scholarly journals Питання зовнішнього контролю якості лабораторних досліджень на сифіліс у лікувальних закладах України

2021 ◽  
pp. 15-19
Author(s):  
V. V. Kutova ◽  
◽  
Ya. F. Kutasevych ◽  
O. N. Belokon ◽  
T. V. Degtyar ◽  
...  
Keyword(s):  
Quality Control ◽  
High Efficiency ◽  
Rapid Test ◽  
Random Errors ◽  
External Quality Control ◽  
Serum Samples ◽  
External Quality ◽  
Serological Tests ◽  
Control Serum ◽  
Comparative Results

The objective of the work is to identify systemic and random errors in the formulation of controlled methods and to achieve comparative results obtained by laboratories participating in external quality control of laboratory tests for syphilis. Materials and methods. Laboratories of three levels took part in the activities of external quality control of serological diagnostics of syphilis: clinical diagnostic laboratories (CDL) of medical institutions of scientific research institutes of the NAMS of Ukraine, serological departments as part of the CDL of the dermatovenerological profile of the RDVD, CDVD. Results. The quality of serological tests for syphilis in 21 CDL (serological departments) was assessed using the following methods: RMP, RPR, Rapid-test, TPHA, FTA-abs, ELISA in three control serum samples according to formal and essential characteristics. The most significant differences in the results were revealed in the study of control serum samples with a low content of antibodies and those without antibodies to the causative agent of syphilis in the non-treponemal RMP test and the treponemal FTA-abs test. Conclusions. The conducted studies have shown the high efficiency of the practical application of the developed system of external quality control of laboratory methods for diagnosing syphilis.

scholarly journals Bioassay for Determining Voriconazole Serum Levels in Patients Receiving Combination Therapy with Echinocandins

2015 ◽  
Vol 60 (1) ◽  
pp. 632-636 ◽  
Author(s):  
Maria Siopi ◽  
Efthymios Neroutsos ◽  
Kalliopi Zisaki ◽  
Maria Gamaletsou ◽  
Maria Pirounaki ◽  
...  
Keyword(s):  
Quality Control ◽  
Combination Therapy ◽  
High Performance ◽  
Rank Correlation ◽  
Control Program ◽  
External Quality Control ◽  
Serum Samples ◽  
External Quality ◽  
Quality Control Program ◽  
Content Type

ABSTRACTVoriconazole levels were determined with high-performance liquid chromatography (HPLC) and a microbiological agar diffusion assay using aCandida parapsilosisisolate in 103 serum samples from an HPLC-tested external quality control program (n= 39), 21 patients receiving voriconazole monotherapy (n= 39), and 7 patients receiving combination therapy (n= 25). The results of the bioassay were correlated with the results obtained from the external quality control program samples and with the HPLC results in sera from patients on voriconazole monotherapy and on combination therapy with an echinocandin (Spearman's rank correlation coefficient [rs], > 0.93; mean ± standard error of the mean [SEM] % difference, <12% ± 3.8%).

Alkaline Phosphatase Activity in Lyophilised Quality Control Serum

1979 ◽  
Vol 16 (1-6) ◽  
pp. 271-274 ◽  
Author(s):  
D. G. Bullock ◽  
F. M. McSweeney ◽  
H. Saidi ◽  
T. P. Whitehead
Keyword(s):  
Quality Control ◽  
Alkaline Phosphatase ◽  
Phosphatase Activity ◽  
Alkaline Phosphatase Activity ◽  
Storage Temperature ◽  
Quality Control Material ◽  
External Quality Control ◽  
Control Material ◽  
External Quality ◽  
Control Serum

The rise in alkaline phosphatase activity has been studied after reconstitution of 16 commercial preparations of lyophilised quality control material. The effects of storage temperature and analytical method on the rise in activity have also been studied, with a view to producing a reconstitution protocol suitable for recommendation to participants in external quality control surveys. Great differences were found in the magnitude of this rise in activity; these differences can be reduced to negligible levels if the material is mixed for 30 minutes at ambient temperature after reconstitution and then stored for not more than 4 hours at 4°C before assay.

scholarly journals The Schemes of External Quality Control in Laboratory Medicine in the Balkans

2007 ◽  
Vol 26 (3) ◽  
pp. 245-247
Author(s):  
Petros Karkalousos
Keyword(s):  
Quality Control ◽  
Scientific Community ◽  
Clinical Chemistry ◽  
Laboratory Medicine ◽  
External Quality Control ◽  
External Quality ◽  
The Balkans ◽  
Control Schemes ◽  
Balkan Countries ◽  
Balkan Region

The Schemes of External Quality Control in Laboratory Medicine in the Balkans There are many differences between the national External Quality Control Schemes all around Europe, but the most important ones are certainly those between the countries of the Balkan region. These differences are due to these countries' different political and financial development, as well as to their tradition and the development of clinical chemistry science in each one. Therefore, there are Balkan countries with very developed EQAS and others where there is no such a scheme. Undoubtedly, the scientific community in these countries wants to develop EQAS despite of the financial and other difficulties.

scholarly journals Necessity of External Quality Control for anti-Mycoplasma pneumoniae IgM antibodies

2008 ◽  
Vol 23 (2) ◽  
Author(s):  
Massimo De Paschale ◽  
Luisa Belvisi ◽  
Debora Cagnin ◽  
Teresa Cerulli ◽  
Maria Teresa Manco ◽  
...  
Keyword(s):  
Quality Control ◽  
Mycoplasma Pneumoniae ◽  
External Quality Control ◽  
External Quality ◽  
Igm Antibodies

scholarly journals External Quality Assessment in the Evaluation of Laboratory Performance of Faecal Culture

2017 ◽  
Vol 10 ◽  
pp. 117863611769125
Author(s):  
Salla J Kiiskinen ◽  
Tarja Ojanen ◽  
Yvonne Björkman ◽  
Harri Laitinen ◽  
Anja Siitonen
Keyword(s):  
Public Health ◽  
Quality Control ◽  
External Quality Assessment ◽  
False Negative ◽  
The Other ◽  
Epidemiological Surveillance ◽  
External Quality Control ◽  
External Quality ◽  
Faecal Culture

In Finland, all laboratories carrying out diagnostics of infectious diseases in humans are approved by the Regional State Administrative Agencies and are obligated to participate in External Quality Assurance rounds. Performance in these rounds is thought to reflect the quality of laboratory work. In the 6-year study period, 17 Finnish laboratories received 48 simulated faecal specimens for the culturing of diarrhoeal pathogens, yielding altogether 586 faecal culture External Quality Control specimens and 581 reports. The results were correct in 92% of all reports and in 67% of all specimens. False-negative Salmonella results were given for 2 of the 18 specimens, one with biochemically atypical Salmonella strain and the other with a low count of Salmonella cells. False-negative Shigella report was given for 6 of the 7 specimens in some participating laboratory. Detection of all common faecal pathogens is especially relevant to patient safety, public health, and epidemiological surveillance.

scholarly journals Paracetamol: A Report of a Regional Quality Control Scheme

1979 ◽  
Vol 16 (1-6) ◽  
pp. 265-270 ◽  
Author(s):  
J. Epton
Keyword(s):  
Quality Control ◽  
Group Performance ◽  
Clinical Importance ◽  
External Quality Control ◽  
External Quality ◽  
Limits Of Detection ◽  
Trouble Shooting ◽  
Control Scheme ◽  
Considerable Impact ◽  
Quality Control Scheme

The results from an external quality control scheme for the assay of paracetamol in serum are reported. A preferential method of assay has not become evident, but, as a result of the scheme, some laboratories have changed or modified their techniques or have re-established the limits of detection. The majority of laboratories were able to estimate paracetamol satisfactorily at those levels which are of clinical importance. The overall group performance has shown little change. The programme has had considerable impact in so far as it has led to a mutually useful interchange of information and trouble shooting.

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