Retrospective study of rescue intra cytoplasmic sperm injection (ICSI) as an emergency procedure aimed at salvaging the IVF ET cycle

Abstract BackgroundOestradiol, an important hormone in follicular development and endometrial receptivity, is closely related to clinical outcomes of fresh in vitro fertilization-embryo transfer (IVF-ET) cycles. A supraphysiologic E2 level is inevitable during controlled ovarian hyper-stimulation (COH), and its effect on the outcome of IVF-ET is controversial. The aim of this retrospective study is to evaluate the association between elevated serum oestradiol (E2) levels on the day of human chorionic gonadotrophin (hCG) administration and neonatal birthweight after IVF-ET cycles.MethodsThe data of 3659 infertile patients with fresh IVF-ET cycles were analysed retrospectively between August 2009 and February 2017 in First Hospital of Zhengzhou University. Patients were categorized by serum E2 levels on the day of hCG administration into six groups: group 1 (serum E2 levels≤1000 pg/mL, n=230), group 2 (serum E2 levels between 1001 and 2000 pg/mL, n=524), group 3 (serum E2 levels between 2001 and 3000 pg/mL, n=783), group 4 (serum E2 levels between 3001 and 4000 pg/mL, n = 721), group 5 (serum E2 levels between 4001 and 5000 pg/mL, n=548 ), and group 6 (serum E2 levels > 5000 pg/mL, n=852). Univariate linear regression was used to evaluate the independent correlation between each factor and outcome index. Multiple logistic regression was used to adjust for confounding factors.ResultsThe LBW rates were as follows: 3.0% (group 1), 2.9% (group 2), 1.9% (group 3), 2.9% (group 4), and 2.0% (group 6) (P =0.629), respectively. There were no statistically significant differences in the incidences of neonatal LBW among the six groups. We did not detect an association between peak serum E2 level during ovarian stimulation and neonatal birthweight after IVF-ET.ConclusionThe results of this retrospective cohort study showed that serum E2 peak levels during ovarian stimulation were not associated with birth weight during IVF cycles. In addition, no association was found between higher E2 levels and increased LBW risk. Our observations suggest that the hyper-oestrogenic milieu during COS does not seem to have adverse effects on the birthweight of offspring after IVF.

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Factors affecting Embryo Quality and Pregnancy Outcome in Intra-Cytoplasmic Sperm Injection using Decapeptyl and Cetrorelix- A retrospective study

Human Reproduction Archives ◽

10.4322/hra.000820 ◽

2021 ◽

Vol 36 ◽

pp. e000820

Author(s):

Laiba Masood ◽

Faiza Alam ◽

Nida Zahid ◽

Ahmed Ayaz ◽

Syed Sajjad Hussain ◽

...

Keyword(s):

Retrospective Study ◽

Pregnancy Outcome ◽

Embryo Quality ◽

Factors Affecting ◽

Intra Cytoplasmic Sperm Injection

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Experience with Fully Covered Self-Expandable Metal Stents for Esophageal Leakage in Children

Klinische Pädiatrie ◽

10.1055/a-1014-3179 ◽

2019 ◽

Vol 232 (01) ◽

pp. 13-19

Author(s):

Bettina Lange ◽

Süha Demirakca ◽

Georg Kähler ◽

Christel Weiß ◽

Lucas Wessel ◽

...

Keyword(s):

Retrospective Study ◽

Weight Gain ◽

Preterm Infants ◽

Relative Weight ◽

Metal Stents ◽

Single Application ◽

Emergency Procedure ◽

Previous Therapy ◽

Age Related ◽

Distal Migration

Abstract Background There is a lack of experience with fully covered self-expandable metal stents (SEMSs) for the treatment of esophageal leakage particularly in infants and neonates. Methods Eight patients (5M, 3F) with a median age of 17 months (range, 1–135 months) who underwent treatment with SEMSs for an anastomotic leakage or perforation of the esophagus were recruited to this retrospective study. Four children were born premature. In six patients the stents were placed primarily as an emergency procedure. Results Median duration of individual stent placement was 42 days (range, 13–72 days). Six out of eight patients (75%) were treated with one stent only. In three preterm infants who had their stents inserted within the first month relative weight gain was 17% compared with 2% in five patients who were treated later in life (p=0.0986). In four cases (50%) distal migration of the stent was observed. Seven out of eight patients (88%) had their leakage resolved after stent therapy. Conclusions Insertion of fully covered SEMSs is an alternative tool for the treatment of esophageal leakage in children and preterm infants, and successful with only one single application in selected cases. It can be used either following previous therapy or as part of an emergency procedure. Because of the absence of manufactured, age-related devices SEMSs that are originally designed for other organs can be applied.

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The impact of paternal age on Intra Cytoplasmic Sperm Injection (ICSI) cycle outcome in ART: a retrospective study

10.26226/morressier.573c1511d462b80296c981cf ◽

2016 ◽

Author(s):

Lale Karakoc Sokmensuer

Keyword(s):

Retrospective Study ◽

Paternal Age ◽

Icsi Cycle ◽

Intra Cytoplasmic Sperm Injection ◽

The Impact ◽

Cycle Outcome

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Effects of Half-Dose and Full-Dose GnRH Antagonists on IVF-ET Outcomes: A Retrospective Study

10.21203/rs.3.rs-418763/v1 ◽

2021 ◽

Author(s):

Yingge Zhao ◽

Fang Lian ◽

Shan Xiang ◽

Yi Yu ◽

Conghui Pang ◽

...

Keyword(s):

Retrospective Study ◽

Pregnancy Rate ◽

Production Rate ◽

Endometrial Receptivity ◽

Small Sample ◽

Clinical Pregnancy ◽

Clinical Pregnancy Rate ◽

Full Dose ◽

Half Dose ◽

Ivf Et

Abstract BackgroundGonadotropin-releasing hormone antagonist(GnRH-ant) has been shown to have a negative effect on endometrial receptivity. Therefore, the use of GnRH-ant dose as small as possible during controlled ovarian stimulation(COS) may has an impact on improving endometrial receptivity and pregnancy rate. However, the GnRH-ant dose is relatively flexible and there is no fixed requirement for guidance. In this retrospective study, we tried to study the effects of half-dose or full-dose GnRH-ant on IVF-ET outcomes.MethodsOf the 316 cycles for 314 patients analyzed in this study, 149 received half-dose GnRH-ant(Group1) and 167 received full-dose GnRH-ant(Group2). According to age and BMI, the two groups were divided into four subgroups. Age subgroups, they were divided into age≤35(subgroupA)and age>35(subgroupB): 180 cycles in subgroup A(107 cycles in subgroupA1,73 cycles in subgroupA2), 136 cycles in subgroup B(42 cycles in subgroup B1,94 cycles in subgroupB2). BMI subgroups, they were divided into BMI<25 (subgroupC)and BMI≥25 (subgroupD):208 cycles in subgroupC(94 cycles in subgroup C1,114 cycles in subgroupC2), 108 cycles in subgroupD (55 cycles in subgroupD1,53 cycles in subgroupD2).ResultsNeither fertilized oocytes and the number of superior-quality embryos nor clinical pregnancy rate and live production rate significantly differed between the two groups. However, the number of retrieved oocytes and available embryos were significantly larger in Group 1 than in Group 2 (8.17±4.10vs.7.07±4.05,2.96±2.03vs.2.52±1.62, respectively,p＜0.05). Indicators in each age subgroups showed no statistical significance.However, in BMI subgroups, neither fertilized oocytes, available embryos and the number of superior-quality embryos nor live production rate significantly differed between the four subgroups. The number of retrieved oocytes was higher in subgroupC1 than in subgroupC2 (8.24±4.04vs.6.83±3.92,p < 0.05), In addition the clinical pregnancy rate was slightly higher in subgroupD1 than in subgroupD2(45.45vs.24.53%,P< 0.05). ConclusionsThe results showed that half-dose GnRH-ant was as effective as full-dose GnRH-ant for most patients. And patients with BMI≥25 may be more suitable for half-dose GnRH-ant. This retrospective analysis and the small sample size are the main limitations of this study, and a large sample RCT will be carried out in the future.Trial registrationRetrospectively registered

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Comparison of Birth Defects in Infants Conceived by Assisted Reproductive Technologies vs. Naturally Conceived Infants in Mashhad, Iran

Galen Medical Journal ◽

10.31661/gmj.v4i4.442 ◽

2015 ◽

Vol 4 (4) ◽

pp. 146-50

Author(s):

Ehsan Shahverdi ◽

Fatemeh Vahid Roodsari ◽

Masoomeh Akhavan Saffar

Keyword(s):

Retrospective Study ◽

In Vitro Fertilization ◽

Birth Defects ◽

Birth Defect ◽

Assisted Reproductive Technologies ◽

Reproductive Technologies ◽

Vitro Fertilization ◽

Intra Cytoplasmic Sperm Injection

Background: Assisted reproductive technologies (ART) are known as a treatment for infertility in which oocyte undergoes manipulation outside body. The aim of this study was to study the evaluation of birth defects in infants conceived through assisted reproductive technologies (ART) and compare them with naturally-conceived infants. Materials and Methods: In this retrospective study, four hundred naturally-conceived infants and 400 infants conceived by ARTs between 20 March and 20 November 2012 in Gha’em Hospital and Sheikh Hospital of Mashhad in Iran participated in this study. Infants were evaluated by a pediatrician at the time of birth, 10 days and 40 days after birth. Correlation between the use of IVF and/or ICSI methods and birth defects was evaluated. Results: Of total 800 infants (450 boys and 350 girls), half of the infants were conceived through natural pregnancy, 200(25%) through in-vitro fertilization (IVF) and 200 (25%) intra- cytoplasmic sperm injection (ICSI). In Infants conceived by IVF, 5 cases (2.5%) had a kind of birth defect just similar to those conceived by ICSI; while 4 cases had birth defects in natural pregnancy. There was no significant correlation between the use of IVF and/or ICSI methods in terms of birth defects (P=0.280).Conclusion: We found that using IVF or ICSI methods is not associated with increasing birth defects.[GMJ.2015;4(4):146-50]

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