scholarly journals Blood Biomarkers and Serologic Immunological Profiles Related to Periodontitis in Abdominal Aortic Aneurysm Patients

2022 ◽  
Vol 11 ◽  
Author(s):  
Leila Salhi ◽  
Patrick Rijkschroeff ◽  
Dorien Van Hede ◽  
Marja L. Laine ◽  
Wim Teughels ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Subgingival Plaque ◽  
Systemic Diseases ◽  
Periodontal Pathogens ◽  
Blood Biomarkers ◽  
Reactive Protein ◽  
Abdominal Aortic ◽  
The Stability ◽  
Post Hoc

BackgroundPeriodontitis is a chronic inflammatory gum disease associated with systemic diseases such as cardiovascular diseases.AimTo investigate the association of systemic blood biomarkers, C-reactive protein (CRP), levels of lipopolysaccharide (LPS), and IgG levels against periodontal pathogens Aggregatibacter actinomycetemcomitans (Aa) and Porphyromonas gingivalis (Pg) with the stability, based on the aortic diameter, the growth rate and the eligibility for surgical intervention, of patients with abdominal aortic aneurysm (AAA).MethodsPatients with stable AAA (n = 30) and unstable AAA (n = 31) were recruited. The anti-A. actinomycetemcomitans and anti-P. gingivalis IgG levels were analyzed by ELISA, the LPS analysis was performed by using the limulus amebocyte lysate (LAL) test, and plasma levels of CRP were determined using an immune turbidimetric method. The association between these blood systemic biomarkers, AAA features, periodontal clinical parameters and oral microbial profiles were explored. Regression models were used to test the relationship between variables.ResultsThe presence of antibodies against Pg and Aa, LPS and high CRP concentrations were found in all AAA patients. The IgG levels were similar in patients with stable and unstable AAA (both for Aa and Pg). Among investigated blood biomarkers, only CRP was associated with AAA stability. The amount of LPS in saliva, supra, and subgingival plaque were significantly associated with the systemic LPS (p <0.05).ConclusionsThis post-hoc study emphasizes the presence of antibodies against Pg and Aa, LPS and high CRP concentrations in all AAA patients. The presence of Pg in saliva and subgingival plaque was significantly associated with the blood LPS levels. For further studies investigating periodontitis and systemic diseases, specific predictive blood biomarkers should be considered instead of the use of antibodies alone.

scholarly journals Plasma C-Reactive Protein and Abdominal Aortic Aneurysm

2018 ◽  
Vol 131 (21) ◽  
pp. 2630-2633 ◽  
Author(s):  
Xue-Ying Qin ◽  
Juan Juan ◽  
Xiao Xiang ◽  
Ying-Qi Wei ◽  
Shang-Wei Zuo ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Abdominal Aortic

Change in high-sensitive C-reactive protein during abdominal aortic aneurysm formation

2009 ◽  
Vol 27 (9) ◽  
pp. 1829-1837 ◽  
Author(s):  
Genya Huang ◽  
Ani Wang ◽  
Xiujuan Li ◽  
Ming Long ◽  
Zhiming Du ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Aneurysm Formation ◽  
Abdominal Aortic

Anemia is Associated With Mortality Following Endovascular Repair of Abdominal Aortic Aneurysm

2012 ◽  
Vol 46 (3) ◽  
pp. 223-228 ◽  
Author(s):  
Athanasios Saratzis ◽  
Nikolaos Melas ◽  
James P. Hunter ◽  
Hannah Dixon ◽  
Peter Nightingale ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Endovascular Repair ◽  
Inflammatory Markers ◽  
Cox Regression ◽  
Reactive Protein ◽  
Markers Of Inflammation ◽  
Kaplan Meier ◽  
Abdominal Aortic ◽  
The Impact

Aim: The aim of this study was to compare midterm mortality between anemic and nonanemic patients undergoing endovascular repair of abdominal aortic aneurysm and to assess a correlation with markers of inflammation. Methods: Anemia was defined as hemoglobin <13 (men) and <12 g/dL (women). The impact of anemia and inflammatory markers on mortality was assessed using Kaplan-Meier curves and Cox regression. Results: A total of 224 patients (12 females [5.36%]; age: 69.73 ± 8.72 years) were included; 102 (45.53%) were anemic. Median follow-up was 17 months (interquartile range: 7-25 months). Nine patients died (1.79%; 8 anemic vs 1 nonanemic). Survival was lower for patients with anemia (log-rank, P = .01). White blood cell count and C-reactive protein (CRP) differed significantly ( P < .001 and P = .01). Anemia and CRP were associated with decreased survival (Cox regression, P = .01, hazard ratio [HR]: 0.35, 95% confidence interval: 0.14-0.84 and P = .002, HR: 1.18, 95% CI: 1.06-1.31). Conclusion: Patients with anemia had decreased survival over the midterm; inflammatory markers were higher among this group.

Circulating Midregional Proadrenomedullin and Risk of Incident Abdominal Aortic Aneurysm: A Prospective Longitudinal Cohort Study

Angiology ◽  
2017 ◽  
Vol 69 (4) ◽  
pp. 333-338 ◽  
Author(s):  
Stefan Acosta ◽  
Anders Gottsäter ◽  
Gunnar Engström ◽  
Olle Melander ◽  
Moncef Zarrouk ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Plasma Concentrations ◽  
Plasma Biomarker ◽  
Longitudinal Cohort ◽  
Reactive Protein ◽  
Abdominal Aortic ◽  
Baseline Incidence ◽  
Prospective Longitudinal ◽  
Prospective Longitudinal Cohort

Prospective clinical plasma biomarker studies in abdominal aortic aneurysm (AAA) pathogenesis have been hampered by the need for very large cohorts and long follow-up time. The main aim of the present study was to evaluate the association of adrenomedullin, a cardiovascular (CV) stress marker, and incident AAA risk. Prospective longitudinal cohort of middle-aged individuals from the CV cohort of the Malmö Diet and Cancer Study (n = 5551; 1991-1994) was assessed. Plasma concentrations of midregional proadrenomedullin (MR-proADM), C-reactive protein (CRP), and conventional risk factors were measured at baseline. Incidence of AAA was studied up to December 31, 2013. Cumulative incidence of AAA was 1.5% (men 2.9%, women 0.5%). Mean age of individuals with incident AAA was 59.7 years at study entry, and AAA was diagnosed on average 14 years later. Adjusting for age, gender, smoking, body mass index, hypertension, diabetes mellitus, and CRP, MR-proADM (hazard ratio: 1.28; 95% confidence interval: 1.01-1.62) was independently associated with incident AAA. The plasma biomarker MR-proADM seems to be a marker of AAA risk, implying that AAA development may be driven by long-standing CV stress on the aortic wall.

scholarly journals Serum C-Reactive Protein Level Is Associated With Abdominal Aortic Aneurysm Size and May Be Produced by Aneurysmal Tissue

Circulation ◽  
2003 ◽  
Vol 107 (8) ◽  
pp. 1103-1105 ◽  
Author(s):  
Tryfon Vainas ◽  
Tim Lubbers ◽  
Frank R.M. Stassen ◽  
Selma B. Herngreen ◽  
Marja P. van Dieijen-Visser ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Protein Level ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Aneurysm Size ◽  
Abdominal Aortic

Fluid displacement from intraluminal thrombus of abdominal aortic aneurysm as a result of uniform compression

Vascular ◽  
2017 ◽  
Vol 25 (5) ◽  
pp. 542-548 ◽  
Author(s):  
Kim van Noort ◽  
Richte CL Schuurmann ◽  
Bryan Wermelink ◽  
Cornelis H Slump ◽  
Karel C Kuijpers ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Abdominal Aortic Aneurysm Repair ◽  
Uniform Compression ◽  
Fluid Displacement ◽  
Abdominal Aortic ◽  
Aortic Thrombus ◽  
The Stability ◽  
Aneurysm Repair ◽  
Aortic Aneurysm Repair

Objectives The results after aneurysm repair with an endovascular aneurysm sealing (EVAS) system are dependent on the stability of the aneurysm sac and particularly the intraluminal abdominal aortic thrombus (ILT). The postprocedural ILT volume is decreased compared with preprocedural ILT volume in aortic aneurysm patients treated with EVAS. We hypothesize that ILT is not stable in all patients and pressurization of the ILT may result in displacement of fluids from the ILT, no differently than serum is displaced from whole blood when it settles. To date, the mechanism and quantification of fluid displacement from ILT are unknown. Methods The study included 21 patients who underwent elective open abdominal aortic aneurysm repair. The ILT was harvested as a routine procedure during the operation. After excision of a histologic sample of the ILT specimen in four patients, ILT volume was measured and the ILT was compressed in a dedicated compression setup designed to apply uniform compression of 200 mmHg for 5 min. After compression, the volumes of the remaining thrombus and the displaced fluid were measured. Results The median (interquartile-range) of ILT volume before compression was 60 (66) mL, and a median of 5.7 (8.4) mL of fluid was displaced from the ILT after compression, resulting in a median thrombus volume decrease of 11% (10%). Fluid components can be up to 31% of the entire ILT volume. Histologic examination of four ILT specimens showed a reduction of the medial layer of the ILT after compression, which was the result of compression of fluid-containing canaliculi. Conclusions Applying pressure of 200 mmHg to abdominal aortic aneurysm ILT resulted in the displacement of fluid, with a large variation among patients. Fluid displacement may result in decrease of ILT volume during and after EVAS, which might have implications on pre-EVAS volume planning and on stability of the endobags during follow-up which may lead to migration, endoleak or both.

scholarly journals B-type natriuretic peptide for prediction of incident clinically significant abdominal aortic aneurysm: A population-based prospective study

2018 ◽  
Vol 23 (1) ◽  
pp. 46-51 ◽  
Author(s):  
Stefan Acosta ◽  
Anders Gottsäter ◽  
Gunnar Engström ◽  
Olle Melander ◽  
Moncef Zarrouk ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Natriuretic Peptide ◽  
Population Based ◽  
Plasma Biomarker ◽  
Reactive Protein ◽  
Abdominal Aortic ◽  
Clinically Significant ◽  
Prospective Longitudinal

Pathogenesis of abdominal aortic aneurysm (AAA) is unclear. The aim of this study was to evaluate inflammatory and hemodynamic plasma biomarkers as predictors for AAA in the prospective longitudinal cohort of middle-aged individuals from the cardiovascular cohort of the Malmö Diet and Cancer Study ( n=5551; 1991–94). C-reactive protein, cystatin C, copeptin, N-terminal pro-B-type natriuretic peptide (N-BNP), midregional pro-atrial natriuretic peptide (MR-proANP) and conventional risk factors at baseline were measured in patients with incident AAA during follow-up and compared to individuals without a diagnosis of AAA. Subjects were followed until 31 December 2013. Multivariable analyses were expressed in terms of hazard ratios (HR) per 1 standard deviation increment of each respective log-transformed plasma biomarker in the Cox proportional hazard models. Mean follow-up time was 20.7 years. Cumulative incidence of AAA was 1.5% (men 2.9%, women 0.5%). Mean age of individuals with incident AAA was 59.7 years at study entry and AAA was diagnosed on average 14 years later. Adjusting for age, sex, smoking, body mass index, hypertension and diabetes mellitus, N-BNP (HR 1.29; 95% CI 1.03–1.62), but not MR-proANP (HR 1.20; 95% CI 0.95–1.50), was independently associated with incident AAA. In conclusion, the plasma biomarker N-BNP was associated with future development of AAA, which implies that this marker is a sensitive indicator of early subclinical cardiovascular disease.

The Influence of COX-2 Single Nucleotide Polymorphisms on Abdominal Aortic Aneurysm Development and the Associated Inflammation

Angiology ◽  
2009 ◽  
Vol 60 (5) ◽  
pp. 576-581 ◽  
Author(s):  
Stephen A. Badger ◽  
Chee V. Soong ◽  
Ian S. Young ◽  
Ann McGinty ◽  
Caroline Mercer ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Serum Concentration ◽  
High Sensitivity ◽  
Nucleotide Polymorphisms ◽  
C Reactive Protein ◽  
Single Nucleotide ◽  
Reactive Protein ◽  
Abdominal Aortic ◽  
Cox 2

Introduction Cyclooxygenase (COX)-2 influences cardiovascular disease and serum concentration of high-sensitivity C-reactive protein (hsCRP). The study purpose was to determine the influence of single nucleotide polymorphisms (SNPs) of the COX-2 gene on abdominal aortic aneurysm (AAA) development and serum hsCRP concentrations. Patients and Methods Patients with AAA and disease-free controls were recruited. High-sensitivity C-reactive protein was measured by an enzyme-linked immunosorbent assay (ELISA) test. The distributions of COX-2 SNPs were investigated (rs20417 and rs4648307). The influence of the COX-2 SNPs on the hsCRP serum concentration was assessed. Results A total of 230 patients with AAA and 279 controls were included. No difference was found in the genotype distribution of the COX-2 SNPs rs20417 ( P = .26) and rs4648307 ( P = .90). They did not influence the hsCRP concentration ( P = .24 and P = .61, respectively). Haplotype analysis of COX-2 SNPs revealed no difference. Conclusion These COX-2 SNPs do not play any role in AAA development and do not influence serum hsCRP. These results differentiate AAA development from atherosclerotic diseases.

Sign in / Sign up

Export Citation Format

Share Document