scholarly journals The Depletion of Carbohydrate Metabolic Genes in the Gut Microbiome Contributes to the Transition From Central Obesity to Type 2 Diabetes

2021 ◽  
Vol 12 ◽  
Author(s):  
Ruikai Jia ◽  
Min Huang ◽  
Lichun Qian ◽  
Xiaoye Yan ◽  
Qing Lv ◽  
...  

Obesity, especially central obesity, is a strong risk factor for developing type 2 diabetes (T2D). However, the mechanism underlying the progression from central obesity to T2D remains unknown. Therefore, we analyzed the gut microbial profiles of central obese individuals with or without T2D from a Chinese population. Here we reported both the microbial compositional and gene functional alterations during the progression from central obesity to T2D. Several opportunistic pathogens were enriched in obese T2D patients. We also characterized thousands of genes involved in sugar and amino acid metabolism whose abundance were significantly depleted in obese T2D group. Moreover, the abundance of those genes was negatively associated with plasma glycemia level and percentage of individuals with impaired plasma glucose status. Therefore, our study indicates that the abundance of those depleted genes can be used as a potential biomarker to identify central obese individuals with high risks of developing T2D.

Diabetes Care ◽  
2006 ◽  
Vol 29 (5) ◽  
pp. 1128-1129 ◽  
Author(s):  
H. Ohnishi ◽  
S. Saitoh ◽  
S. Takagi ◽  
N. Katoh ◽  
Y. Chiba ◽  
...  

JAMA ◽  
2013 ◽  
Vol 310 (8) ◽  
pp. 821 ◽  
Author(s):  
Lu Qi ◽  
Qibin Qi ◽  
Sabrina Prudente ◽  
Christine Mendonca ◽  
Francesco Andreozzi ◽  
...  

2021 ◽  
Author(s):  
TAKUMI KITAMOTO ◽  
Taiyi Kuo ◽  
Atsushi Okabe ◽  
Atsushi Kaneda ◽  
Domenico Accili

Abnormalities of lipid/lipoprotein and glucose metabolism are hallmarks of hepatic insulin resistance in type 2 diabetes. The former antedate the latter, but the latter become progressively refractory to treatment and contribute to therapeutic failures. It's unclear whether the two processes share a common pathogenesis and what underlies their progressive nature. In this study, we investigated the hypothesis that genes in the lipid/lipoprotein pathway and those in the glucose metabolic pathway are governed by different transcriptional logics that affect their response to physiologic (fasting/refeeding) as well as pathophysiologic cues (insulin resistance and hyperglycemia). To this end, we obtained genomic and transcriptomic maps of the key insulin-regulated transcription factor, FoxO1, and integrated them with those of CREB, PPARα, and glucocorticoid receptor. We found an enrichment of glucose metabolic genes among those regulated by intergenic and promoter enhancers in a fasting-dependent manner, while lipid genes were enriched among fasting-dependent intron enhancers and fasting-independent enhancer-less introns. Glucose genes also showed a remarkable transcriptional resiliency, i.e., an enrichment of active marks at shared PPARα/FoxO1 regulatory elements when FoxO1 was inactivated. Surprisingly, the main features associated with insulin resistance and hyperglycemia were a ″spreading″ of FoxO1 binding to enhancers, and the emergence of target sites unique to this condition. We surmise that this unusual pattern correlates with the progressively intractable nature of hepatic insulin resistance. This transcriptional logic provides an integrated model to interpret the combined lipid and glucose abnormalities of type 2 diabetes.


2020 ◽  
Vol 42 (3) ◽  
pp. 92-96
Author(s):  
Ishwor Sharma ◽  
Sanjay K Gupta ◽  
Kiran Niraula

Introduction Overweight and obesity with their surrogate anthropometric markers like body mass index (BMI), waist circumference (WC) and waist hip ratio (WHR) have been shown to be strongly associated with Type 2 diabetes mellitus. Neck circumference (NC) though less used can be an equally effective alternative to diagnose overweight and obesity in patients with Type 2 diabetes mellitus in a resource limited setting. MethodsPatients who had Type 2 Diabetes Mellitus for 5 years or more and above 35 years underwent simple random sampling. Weight, height, WC and NC were measured. BMI was calculated and patients were graded into overweight and obesity based on the Asian cutoffs for BMI and abdominal obesity. ResultsAmong 100 patients enrolled in this study, 45% were men and the mean age was 53.05. Mean neck circumference was 36.55 ± 1.28 cm and 35.27 ± 1.78 cm for male and female respectively. NC was positively correlated with WC and BMI in both men and women (p ˂ 0.001). In the ROC curves, NC presented the largest area under the curve (AUC) for overweight in males (p ˂ 0.001), while NC presented a large AUC for central obesity in both genders. Furthermore, the cut off value of neck circumference for overweight was 35.6 cm in males vs 35.2 cm in females and for central obesity was 36.75 cm in males vs 34.75 cm in females. ConclusionNeck circumference was positively associated with overweight and central obesity in patients with type 2 diabetes mellitus.


2017 ◽  
Vol 10 (2) ◽  
pp. 109
Author(s):  
Riyanto Riyanto

<strong><strong></strong></strong><strong><em>Background:</em></strong><em> Type 2 diabetes is a disorder that is influenced by multifactors, involving both genetic and environmental factors. <strong>Purpose:</strong> This study aims to find a large estimate of hereditary risk factors for type 2 events by controlling controlling for other confounding variables. <strong>Methods:</strong> This study used a cross sectional design analysis model estimation with the main variable heredity. The research sample of at least 249 respondents. Measurement and observation of research variables using interview and observation methods. Multivariate analysis of estimation models uses multiple logistic regression tests and calculated attributable fraction percent (AF%). <strong>Results:</strong> The results of the final multivariate modeling analysis showed heredity was associated with the incidence of type 2 Diabetes (p value 0,000), after being controlled by confounding factors for BMI, occupation, age and central obesity with ORadjusted 19.8; 95% CI: 1,911-9,459). Calculation of the potential impact size (AF%) results of the analysis obtained 48.15%. <strong>Conclusion:</strong> The estimated magnitude of respondents who have inherited risk factors is 19.8 times more likely to have diabetes than those without heredity after being controlled by confounders of BMI, occupation and age and central obesity. People with Type 2 Diabetes who have a history of diabetes, live a healthy lifestyle, so that around 48.15% of diabetes can be prevented through hereditary factors.</em>


Diabetes Care ◽  
2015 ◽  
Vol 38 (7) ◽  
pp. 1306-1311 ◽  
Author(s):  
Tao Huang ◽  
Qibin Qi ◽  
Yan Zheng ◽  
Sylvia H. Ley ◽  
JoAnn E. Manson ◽  
...  

2020 ◽  
Vol 9 (2) ◽  
pp. 369 ◽  
Author(s):  
Agnieszka Sroka-Oleksiak ◽  
Agata Młodzińska ◽  
Małgorzata Bulanda ◽  
Dominika Salamon ◽  
Piotr Major ◽  
...  

Numerous scientific studies confirm that, apart from environmental and genetic factors, a significant role is played by gastrointestinal microbiota in the aetiology of type 2 diabetes and obesity. Currently, scientists mainly focus on the distal intestinal microbiota, while the equally important proximal parts of the intestine are overlooked. The aim of the study was a qualitative analysis of the structure of the duodenal mucosa microbiota in groups of patients with obesity and with type 2 diabetes and where obesity qualified for bariatric surgery: sleeve gastrectomy. The microbiological results obtained were compared with some clinical parameters. As a result, it was possible to determine the microbiological core that the treatment and control groups had in common, including phyla: Firmicutes, Proteobacteria, and Actinobacteria. The patients with obesity and with type 2 diabetes and obesity presented a significantly lower number of genus Bifidobacterium compared to healthy subjects. Furthermore, the numbers of Bifidobacterium were positively correlated with the high density lipoprotein (HDL) concentration in the groups under study. The obtained results indicate that bacteria of the genus Bifidobacterium should be considered in the future in the context of a potential biomarker in the progress of type 2 diabetes and obesity.


2020 ◽  
Vol 21 (21) ◽  
pp. 8075
Author(s):  
Milou M. Oosterwijk ◽  
Stephan J.L. Bakker ◽  
Tom Nilsen ◽  
Gerjan Navis ◽  
Gozewijn D. Laverman

Circulating calprotectin is a potential biomarker for endovascular inflammation in type 2 diabetes mellitus (T2DM). We investigated the determinants of calprotectin and its relationship with the presence of cardiovascular disease (CVD) in 362 T2DM patients included in the Diabetes and Lifestyle Cohort Twente-1 (DIALECT-1) study. Lifestyle exposures, including nutrition, were determined by validated questionnaires. CVD was defined as coronary artery diseases, strokes, and peripheral artery diseases. Median serum calprotectin levels were 1.04 mg/L [IQR: 0.73–1.46 mg/L] and were higher in women (1.11 mg/L) than men (0.96 mg/L, p = 0.007). Current smoking was a major independent determinant of circulating calprotectin, with a 51% higher calprotectin compared to never smoking (p < 0.001). Albuminuria (p = 0.011), former smoking (p = 0.023), and intake of mono- and disaccharides (p = 0.005) also contributed independently to circulating calprotectin. Each incremental increase in calprotectin level was associated with 1.36-times higher odds for CVD (95% CI 1.04–1.77, p = 0.026). In the current study, calprotectin was the only inflammatory parameter significantly associated with CVD. The strong association of circulating calprotectin with smoking, a well-known direct cause of vascular inflammation, and also with CVD, stresses the urge for further research to define its role as a biomarker in T2DM.


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