scholarly journals Advanced Warning of Aortic Dissection on Non-Contrast CT: The Combination of Deep Learning and Morphological Characteristics

2022 ◽  
Vol 8 ◽  
Author(s):  
Yan Yi ◽  
Li Mao ◽  
Cheng Wang ◽  
Yubo Guo ◽  
Xiao Luo ◽  
...  
Keyword(s):  
Deep Learning ◽  
Aortic Dissection ◽  
Sensitivity And Specificity ◽  
Morphological Characteristics ◽  
Learning Model ◽  
Integrated Model ◽  
Ct Scans ◽  
Proposed Model ◽  
Contrast Ct ◽  
Deep Learning Model

Background: The identification of aortic dissection (AD) at baseline plays a crucial role in clinical practice. Non-contrast CT scans are widely available, convenient, and easy to perform. However, the detection of AD on non-contrast CT scans by radiologists currently lacks sensitivity and is suboptimal.Methods: A total of 452 patients who underwent aortic CT angiography (CTA) were enrolled retrospectively from two medical centers in China to form the internal cohort (341 patients, 139 patients with AD, 202 patients with non-AD) and the external testing cohort (111 patients, 46 patients with AD, 65 patients with non-AD). The internal cohort was divided into the training cohort (n = 238), validation cohort (n = 35), and internal testing cohort (n = 68). Morphological characteristics were extracted from the aortic segmentation. A deep-integrated model based on the Gaussian Naive Bayes algorithm was built to differentiate AD from non-AD, using the combination of the three-dimensional (3D) deep-learning model score and morphological characteristics. The areas under the receiver operating characteristic curve (AUCs), accuracy, sensitivity, and specificity were used to evaluate the model performance. The proposed model was also compared with the subjective assessment of radiologists.Results: After the combination of all the morphological characteristics, our proposed deep-integrated model significantly outperformed the 3D deep-learning model (AUC: 0.948 vs. 0.803 in the internal testing cohort and 0.969 vs. 0.814 in the external testing cohort, both p < 0.05). The accuracy, sensitivity, and specificity of our model reached 0.897, 0.862, and 0.923 in the internal testing cohort and 0.730, 0.978, and 0.554 in the external testing cohort, respectively. The accuracy for AD detection showed no significant difference between our model and the radiologists (p > 0.05).Conclusion: The proposed model presented good performance for AD detection on non-contrast CT scans; thus, early diagnosis and prompt treatment would be available.

scholarly journals Performance Comparison of the Deep Learning and the Human Endoscopist for Bleeding Peptic Ulcer Disease

2021 ◽  
Author(s):  
Hsu-Heng Yen ◽  
Ping-Yu Wu ◽  
Pei-Yuan Su ◽  
Chia-Wei Yang ◽  
Yang-Yuan Chen ◽  
...  
Keyword(s):  
Peptic Ulcer ◽  
Deep Learning ◽  
Sensitivity And Specificity ◽  
Endoscopic Therapy ◽  
Learning Model ◽  
Ulcer Bleeding ◽  
Learning Models ◽  
Peptic Ulcer Bleeding ◽  
Ulcer Disease ◽  
Deep Learning Model

Abstract Purpose Management of peptic ulcer bleeding is clinically challenging. Accurate characterization of the bleeding during endoscopy is key for endoscopic therapy. This study aimed to assess whether a deep learning model can aid in the classification of bleeding peptic ulcer disease. Methods Endoscopic still images of patients (n = 1694) with peptic ulcer bleeding for the last 5 years were retrieved and reviewed. Overall, 2289 images were collected for deep learning model training, and 449 images were validated for the performance test. Two expert endoscopists classified the images into different classes based on their appearance. Four deep learning models, including Mobile Net V2, VGG16, Inception V4, and ResNet50, were proposed and pre-trained by ImageNet with the established convolutional neural network algorithm. A comparison of the endoscopists and trained deep learning model was performed to evaluate the model’s performance on a dataset of 449 testing images. Results The results first presented the performance comparisons of four deep learning models. The Mobile Net V2 presented the optimal performance of the proposal models. The Mobile Net V2 was chosen for further comparing the performance with the diagnostic results obtained by one senior and one novice endoscopists. The sensitivity and specificity were acceptable for the prediction of “normal” lesions in both 3-class and 4-class classifications. For the 3-class category, the sensitivity and specificity were 94.83% and 92.36%, respectively. For the 4-class category, the sensitivity and specificity were 95.40% and 92.70%, respectively. The interobserver agreement of the testing dataset of the model was moderate to substantial with the senior endoscopist. The accuracy of the determination of endoscopic therapy required and high-risk endoscopic therapy of the deep learning model was higher than that of the novice endoscopist. Conclusions In this study, the deep learning model performed better than inexperienced endoscopists. Further improvement of the model may aid in clinical decision-making during clinical practice, especially for trainee endoscopist.

scholarly journals Content Noise Detection Model Using Deep Learning in Web Forums

2020 ◽  
Vol 12 (12) ◽  
pp. 5074
Author(s):  
Jiyoung Woo ◽  
Jaeseok Yun
Keyword(s):  
Machine Learning ◽  
Deep Learning ◽  
Learning Model ◽  
Detection Model ◽  
Proposed Model ◽  
Web Forum ◽  
Web Forums ◽  
Conventional Machine ◽  
Text Features ◽  
Deep Learning Model

Spam posts in web forum discussions cause user inconvenience and lower the value of the web forum as an open source of user opinion. In this regard, as the importance of a web post is evaluated in terms of the number of involved authors, noise distorts the analysis results by adding unnecessary data to the opinion analysis. Here, in this work, an automatic detection model for spam posts in web forums using both conventional machine learning and deep learning is proposed. To automatically differentiate between normal posts and spam, evaluators were asked to recognize spam posts in advance. To construct the machine learning-based model, text features from posted content using text mining techniques from the perspective of linguistics were extracted, and supervised learning was performed to distinguish content noise from normal posts. For the deep learning model, raw text including and excluding special characters was utilized. A comparison analysis on deep neural networks using the two different recurrent neural network (RNN) models of the simple RNN and long short-term memory (LSTM) network was also performed. Furthermore, the proposed model was applied to two web forums. The experimental results indicate that the deep learning model affords significant improvements over the accuracy of conventional machine learning associated with text features. The accuracy of the proposed model using LSTM reaches 98.56%, and the precision and recall of the noise class reach 99% and 99.53%, respectively.

scholarly journals ECOVNet: a highly effective ensemble based deep learning model for detecting COVID-19

2021 ◽  
Vol 7 ◽  
pp. e551
Author(s):  
Nihad Karim Chowdhury ◽  
Muhammad Ashad Kabir ◽  
Md. Muhtadir Rahman ◽  
Noortaz Rezoana
Keyword(s):  
Deep Learning ◽  
Detection System ◽  
Learning Model ◽  
Classification Performance ◽  
Data Sets ◽  
X Rays ◽  
Proposed Model ◽  
Highly Effective ◽  
Chest X Ray ◽  
Deep Learning Model

The goal of this research is to develop and implement a highly effective deep learning model for detecting COVID-19. To achieve this goal, in this paper, we propose an ensemble of Convolutional Neural Network (CNN) based on EfficientNet, named ECOVNet, to detect COVID-19 from chest X-rays. To make the proposed model more robust, we have used one of the largest open-access chest X-ray data sets named COVIDx containing three classes—COVID-19, normal, and pneumonia. For feature extraction, we have applied an effective CNN structure, namely EfficientNet, with ImageNet pre-training weights. The generated features are transferred into custom fine-tuned top layers followed by a set of model snapshots. The predictions of the model snapshots (which are created during a single training) are consolidated through two ensemble strategies, i.e., hard ensemble and soft ensemble, to enhance classification performance. In addition, a visualization technique is incorporated to highlight areas that distinguish classes, thereby enhancing the understanding of primal components related to COVID-19. The results of our empirical evaluations show that the proposed ECOVNet model outperforms the state-of-the-art approaches and significantly improves detection performance with 100% recall for COVID-19 and overall accuracy of 96.07%. We believe that ECOVNet can enhance the detection of COVID-19 disease, and thus, underpin a fully automated and efficacious COVID-19 detection system.

scholarly journals Hybrid deep learning model using recurrent neural network and gated recurrent unit for heart disease prediction

2021 ◽  
Vol 11 (6) ◽  
pp. 5467
Author(s):  
Surenthiran Krishnan ◽  
Pritheega Magalingam ◽  
Roslina Ibrahim
Keyword(s):  
Neural Network ◽  
Heart Disease ◽  
Deep Learning ◽  
Recurrent Neural Network ◽  
Short Term Memory ◽  
Learning Model ◽  
Disease Prediction ◽  
The Neural Network ◽  
Proposed Model ◽  
Deep Learning Model

<span>This paper proposes a new hybrid deep learning model for heart disease prediction using recurrent neural network (RNN) with the combination of multiple gated recurrent units (GRU), long short-term memory (LSTM) and Adam optimizer. This proposed model resulted in an outstanding accuracy of 98.6876% which is the highest in the existing model of RNN. The model was developed in Python 3.7 by integrating RNN in multiple GRU that operates in Keras and Tensorflow as the backend for deep learning process, supported by various Python libraries. The recent existing models using RNN have reached an accuracy of 98.23% and deep neural network (DNN) has reached 98.5%. The common drawbacks of the existing models are low accuracy due to the complex build-up of the neural network, high number of neurons with redundancy in the neural network model and imbalance datasets of Cleveland. Experiments were conducted with various customized model, where results showed that the proposed model using RNN and multiple GRU with synthetic minority oversampling technique (SMOTe) has reached the best performance level. This is the highest accuracy result for RNN using Cleveland datasets and much promising for making an early heart disease prediction for the patients.</span>

scholarly journals Multi-Task Model for Esophageal Lesion Analysis Using Endoscopic Images: Classification with Image Retrieval and Segmentation with Attention

Sensors ◽  
2021 ◽  
Vol 22 (1) ◽  
pp. 283
Author(s):  
Xiaoyuan Yu ◽  
Suigu Tang ◽  
Chak Fong Cheang ◽  
Hon Ho Yu ◽  
I Cheong Choi
Keyword(s):  
Deep Learning ◽  
Image Retrieval ◽  
Learning Model ◽  
Endoscopic Images ◽  
Proposed Model ◽  
Esophageal Lesion ◽  
Lesion Analysis ◽  
Diagnosis Accuracy ◽  
Segmentation Task ◽  
Deep Learning Model

The automatic analysis of endoscopic images to assist endoscopists in accurately identifying the types and locations of esophageal lesions remains a challenge. In this paper, we propose a novel multi-task deep learning model for automatic diagnosis, which does not simply replace the role of endoscopists in decision making, because endoscopists are expected to correct the false results predicted by the diagnosis system if more supporting information is provided. In order to help endoscopists improve the diagnosis accuracy in identifying the types of lesions, an image retrieval module is added in the classification task to provide an additional confidence level of the predicted types of esophageal lesions. In addition, a mutual attention module is added in the segmentation task to improve its performance in determining the locations of esophageal lesions. The proposed model is evaluated and compared with other deep learning models using a dataset of 1003 endoscopic images, including 290 esophageal cancer, 473 esophagitis, and 240 normal. The experimental results show the promising performance of our model with a high accuracy of 96.76% for the classification and a Dice coefficient of 82.47% for the segmentation. Consequently, the proposed multi-task deep learning model can be an effective tool to help endoscopists in judging esophageal lesions.

scholarly journals Evaluating the Accuracy of Breast Cancer and Molecular Subtype Diagnosis by Ultrasound Image Deep Learning Model

2021 ◽  
Vol 11 ◽  
Author(s):  
Xianyu Zhang ◽  
Hui Li ◽  
Chaoyun Wang ◽  
Wen Cheng ◽  
Yuntao Zhu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Deep Learning ◽  
Sensitivity And Specificity ◽  
Molecular Subtypes ◽  
Learning Model ◽  
Breast Ultrasound ◽  
Ultrasound Images ◽  
Test Set ◽  
External Test ◽  
Deep Learning Model

Background: Breast ultrasound is the first choice for breast tumor diagnosis in China, but the Breast Imaging Reporting and Data System (BI-RADS) categorization routinely used in the clinic often leads to unnecessary biopsy. Radiologists have no ability to predict molecular subtypes with important pathological information that can guide clinical treatment.Materials and Methods: This retrospective study collected breast ultrasound images from two hospitals and formed training, test and external test sets after strict selection, which included 2,822, 707, and 210 ultrasound images, respectively. An optimized deep learning model (DLM) was constructed with the training set, and the performance was verified in both the test set and the external test set. Diagnostic results were compared with the BI-RADS categorization determined by radiologists. We divided breast cancer into different molecular subtypes according to hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) expression. The ability to predict molecular subtypes using the DLM was confirmed in the test set.Results: In the test set, with pathological results as the gold standard, the accuracy, sensitivity and specificity were 85.6, 98.7, and 63.1%, respectively, according to the BI-RADS categorization. The same set achieved an accuracy, sensitivity, and specificity of 89.7, 91.3, and 86.9%, respectively, when using the DLM. For the test set, the area under the curve (AUC) was 0.96. For the external test set, the AUC was 0.90. The diagnostic accuracy was 92.86% with the DLM in BI-RADS 4a patients. Approximately 70.76% of the cases were judged as benign tumors. Unnecessary biopsy was theoretically reduced by 67.86%. However, the false negative rate was 10.4%. A good prediction effect was shown for the molecular subtypes of breast cancer with the DLM. The AUC were 0.864, 0.811, and 0.837 for the triple-negative subtype, HER2 (+) subtype and HR (+) subtype predictions, respectively.Conclusion: This study showed that the DLM was highly accurate in recognizing breast tumors from ultrasound images. Thus, the DLM can greatly reduce the incidence of unnecessary biopsy, especially for patients with BI-RADS 4a. In addition, the predictive ability of this model for molecular subtypes was satisfactory,which has specific clinical application value.

Hybrid Deep Learning Model For Diagnosis Of Covid-19 Using Ct Scans And Clinical/Demographic Data

2021 ◽  
Author(s):  
Parnian Afshar ◽  
Shahin Heidarian ◽  
Farnoosh Naderkhani ◽  
Moezedin Javad Rafiee ◽  
Anastasia Oikonomou ◽  
...  
Keyword(s):  
Deep Learning ◽  
Demographic Data ◽  
Learning Model ◽  
Ct Scans ◽  
Deep Learning Model

scholarly journals An Improved Deep Learning Model for Traffic Crash Prediction

2018 ◽  
Vol 2018 ◽  
pp. 1-13 ◽  
Author(s):  
Chunjiao Dong ◽  
Chunfu Shao ◽  
Juan Li ◽  
Zhihua Xiong
Keyword(s):  
Deep Learning ◽  
Feature Learning ◽  
Learning Model ◽  
Fine Tuning ◽  
Crash Prediction ◽  
Traffic Crash ◽  
Explanatory Variables ◽  
Feature Representations ◽  
Proposed Model ◽  
Deep Learning Model

Machine-learning technology powers many aspects of modern society. Compared to the conventional machine learning techniques that were limited in processing natural data in the raw form, deep learning allows computational models to learn representations of data with multiple levels of abstraction. In this study, an improved deep learning model is proposed to explore the complex interactions among roadways, traffic, environmental elements, and traffic crashes. The proposed model includes two modules, an unsupervised feature learning module to identify functional network between the explanatory variables and the feature representations and a supervised fine tuning module to perform traffic crash prediction. To address the unobserved heterogeneity issues in the traffic crash prediction, a multivariate negative binomial (MVNB) model is embedding into the supervised fine tuning module as a regression layer. The proposed model was applied to the dataset that was collected from Knox County in Tennessee to validate the performances. The results indicate that the feature learning module identifies relational information between the explanatory variables and the feature representations, which reduces the dimensionality of the input and preserves the original information. The proposed model that includes the MVNB regression layer in the supervised fine tuning module can better account for differential distribution patterns in traffic crashes across injury severities and provides superior traffic crash predictions. The findings suggest that the proposed model is a superior alternative for traffic crash predictions and the average accuracy of the prediction that was measured by RMSD can be improved by 84.58% and 158.27% compared to the deep learning model without the regression layer and the SVM model, respectively.

scholarly journals Novel deep learning-based transcriptome data analysis for drug-drug interaction prediction with an application in diabetes

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Qichao Luo ◽  
Shenglong Mo ◽  
Yunfei Xue ◽  
Xiangzhou Zhang ◽  
Yuliang Gu ◽  
...  
Keyword(s):  
Deep Learning ◽  
Drug Interaction ◽  
Learning Model ◽  
Superior Performance ◽  
Public Health Issue ◽  
Transcriptome Data ◽  
Proposed Model ◽  
Drug Drug Interaction ◽  
Deep Learning Model ◽  
Drugbank Database

Abstract Background Drug-drug interaction (DDI) is a serious public health issue. The L1000 database of the LINCS project has collected millions of genome-wide expressions induced by 20,000 small molecular compounds on 72 cell lines. Whether this unified and comprehensive transcriptome data resource can be used to build a better DDI prediction model is still unclear. Therefore, we developed and validated a novel deep learning model for predicting DDI using 89,970 known DDIs extracted from the DrugBank database (version 5.1.4). Results The proposed model consists of a graph convolutional autoencoder network (GCAN) for embedding drug-induced transcriptome data from the L1000 database of the LINCS project; and a long short-term memory (LSTM) for DDI prediction. Comparative evaluation of various machine learning methods demonstrated the superior performance of our proposed model for DDI prediction. Many of our predicted DDIs were revealed in the latest DrugBank database (version 5.1.7). In the case study, we predicted drugs interacting with sulfonylureas to cause hypoglycemia and drugs interacting with metformin to cause lactic acidosis, and showed both to induce effects on the proteins involved in the metabolic mechanism in vivo. Conclusions The proposed deep learning model can accelerate the discovery of new DDIs. It can support future clinical research for safer and more effective drug co-prescription.

scholarly journals An Interpretable Deep Learning Model for Automatic Sound Classification

Electronics ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 850
Author(s):  
Pablo Zinemanas ◽  
Martín Rocamora ◽  
Marius Miron ◽  
Frederic Font ◽  
Xavier Serra
Keyword(s):  
Deep Learning ◽  
Web Application ◽  
Domain Knowledge ◽  
Learning Model ◽  
Unintended Effects ◽  
Learning Models ◽  
Time Frequency ◽  
Sound Classification ◽  
Proposed Model ◽  
Deep Learning Model

Deep learning models have improved cutting-edge technologies in many research areas, but their black-box structure makes it difficult to understand their inner workings and the rationale behind their predictions. This may lead to unintended effects, such as being susceptible to adversarial attacks or the reinforcement of biases. There is still a lack of research in the audio domain, despite the increasing interest in developing deep learning models that provide explanations of their decisions. To reduce this gap, we propose a novel interpretable deep learning model for automatic sound classification, which explains its predictions based on the similarity of the input to a set of learned prototypes in a latent space. We leverage domain knowledge by designing a frequency-dependent similarity measure and by considering different time-frequency resolutions in the feature space. The proposed model achieves results that are comparable to that of the state-of-the-art methods in three different sound classification tasks involving speech, music, and environmental audio. In addition, we present two automatic methods to prune the proposed model that exploit its interpretability. Our system is open source and it is accompanied by a web application for the manual editing of the model, which allows for a human-in-the-loop debugging approach.

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