scholarly journals Association Between Perforating Scleral Vessel and Myopic Maculopathy: A Cross-Sectional Study of a Chinese Cohort

2022 ◽  
Vol 8 ◽  
Author(s):  
Huimin Yu ◽  
Jinfu Sun ◽  
Huan Luo ◽  
Zhitao Wang ◽  
Xufang Sun
Keyword(s):  
Protective Factors ◽  
Cross Sectional Study ◽  
Pathologic Myopia ◽  
Cross Sectional ◽  
Different Types ◽  
Chinese Cohort ◽  
Cilioretinal Artery ◽  
Fundus Photographs ◽  
Stratified Analysis ◽  
Myopic Maculopathy

Purpose: To investigate the association between perforating scleral vessel (PSV) and different types of myopic maculopathy (MM) in a highly myopic population.Methods: In total, 188 highly myopic eyes (117 participants) were enrolled. Each participant underwent detailed history taking and ocular examinations. Based on fundus photographs and optical coherence tomography, patients were subdivided into the non-MM group and MM group. Based on a new classification system (ATN), MM cases were classified as myopic atrophy maculopathy (MAM), myopic tractional maculopathy (MTM), and myopic neovascular maculopathy (MNM). The number of PSV and the macular choroidal thickness (mChT) were measured.Results: Compared with non-MM group, MM group was characterized by relatively larger age (48.40 vs. 32.34; p < 0.001), longer axial length (AL, 29.72 vs. 27.75, p < 0.001), thinner mChT (52.90 vs. 122.52; p < 0.001), and lower PSV counts (6.73 vs. 9.47, p ≤ 0.001). The non-MM group had higher PSV counts in total area (0–9 mm, 9.47 vs. 6.73, p < 0.001) and perifovea area (3–9 mm, 7.25 vs. 4.71, p < 0.001) compared to the MM group. Univariate and multivariate analyses showed that PSV count had no association with MAM (p = 0.2419) and MTM (p = 0.5678). Total PSV count [odds ratio (OR) 0.78, 95% CI 0.64–0.95, p = 0.0149] and perifovea PSV count (OR 0.80, 95% CI 0.65–0.98, p = 0.0299) were both protective factors for MNM. The stratified analysis revealed that in groups with AL <28 mm, or mChT <50 μm, or mChT ≥100 μm, or eyes with cilioretinal artery, PSV count had no significant association with MNM.Conclusion: Higher PSV counts in perifovea area (3–9 mm centered fovea) and total area (0–9 mm centered fovea) were protective factors for MNM, whereas PSV count had no association with MAM and MTM. These findings may provide novel insights into the mechanisms of pathologic myopia.

scholarly journals Decreased choroidal and scleral thicknesses in highly myopic eyes with posterior staphyloma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Un Chul Park ◽  
Eun Kyoung Lee ◽  
Bo Hee Kim ◽  
Baek-Lok Oh
Keyword(s):  
Choroidal Thickness ◽  
Structural Changes ◽  
Meta Analysis ◽  
Cross Sectional Study ◽  
Pathologic Myopia ◽  
Sectional Study ◽  
Cross Sectional ◽  
Swept Source ◽  
Posterior Staphyloma ◽  
Myopic Maculopathy

AbstractIn this cross-sectional study, we investigated choroidal thickness (CT) and scleral thickness (ST) in highly myopic eyes and their associations with ocular factors. Patients underwent widefield swept-source optical coherence tomography (OCT) to measure the CT and ST at the subfovea and 3000 μm superior, inferior, temporal, and nasal to the fovea and macular curvature. A total of 237 eyes (154 patients) were included. At all five measurement points, thinner CTs and STs were associated with longer axial lengths (r = − 0.548 to − 0.357, all P < 0.001) and greater macular curvatures (r = − 0.542 to − 0.305, all P < 0.001). The CT and ST were significantly thinner in eyes with posterior staphyloma than in those without at all measurement points (all P ≤ 0.006) but did not differ between eyes with the wide macular and narrow macular type of staphyloma. Eyes with myopic maculopathy of category ≥ 3 according to the International Meta-Analysis for Pathologic Myopia classification had significantly thinner CTs and STs than those with category ≤ 2 (all P ≤ 0.005). In highly myopic eyes, a decrease in the CT and ST was more pronounced in eyes with more structural changes, such as longer axial length, steeper macular curvature, and the presence of posterior staphyloma.

Prevalence and risk factors of myopic maculopathy in rural southern China: the Yangxi Eye Study

2019 ◽  
Author(s):  
Zhixi Li ◽  
Ran Liu ◽  
Guangming Jin ◽  
Jason Ha ◽  
Xiaohu Ding ◽  
...  
Keyword(s):  
Southern China ◽  
Population Based ◽  
Cross Sectional Study ◽  
Fundus Photography ◽  
Cluster Sampling ◽  
Cross Sectional ◽  
Chorioretinal Atrophy ◽  
Southern Chinese ◽  
Fundus Photographs ◽  
Myopic Maculopathy

AimsTo evaluate the prevalence of myopic maculopathy among participants aged 50 years and older in rural southern China.MethodsPopulation-based, cross-sectional study. Subjects were recruited using cluster sampling from Yangxi County, Guangdong Province, China from August to November in 2014. Non-cycloplegic autorefraction and fundus photography were performed on all of the participants. Myopic maculopathy was graded based on fundus photographs using the International Classification of Myopic Maculopathy.ResultsAmong 5825 individuals who participated (90.7% response rate), a total of 4469 participants with gradable fundus photographs for myopic maculopathy and automated refractive data were included in this study. The mean age of these participants was 65.50±9.70 years. The crude prevalence of myopic maculopathy was 1.4% (62/4469; 95% confidence interval [CI] 1.0% to 1.8 %) and age-standardised prevalence was 1.2% (95% CI 1.1% to 1.2%). Diffuse chorioretinal atrophy, patchy chorioretinal atrophy, macular atrophy, lacquer cracks and staphyloma were observed in 43 (1.0%), 3 (0.1%), 1 (0.1%), 15 (0.3%) and 8 eyes (0.2%), respectively. Myopic maculopathy was more common in eyes of older participants (OR 1.07; 95% CI 1.03 to 1.11) and more myopic spherical equivalence (OR 1.69; 95% CI 1.57 to 1.84).ConclusionThe prevalence of myopic maculopathy was low among the rural southern Chinese population. Diffuse chorioretinal atrophy was the most common retinal finding among Chinese myopes.

scholarly journals Diabetic maculopathy: multicolour and SD-OCT versus fundus photography

2021 ◽  
Vol 6 (1) ◽  
pp. e000514
Author(s):  
Obaid Kousha ◽  
Martina Maria Delle Fave ◽  
Mariano Cozzi ◽  
Elisa Carini ◽  
Sergio Pagliarini
Keyword(s):  
Macular Oedema ◽  
Cross Sectional Study ◽  
Fundus Photography ◽  
Diabetic Maculopathy ◽  
Perfect Agreement ◽  
Cross Sectional ◽  
Clinically Significant ◽  
Fundus Photographs ◽  
Diabetic Eye Screening ◽  
Sd Oct

ObjectiveThe English Diabetic Eye Screening (DES) programme recommends patients with M1 diabetic maculopathy to be referred to hospital eye services. DES uses flash fundus photography as the reference standard for maculopathy grading. We compared multicolour versus non-stereoscopic fundus photography at identifying M1 maculopathy, with spectral domain optical coherence tomography (SD-OCT) identifying macular thickening.Methods and analysisThis cross-sectional study included 345 patients with R1M1 referred from DES and reviewed in secondary care with fundus photographs, multicolour and SD-OCT. Maculopathy was graded based on DES exudate criteria on both multicolour and fundus photography in a blind fashion by two independent graders. Macular thickness was ascertained on SD-OCT.ResultsIntergrader agreement on grading maculopathy using fundus photography (Cohen’s κ=0.91) and multicolour (Cohen’s κ=0.82) was ‘almost perfect’. Agreement between fundus photography and multicolour on grading maculopathy (Cohen’s κ=0.76) was ‘substantial’. Compared with fundus photography, multicolour had sensitivity of 87% (95% CI 81% to 93%) and specificity of 90% (95% CI 87% to 94%) in detecting M1 maculopathy. SD-OCT identified 84 eyes with macular thickening, 47 of which were graded as M0 by fundus photography. 5 eyes with exudates and severe macular oedema requiring urgent intervention were also missed on fundus photography but not on multicolour. Multicolour, when complemented by SD-OCT, did not miss any clinically significant macular oedema.ConclusionMulticolour integrates synergistically in a single platform with SD-OCT providing effective monitoring of M1 diabetic maculopathy. The need for fundus photography is eliminated by multicolour/SD-OCT in dedicated R1M1 virtual clinics not requiring parallel diabetic retinopathy grading.

Visual field defects and myopic macular degeneration in Singapore adults with high myopia

2021 ◽  
pp. bjophthalmol-2020-318674
Author(s):  
Carla Lanca ◽  
Chen Hsin Sun ◽  
Rachel Chong ◽  
Yee Ling Wong ◽  
Monisha Esther Nongpiur ◽  
...  
Keyword(s):  
Visual Field ◽  
Macular Degeneration ◽  
High Myopia ◽  
Cross Sectional Study ◽  
Visual Field Defects ◽  
Mean Deviation ◽  
Cross Sectional ◽  
Sensitivity Loss ◽  
Fundus Photographs ◽  
Generalised Estimating Equations

AimsTo characterise the association between visual field (VF) defects and myopic macular degeneration (MMD) in highly myopic adults without glaucoma.MethodsParticipants (n=106; 181 eyes) with high myopia (HM; spherical equivalent ≤−5.0 D or axial length (AL) ≥26 mm), after excluding glaucoma and glaucoma suspects, from the Singapore Epidemiology of Eye Diseases-HM study were included in this cross-sectional study. Humphrey VF (central 24–2 threshold), cup-disc ratio (CDR) and intraocular pressure (IOP) measurements were performed. Mean deviation (MD) and pattern SD (PSD), VF defects (normal or abnormal; p<0.05 in ≥3 non-edge contiguous locations) and pattern (eg, generalised sensitivity loss) were analysed. MMD presence was diagnosed from fundus photographs. Generalised estimating equations were used for analysing factors (MD, PSD, VF defects, CDR and IOP) associated with MMD.ResultsMean age was 55.4±9.9 years and 51.9% were women (AL=26.7±1.1 mm). MMD eyes had lower MD (−3.8±2.9 dB vs −1.1±1.4 dB) and higher PSD (2.8±1.7 dB vs 1.7±0.6 dB). A higher percentage of MMD eyes (n=48) had abnormal VF (62.5% vs 28.6%; p<0.001) compared with no MMD (n=133 eyes). VF pattern in MMD eyes was significantly different from eyes without MMD (p=0.001) with greater generalised sensitivity loss (53.3% vs 10.5%) and arcuate defects (16.7% vs 10.5%). In multivariate analyses, MD (OR=1.52) and PSD (OR=1.67) were significantly (p=0.003) associated with MMD, but VF defects were not associated with MMD.ConclusionHighly myopic adults with MMD may have VF loss when compared with highly myopic patients without MMD even in adults without glaucoma.

Pattern of Thalassemia and Hemoglobinopathies Among Anemic Under-Five Children of Northern Bangladesh: A Hospital Based Cross Sectional Study

2021 ◽  
Author(s):  
Md. Abdur Rafi ◽  
M. Morsed Zaman ◽  
Md. Golam Hossain
Keyword(s):  
Cross Sectional Study ◽  
Severe Form ◽  
Health Concern ◽  
Sectional Study ◽  
Cross Sectional ◽  
Hemoglobin E ◽  
Under Five ◽  
Under Five Children ◽  
Thalassemia Minor ◽  
Different Types

Abstract Background Congenital hemoglobin defects are significant global health concern affecting more than 330,000 newborns every year. In Bangladesh more than half of the under-five children are anemic, but the contribution of hemoglobin disorders to childhood anemia is quite unexplored. Hence, the objective of the present study was to investigate the prevalence and pattern of hemoglobinopathies among anemic under-five (age 6–59 months) children visiting the hematology department of Rajshahi Medical College Hospital (RMCH). Methods This was a retrospective cross-sectional study among anemic patients aged between 6 to 59 months conducted in the hematology department of RMCH from July 2018 to June 2020. The guideline of WHO was used to define the severity of anemia. Hemoglobinopathies was measured using standard methods. Chi-square test was used to find the association between two categorical factors. Results Female and younger children included in the study were more likely to suffer from moderate to severe form of anemia compared to their counterparts. Out of 534 patients 183 were suffering from different types of hemoglobinopathies (prevalence 34.3%). E-β-Thalassemia was the most common type of hemoglobinopathy (14%) followed by Hemoglobin E trait (11%) and β-Thalassemia minor (5.6%). Prevalence of these hemoglobin disorders was comparatively higher among female and older children (p < 0.05). Patients with E-β-Thalassemia and β-Thalassemia major of our study were mostly suffering from severe form of anemia while patients with hemoglobin E trait and β-Thalassemia minor were mostly suffering from mild anemia (p < 0.01). Conclusions A remarkable number of children were suffering from severe anemia and different types of hemoglobinopathies. Gender and age group were the risk factors of anemia and hemoglobinopathies among under-five children. Health authorities of Bangladesh should especially take care of anemic children in this country.

scholarly journals A cross-sectional study of pain severity in patients suffering from different types of primary headache in the hospital setting

2020 ◽  
Vol 8 (5) ◽  
pp. 1740
Author(s):  
Sanjay Prasad ◽  
Abhay Paliwal ◽  
Ram Ghulam Razdan
Keyword(s):  
Primary Headache ◽  
Cross Sectional Study ◽  
Tension Type Headache ◽  
Pain Severity ◽  
Sectional Study ◽  
Headache Disorders ◽  
Cross Sectional ◽  
Different Types ◽  
Type Headache ◽  
The Impact

Background: Primary headache disorders including migraine and tension-type headache (TTH) are of great importance to global public health due to its high prevalence, but very few studies have been conducted to know its prevalence and pain severity of different types of primary headache. Aim of this study was to investigate the subtypes and pain severity of different types of primary headache in hospital setting.Methods: This study is a cross-sectional study with 200 sample size. Includes patients with Primary headache in department of Psychiatry, MGMMC, Indore. Patient aged between 18-65 years, both gender. Diagnosis of headache was done clinically in accordance with International Classification of Headache disorders (ICHD- 3). Semi-structured headache questionnaire, Comparative pain scale were used for assessment of samples.Results: Among 200 patients, Tension type headache was 73.5%, Migraine was 22%, Mixed headache was in 4.5% patients. Majority of migraine and mixed headache cases had severe pain at 93.2% & 55.6% respectively. Majority of TTH cases had moderate pain in 42.2% patients.Conclusions: Study has shown assessments of severity of pain, can be used to assess the impact of Primary headache on patient’s quality of life.

Knowledge and Determinants of Health Consequences of Cigarette Smoking Among Vietnamese Adults, 2015

2019 ◽  
Vol 31 (5) ◽  
pp. 463-475 ◽  
Author(s):  
An Thi Minh Dao ◽  
Huong Thi Thu Nguyen ◽  
Giang Bao Kim ◽  
Hai Thi Phan ◽  
Huy Van Nguyen ◽  
...  
Keyword(s):  
Cigarette Smoking ◽  
Cross Sectional Study ◽  
Tobacco Product ◽  
Determinants Of Health ◽  
Health Consequences ◽  
Sampling Frame ◽  
Cross Sectional ◽  
Different Types ◽  
The Difference ◽  
Specific Health

Background. Vietnam was one of 16 countries that implemented the second round of the GATS (Global Adult Tobacco Survey) in 2015. Aims. To assess knowledge and determinants of health consequences of different types of cigarette smoking among Vietnamese adults. Methods. A cross-sectional study among adults aged 15 years combined with using 15% of the master sample from the national sampling frame of the population and housing census was conducted. Multilevel analysis using Poisson regression was undertaken. Results. Knowledge on the health consequences of cigarette smoking has not significantly improved in the GATS-2015. Adults believe that active smoking had more of an impact on health than secondhand smoking and 24.5% and 43% of them answered that smoking light and e-cigarettes, respectively, causes less harm than regular cigarettes, and 17.3% and 18.1% of adults are not aware of the difference between them, respectively. Conclusion. Household and community’s role had little impact in the adult knowledge of smoking health consequences. It is necessary to disseminate information on the “other tobacco product” and to improve public knowledge on specific health consequences, to enhance household and community’s role in conveying health education messages to individuals.

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