A study of the state of implementation of oral challenge testing for food allergies

2014 ◽  
Vol 28 (3) ◽  
pp. 356-363
Author(s):  
Seigo Korematsu ◽  
Masafumi Zaitsu ◽  
Michiko Fujitaka ◽  
Kazuyo Kuzume ◽  
Mika Ogata ◽  
...  
Keyword(s):  
The State ◽  
Oral Challenge ◽  
Food Allergies ◽  
Challenge Testing

Anaphylaxis Induced by Exercise or Cold Stimulation with Hyperleukotrieneuria During a Challenge Testing Not Containing Food Ingestion

2020 ◽  
Author(s):  
Chikako Motomura ◽  
Koji Ide ◽  
Terufumi Shimoda ◽  
Hiroshi Odajima
Keyword(s):  
Cold Water ◽  
Challenge Test ◽  
Food Allergies ◽  
Food Ingestion ◽  
Post Challenge ◽  
Loading Test ◽  
Cold Stimulation ◽  
Plasma Adrenaline ◽  
Challenge Testing ◽  
Cold Drink

Abstract Background: Exercise-induced anaphylaxis (EIA) is rare and a potentially life-threatening disorder that can develop independently without food ingestion. Cold drinks can also trigger symptoms in some patients with cold-induced anaphylaxis. We present the case of a patient with exercise and cold-induced anaphylaxis that was diagnosed based on hyperleukotrieneuria in exercise loading and cold-drink challenge testing.Case presentation: A 12-year-old girl presented with acute flushing, cyanosis, swollen eyelids, and dyspnea after an endurance run in winter or swimming in a cold-water pool. She also developed dyspnea after having a cold drink. She had no history of food allergies or atopy. No association was noted between anaphylaxis and food intake in her history. On the 1st day, she ingested 200 mL cold water at a temperature of 5°C in 30 s, which did not trigger any symptomatic responses, but urinary LTE4 level increased (pre-challenge test 295 pg/mg.cr, post-challenge test 400 pg/mg.cr). On the 2nd day, she underwent the exercise loading test according to the Bruce protocol by increasing the power of exercise every 2 min using an ergometer. She had been fasting for >15 h and did not have breakfast. Just after the exercise loading test, the plasma adrenaline and noradrenaline increased. At 15min. after the exercise loading test, the plasma adrenaline and histamine (pre-challenge test 0.7 ng/mL, 15min.post-challenge test 81 ng/mL) rised sharply with anaphylaxis symptom accompaneid by increasing of urinary LTE4 (pre-challenge test 579 pg/mg.cr, post-challenge test 846 pg/mg.cr). After she was discharged, she was restricted from strenuous exercise especially in cold environments and prescribed an adrenaline autoinjector.Conclusion: To our knowledge, cold stimulation becomes a co-effector for EIA. Measurements of urinary LTE4 levels during challenge testing are useful to diagnose anaphylaxis induced by exercise or cold stimulation.

scholarly journals Diagnosis of food allergies: the impact of oral food challenge testing

2013 ◽  
Vol 3 (1) ◽  
pp. 59 ◽  
Author(s):  
Komei Ito
Keyword(s):  
Food Challenge ◽  
Oral Food Challenge ◽  
Food Allergies ◽  
Challenge Testing ◽  
The Impact

scholarly journals Using Oral Challenge Testing to Assess Insulin Action and Secretion With Mathematical Modeling

Diabetes ◽  
2014 ◽  
Vol 63 (4) ◽  
pp. 1188-1190 ◽  
Author(s):  
M. A. Staten ◽  
D. E. Kelley
Keyword(s):  
Mathematical Modeling ◽  
Insulin Action ◽  
Oral Challenge ◽  
Challenge Testing

Diagnostic Value of Oral Challenge Testing in the Diagnosis of Macrolide Hypersensitivity

2018 ◽  
Vol 6 (2) ◽  
pp. 521-527 ◽  
Author(s):  
Derya Ünal ◽  
Semra Demir ◽  
Aslı Gelincik ◽  
Müge Olgaç ◽  
Raif Coşkun ◽  
...  
Keyword(s):  
Diagnostic Value ◽  
Oral Challenge ◽  
Challenge Testing

Diagnosing and Treating Food Allergies: The State of the Research

2010 ◽  
Author(s):  
Jennifer Chafen ◽  
Sydne Newberry ◽  
Marc Riedl ◽  
Dena Bravata ◽  
Margaret Maglione ◽  
...  
Keyword(s):  
The State ◽  
Food Allergies

Provocation-Neutralization: A Two-Part Study Part I. The Intracutaneous Provocative Food Test: A Multi-Center Comparison Study

1988 ◽  
Vol 99 (3) ◽  
pp. 263-271 ◽  
Author(s):  
William P. King ◽  
Wallace A. Rubin ◽  
Richard G. Fadal ◽  
Walter A. Ward ◽  
Richard J. Trevino ◽  
...  
Keyword(s):  
Clinical Usefulness ◽  
Oral Challenge ◽  
Food Allergies ◽  
Comparison Study ◽  
Double Blind ◽  
Symptom Provocation ◽  
Level Of Confidence ◽  
Skin Response ◽  
Blind Comparison ◽  
Geographical Locations

This study investigated the clinical usefulness of the intracutaneous provocative-neutralization food test (IPFT). Thirty-seven patients were tested for five identical food allergies by eight physicians in different geographical locations. Throughout the study, comparison was made between the IPFT when interpreted by skin response (IPFT SK) and when interpreted by symptom provocation (IPFT PR). Double-blind IPFT results were compared with those of previously accomplished oral challenge food tests (OCFT). IPFT reliability was determined by a double-blind comparison of the initial IPFT, with two subsequent IPFTs performed 7 days apart. Correlation of the IPFT SK and IPFT PR with the OCFT provided validity coefficients of 0.78 and 0.61 respectively, both significant beyond the 0.01 level of confidence. Reliability of the IPFT SK and IPFT PR was shown to be 0.68 and 0.40, respectively. The IPFT SK was significant beyond the 0.01 level of confidence and the IPFT PR was significant beyond the 0.05 level of confidence.

scholarly journals Exercise-induced anaphylaxis unrelated to food ingestion and with hyperleukotrieneuria during challenge testing

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Chikako Motomura ◽  
Koji Ide ◽  
Terufumi Shimoda ◽  
Hiroshi Odajima
Keyword(s):  
Cold Water ◽  
Challenge Test ◽  
Food Allergies ◽  
Strenuous Exercise ◽  
Food Ingestion ◽  
Post Challenge ◽  
Loading Test ◽  
Plasma Adrenaline ◽  
Challenge Testing ◽  
Exercise Induced

Abstract Background Exercise-induced anaphylaxis (EIA) is a rare and potentially life-threatening disorder that can develop independently without food ingestion. Cold drinks can also trigger symptoms in some patients with cold-induced anaphylaxis. We present a case of a patient with EIA that was diagnosed on the basis of positive exercise loading test with hyperleukotrieneuria. Case presentation A 12-year-old girl presented with acute flushing, cyanosis, swollen eyelids, and dyspnea after an endurance run in winter or swimming in a cold-water pool. She also developed dyspnea after having a cold drink. She had no history of food allergies, atopy, or asthma. No association was noted between anaphylaxis and food intake in her history. On the first day, she ingested 200 mL of 5 °C cold water in 30 s, which did not trigger symptomatic responses, but her urinary leukotriene E4 (LTE4) level increased (pre-challenge test: 295 pg/mg-creatinine (cr), post-challenge test: 400 pg/mg-cr). On the second day, she underwent the exercise loading test according to the Bruce protocol by using an ergometer to increase the power of exercise every 2 min. She had been fasting for > 15 h and did not have breakfast. Just after the exercise loading test, the plasma adrenaline and noradrenaline increased. At 15 min after the exercise loading test, her plasma adrenaline and histamine (pre-challenge test: 0.7 ng/mL, 15 min post-challenge test: 81 ng/mL) rose sharply with anaphylaxis symptoms accompanied by increasing urinary LTE4 (pre-challenge test: 579 pg/mg-cr, post-challenge test: 846 pg/mg-cr). After she was discharged, she was restricted from strenuous exercise especially in cold environments and prescribed an adrenaline autoinjector. Conclusion Cold stimulation can become a co-effector of EIA. Measurements of urinary LTE4 levels during challenge testing are useful for diagnosing EIA and capture the pre-anaphylaxis stage.

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