scholarly journals INFLUENCE OF BIOLOGICALLY ACTIVE SUBSTANCES OF PROPOLIS ON BIOCHEMICAL INDICATORS OF BLOOD AND MORPHOMETRIC INDICATORS OF INTESTINE OF YOUNG PIGS

2021 ◽  
Vol 2021 (1) ◽  
pp. 55-64
Author(s):  
Nikolay Gaponov
Keyword(s):  
Experimental Studies ◽  
Biological Properties ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Intestinal Cell ◽  
Control Group ◽  
Medicine Research ◽  
Young Pigs ◽  
Experimental Group ◽  
Active Substances

This paper presents the results of experimental studies the influence of biologically active substances of propolis on micromorphometric parameters of the ileum in young pigs. The results of the experiment make it possible to ascertain a change in the functional activity of the studied organ after the use of the drug from propolis. Since the most active process of absorption of monomeric hydrolysis products, especially amino acids and carboxylic acids, occurs in the ileum. Hydrolysis of intermediate products to monomers and preparation of the transition to absorption is carried out by enzymes fixed on the intestinal cell membranes. And the level of bioconversion of feed and retention of nutrients depends on their shape and structure, which ultimately affects the payment for feed with products. Therefore, the study of the histology of the small intestine and especially the ileum is of great importance. So, as a result of the study, it was found that the most characteristic histological changes in the structural components of the intestinal wall are observed in young animals of the experimental groups. The thickness of the main lamina of the mucous membrane of the ileum in piglets in the control group is 308.28 ± 2.81 µm, in piglets in the experimental group – 255.49 ± 0.75 µm. The height of the villi of the ileum, in the animals of the control group, is significantly lower and amounts to 193.89 ± 2.66 µm versus 280.97 ± 3.37 µm in the experimental group. Similar changes are observed in young animals of the older age group. The height of intestinal villi in pigs of the experimental group significantly exceeds the indicator of the control group and is 256.89 ± 1.62 µm and 163.96 ± 0.61 µm, respectively. The muscle plate of the intestinal mucosa of the pigs in the experimental group is significantly thicker than the control and is 17.8 ± 0.2 μm and 8.89 ± 0.08 μm, respectively. The obtained experimental material substantially supplements the information on the biological properties of propolis preparations. In practical veterinary medicine, research results can be taken into account when prescribing propolis for medicinal and prophylactic purposes. Since histological analysis of intestinal sections did not reveal destructive or pathological changes in any of the compared groups. In feeding, using the obtained practical material, we can specify the stimulating effect of the propolis preparation to intensify the growth of animals depending on the age of the pigs.

scholarly journals Influence of propolis biologically active substances on blood biochemical parameters and morphometric indicators of intestines of store pigs

2020 ◽  
Vol 222 ◽  
pp. 02005
Author(s):  
N.V. Gaponov ◽  
G.L. Yagovenko ◽  
A.N. Stepanova ◽  
O.P Neverova ◽  
O.V. Gorelik
Keyword(s):  
Biological Properties ◽  
Intestinal Wall ◽  
Biologically Active ◽  
Control Group ◽  
Histological Changes ◽  
Blood Biochemical ◽  
Young Pigs ◽  
Experimental Group ◽  
Active Substances ◽  
Water Alcohol

The results of research in some cases allow to judge the change in the functional activity of the studied organs after the use of the preparation. The obtained factual material significantly supplements the information about the biological properties of the propolis water-alcohol emulsion. In practical veterinary medicine, the results of research can be taken into account when prescribing propolis for therapeutic and preventive purposes. Thus, as a result of the study, it was found that the most characteristic histological changes in the structural components of the intestinal wall are observed in the ileum of young pigs and pigs of the experimental groups. The height of this intestine villi in young pigs of the experimental group is 280.97 ± 3.37 microns, and in the control group - 193.89 ± 2.66 microns (p< 0.001). In pigs treated with the preparation, the villi also have a higher height - 256.89 ± 1.62 microns compared to 163.96 ± 0.61 microns in the control group. In young pigs and pigs of the control groups, the shape of the ileum villi is finger-shaped or bottle-shaped, and in animals of the experimental groups their forms are more differentiated - bottle-shaped, leaf-shaped and dome-shaped. This will allow store pigs receiving propolis preparation to better absorb the nutrients of the diet and gain weight faster. The research results are of interest to researchers developing propolis preparations for oral use.

scholarly journals THE INFLUENCE OF BIOLOGICALLY ACTIVE SUBSTANCES ON SHEEP RUMEN METABOLISM

2021 ◽  
pp. 35-41
Author(s):  
А.В. МИШУРОВ
Keyword(s):  
Rumen Fluid ◽  
The Body ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Control Group ◽  
Potential Productivity ◽  
Organic Iodine ◽  
Rumen Metabolism ◽  
Experimental Group ◽  
Active Substances

Проблема и цель. Для повышения эффективности использования питательных веществ кормов целесообразно применение биологически активных веществ (БАВ), способствующих улучшению физиологических процессов в организме животных для реализации их генетического потенциала – продуктивности. Целью исследований являлось изучить влияние БАВ (дигидроквертицина и органического йода) на рубцовый метаболизм у овец. Методология. Опыт проведен методом групп периодов в условиях физиологического двора ФНЦ ВИЖ имени Л.К. Эрнста, на овцах аналогах (n=6), имеющих хронические фистулы рубца по Басову. Животные 1-й опытной группы в дополнение к основному рациону получали 100 мл ДКВ, в рацион 2-й опытной группы добавляли 100 мг ДКВ и 1,05 мг органического йода. Результаты. Использование добавок в рационах животных опытных групп повлияло на общее содержание микроорганизмов в рубцовой жидкости, составившее во второй опытной группе 1,021 г/100 мл, что выше чем в первой опытной группе на 12,7 %, и выше, чем в контрольной, на 15,4 %. При этом образование бактерий в рубцовой жидкости в первой опытной группе было выше на 22,5 %, а во второй – на 8,7 % относительно контроля. Выявлен более низкий уровень концентрации аммиака в содержимом рубца животных первой опытной группы на 4,2 мг/% относительно контрольной и на 7,1 мг/% – второй опытной группы, что взаимосвязано с более эффективным его использованием рубцовой микрофлорой. Заключение. Полученные данные свидетельствуют о том, что использование в рационе изучаемых биологически активных веществ способствовало наибольшему развитию и жизнедеятельности микроорганизмов рубца и в целом способствовало регуляции положительной динамики рубцового метаболизма, оказало положительное влияние на образование и усвояемость азота. Problem and purpose. To increase the efficiency of the use of feed nutrients, it is advisable to use biologically active substances that contribute to the improvement of physiological processes in the body of animals for the realization of their genetic potential - productivity. The aim of the research was to study the effect of biologically active substances (dihydroquerticin and organic iodine) on rumen metabolism in sheep. Methodology. The experiment was carried out by the method of groups of periods in the conditions of the physiological yard of L.K. Ernst Federal Research Center for Animal Husbandry), on sheep analogs (n=6) with chronic rumen fistulas according to Basov. Animals of the 1st experimental group received 100 ml of DHQ in addition to the main diet. The 2nd experimental group got 100 mg of DHQ and 1.05 mg of organic iodine. Results. The use of additives in the diets of the animals of the experimental groups influenced the total content of microorganisms in the rumen fluid, which was 1.021 g / 100 ml in the second experimental group, that was higher than in the first experimental group by 12.7 %, and in the control group by 15.4 %. At the same time, the formation of bacteria in the rumen fluid in the 1st experimental group was 22.5 % higher and it was 8.7 % higher in the 2nd group relative to the control. A lower level of ammonia concentration in the rumen of animals of the 1st experimental group was 4.2 mg/% lower relative to the control and by 7.1 mg/% in the 2nd experimental group, that was interrelated with its more effective use of rumen microflora. Conclusion. The data obtained indicated that the use of the studied biologically active substances in the diet promoted the greatest development and vital activity of rumen microorganisms and, in general, contributed to the regulation of the positive dynamics of rumen metabolism, had a positive effect on the formation and assimilation of nitrogen.

scholarly journals THE USE OF BIOLOGICALLY ACTIVE SUBSTANCES OF VARIOUS NATURAL ORIGIN FOR THE CORRECTION OF HEMATOPOIESIS IN RABBITS

2021 ◽  
pp. 18-23
Author(s):  
Л.Г. КАШИРИНА ◽  
С.А. ДЕНИКИН ◽  
И.В. ЩЕРБАКОВА
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Experimental Studies ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Oxide Shell ◽  
Cobalt Powder ◽  
Natural Origin ◽  
Experimental Group ◽  
Active Substances

Проблема и цель. Целью настоящего исследования являлось изучение механизмов действия биологически активных веществ различного природного происхождения для коррекции гемопоэза у кроликов. Методология. Для достижения цели были проведены экспериментальные исследования на кроликах-самцах калифорнийской породы в возрасте 4-5 месяцев, живой массой 2370,0±120,0 г, сформированных в 3 группы (2 опытные и контрольная) по 10 голов, в условиях вивария ФГБОУ ВО Рязанского государственного агротехнологического университета. Острая постгеморрагическая анемия была искусственно смоделирована за 5 суток до экспериментальных исследований по показателям количества эритроцитов, гемоглобина, гематокритной величины, путем двукратного кровопускания 40 % объема крови. В качестве биологически активного вещества растительного происхождения был применен настой плодов Ирги обыкновенной (НПИО) и в качестве минерального – наноразмерный порошок кобальта (НРПК). Результаты. Результаты настоящего исследования показали, что оба представителя биологически активных веществ зарекомендовали себя с положительной стороны. В опытных группах под их воздействием процесс восстановления осуществлялся быстрее по сравнению с контролем. Уровень эритроцитов достигал нормативных показателей в опытной группе 1 (с применением НПИО) на 8-е сутки, в опытной группе 2 (с применением НРПК) – на 14-е сутки, а гемоглобина на 8-е и 12-е сутки, соответственно, в то время как в контроле только к 18-м суткам. Заключение. В результате исследования было установлено, что наилучшим образом зарекомендовал себя наноразмерный порошок кобальта, механизм действия которого объясняется малым размером частиц, влияющих на увеличение мембранной проницаемости и усиление процесса усвоения кобальта за счет энергии, образующейся при разрушении оксидной оболочки, окружающей частицу порошка. В отличие от настоя плодов Ирги обыкновенной, который вводился в рационы ежедневно, наноразмерный порошок кобальта уже при повторном введении в организм кроликов способствовал достижению уровня нормативных показателей. Problem and aim. The aim was to study the mechanisms of action of biologically active substances of various natural origin for the correction of hematopoiesis in rabbits. Methodology. To achieve this aim, experimental studies were conducted on male rabbits of the California breed at the age of 4-5 months, with a live weight of 2370.0±120.0 g, formed in 3 groups of 10 heads, in the vivarium of the Ryazan State Agrotechnological University. Acute post-hemorrhagic anemia was artifcially modeled, 5 days before the experimental studies, according to the indicators of the number of red blood cells, hemoglobin, hematocrit value, by double bloodletting 40 % of the blood volume. As a biologically active substance of plant origin was usedan infusion of shadberry (IS), and as a mineral - nanoscale cobalt powder (NCP). Results. The results of this study showed that both representatives of biologically active substances have proven themselves on the positive side. In the Experimental Groups, under their infuence, the recovery process was carried out faster than in the Control Group. The level of red blood cells reached the standard indicators in the Experimental group 1 (IS) on day 8, in the Experimental Group 2 (NCP) on day 14, and hemoglobin on day 8 and 12, respectively, while in the Control only by day 18. Conclusion. In the result of the study it was found that the best way has established itself nanosized powder cobalt, whose mechanism is due to a small particle size, afect the increase in membrane permeability and increased absorption of cobalt due to the energy generated during the fracture of the oxide shell surrounding the particle of the powder. In contrast to the infusion of the infusion of shadberry, which was introduced into the diets daily, nanoscale cobalt powder already when re-introduced into the body of rabbits contributed to achieving the level of regulatory indicators.

CONSUMER PROPERTIES OF PASTA WITH POWDER FROM MARIGOLD INFLORESCENCES (TAGETES L.)

2021 ◽  
Vol 40 (4) ◽  
pp. 102-112
Author(s):  
SHAPOVALOVA Nataliia ◽  
VEZHLIVTSEVA Svitlana ◽  
ANTIUSHKO Dmytro
Keyword(s):  
Raw Materials ◽  
Experimental Studies ◽  
The Body ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Organoleptic Properties ◽  
Biological Value ◽  
Plant Raw Materials ◽  
Active Substances

Background. The deficiency of essential nutrients in the human body is the root cause of reduced efficiency, general resistance of the body to various diseases. That is an urgent problem in the context of the spread of coronavirus infection. In this regard, the search for opportunities to meet the needs of the population in food products that contain biologically active substances (BAS) through the use of high-value and at the same time available plant raw materials is extremely important. Marigolds attract special attention among such raw materials. The aim of the work is to study the chemical composition and evaluate the consumer properties of Tagetes L. varieties, zoned in the Kiev region, to prove the possibility of increasing the biological value of pasta by adding to their recipe powder from marigold inflorescences. Materials and methods. The object of research is pasta of B group (noodles). Inflorescences of marigolds of different varieties gathered during the flowering period in July-September 2019–2020 in the territory of Vasylkiv and Obukhiv districts of Kyiv region, Ukraine were used as enriching plant raw materials. The quality of finished pasta was assessed by organoleptic and physicochemical indexes (moisture content and titratable acidity). The content of mineral elements in the fine powder of marigold inflorescences was determined on the EXHERT-3L device, the quantitative composition and BAS identification – by spectrophotometric analysis on the device Specord-200 Analytic Jena UV-vis. The integrated quality index of pasta products was calculated taking into account the importance factors of individual indexes. Results. Comparing the obtained results, we can state that all the studied varieties – Gold Kopfen, Orange Flame, Hawaii, Equinox are characterized by high biological value, regardless of the area of collection. As a result of calculated and experimental studies it was determined that the addition of 7 % of the supplement does not provide the required supply of vitamins and minerals. Replacing the flour in the recipe by 20 % significantly improves the mineral composition, but deteriorates the taste and aromatic properties of pasta. The most optimal and rational amount of added additive is 15 %, as it improves the organoleptic properties of pasta and enriches their BAS. Conclusion. The usage of non-traditional vegetable raw materials, in particular powder from marigold inflorescences, which is rich in biologically active substances, allows not only to expand the range, improve the quality of finished products, but also increase the biological value of the product. The optimal amount of additive –powder from marigold inflorescences, was defined. It is 15 % by weight of flour in the production of noodles. This concentration allows not only to improve the organoleptic properties, but also to increase the content of biologically active substances – vitamins, micro- and macronutrients. The usage of non-traditional natural raw materials (powder from marigold inflorescences) allows to abandon artificial colorsand give the finished pasta a pleasant colorand aroma.

COMPLEX FEED ADDITIVE TO NORMALIZE METABOLIC PROCESSES OF COWS

2021 ◽  
pp. 30-33
Author(s):  
Н.В. БОГОЛЮБОВА ◽  
Р.А. РЫКОВ
Keyword(s):  
The Body ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Feed Additive ◽  
Feed Supplement ◽  
Metabolic Processes ◽  
Activity Of Enzymes ◽  
Experimental Group ◽  
Active Substances ◽  
Alt Activity

Изучен способ нормализации обменных процессов и повышения продуктивности молочных коров при использовании комплекса биологически активных веществ. Эксперимент проведен на коровах голштинской породы (n=12) с продуктивностью за предыдущую лактацию 9000 кг молока. За 20 дней до отела и в течение 65 дней после коровы опытной группы получали комплексную кормовую добавку (ККД), включающую минерал шунгит, холин в «защищенной» форме, пробиотик «Целлобактерин+» и жмых льняной, в количестве 200 г на голову в сутки в смеси с концентратами. Для изучения обменных процессов в организме коров (n=5) в конце опыта отобраны пробы крови и определены основные биохимические показатели. Для оценки продуктивных качеств проводили контрольные дойки. Отмечено повышение в крови коров опытной группы концентрации общего белка на 2,8%, глюкозы — на 26,8% (P≤0,01), фосфолипидов — на 15,2% (P≤0,05), снижение мочевины на 23,6% (P≤0,05), билирубина — на 23,8% (P≤0,01), активности АЛТ на 13,11 (P≤0,05), АСТ — на 14,6% (P≤0,05). Использование ККД позволило снизить и привести в норму активность ферментов: лактатдегидрогеназы (ЛДГ), гаммаглутаминтрансферазы (ГГТ), креатинкиназы. Повышение интенсивности обменных процессов и нормализация показателей, характеризующих работу печени с использованием в питании комплекса биологически активных веществ ферментно-пробиотического, антиоксидантного и липотропно-гепатопротекторного действия, привело к повышению молочной продуктивности. A method of normalizing metabolic processes and increasing the productivity of dairy cows using a complex of biologically active substances has been studied. The experiment was carried out on Holstein cows (n = 12) with a productivity for the previous lactation of 9000 kg of milk. 20 days before calving and within 65 days after the cows of the experimental group received a complex feed supplement (CFS), including the mineral shungite, choline in a "protected" form, the probiotic "Cellobacterin +" and flaxseed cake, in an amount of 200 g per head per day mixed with concentrates. To study metabolic processes in the body of cows (n = 5), at the end of the experiment, blood samples were taken and the main biochemical parameters were determined. To assess the productive qualities, control milking was carried out. An increase in the blood of cows of the experimental group was noted in the concentration of total protein by 2.8%, glucose - by 26.8% (P≤0.01), phospholipids — by 15.2% (P≤0.05), a decrease in urea by 23,6% (P≤0.05), bilirubin - by 23.8% (P≤0.01), ALT activity by 13.11 (P≤0.05), AST — by 14.6% (P≤ 0.05). The use of CFS made it possible to reduce and normalize the activity of enzymes: lactate dehydrogenase (LDH), gamma glutamine transferase (GGT), creatine kinase. An increase in the intensity of metabolic processes and the normalization of indicators characterizing the work of the liver with the use of a complex of biologically active substances of enzymatic-probiotic, antioxidant and lipotropic-hepatoprotective action in the diet led to an increase in milk productivity.

scholarly journals Effects of biologically active substances on interior indicators of pigs in the early postnatal period

2019 ◽  
pp. 69-72
Author(s):  
Olga Nikolaevna Polozyuk ◽  
Tatyana Ivanovna Lapina
Keyword(s):  
Gastrointestinal Tract ◽  
Blood Serum ◽  
Dietary Supplements ◽  
Postnatal Period ◽  
Biologically Active ◽  
Control Group ◽  
Control Groups ◽  
And Control ◽  
Experimental Group ◽  
Active Substances

The authors found out that the application  of dietary supplements "Glimalask Lact" allowed preventing the disorder of the gastrointestinal tract and saving all piglets throughout the experiment.  After application of "Agrocid super oligo", the safety of purebred piglets was 100 %, and for two pedigree piglets it was 96.7%.   In piglets of the 1st and 2nd control groups, disorder of the gastrointestinal tract was noted during the completion of colostral immunity and at weaning from sows.  The safety of purebred piglets was 96.7%, and of the two pedigree piglets  it was 93.4%. The number of γg-globulins in the blood serum of two breed piglings treated with the Glimalask Lact supplement increased by 3.5 and 2.5% compared to the piglets of the experimental group fed with Agrocid super oligo, and of the control group, The number of g-globulins in the blood serum of purebred  piglets it increased by 2.4 and 3.1% compared with analogues of the experimental and control groups.

scholarly journals CAUSES OF THE DEVELOPMENT OF CORONARY SYNDROME X IN WOMEN

2020 ◽  
Vol 20 (3) ◽  
pp. 148-152
Author(s):  
I.V. Tsiganenko ◽  
L.K. Ovcharenko
Keyword(s):  
Endothelial Cells ◽  
Platelet Aggregation ◽  
Vascular Endothelium ◽  
Density Lipoprotein ◽  
Biologically Active ◽  
Syndrome X ◽  
Control Group ◽  
Coronary Syndrome ◽  
Experimental Group ◽  
Active Substances

The work considers the causes of the coronary X syndrome development in women by assessing the experimental group and the control group with typical angina pectoris with angiographically altered vessels. Each group included 30 patients. When studingy medical records of the patients in the study group, we found out that in the reproductive period all of them had hyperestrogenemia, confirmed by the laboratory data, with the corresponding consequences in the form of various gynecological diseases, while the patients of the control group had unburdened gynaecological history. In terms of the lipid spectrum, the results turned out to be opposite. In the experimental group, the rates were within the normal range, and the control level of LDL-C significantly exceeded the required values. Despite the fact that estrogens increase the concentration of high density lipoprotein (HDL) in the blood and lower the content of low density lipoprotein (LDL) that are atherogenic, their surplus has a less negative effect than their lack, as the risk of developing atherosclerosis increases with decreasing concentration, and with an increase there is a risk of developing endothelial dysfunction, which provokes the development of coronary syndrome X. These date confirm the development of endothelial dysfunction in the patients of the experimental group with hyperestrogenemia in the history resulted from the impairment of the process of proliferation of endothelial cells with subsequent imbalance of secretion of biologically active substances. Among them, there is nitric oxide, which causes the relaxation of smooth myocytes, thus resulting in vasodilatation, and endothelins, providing the opposite, vasodilating effect. Prostacyclines and thrombomodulins secreted by the vascular endothelium in physiological conditions, counteract platelet aggregation. In the case of damage to the vascular wall, the production of prostacyclin and thrombomodulin is suppressed, but the release of thromboplastin, platelet activation factor and von Willerband factor activates that promote platelet aggregation and blood clotting. Under the participation of other physiologically active substances, selectins, endothelial cells promote adhesion to their surface and further penetration into the site of inflammation of neutrophils, blood acidophils. Selectin is accumulated in the cytoplasm of the endothelial cells in the form of specific electron-cellular inclusions, the so-called bodies of Weibel-Palade. Normally, vascular endothelium is impervious to blood components. However, being affected by a number of factors, and in particular histamine, endothelial cells lose contact with each other and decrease in number. This leads to the release of water and plasma proteins into the intercellular medium causing oedema. Due to the ability of the inner layer of vessels to produce a large number of biologically active substances, such changes can hardly be corrected by therapy.

scholarly journals The Effectiveness of Bioadditive Use in the Diets of Heifers of a Covering Age

2020 ◽  
Author(s):  
А.И. Фролов ◽  
А.Н. Бетин
Keyword(s):  
Body Weight Gain ◽  
Food Supplement ◽  
Biologically Active ◽  
Farm Animals ◽  
Control Group ◽  
Copper Zinc ◽  
Feeding Technology ◽  
Positive Effect ◽  
Experimental Group ◽  
Active Substances

Жизненно важными микроэлементами для жвачных животных являются медь, цинк, марганец, железо, кобальт, йод, селен. Микроэлементы, в которых атом металла соединён и защищён белковыми молекулами, улучшают воспроизводительные качества самок за счёт повышения оплодотворяемости, уменьшения эмбриональной смертности, улучшения состояния мочеполовой системы или повышения интенсивности функционирования яичников. Поэтому в настоящее время актуальными являются разработка и внедрение в технологию кормления сельскохозяйственных животных наиболее эффективных препаратов с необходимыми биологически активными веществами. На основании проведённого исследования дано практическое обоснование использования в технологии кормления тёлок отечественной кормовой биодобавки на основе гидролизата соевого белка, витаминов и микроэлементов. Установлено её положительное действие на некоторые функции органов и систем животных. Экспериментально доказана эффективность её применения для оптимизации обменных процессов и повышения воспроизводительных функций тёлок. Так, биохимическим исследованием образцов крови подопытных животных установлено, что количество кальция и фосфора в крови у тёлок опытной группы по сравнению с контролем было достоверно выше на 2,35 и 2,9% соответственно. Эритропоэтическая фракция была более выражена у молодняка опытной группы. У тёлок опытной группы время от начала скармливания препарата до первой выраженной охоты и осеменения, по сравнению с контрольными животными, сократилось на 16%, а период от начала скармливания препарата до плодотворного осеменения – на 25,7%. Количество тёлок, пришедших в охоту и осеменённых в первый месяц, в опытной группе по сравнению с контрольной было на 43% больше. Оплодотворяемость тёлок опытной группы за учётный период составила 95%, что на 20% больше, чем у животных контрольной группы. Включение в рацион тёлок биодобавки в дозе 100 мл/гол. позволило получить дополнительно на 8,5% больше валового прироста живой массы по отношению к их аналогам. The vital trace nutrients for ruminants are copper, zinc, manganese, iron, cobalt, iodine, selenium. Microelements in which a metal atom is jointed and protected by protein molecules improve the reproductive qualities of females by increasing fertility, reducing embryonic mortality, improving the state of the genito-urinary system or increasing the intensity of ovarian functioning. Therefore the development and implementation of the most effective preparations with the necessary biologically active substances in the technology of feeding farm animals is currently relevant. On the ground of conducted research a practical substantiation of the use of domestic food supplement based on the hydrolyzate of soy protein, vitamins and trace nutrients in the feeding technology of heifers is given. Its positive effect on some functions of animal organs and systems has been established. The effectiveness of its application to optimize metabolic processes and increase the reproductive functions of heifers has been experimentally proven. Thus a biochemical blood samples analysis of experimental animals found that the amount of calcium and phosphorus in the blood of the heifers of the experimental group compared with the control was significantly higher by 2.35 and 2.9% respectively. The erythropoietic fraction was more defined in the young experimental group. In heifers of the experimental group the time from the beginning of feeding the drug to the first defined heat and insemination compared with control animals decreased by 16% and the period from the beginning of feeding the drug to prolific insemination – by 25.7%. The number of heifers that came to the heat and inseminated in the first month in the experimental group was 43% higher than the control group. The impregnation capacity of the heifers of the experimental group during the record period was 95% which is 20% more than in animals of the control group. Inclusion in the diet of heifers bioadditive at a dose of 100 ml / goal allowed obtaining additionally 8.5% more the gross body weight gain relative to their analogs.

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