scholarly journals Orofacial Cleft Frequency Differences Depending on Geographic Origin: Coast vs. Inland

2021 ◽  
Vol 2 ◽  
Author(s):  
Alexandre Rezende Vieira ◽  
Paulo Germano Cavalcanti Furtado ◽  
Valdécio Vasconcelos Lacerda Filho ◽  
Jéssica Amorim Teotônio Pereira ◽  
Isabelle Silvério Tenório ◽  
...  

Objective: Cleft lip and/or palate is the most common congenital anomaly in a human face, with a multifactorial and complex etiology. Although many studies have been developed, the role of the environment is still unclear. This study aims to test the hypothesis that differences in lifestyle and environment change the reproductive risks of orofacial clefts.Methods: A total of 2,422 medical records of individuals born with cleft lip and/or palate in a reference center in the northeast of Brazil over a period of 30 years were analyzed. Data on the cleft type, geographic origin of the patient (coast or inland), presence of associated congenital anomalies or syndromes, maternal age, and maternal parity were recorded. Differences in frequencies between the cleft types were compared based on geographic origin, maternal age, and parity. Chi-square, Student's t, Kruskal–Wallis, and logistic regression were used to analyze the interference of covariables on the cleft type.Results: The distribution of cleft types was significantly different between the coastal and inland areas (chi-square test, p < 0.0001). A higher frequency of cleft lip with or without palate was observed the inland area (chi-square test, p = 0.0006), while cleft palate only (chi-square test, p = 0.003) and rare facial clefts (chi-square test, p = 0.004) were more frequent in the coastal area. No difference was found in the distribution of maternal age (t-test, p > 0.05) between the two geographic areas, but parity was higher inland (t-test, p = 0.04). Logistic regression suggested that parity explained just a small portion of the differences in frequency between cleft types of the coast vs. inland.Conclusion: Frequency of orofacial cleft types differs by geographic area in this region of the South American continent.

RSBO ◽  
2017 ◽  
Vol 14 (2) ◽  
pp. 86-93
Author(s):  
Madiana Magalhães Moreira ◽  
Pedro Diniz Rebouças ◽  
Maria Lúcia Bonfim Chagas ◽  
Luan Cartaxo Félix ◽  
Paulo Goberlânio de Barros Silva ◽  
...  

Cleft lip and palate (CLP) is the most frequent congenital malformation among the anomalies of the head and neck. The orthopedic/orthodontic treatment is included in the rehabilitation of these individuals, however there is no consensus in the literature regarding the ideal time for its beginning. Objective: To verify and characterize the profile of individuals with CLP treated at a reference hospital of the northeast of Brazil from 1998 to 2013 and its association with the beginning of the orthopedic/ orthodontic treatment. Material and methods: Through direct observation of medical records, panoramic radiograph, and study casts of 323 individuals, data regarding sex, cleft type, origin and age of beginning of the orthopedic/orthodontic treatment were surveyed and analyzed using the chi-square test, considering a 5% level of significance. Results: Most of the individuals had transforamen and the unilateral cleft was the most prevalent (p<0.05). Females were statistically more affected by post-foramen cleft and males by trans-foramen cleft (p><0.05). Most individuals with trans-foramen cleft and post-foramen cleft started the orthopedic/ orthodontic treatment between 8 and 12 years old (p><0.05). No statistically significant differences occurred relating the beginning><0.05). Females were statistically more affected by post-foramen cleft and males by trans-foramen cleft (p<0.05). Most individuals with trans-foramen cleft and post-foramen cleft started the orthopedic/ orthodontic treatment between 8 and 12 years old (p<0.05). No statistically significant differences occurred relating the beginning> <0.05). No statistically significant differences occurred relating the beginning of the orthopedic/orthodontic treatment with geographic origin and sex of, although most of them have started treatment at late mixed dentition. Conclusion: Regardless of gender, origin, or cleft type, most patients started orthopedic treatment up to 12 years-old, an age considered ideal by most protocols. Unilateral and trans-foramen cleft were the most prevalent cleft types. post-foramen cleft affected more females, while trans-foramen cleft affected more males.


2020 ◽  
Vol 1 (3) ◽  
pp. 190-196
Author(s):  
Yunitasari ◽  
Nopi Sani ◽  
Arti Febriyani ◽  
I Nengah Budiarta

Abnormalities lip and palate or cleft lip commonly called congenital abnormality or labioschizis is a gap between the right and/or left lip. The incidence of cleft lip with or without cleft palate is one per 700-1000 births worldwide and Asians have the highest risk. Infant death or disability, even the mother died during childbirth in pregnancy aged 35 years and over. Giving birth at the age of 35 years and over, babies who are born susceptible to genetic abnormalities. The purpose of this study was to determine the relationship between maternal age of  ≥35 years with labioschizis incident. This study used cross-sectional design: Retrospective, data was collected from the medical records during the period 1 January 2018 to 31 December 2018. The number of samples of 138 respondents, data was analyzed using the chi-square test with a significance level of ρvalue < 0.05. The results showed that most respondents had labioschizis namely 65.9%, while 34.1% of respondents experienced palatoschizis and labiognatoschizis. The lives of most mothers with children experiencing labioschizis are ≥35 years of age is 57.1%. The results of the study there was no correlation between a maternal age ≥ 35 years with the incidence labioschizis with value 0.793 ρvalue means sig >0.05. However, based on the data that researchers get the respondent with maternal age of 35 years tend to have labioschizis, meaning that the older a pregnant woman would be more risk of having babies with labioschizis.


2021 ◽  
Vol 2 (2) ◽  
pp. 38-49
Author(s):  
Asriwati Amirah ◽  
Thomson P Nadapdap ◽  
Suryani Suryani

This study aims to determine the factors associated with neonatal mortality 0-28 days in Central Aceh District in 2020. This research is a quantitative study with a case control research design and uses a retrospective approach. The study population was all mothers giving birth whose babies died at the age of 0-28 days from January to December 2020. The sample in this study was 120 respondents consisting of 60 cases and 60 controls. The sampling technique used was total sampling. Data analysis using chi square test and multiple logistic regression test. The results of the bivariate analysis using the chi square test showed that there were 2 variables that were significantly related to neonatal mortality, namely the maternal age variable with p value = 0.012 and the pregnancy examination variable with p value = 0.047. The results of multivariate analysis with multiple logistic regression test showed that there were 3 variables that influenced neonatal mortality, namely the maternal age variable with a p value of 0.001, the birth spacing variable with a p value of 0.018 and the pregnancy examination variable with a p value of 0.018, while the most dominant variable affecting the incidence of death Neonatal age is the variable of maternal age with an OR value of 4.397.


RSBO ◽  
2017 ◽  
Vol 1 (2) ◽  
pp. 86 ◽  
Author(s):  
Madiana Magalhães Moreira ◽  
Pedro Diniz Rebouças ◽  
Maria Lúcia Bonfim Chagas ◽  
Luan Cartaxo Félix ◽  
Mário Rogério Mota

Cleft lip and palate (CLP) is the most frequent congenital malformation among the anomalies of the head and neck. The orthopedic/orthodontic treatment is included in the rehabilitation of these individuals, however there is no consensus in the literature regarding the ideal time for its beginning. Objective: To verify and characterize the profile of individuals with CLP treated at a reference hospital of the northeast of Brazil from 1998 to 2013 and its association with the beginning of the orthopedic/ orthodontic treatment. Material and methods: Through direct observation of medical records, panoramic radiograph, and studycasts of 323 individuals, data regarding sex, cleft type, origin and age of beginning of the orthopedic/orthodontic treatment were surveyed and analyzed using the chi-square test, considering a 5% level of significance. Results: Most of the individuals had transforamen and the unilateral cleft was the most prevalent (p<0.05). Females were statistically more affected by post-foramen cleftand males by trans-foramen cleft (p<0.05). Most individuals with trans-foramen cleft and post-foramen cleft started the orthopedic/ orthodontic treatment between 8 and 12 years old (p<0.05). No statistically significant differences occurred relating the beginning of the orthopedic/orthodontic treatment with geographic origin and sex of, although most of them have started treatment at late mixed dentition. Conclusion: Regardless of gender, origin, or cleft type, most patients started orthopedic treatment up to 12 years-old, an age considered ideal by most protocols. Unilateral and trans-foramen cleft were the most prevalent cleft types. post-foramen cleft affected more females, while trans-foramen cleft affected more males.


Author(s):  
Corrie Miller ◽  
Eunjung Lim

Abstract Aims Gestational diabetes (GDM) increases the risk of developing type 2 diabetes and thus warrants earlier and more frequent screening. Women who give birth to a macrosomic infant, as defined as a birthweight greater than 9 lbs. (or approximately 4000 g), are encouraged to also get early type 2 diabetes screening, as macrosomia may be a surrogate marker for GDM. This study investigates whether a macrosomic infant, as defined as 9lbs, apart from GDM, increases the risk for diabetes later in life. Methods Data on parous women from the National Health and Nutrition Examination Survey (NHANES) 2007–2016 were utilized. Rates of diabetes were compared in those with and without macrosomic infants in Rao-Scott’s chi-square test. Multiple logistic regression was used to test the independent effect of macrosomia on type 2 diabetes controlling for the confounding covariates and adjusting for the complex sampling design. To investigate how onset time affects diabetes, we implemented Cox proportional hazard regressions on time to have diabetes. Results Among 10,089 parous women, macrosomia significantly increased the risk of maternal diabetes later in life in the chi-square test and logistic regression. Independent of GDM, women who deliver a macrosomic infant have a 20% higher chance of developing diabetes compared to women who did not. The expected hazards of having type 2 diabetes is 1.66 times higher in a woman with macrosomic infant compared to counterparts. Conclusions Women who gave birth to a macrosomic infant in the absence of GDM should be offered earlier and more frequent screening for type 2 diabetes.


Author(s):  
Gengyu Han ◽  
Jingshu Zhang ◽  
Shang Ma ◽  
Ruoran Lu ◽  
Jiali Duan ◽  
...  

Background: Given the widespread prevalence and serious nature of Internet addiction (IA), this study aimed to estimate the prevalence of IA and assess the relationships between IA and combinations of physical activity (PA) and screen-based sedentary behavior (SB) among adolescents in China. Methods: This cross-sectional study surveyed 31,954 adolescents in grades 7 to 12 in Beijing. IA, PA, screen-based SB, and other information were obtained from a self-administrated questionnaire. The chi-square test and mixed-effects logistic regression model were applied to estimate the relationship between IA and combinations of PA and screen-based SB. Results: 6.2% of the surveyed adolescents reported IA and the prevalence of low PA/high screen-based SB, high PA/high screen-based SB, low PA/low screen-based SB, and high PA/low screen-based SB were 53.7%, 19.5%, 18.8%, and 8.0%, respectively. Mixed-effects logistic regression analysis showed that adolescents with low PA/high screen-based SB were 1.99 (95% confidence interval, 1.62–2.44, P < .001) times more likely to prefer IA than those with high PA/low screen-based SB. Conclusions: The prevalence of IA among Chinese adolescents is still high. Intervention programs like maintaining sufficient PA and reducing screen-based SB might contribute to reducing their IA.


1970 ◽  
Vol 28 (5) ◽  
Author(s):  
Adebola Emmanuel Orimadegun ◽  
Bose Etaniamhe Orimadegun ◽  
Elijah Afolabi Bamgboye

BACKGROUND: Unresolved questions remain concerning the protective effect and duration of immunity acquired from mothers. This study investigated persistence of immunity against tetanus in the first two weeks of life among neonates in Nigeria.METHODS: In a longitudinal study, 244 primiparous mothers and their newborns were consecutively recruited at 16 selected Primary Healthcare Centres in Ibadan, Nigeria. All the newborns were tested for protection against tetanus using a validated rapid diagnostic, “Tetanos Quick Sticks” (TQS) on days 1, 7 and 14. Persistent immunity was defined as positive TQS result on day-14. Data were analysed using descriptive statistics, Chi-square and logistic regression at p = 0.05.RESULTS: There were 137(56.1%) male neonates; 87.7% were delivered at ≥37weeks of gestation. The prevalence of protective immunity against tetanus (PIaT) among neonates on day-1 was 63.5%; 119 out of 153 neonates remained positive to TQS test by day-14, giving a persistence rate of 77.8%. Independent predictors of persistent PIaT were residence in urban area (OR = 9.66; 95% CI = 2.42-38.45), maternal age (OR = 2.06; 95% CI = 1.49-2.85) and gestational age (OR = 1.84; 95% CI = 1.23-2.74).CONCLUSION: Protective immunity against tetanus waned in some neonates over the first two weeks of life, and this decline was inversely related to maternal and gestational ages.


2021 ◽  
Author(s):  
Rong Xue ◽  
Ningdao Li ◽  
Zhurong Ji ◽  
Xingdong Cheng ◽  
Zhuqiu Zhang ◽  
...  

Abstract Background: Dysphagia is one of the most common complications after anterior cervical spine surgery. The study aimed to evaluate the risk factors for dysphagia after anterior cervical discectomy and fusion (ACDF) with the Zero-P Implant System by multidimensional analysis and investigated the predictive values of these risk factors for dysphagia. Methods: A retrospective analysis of 260 patients who underwent ACDF with the Zero-P Implant System and had at least 2 year of follow-up ware performed. All patients were divided into a non-dysphagia group and a dysphagia group. Sex, age, body mass index (BMI), intraoperative time, estimated blood loss, diabetes mellitus, hypertension, smoking, alcohol consumption, prevertebral soft-tissue thickness, the levels of surgery, O-C2 angle, C2–7 angle, T1 slope and segmental angle were analyzed. Chi-square test and logistic regression were performed to analyze the predictive value of each dimension for dysphagia. Results: In total, the non-dysphagia group comprised 170 patients and the dysphagia group comprised 90 patients. Chi-square test results indicated that number of operated levels, operation time dT1 slope, dO-C2 angle, dC2–7 angle, segmental angle and dPSTT were associated with a high incidence of dysphagia. Multivariate logistic regression analysis showed that number of operated levels, operation time, dC2–7 angle and dPSTT were significantly associated with postoperative dysphagia.Conclusions: Number of operated levels, operation time, dC2–7 angle and dPSTT were significantly associated with postoperative dysphagia. In additionally, sufficient preoperative preparation, evaluation combining with proficient and precise treatment measures are suggested to reduce the incidence of postoperative dysphagia when ACDF is performed.


2017 ◽  
Vol 39 (2) ◽  
pp. 103
Author(s):  
Muhammad Iqbal ◽  
Susetyowati Susetyowati ◽  
Martalena Br Purba

The improvement of patients’ food satisfaction and acceptance in the hospitals is primarily needed in the food service  system.  Room service is a new concept in the food service area. This study aims to compare the effects of two different types of food service systems; room service and conventional service system. The study with quasi-experimental design is conducted to the subject of 66 inpatients who were taken using a quota sampling method. Subjects were divided into different groups, the treatment groups (room service) and control groups (conventional). Leftover food between groups was compared for 9 large meals to determine acceptability. Food satisfaction is measured on the last day with using questionnaire. The study was conducted in April-June 2014. Chi-Square test and logistic regression were used for analysis of research data. There were significant differences food satisfaction (RR=4.6; p=0.0001) and food acceptance (RR=1.94; p=0.0488) between control and treatment group. The logistic regression test showed that room service group had higher food satisfaction and food acceptance level than control group after controlling confounding factors, which were 12,11 times (95% CI 3,593 – 37,219) and 2,38 times (95% CI 0,68-8,31), respectively. The room service increases food satisfaction and food acceptance of patients compared with conventional systems.


2018 ◽  
Vol 11 (1) ◽  
pp. 21
Author(s):  
Army Novitasari ◽  
Gangsar Indah Lestari ◽  
Martini Fairus

<p><strong><em>Background:</em></strong><strong><em> </em></strong><em>The most common reproductive disease among Indonesian women is uterine myoma. The number of occurrences of this disease in Indonesia ranks second after cervical cancer. </em><strong><em>Purpose:</em></strong><em> </em><em>This study aims to determine the relationship between maternal age and parity with the incidence of uterine myoma at Mardi Waluyo Metro Hospital in 2016.</em><em> </em><strong><em>Methods:</em></strong><em> </em><em>This study uses a cross sectional design. The study sample was 141 respondents. The independent variable of the study was maternal age and parity, while the dependent variable was uterine myoma. Data analysis using univariate and bivariate analysis. Bivariate analysis using chi square test.</em><em> </em><strong><em>Results:</em></strong><em> </em><em>The results showed that there was a relationship between maternal age (p = 0,000) and parity (p = 0,000) with the incidence of uterine myoma at Mardi Waluyo Metro Hospital.</em><em> </em><strong><em>Conclusion:</em></strong><em> </em><em>The conclusions of this study are maternal age and parity are factors that increase the incidence of uterine myoma. Prevention efforts and reducing the incidence of uterine myoma need to be improved by early detection of women with age and risky parity.</em><em></em></p>


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