scholarly journals Diosmin Alleviates Venous Injury and Muscle Damage in a Mouse Model of Iliac Vein Stenosis

2022 ◽  
Vol 8 ◽  
Author(s):  
Zhiye Guo ◽  
Xiaolong Du ◽  
Yihua Zhang ◽  
Chunwan Su ◽  
Feng Ran ◽  
...  
Keyword(s):  
Mouse Model ◽  
Therapeutic Effect ◽  
Iliac Vein ◽  
Chronic Venous Disease ◽  
Venous Disease ◽  
Sequencing Analysis ◽  
Venous Injury ◽  
Venous Diseases ◽  
Vein Stenosis ◽  
Dose Dependent

Chronic venous disease (CVD) is a progressive inflammatory disease that increases in prevalence with age. Elucidating the underlying molecular mechanism of CVD development is essential for disease prevention and treatment. This study constructed a mouse model of iliac vein stenosis to explore the mechanism of the CVD disease progression, and diosmin was administered as a positive control (as recommended by clinical practice). The mouse model was established successfully with iliac vein stenosis, leading to the expansion of the intercellular space and venous leakage. Conversely, micronized diosmin showed a dose-dependent therapeutic effect for these manifestations. Concerning the mechanism, iliac vein stenosis caused an inflammatory response in veins, while diosmin suppressed this increase. Furthermore, RNA sequencing analysis indicated that diosmin significantly improved muscle function through actin filament organization and muscle contraction. These results indicated that the mouse model of iliac vein stenosis is a reliable model to study venous diseases. Furthermore, the dose-dependent therapeutic effect of diosmin on stenosis (without toxic side-effects) suggests greater protection against venous diseases at higher doses of diosmin.

Computed tomography venography versus intravascular ultrasound in the diagnosis of iliofemoral vein stenosis

VASA ◽  
2021 ◽  
Vol 50 (1) ◽  
pp. 38-44
Author(s):  
Ming Ren Toh ◽  
Karthikeyan Damodharan ◽  
Han Hui Mervin Nathan Lim ◽  
Tjun Yip Tang
Keyword(s):  
Computed Tomography ◽  
Diagnostic Performance ◽  
Iliac Vein ◽  
Chronic Venous Disease ◽  
Diagnostic Tools ◽  
Venous Disease ◽  
Significant Stenosis ◽  
Vein Segment ◽  
Vein Stenosis ◽  
Computed Tomography Venography

Summary: Background: Iliofemoral vein stenosis can cause debilitating chronic venous disease. Diagnostic tools include both computed tomography venography (CTV) and intravascular ultrasonography (IVUS). We aim to compare the diagnostic performance of CTV and IVUS. Patients and methods: We performed a retrospective study of patients with chronic venous disease presenting with iliac vein compression or post-thrombotic limb symptoms, excluding those with acute deep vein thrombosis, high anaesthesia risk, or who had contrast allergy. All patients received CTV before IVUS, as part of the diagnostic work-up and intervention. The cross-sectional area (CSA) of iliofemoral vein segments obtained from both studies were compared against reference CSAs to derive percentage stenosis. A 50% reduction in CSA was considered significant. Results: We studied 50 patients between May 2018 and April 2019. 58% of patients had severe disease CEAP C5-6. 48% of patients had at least one vein segment with significant stenosis. The left proximal common iliac vein was the most commonly stenosed vein segment (n = 12, 24% on IVUS). CSA measurements from CTV were greater than those of IVUS, with a correlation coefficient of 0.57 (p < 0.005). Conversely, percentage stenosis measured on CTV was lower than on IVUS, with approximately one-third of significant stenosis missed on CTV (58 veins from CTV vs. 78 from IVUS, p < 0.005). With IVUS as the gold standard, CTV has low sensitivity (37.2%, 95% CI 26.5–48.9) and high specificity (92.5%, 95% CI 89.3–94.9) in detecting significant stenosis. Conclusions: CTV has limited diagnostic performance in identifying iliofemoral vein stenosis. Patients with normal CTV findings should proceed with IVUS imaging if the clinical features are supportive of iliofemoral vein stenosis.

Optimal sizing of iliac vein stents

2017 ◽  
Vol 33 (7) ◽  
pp. 451-457 ◽  
Author(s):  
Seshadri Raju ◽  
William J Buck ◽  
William Crim ◽  
Arjun Jayaraj
Keyword(s):  
Therapeutic Option ◽  
Femoral Vein ◽  
Iliac Vein ◽  
Chronic Venous Disease ◽  
Venous Disease ◽  
Initial Procedure ◽  
The Common ◽  
The Right ◽  
Vein Stenosis ◽  
Scaling Rule

Background Iliac vein stenting has emerged as a therapeutic option in chronic venous disease. The optimal stent size is unknown but should match normal caliber at a minimum. Methods Teleology: The iliac-femoral outflow caliber was measured by Duplex in healthy volunteers to determine normal caliber. Patient IVUS data: The distribution curve of IVUS planimetry data in 345 chronic venous disease limbs was analyzed: values at the right tail end of the curve should approach normal values according to distribution theory. The optimal stent size was also projected using Poiseuille equation and Young’s scaling rule. Results The optimal stent sizes in the common iliac, external iliac, and common femoral vein segments are: 16, 14, and 12 mm diameters, respectively. Conclusion Stent correction of iliac vein stenosis should aim to restore the lumen to the minimum recommended caliber during the initial procedure and later re-interventions.

Endovenous stenting in chronic venous disease secondary to iliac vein obstruction

2019 ◽  
Vol 26 (2) ◽  
Author(s):  
Mohamed A. Taha ◽  
Tristan Lane ◽  
Joseph Shalhoub ◽  
Alun H. Davies
Keyword(s):  
Iliac Vein ◽  
Chronic Venous Disease ◽  
Venous Disease

scholarly journals A Systematic Review of Endovenous Stenting in Chronic Venous Disease Secondary to Iliac Vein Obstruction

2016 ◽  
Vol 63 (2) ◽  
pp. 555-556 ◽  
Author(s):  
M.J. Seager ◽  
A. Busuttil ◽  
B. Dharmarajah ◽  
A.H. Davies
Keyword(s):  
Systematic Review ◽  
Iliac Vein ◽  
Chronic Venous Disease ◽  
Venous Disease

scholarly journals Interrelation of venous and osteoarticular pathology in patients with Giacomini's vein

2021 ◽  
Author(s):  
G. V. Yarovenko ◽  
A. I. Zhdanova
Keyword(s):  
Soft Tissues ◽  
Lower Extremities ◽  
Chronic Venous Disease ◽  
Venous Stasis ◽  
Venous Disease ◽  
Pearson Criterion ◽  
The Third ◽  
Group I ◽  
Venous Diseases ◽  
The Relationship

Objective: To establish a possible relationship between the Giacomini vein and osteoarticular pathology of the lower extremities in chronic venous diseases (CVD).Materials and methods. In 115 examined patients (out of 321), we identified the Giacomini vein (92 women, 23 men). The average age of men was 44.82 ± 1.62 years; women – 45.36 ± 3.31 years. All patients were divided into 3 groups by anatomical randomization. The first group was without pathology, the second group of patients had only CVD, and the third group included patients with CVD and osteoarticular pathology. The criteria for inclusion in the groups were: the presence of Giacomini vein in patients, chronic venous disease and osteoarticular pathology on one or both lower extremities. Exclusion criteria: age of patients less than 18 years, the presence of CVD C5-C6 according to the CEAP classification, post-traumatic changes in the osteoarticular system, post-thrombotic transformation of the veins of the lower extremities. Using triplex angioscanning, the anatomical features of the structure of the venous system of the lower extremities were assessed. The study of the condition of the foot was carried out using the Friedland method.Results. Group I with an absolute norm of the venous and osteoarticular systems included 30 people (26 %). The second group consisted of 45 patients (39.22 %) with CVD C0-C4 according to CEAP, and the third group consisted of 40 patients (34.78 %) who, in addition to venous, osteoarticular pathology. Chronic venous diseases in patients of groups II and III were distributed as follows: C0 – 25.6 %; C1 – 16.4 %; C2 – 49.4 %; C3 – 4.3 %; C4 – 4.3 % on the CEAP scale. Among the osteoarticular pathology, the most numerous group consisted of changes in the configuration of the foot, non-traumatic deformities – 32 (27.81 %) cases. To confirm the relationship between venous and osteoarticular pathology, we used the Pearson criterion. We found a significant correlation in the presence of nontraumatic deformities of the foot in the group of patients with CVD (Pearson's criterion 0.749642; p < 0.22). A strong correlation was established between the age of patients and changes in the venous and osteoarticular systems of the lower extremities (Pearson's criterion 0.7677696; p < 0.22), which confirms the relationship between the development of nontraumatic changes in the foot and CVD in patients with Giacomini vein with age.Conclusion. It was found that the presence of an altered Giacomini vein leads to an aggravation of venous stasis in the lower extremities, which in turn increases the likelihood of developing venous pathology. Chronic diseases of the veins of the lower extremities contribute to dystrophic changes in soft tissues, most pronounced in the distal part of the extremity and, as a consequence, predispose to the development of osteoarticular pathology. 

scholarly journals Portuguese translation and Brazilian cultural adaptation of the Assessment of Burden in Chronic Venous Disease questionnaire (ABC-V)

2018 ◽  
Vol 28 (1) ◽  
pp. 89 ◽  
Author(s):  
Rafael Cunha de Almeida ◽  
Paulo Roberto Zamfolini Zachêu ◽  
Mariana Terra Diniz ◽  
Maria Carolina Cozzi Pires de Oliveira Dias ◽  
Isabella Cherkezian Guiguer ◽  
...  
Keyword(s):  
Chronic Venous Disease ◽  
Public Health Issue ◽  
Venous Disease ◽  
Culturally Adapted ◽  
Venous Diseases ◽  
Wide Range ◽  
Draft Version ◽  
Pilot Sample ◽  
The Impact ◽  
Disease Questionnaire

Introduction: The Assessment of Burden in Chronic Venous Disease questionnaire (ABC-V) is a valuable tool for assessing the impact that chronic venous disease (CVD) has on patients’ quality of life (QL). There was a need for a translated and adapted version suitable for use in the Brazilian population. CVD is becoming a public health issue as the incidence and prevalence are high. The ABC-V can be used to collect information on patients’ QL and thus the development of a Brazilian version that facilitates research into the CVD population. Objective: To provide translation and cultural validation of the Assessment of Burden in Chronic-Venous Disease (ABC-V) questionnaire for the Portuguese language. Methods: The ABC-V was translated into Portuguese by two bilingual translators working independently. The translators then created a consensus version, which was translated back into English by two native English speakers. Finally all the versions were analysed by a committee of with expertise in translation and the two cultures involved. The committee produced a draft Portuguese-language version which was tested in a pilot sample of between 30 and 40 people. The committee evaluated feedback from the pilot sample on the clarity and comprehensibility of the draft version.  Results: The draft version was completed by 31 patients at the Chronic Venous Diseases Department of Padre Anchieta’s Teaching Hospital. With the analysis of the questionnaires used in the pre-test, it is possible to observe that in English, unlike Portuguese, verbs are often used in the passive tense. It also emerged that there was a need to use more colloquial terms and expressions so that the question would be easier to understand, whilst preserving the meaning of the original items. Changing the tone of the questionnaire in this way should make it more suitable for use with people from a wide range of socioeconomic levels, especially those with lower social status and less education. Because the questions are qualitative rather than quantitative they are more open to interpretation and elicit more subjective responses. This creates an additional difficulty in adapting the questionnaire for the Brazilian cultural context. The data from pilot-testing of the draft version was used to develop a translated and culturally adapted version of the ABC-V using the procedure described by Beaton et al.  Conclusion: A translated and culturally adapted version of the ABC-V suitable for use in Brazil has been developed and can be used to evaluate changes in the QL of Brazilian patients with CVD.

scholarly journals A Case of Successful Iliofemoral Vein Stenting from Great Saphenous Vein Access

2018 ◽  
Vol 21 (6) ◽  
pp. E472-E475
Author(s):  
Hae Won Jung ◽  
Chul-Min Ahn ◽  
Young-Guk Ko
Keyword(s):  
Clinical Significance ◽  
Treatment Option ◽  
Saphenous Vein ◽  
Great Saphenous Vein ◽  
Good Alternative ◽  
Iliac Vein ◽  
Chronic Venous Disease ◽  
Venous Disease ◽  
Vein Access ◽  
Successful Case

Chronic venous disease is strongly associated with morbidity and leads to considerable medical costs. Therefore, its clinical significance is very important. Currently, iliac vein stenting is the first treatment option for chronic venous disease due to iliac vein obstruction. For iliac vein stenting, ipsilateral femoral or popliteal vein access is common. However, great saphenous vein access may be a good alternative if there is obstruction in the ipsilateral femoropopliteal vein. Until now, there has been no reported case of successful iliac vein stenting using great saphenous vein access. We report the first successful case of iliofemoral vein stenting from great saphenous vein access.

Thermal Diagnostics in Chronic Venous Disease

2017 ◽  
pp. 34-54
Author(s):  
Armand Cholewka ◽  
Karolina Sieroń-Stołtny ◽  
Joanna Kajewska ◽  
Agnieszka Cholewka ◽  
Zofia Drzazga ◽  
...  
Keyword(s):  
Lower Limb ◽  
Thermal Imaging ◽  
Screening Method ◽  
Lower Extremities ◽  
Chronic Venous Disease ◽  
Venous Disease ◽  
Venous Diseases ◽  
Diagnostic Usefulness ◽  
Thermovision Diagnostics ◽  
Thermal Diagnostics

The aim of the study was to determine the diagnostic usefulness of thermal imaging as tool to find quantitative parameters in lower-limb primary chronic venous diseases and insufficiency of superficial veins. There were significant differences obtained in thermal maps of lower extremities between patients and healthy. The correlations were obtained between temperature parameters counted from thermal imaging and duplex scanning. Such results also suggest that thermovision diagnostics may be useful as a complementary and first of all objective method that can be used in the diagnosis of chronic venous diseases in the lower extremities. It may suggest that thermovision may be used as a screening method or together with an ultrasound diagnosis in different superficial veins disorders.

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