A Systematic Review and Meta-Analysis on Multiple Cytokine Gene Polymorphisms in the Pathogenesis of Periodontitis

AimPeriodontitis is an inflammatory disease that destroys both soft and hard periodontal tissues. However, a complex periodontal cytokine network remains unclear. This systematic review explored multiple cytokine gene polymorphisms in the pathogenesis of periodontitis.Material and MethodsA systematic search was performed using the databases from previous publications, which indicated the association between cytokine polymorphisms and periodontitis pathogenesis. Meta-analysis was conducted using fixed or randomized models to calculate the significance of multiple cytokine polymorphisms. A total of 147 articles were analyzed with polymorphisms in 12 interleukins [Th1 (IL-2, IFN-γ, and TNF-α), Th2 (IL-4 and IL-13), Th17 (IL-1α, IL-1β, IL-6, and IL-17), and Treg cytokines (IL-10 and TGF-β)]. Doi plot was used to probe the occurrence of publication bias.ResultsThe polymorphisms of IL-2 and TNF-α of Th1 cytokine family may be associated with the pathogenesis or the prevention of periodontitis risk, while the polymorphism of IFN-γ is not related to periodontitis risk. The polymorphisms for IL-4 and IL-13 of Th2 cytokine family are not found to be associated with the pathogenesis of periodontitis. For the polymorphisms of the members of Th17 cytokine family, different IL-1α polymorphisms may have inverse actions in the pathogenesis of periodontitis. IL-1β is a noteworthy cytokine biomarker in periodontitis development and progression. IL-6 may have a protective function in the inflammatory responses of periodontitis, and IL-17 has a weak relationship the inflammatory responses. The polymorphisms for the members of Treg cell cytokines may have a protective function against periodontitis risk. LFK indexes show the major asymmetry due to publication bias.ConclusionIL-1β is a notable cytokine biomarker in periodontitis risk. Treg cytokines favor an anti-inflammatory and protective environment. Further data are needed to confirm the present conclusion due to publication bias.

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Cytokine gene polymorphisms are associated with irritable bowel syndrome: a systematic review and meta-analysis

Neurogastroenterology & Motility ◽

10.1111/j.1365-2982.2012.01990.x ◽

2012 ◽

Vol 24 (12) ◽

pp. 1102-e566 ◽

Cited By ~ 34

Author(s):

M. Bashashati ◽

N. Rezaei ◽

H. Bashashati ◽

A. Shafieyoun ◽

N. E. Daryani ◽

...

Keyword(s):

Systematic Review ◽

Irritable Bowel Syndrome ◽

Gene Polymorphisms ◽

Meta Analysis ◽

Cytokine Gene ◽

Cytokine Gene Polymorphisms ◽

Irritable Bowel

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Meta-Analysis of Cytokine Gene Polymorphisms and Outcome of Heart Transplantation

BioMed Research International ◽

10.1155/2013/387184 ◽

2013 ◽

Vol 2013 ◽

pp. 1-8

Author(s):

Sasitorn Yongcharoen ◽

Sasivimol Rattanasiri ◽

D. Olga McDaniel ◽

Mark McEvoy ◽

Chukiat Viwatwongkaseam ◽

...

Keyword(s):

Heart Transplantation ◽

Publication Bias ◽

Graft Rejection ◽

Gene Polymorphisms ◽

Meta Analysis ◽

Cytokine Gene ◽

Control Groups ◽

Increased Risk ◽

Minor Alleles ◽

Cytokine Gene Polymorphisms

We performed a systematic review and meta-analysis with the aim of assessing the association between cytokine gene polymorphisms and graft rejection in heart transplantation. We identified relevant studies from Medline and Embase using PubMed and Ovid search engines, respectively. Allele frequencies and allele and genotypic effects were pooled. Heterogeneity and publication bias were explored. Four to 5 studies were included in pooling of 3 gene polymorphisms. The prevalences of the minor alleles for TNFα-308, TGFβ1-c10, and TGFβ1-c25 were 0.166 (95% CI: 0.129, 0.203), 0.413 (95% CI: 0.363, 0.462), and 0.082 (95% CI: 0.054, 0.111) in the control groups, respectively. Carrying the A allele for the TNFα-308 had 18% (95% CI of OR: 0.46, 3.01) increased risk, but this was not significant for developing graft rejection than the G allele. Conversely, carrying the minor alleles for both TGFβ1-c10 and c25 had nonsignificantly lower odds of graft rejection than major alleles, with the pooled ORs of 0.87 (95% CI: 0.65, 1.18) and 0.70 (95% CI: 0.40, 1.23), respectively. There was no evidence of publication bias for all poolings. An updated meta-analysis is required when more studies are published to increase the power of detection for the association between these polymorphisms and allograft rejection.

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Association Between Cytokine Gene Polymorphisms and Gastric Precancerous Lesions: Systematic Review and Meta-analysis

Cancer Epidemiology Biomarkers & Prevention ◽

10.1158/1055-9965.epi-09-0917 ◽

2010 ◽

Vol 19 (3) ◽

pp. 762-776 ◽

Cited By ~ 35

Author(s):

Bárbara Peleteiro ◽

Nuno Lunet ◽

Carla Carrilho ◽

Cecília Durães ◽

José Carlos Machado ◽

...

Keyword(s):

Systematic Review ◽

Gene Polymorphisms ◽

Precancerous Lesions ◽

Meta Analysis ◽

Cytokine Gene ◽

Cytokine Gene Polymorphisms

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The association between cytokine gene polymorphisms and graft rejection in liver transplantation: A systematic review and meta-analysis

Transplant Immunology ◽

10.1016/j.trim.2012.10.003 ◽

2013 ◽

Vol 28 (1) ◽

pp. 62-70 ◽

Cited By ~ 5

Author(s):

Sasivimol Rattanasiri ◽

D. Olga McDaniel ◽

Mark McEvoy ◽

Thunyarat Anothaisintawee ◽

Abhasnee Sobhonslidsuk ◽

...

Keyword(s):

Systematic Review ◽

Liver Transplantation ◽

Graft Rejection ◽

Gene Polymorphisms ◽

Meta Analysis ◽

Cytokine Gene ◽

Cytokine Gene Polymorphisms

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Associations between cytokine gene polymorphisms and susceptibility to Helicobacter pylori infection and Helicobacter pylori related gastric cancer, peptic ulcer disease: A meta-analysis

PLoS ONE ◽

10.1371/journal.pone.0176463 ◽

2017 ◽

Vol 12 (4) ◽

pp. e0176463 ◽

Cited By ~ 13

Author(s):

Jingjing Ma ◽

Dandan Wu ◽

Xue Hu ◽

Jiao Li ◽

Mingwei Cao ◽

...

Keyword(s):

Gastric Cancer ◽

Helicobacter Pylori ◽

Peptic Ulcer ◽

Peptic Ulcer Disease ◽

Gene Polymorphisms ◽

Meta Analysis ◽

Helicobacter Pylori Infection ◽

Cytokine Gene ◽

Ulcer Disease ◽

Cytokine Gene Polymorphisms

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Protein Cytokines, Cytokine Gene Polymorphisms, and Potential Acute Coronary Syndrome Symptoms

Biological Research For Nursing ◽

10.1177/1099800419857819 ◽

2019 ◽

Vol 21 (5) ◽

pp. 552-563

Author(s):

Sahereh Mirzaei ◽

Larisa Burke ◽

Anne G. Rosenfeld ◽

Susan Dunn ◽

Jennifer R. Dungan ◽

...

Keyword(s):

Acute Coronary Syndrome ◽

Gene Polymorphisms ◽

Nucleotide Polymorphisms ◽

Cytokine Gene ◽

Chest Discomfort ◽

Specific Symptom ◽

Arm Pain ◽

Coronary Syndrome ◽

Tnf Α ◽

Cytokine Gene Polymorphisms

The purpose of this study was to determine whether relationships exist among protein cytokines, cytokine gene polymorphisms, and symptoms of potential acute coronary syndrome (ACS). Participants included 438 patients presenting to the emergency department (ED) whose symptoms triggered a cardiac evaluation (206 ruled in and 232 ruled out for ACS). Presence or absence of 13 symptoms was recorded upon arrival. Levels of tumor necrosis factor α (TNF-α), interleukin (IL)-6, and IL-18 were measured for all patients. A pilot analysis of 85 patients (ACS = 49; non-ACS = 36) genotyped eight single-nucleotide polymorphisms (SNPs; four TNF and four IL6 SNPs). Logistic regression models were tested to determine whether cytokines or SNPs predicted symptoms. Increased levels of TNF-α and IL-6 were associated with a decreased likelihood of chest discomfort for all patients. Increased levels of IL-6 were associated with a lower likelihood of chest discomfort and chest pressure for ACS patients, and an increased likelihood of shoulder and upper back pain for non-ACS patients. Elevated IL-18 was associated with an increased likelihood of sweating in patients with ACS. Of the four TNF SNPs, three were associated with shortness of breath, lightheadedness, unusual fatigue, and arm pain. In all, protein cytokines and TNF polymorphisms were associated with 11 of 13 symptoms assessed. Future studies are needed to determine the predictive ability of cytokines and related SNPs for a diagnosis of ACS or to determine whether biomarkers can identify patients with specific symptom clusters.

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