S. Antunes ◽

D. Herchenhorn ◽

C. M. Araujo ◽

E. Cabral ◽

E. M. d. S. Ferreira ◽

...

Keyword(s):

Head And Neck ◽

Laser Therapy ◽

Oral Mucositis ◽

Phase Iii ◽

Low Level Laser Therapy ◽

Limiting Factor ◽

Phase Iii Trial ◽

Low Level ◽

Low Level Laser ◽

Level Laser

LBA5524 Background: Oral mucositis (OM) remains a limiting factor in in head and neck squamous cell carcinomas (HNSCC) patients (pts) treated with chemoradiation (CRT) leading to pain, dysphagia, and weight loss. Low-level laser therapy (LLLT) emerges as a promising, preventive therapy of CRT-induced OM. Yet, a definitive randomized trial supporting its use is lacking. This study was designed to assess the efficacy of LLLT in reducing the incidence and/or severity of OM. Methods: Assuming OM grade (G3) for placebo 0.4 (P0); LLLT 0.15 (P1) ; β=0.2; α=0.05, sample size was 94 pts. From Jun 2007 to Dec 2010, 47 LLLT and 47 placebo pts bearer of HNSCC of nasopharynx, oropharynx and hipopharynx entered a prospective, randomized, double blind, placebo-controlled, phase III trial. CRT consisted of conventional RT 70.2 Gy (1.8Gy/d, 5 times/wk) + concurrent cisplatin 100 mg/m2 every 3 wks. Main endpoints were OM incidence and severity, RT interruptions due to OM and pain intensity. The LLLT used daily was a diode InGaAlP (660nm-100mW-4J/cm²). OM evaluation was done by WHO and OMAS scale. Results: Mean age was 54.6 and 87.2% of pts were male. Primary site: oropharynx (74 pts), nasopharynx (9 pts), hypopharynx (11 pts). In the LLLT arm the incidence of OM G 3/4 was only 6.4% versus 48% in the placebo arm; HR of 0.13 (IC 95%, p<0.001). Besides in the LLLT arm 51% of pts did not have ulcers versus 17% in placebo arm (p<0.001). LLLT pts had less severe pain (p=0.012), used less narcotic analgesic, HR 0.33 (IC 95%, p<0.001) and required less gastrostomia, HR 0.037 (IC 95%, p= 0.005). No LLLT pts had RT interrupted due to OM. EORTC QLQ-C30 and its specific head and neck module QLQ-H&N35 were applied. Results clearly favored the LLLT arm. In QLQ-C30 benefit was seen in both physical and emotional functioning (p=0.037), fatigue (p=0.011), pain (p=0.043); and in QLQ-H&N35, pain (p=0.007), swallowing (p=0.001) and trouble with social eating (p=0.026). Conclusions: Our results indicate that upfront LLLT in HNSCC pts submitted to CRT is an effective tool in reducing G 3/4 OM, oral pain, use of narcotic and gastrostomia. QoL data supports the efficacy findings. Thereby LLLT should be the new standard of care in this setting.

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LOW-LEVEL LASER THERAPY APPLICATION FOR ODYNOPHAGIA ANALGESIA CAUSED BY HEAD AND NECK RADIOTHERAPY: AN ANATOMIC STUDY

Oral Surgery Oral Medicine Oral Pathology and Oral Radiology ◽

10.1016/j.oooo.2019.06.763 ◽

2020 ◽

Vol 129 (1) ◽

pp. e180

Author(s):

GABRIELA PASQUALIN GHIDINI ◽

GUILHERME HENRIQUE RIBEIRO ◽

LILIANE JANETE GRANDO ◽

MARIÁH LUZ LISBOA ◽

CLÁUDIA TIEMI MITUUTI ◽

...

Keyword(s):

Head And Neck ◽

Laser Therapy ◽

Low Level Laser Therapy ◽

Anatomic Study ◽

Low Level ◽

Low Level Laser ◽

Level Laser ◽

Head And Neck Radiotherapy

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Effect of Low-Level Laser Therapy in Treatment of Chemotherapy Induced Oral Mucositis

Journal of lasers in medical sciences ◽

10.15171/jlms.2019.20 ◽

2019 ◽

Vol 10 (2) ◽

pp. 125-130

Author(s):

Soheir Shehata Rezk-Allah ◽

Heba Mohamed Abd Elshafi ◽

Reem Jan Farid ◽

Mohamed Abd Elrahman Hassan ◽

Samy A. Alsirafy

Keyword(s):

Breast Cancer ◽

Head And Neck ◽

Cancer Patients ◽

Laser Therapy ◽

Oral Mucositis ◽

Low Level Laser Therapy ◽

Breast Cancer Patients ◽

Low Level Laser ◽

Level Laser ◽

Tnf Α

Introduction: Oral mucositis (OM) is an unavoidable condition of the oral cavity that accompanies chemotherapy for various malignant cases. Chemotherapy-induced oral Mucositis (COM) is a frequent complication due to mucotoxic drugs and is known to deteriorate the general health significantly, while negatively affecting the quality of life (QOL). Studies have reported that low-level laser therapy (LLLT) promotes the tissue healing. The objective of the present study was to explore the efficacy of gallium-arsenide (GaAs) laser in treating COM and its impact on inflammatory cytokine levels in patients receiving chemotherapy for various malignancies. Methods: A total of 80 patients with COM received LLLT 6 days/week. OM was graded according to the World Health Organization (WHO) grading scale. The outcome parameters were the serum levels of tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) measured before, during and after administration of LLLT. Results: After LLLT, a significant decrease was found in the mean values of mucositis grade from 2.35 ± 0.695 to 1.13 ± 0.333 after (P < 0.001). A significant reduction in the level of TNF-α was found after LLLT among breast cancer patients (P = 0.0045), but not in head and neck cancer and lymphoma patients. A significant reduction was also found in IL-6 level after treatment among head and neck and breast cancer patients (P = 0.0307 and 0.019, respectively). Conclusion: The use of GaAs LLLT in treating COM in patients with various malignancies is well tolerated by patients, it results in improvement of mucositis, however; mechanism of action does not seem to be completely linked to the change of pro or anti-inflammatory cytokines.

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