scholarly journals Electrochemical Sensors and Biosensors for the Analysis of Tea Components: A Bibliometric Review

2022 ◽  
Vol 9 ◽  
Author(s):  
Jinhua Shao ◽  
Chao Wang ◽  
Yiling Shen ◽  
Jinlei Shi ◽  
Dongqing Ding
Keyword(s):  
Bibliometric Analysis ◽  
High Performance ◽  
Electrochemical Sensors ◽  
Materials Science ◽  
Low Cost ◽  
Relevant Literature ◽  
Electrochemical Techniques ◽  
High Sensitivity ◽  
Electrochemical Analysis ◽  
Electrochemical Biosensing

Tea is a popular beverage all around the world. Tea composition, quality monitoring, and tea identification have all been the subject of extensive research due to concerns about the nutritional value and safety of tea intake. In the last 2 decades, research into tea employing electrochemical biosensing technologies has received a lot of interest. Despite the fact that electrochemical biosensing is not yet the most widely utilized approach for tea analysis, it has emerged as a promising technology due to its high sensitivity, speed, and low cost. Through bibliometric analysis, we give a systematic survey of the literature on electrochemical analysis of tea from 1994 to 2021 in this study. Electrochemical analysis in the study of tea can be split into three distinct stages, according to the bibliometric analysis. After chromatographic separation of materials, electrochemical techniques were initially used only as a detection tool. Many key components of tea, including as tea polyphenols, gallic acid, caffeic acid, and others, have electrochemical activity, and their electrochemical behavior is being investigated. High-performance electrochemical sensors have steadily become a hot research issue as materials science, particularly nanomaterials, and has progressed. This review not only highlights these processes, but also analyzes and contrasts the relevant literature. This evaluation also provides future views in this area based on the bibliometric findings.

scholarly journals Nanomaterials-Based Electrochemical Sensors for In Vitro and In Vivo Analyses of Neurotransmitters

2018 ◽  
Vol 8 (9) ◽  
pp. 1504 ◽  
Author(s):  
Sharmila Durairaj ◽  
Boopathi Sidhureddy ◽  
Joseph Cirone ◽  
Aicheng Chen
Keyword(s):  
Electrochemical Sensors ◽  
Point Of Care ◽  
Electrochemical Techniques ◽  
High Sensitivity ◽  
Electrochemical Analysis ◽  
Detection Techniques ◽  
Efficient Detection ◽  
Sensitivity And Selectivity

Neurotransmitters are molecules that transfer chemical signals between neurons to convey messages for any action conducted by the nervous system. All neurotransmitters are medically important; the detection and analysis of these molecules play vital roles in the diagnosis and treatment of diseases. Among analytical strategies, electrochemical techniques have been identified as simple, inexpensive, and less time-consuming processes. Electrochemical analysis is based on the redox behaviors of neurotransmitters, as well as their metabolites. A variety of electrochemical techniques are available for the detection of biomolecules. However, the development of a sensing platform with high sensitivity and selectivity is challenging, and it has been found to be a bottleneck step in the analysis of neurotransmitters. Nanomaterials-based sensor platforms are fascinating for researchers because of their ability to perform the electrochemical analysis of neurotransmitters due to their improved detection efficacy, and they have been widely reported on for their sensitive detection of epinephrine, dopamine, serotonin, glutamate, acetylcholine, nitric oxide, and purines. The advancement of electroanalytical technologies and the innovation of functional nanomaterials have been assisting greatly in in vivo and in vitro analyses of neurotransmitters, especially for point-of-care clinical applications. In this review, firstly, we focus on the most commonly employed electrochemical analysis techniques, in conjunction with their working principles and abilities for the detection of neurotransmitters. Subsequently, we concentrate on the fabrication and development of nanomaterials-based electrochemical sensors and their advantages over other detection techniques. Finally, we address the challenges and the future outlook in the development of electrochemical sensors for the efficient detection of neurotransmitters.

scholarly journals Bio- and Biomimetic Receptors for Electrochemical Sensing of Heavy Metal Ions

Sensors ◽  
2020 ◽  
Vol 20 (23) ◽  
pp. 6800
Author(s):  
Angela Maria Stortini ◽  
Maria Antonietta Baldo ◽  
Giulia Moro ◽  
Federico Polo ◽  
Ligia Maria Moretto
Keyword(s):  
Inductively Coupled Plasma ◽  
High Performance ◽  
Electrochemical Sensors ◽  
Low Cost ◽  
Environmental Pollutants ◽  
Analytical Techniques ◽  
High Sensitivity ◽  
Electrochemical Sensing ◽  
Anthropogenic Sources ◽  
Analytical Tools

Heavy metals ions (HMI), if not properly handled, used and disposed, are a hazard for the ecosystem and pose serious risks for human health. They are counted among the most common environmental pollutants, mainly originating from anthropogenic sources, such as agricultural, industrial and/or domestic effluents, atmospheric emissions, etc. To face this issue, it is necessary not only to determine the origin, distribution and the concentration of HMI but also to rapidly (possibly in real-time) monitor their concentration levels in situ. Therefore, portable, low-cost and high performing analytical tools are urgently needed. Even though in the last decades many analytical tools and methodologies have been designed to this aim, there are still several open challenges. Compared with the traditional analytical techniques, such as atomic absorption/emission spectroscopy, inductively coupled plasma mass spectrometry and/or high-performance liquid chromatography coupled with electrochemical or UV–VIS detectors, bio- and biomimetic electrochemical sensors provide high sensitivity, selectivity and rapid responses within portable and user-friendly devices. In this review, the advances in HMI sensing in the last five years (2016–2020) are addressed. Key examples of bio and biomimetic electrochemical, impedimetric and electrochemiluminescence-based sensors for Hg2+, Cu2+, Pb2+, Cd2+, Cr6+, Zn2+ and Tl+ are described and discussed.

scholarly journals Integrating high-performing electrochemical transducers in lateral flow assay

2021 ◽  
Author(s):  
Antonia Perju ◽  
Nongnoot Wongkaew
Keyword(s):  
High Performance ◽  
Point Of Care ◽  
Low Cost ◽  
High Sensitivity ◽  
Lateral Flow ◽  
Analytical Performance ◽  
Label Free ◽  
High Performing ◽  
Lateral Flow Assays ◽  
Electrochemical Transducers

AbstractLateral flow assays (LFAs) are the best-performing and best-known point-of-care tests worldwide. Over the last decade, they have experienced an increasing interest by researchers towards improving their analytical performance while maintaining their robust assay platform. Commercially, visual and optical detection strategies dominate, but it is especially the research on integrating electrochemical (EC) approaches that may have a chance to significantly improve an LFA’s performance that is needed in order to detect analytes reliably at lower concentrations than currently possible. In fact, EC-LFAs offer advantages in terms of quantitative determination, low-cost, high sensitivity, and even simple, label-free strategies. Here, the various configurations of EC-LFAs published are summarized and critically evaluated. In short, most of them rely on applying conventional transducers, e.g., screen-printed electrode, to ensure reliability of the assay, and additional advances are afforded by the beneficial features of nanomaterials. It is predicted that these will be further implemented in EC-LFAs as high-performance transducers. Considering the low cost of point-of-care devices, it becomes even more important to also identify strategies that efficiently integrate nanomaterials into EC-LFAs in a high-throughput manner while maintaining their favorable analytical performance.

scholarly journals Molecularly Imprinted Polymers Combined with Electrochemical Sensors for Food Contaminants Analysis

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4607
Author(s):  
Dounia Elfadil ◽  
Abderrahman Lamaoui ◽  
Flavio Della Pelle ◽  
Aziz Amine ◽  
Dario Compagnone
Keyword(s):  
Food Safety ◽  
Molecularly Imprinted Polymers ◽  
Electrochemical Sensors ◽  
Low Cost ◽  
Electrochemical Analysis ◽  
Ease Of Use ◽  
Electrochemical Sensing ◽  
Food Contaminants ◽  
Molecularly Imprinted ◽  
Imprinted Polymers

Detection of relevant contaminants using screening approaches is a key issue to ensure food safety and respect for the regulatory limits established. Electrochemical sensors present several advantages such as rapidity; ease of use; possibility of on-site analysis and low cost. The lack of selectivity for electrochemical sensors working in complex samples as food may be overcome by coupling them with molecularly imprinted polymers (MIPs). MIPs are synthetic materials that mimic biological receptors and are produced by the polymerization of functional monomers in presence of a target analyte. This paper critically reviews and discusses the recent progress in MIP-based electrochemical sensors for food safety. A brief introduction on MIPs and electrochemical sensors is given; followed by a discussion of the recent achievements for various MIPs-based electrochemical sensors for food contaminants analysis. Both electropolymerization and chemical synthesis of MIP-based electrochemical sensing are discussed as well as the relevant applications of MIPs used in sample preparation and then coupled to electrochemical analysis. Future perspectives and challenges have been eventually given.

scholarly journals Carbon nanomaterial hybrids via laser writing for high-performance non-enzymatic electrochemical sensors: a critical review

2021 ◽  
Author(s):  
Marcel Simsek ◽  
Nongnoot Wongkaew
Keyword(s):  
Noble Metal ◽  
Critical Review ◽  
High Performance ◽  
Carbon Nanomaterials ◽  
Electrochemical Sensors ◽  
Low Cost ◽  
Three Dimensional ◽  
Laser Writing ◽  
Enzyme Mimicking ◽  
Natural Enzyme

AbstractNon-enzymatic electrochemical sensors possess superior stability and affordability in comparison to natural enzyme-based counterparts. A large variety of nanomaterials have been introduced as enzyme mimicking with appreciable sensitivity and detection limit for various analytes of which glucose and H2O2 have been mostly investigated. The nanomaterials made from noble metal, non-noble metal, and metal composites, as well as carbon and their derivatives in various architectures, have been extensively proposed over the past years. Three-dimensional (3D) transducers especially realized from the hybrids of carbon nanomaterials either with metal-based nanocatalysts or heteroatom dopants are favorable owing to low cost, good electrical conductivity, and stability. In this critical review, we evaluate the current strategies to create such nanomaterials to serve as non-enzymatic transducers. Laser writing has emerged as a powerful tool for the next generation of devices owing to their low cost and resultant remarkable performance that are highly attractive to non-enzymatic transducers. So far, only few works have been reported, but in the coming years, more and more research on this topic is foreseeable. Graphical abstract

Covalent Organic Frameworks for Electrochemical Sensors: Recent Research and Future Prospects

2021 ◽  
Vol 17 ◽  
Author(s):  
Linyu Wang ◽  
Shasha Hong ◽  
Yuxi Yang ◽  
Yonghai Song ◽  
Li Wang
Keyword(s):  
Specific Surface ◽  
Electrochemical Sensors ◽  
Gas Adsorption ◽  
Low Cost ◽  
High Sensitivity ◽  
Crystalline Polymer ◽  
Synthesis Methods ◽  
High Porosity ◽  
Covalent Organic Frameworks ◽  
Covalent Bonds

Background: In recent years, electrochemical sensors are widely preferred because of their high sensitivity, rapid response, low cost and easy miniaturization. Covalent organic frameworks (COFs), a porous crystalline polymer formed by organic units connected by covalent bonds, have been widely used in gas adsorption and separation, drug transportation, energy storage, photoelectric catalysis, electrochemistry and other aspects due to their large specific surface, excellent stability, high inherent porosity, good crystallinity as well as structural and functional controllability. The topological structure of COFs can be designed in advance, the structural units and linkage are diversified, and the structure is easy to be functionalized, which are all beneficial to their application in electrochemical sensors. Methods: The types, synthesis methods, properties of covalent organic frameworks and some examples of using covalent organic frameworks in electrochemical sensors are reviewed. Results: Due to their characteristics of a large specific surface, high porosity, orderly channel and periodically arranged π electron cloud, COFs are often used to immobilize metal nanoparticles, aptamers or other materials to achieve the purpose of building electrochemical sensors with high sensitivity and good stability. Since the structure of COFs can be predicted, different organic units can build COFs with different structures and properties. Therefore, organic units with certain functional groups can be selected to build COFs with certain properties and used directly for electrochemical sensors. Conclusion: COFs have a good application prospect in electrochemical sensors.

Development of a high-performance, blood-based screening diagnostic to detect early-stage breast cancer.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e22083-e22083
Author(s):  
Joseph Wagner ◽  
Karen Chapman ◽  
Maria Prendes-Garcia ◽  
Markus Lacher ◽  
Jennifer Kidd ◽  
...  
Keyword(s):  
Breast Cancer ◽  
High Performance ◽  
Early Stage ◽  
Low Cost ◽  
High Sensitivity ◽  
Screening Mammography ◽  
Early Stage Breast Cancer ◽  
Breast Cancer Patients ◽  
Elevated Expression ◽  
Sera Samples

e22083 Background: Limitations of current screening mammography, particularly in younger women, demonstrate the need for an alternative breast cancer screening strategy. A non-invasive, easily interpreted and low cost test should address this need. Methods: Gene expression microarray analysis was carried out on 128 individual tumor samples representing over 20 tumor types, 86 samples representing 31 diverse normal tissue types, 68 tumor cell lines and 97 diverse normal primary cell cultures. Genes were ranked for elevated expression in either: i) a large number and variety of tumors relative to normal tissues, or ii) in breast tumors. Elevated expression was verified for a subset of genes using qPCR in a set of independent RNA samples. Proteins coded by genes elevated in breast cancer samples were analyzed in a retrospective training set of breast cancer patient sera samples with cancer-free patient and benign pathology controls using ELISA or bead-based detection assay. Results: Based on availability of suitable reagents, 25 candidate biomarkers were assessed in patient sera samples (31-227 patient samples per biomarker) using ELISA or bead-based assays. Individually, the performance of individual markers varied (ROC AUC, 0.51 - 0.88); however, when expression levels of the best performing markers were combined, the multiplex test demonstrated high-sensitivity (>80%) and specificity (>90%) in identifying early-stage breast cancer patients. Conclusions: A multiplex, proteomic-based approach may provide for a high-performance, blood-based screening diagnostic for breast cancer.

scholarly journals Simple, sensitive and cost-effective detection of wAlbB Wolbachia in Aedes mosquitoes, using loop mediated isothermal amplification combined with the electrochemical biosensing method

2021 ◽  
Author(s):  
Pattamaporn Kittayapong ◽  
Parinda Thayanukul ◽  
Benchaporn Lertanantawong ◽  
Worachart Sirawaraporn ◽  
Surat Charasmongkolcharoen ◽  
...  
Keyword(s):  
Low Cost ◽  
High Sensitivity ◽  
Cost Effective ◽  
Isothermal Amplification ◽  
Loop Mediated Isothermal Amplification ◽  
Control Programs ◽  
Electrochemical Biosensing ◽  
Dna Strand Displacement ◽  
Displacement Based ◽  
Dna Strand

Background Wolbachia is an endosymbiont bacterium generally found in about 40% of insects, including mosquitoes, but it is absent in Aedes aegypti which is an important vector of several arboviral diseasesdengue, chikungunya, Zika, and yellow fever. The evidence that Wolbachia trans-infected Ae. aegypti mosquitoes lost their vectorial competence and became less capable of transmitting arboviruses to human hosts highlights the potential of using Wolbachia - based approaches for prevention and control of arboviral diseases. Recently, release of Wolbachia trans-infected Ae. aegypti has been deployed widely in many countries for the control of mosquito-borne viral diseases. Field surveillance and monitoring of Wolbachia presence in released mosquitoes is important for the success of these control programs. So far, a number of studies have reported the development of loop mediated isothermal amplification (LAMP) assays to detect Wolbachia in mosquitoes, but the methods still have some specificity issues. Methodology/Principal Findings We describe here the development of a LAMP combined with the DNA strand displacement-based electrochemical sensor (BIOSENSOR) method to detect wAlbB Wolbachia in trans-infected Ae . aegypti . Our developed LAMP primers were more specific to wAlbB detection than those of the previous published ones if  the assays were conducted with low-cost and non-specific detecting dyes. The detection capacity of our LAMP technique was 3.8 nM and the detection limit reduced to 2.16 fM when combined with the BIOSENSOR. Our study demonstrates that the BIOSENSOR can also be applied as a stand-alone method for detecting Wolbachia ; and it showed high sensitivity when used with the crude DNA extracts of macerated mosquito samples without DNA purification. Conclusions/Significance Our results suggest that both LAMP and BIOSENSOR, either used in combination or stand-alone, are robust and sensitive. The methods have good potential for routine detection of Wolbachia in mosquitoes during field surveillance and monitoring of Wolbachia -based release programs, especially in countries with limited resources.

scholarly journals High-Sensitivity Flexible Pressure Sensor-Based 3D CNTs Sponge for Human–Computer Interaction

Polymers ◽  
2021 ◽  
Vol 13 (20) ◽  
pp. 3465
Author(s):  
Jianli Cui ◽  
Xueli Nan ◽  
Guirong Shao ◽  
Huixia Sun
Keyword(s):  
Pressure Sensor ◽  
High Performance ◽  
Large Scale ◽  
Low Cost ◽  
Pressure Sensors ◽  
Chemical Vapor ◽  
High Sensitivity ◽  
Wearable Electronics ◽  
Wide Range ◽  
Flexible Pressure Sensors

Researchers are showing an increasing interest in high-performance flexible pressure sensors owing to their potential uses in wearable electronics, bionic skin, and human–machine interactions, etc. However, the vast majority of these flexible pressure sensors require extensive nano-architectural design, which both complicates their manufacturing and is time-consuming. Thus, a low-cost technology which can be applied on a large scale is highly desirable for the manufacture of flexible pressure-sensitive materials that have a high sensitivity over a wide range of pressures. This work is based on the use of a three-dimensional elastic porous carbon nanotubes (CNTs) sponge as the conductive layer to fabricate a novel flexible piezoresistive sensor. The synthesis of a CNTs sponge was achieved by chemical vapor deposition, the basic underlying principle governing the sensing behavior of the CNTs sponge-based pressure sensor and was illustrated by employing in situ scanning electron microscopy. The CNTs sponge-based sensor has a quick response time of ~105 ms, a high sensitivity extending across a broad pressure range (less than 10 kPa for 809 kPa−1) and possesses an outstanding permanence over 4,000 cycles. Furthermore, a 16-pixel wireless sensor system was designed and a series of applications have been demonstrated. Its potential applications in the visualizing pressure distribution and an example of human–machine communication were also demonstrated.

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