Research Progress in the Treatment of Complications and Sequelae of COVID-19

With the improvement in the understanding of COVID-19 and the widespread vaccination of COVID-19 vaccines in various countries, the epidemic will be brought under control soon. However, multiple viruses could result in the post-viral syndrome, which is also common among patients with COVID-19. Therefore, the long-term consequences and the corresponding treatment of COVID-19 should be the focus in the post-epidemic era. In this review, we summarize the therapeutic strategies for the complications and sequelae of eight major systems caused by COVID-19, including respiratory system, cardiovascular system, neurological system, digestive system, urinary system, endocrine system, reproductive system and skeletal complication. In addition, we also sorted out the side effects reported in the vaccine trials. The purpose of this article is to remind people of possible complications and sequelae of COVID-19 and provide robust guidance on the treatment. It is extremely important to conduct long-term observational prognosis research on a larger scale, so as to have a comprehensive understanding of the impact of the SARS-CoV-2 on the human body and reduce complications to the greatest extent.

Download Full-text

Risk of developing second malignant neoplasms in patients with neuroblastoma: a population study of the US SEER database

Radiation Oncology ◽

10.1186/s13014-021-01943-x ◽

2021 ◽

Vol 16 (1) ◽

Author(s):

Hongnan Zhen ◽

Hui Guan ◽

Jiabin Ma ◽

Wenhui Wang ◽

Shen Jing ◽

...

Keyword(s):

Risk Factor ◽

Digestive System ◽

Survival Rates ◽

Endocrine System ◽

Malignant Neoplasms ◽

Seer Database ◽

The Us ◽

Second Malignant Neoplasms ◽

Risk Patients

Abstract Background Neuroblastoma is a common extracranial malignant tumor in children. Its main treatment modality is a combination of chemotherapy, radiotherapy, and surgery. Given the advances in chemotherapy regimens and the widespread use of bone marrow transplantation over the decades, there has been improvement in treatment efficacy, which has led to prolonged patient survival. Accordingly, long-term complications have become a growing concern among physicians and patients. This study aimed to analyze the survival rate of patients with neuroblastoma and the risk factors for developing second malignant neoplasms (SMNs). Methods The SEER 18 Regs (1973–2015) and SEER 9 Regs (1973–2015) data of the surveillance, epidemiology, and end results (SEER) database of the US National Cancer Institute were adopted for survival and SMN analysis. Results The 5-, 10-, and 20-year overall survival rates of patients with neuroblastoma were 67%, 65%, and 62%, respectively. Among 38 patients with neuroblastoma who presented with SMNs, those with abdomen as the primary site accounted for the majority (63.2%), followed by those with thorax (26.3%) and other sites (10.5%). SMNs occurred more commonly in non-specific neuroblastoma (incidence: 0.87%) than ganglioneuroblastoma (incidence: 0.3%). Compared with the general population, the risk of SMN is significantly higher (SIR = 4.36). The risk of developing SMNs was significantly higher in the digestive system (SIR = 7.29), bones and joints (SIR = 12.91), urinary system (SIR = 23.48), brain and other nervous systems (SIR = 5.70), and endocrine system (SIR = 5.84). Multivariate analysis revealed that the year of diagnosis (OR = 2.138, 95% CI = 1.634–2.797, p < 0.001) was the only independent risk factor for developing SMNs. Conclusion This study identifies the risk factor for developing SMNs in patients with neuroblastoma, which could facilitate individualized screening for high-risk patients, to allow early diagnosis and treatment of SMNs.

Download Full-text

SARS-CoV-2 (COVID-19) and the Endocrine System

Journal of the Endocrine Society ◽

10.1210/jendso/bvaa144 ◽

2020 ◽

Vol 4 (11) ◽

Author(s):

Michelle D Lundholm ◽

Caroline Poku ◽

Nicholas Emanuele ◽

Mary Ann Emanuele ◽

Norma Lopez

Keyword(s):

Severe Disease ◽

Clinical Manifestations ◽

Endocrine System ◽

The Body ◽

Active Area ◽

Gonadal Function ◽

Long Term Effects ◽

The World ◽

The Impact

Abstract As SARS-CoV-2 (COVID-19) overtakes the world, causing moderate to severe disease in about 15% of infected patients, COVID-19 is also found to have widespread effects throughout the body with a myriad of clinical manifestations including the endocrine system. This manuscript reviews what is known about the impact of COVID-19 on the pathophysiology and management of diabetes (both outpatient and inpatient) as well as pituitary, adrenal, thyroid, bone, and gonadal function. Findings in this area are evolving, and long-term effects of infection remain an active area of further research.

Download Full-text

Risk of Developing Second Malignant Neoplasms in Patients with Neuroblastoma: A Population Study of the US SEER Database

10.21203/rs.3.rs-929576/v1 ◽

2021 ◽

Author(s):

Hongnan Zhen ◽

Hui Guan ◽

Jiabin Ma ◽

Wenhui Wang ◽

Shen Jing ◽

...

Keyword(s):

Risk Factor ◽

Digestive System ◽

Survival Rates ◽

Endocrine System ◽

Malignant Neoplasms ◽

Seer Database ◽

The Us ◽

Second Malignant Neoplasms ◽

Risk Patients

Abstract Background: Neuroblastoma is a common extracranial malignant tumor in children. Its main treatment modality is a combination of chemotherapy, radiotherapy, and surgery. Given the advances in chemotherapy regimens and the widespread use of bone marrow transplantation over the decades, there has been improvement in treatment efficacy, which has led to prolonged patient survival. Accordingly, long-term complications have become a growing concern among physicians and patients. This study aimed to analyze the survival rate of patients with neuroblastoma and the risk factors for developing second malignant neoplasms (SMNs).Methods: The SEER 18 Regs (1973-2015) and SEER 9 Regs (1973-2015) data of the Surveillance, Epidemiology, and End Results (SEER) database of the US National Cancer Institute were adopted for survival and SMN analysis.Results: The 5-, 10-, and 20-year overall survival rates of patients with neuroblastoma were 67%, 65%, and 62%, respectively. Among 38 patients with neuroblastoma who presented with SMNs, those with abdomen as the primary site accounted for the majority (63.2%), followed by those with thorax (26.3%) and other sites (10.5%). SMNs occurred more commonly in non-specific neuroblastoma (incidence: 0.87%) than ganglioneuroblastoma (incidence: 0.3%). Compared with the general population, the risk of SMN is significantly higher (SIR=4.36). The risk of developing SMNs was significantly higher in the digestive system (SIR =7.29), bones and joints (SIR = 12.91), urinary system (SIR = 23.48), brain and other nervous systems (SIR = 5.70), and endocrine system (SIR = 5.84). Multivariate analysis revealed that the year of diagnosis (OR=2.138, 95%CI=1.634-2.797, p＜0.001) was the only independent risk factor for developing SMNs.Conclusion: This study identifies the risk factor for developing SMNs in patients with neuroblastoma, which could facilitate individualized screening for high-risk patients, to allow early diagnosis and treatment of SMNs.

Download Full-text

Analysis of the impact of organochlorine compounds contained in the water network of the domestic water supply on the health of population in cities of the Perm Krai

Hygiene and Sanitation ◽

10.18821/0016-9900-2016-95-1-14-17 ◽

2019 ◽

Vol 95 (1) ◽

pp. 14-17

Author(s):

A. S. Sboev ◽

Christina V. Romanenko

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Drinking Water ◽

Digestive System ◽

Endocrine System ◽

Organochlorine Compounds ◽

Excretory System ◽

Oral Exposure ◽

The Impact ◽

Perm Region

The article presents the analysis of the impact of drinking water organochlorine compounds on the population health (Perm region). Results of the carcinogenic and non-carcinogenic health risk assessment for population of the city of Perm and the Perm region under the chronic oral exposure of organochlorine compounds in drinking water are presented. Real concentrations of organochlorine compounds in drinking water were determined to be potent of emerging an unacceptable risk of diseases of the digestive system, endocrine system, hormone system, excretory system, central nervous system and the blood system. According to the results of epidemiological studies there was established the statistically significant relation between the consumption of water containing organochlorine compounds and the development of diseases of the digestive system, endocrine system, central nervous system, and excretory system.

Download Full-text

Research Progress on Neurological System and Endocrine System of Ginsenoside

Hans Journal of Food and Nutrition Science ◽

10.12677/hjfns.2016.52006 ◽

2016 ◽

Vol 05 (02) ◽

pp. 31-36

Author(s):

睿刘

Keyword(s):

Endocrine System ◽

Research Progress ◽

Neurological System

Download Full-text

Skeletal Morbidity in Children and Adolescents during and following Cancer Therapy

Hormone Research in Paediatrics ◽

10.1159/000494809 ◽

2018 ◽

Vol 91 (2) ◽

pp. 137-151 ◽

Cited By ~ 2

Author(s):

Sogol Mostoufi-Moab ◽

Leanne M. Ward

Keyword(s):

Cancer Therapy ◽

Children And Adolescents ◽

Bone Health ◽

Early Recognition ◽

Childhood Cancer Survivors ◽

Therapeutic Strategies ◽

Skeletal Abnormalities ◽

The Impact

Skeletal abnormalities are common in children and adolescents diagnosed and treated for a malignancy. The spectrum ranges from mild pain to debilitating osteonecrosis and fractures. In this review, we summarize the impact of cancer therapy on the developing skeleton, provide an update on therapeutic strategies for prevention and treatment, and discuss the most recent advances in musculoskeletal research. Early recognition of skeletal abnormalities and strategies to optimize bone health are essential to prevent long-term skeletal sequelae and diminished quality of life in childhood cancer survivors.

Download Full-text

Modeling COVID-19 vaccine efficacy and coverage towards herd-immunity in the Basque Country, Spain

10.1101/2021.07.12.21260390 ◽

2021 ◽

Author(s):

Nico Stollenwerk ◽

Javier Mar ◽

Joseba Bidaurrazaga Van-Dierdonck ◽

Oliver Ibarrondo ◽

Carlo Estadilla ◽

...

Keyword(s):

Vaccine Efficacy ◽

Basque Country ◽

Severe Disease ◽

Herd Immunity ◽

Dose Administration ◽

Vaccine Trials ◽

The Impact ◽

Sterilizing Immunity ◽

Full Immunization

Vaccines have measurable efficacies, obtained first from vaccine trials. However, vaccine efficacy is not a static measure upon licensing, and the long term population studies are very important to evaluate vaccine performance and impact. COVID-19 vaccines were developed in record time and although the extent of sterilizing immunity is still under evaluation, the currently licensed vaccines are extremely effective against severe disease, with vaccine efficacy significantly higher after the full immunization schedule. We investigate the impact of vaccines which have different efficacies after first dose and after the second dose administration schedule, eventually considering different efficacies against severe disease as opposed to overall infection. As a proof of concept, we model the vaccine performance of hospitalization reduction at the momentary scenario of the Basque Country, Spain, with population in a mixed vaccination setting, giving insights into the population coverage needed to achieve herd immunity in the current vaccination context.

Download Full-text

Suppressed, but Not Forgotten

Swiss Journal of Psychology ◽

10.1024/1421-0185/a000033 ◽

2011 ◽

Vol 70 (1) ◽

pp. 5-11 ◽

Cited By ~ 8

Author(s):

Beat Meier ◽

Anja König ◽

Samuel Parak ◽

Katharina Henke

Keyword(s):

Memory Trace ◽

Thought Suppression ◽

Test Phase ◽

Indirect Test ◽

Final Test ◽

Test Experiment ◽

And Control ◽

Cue Words ◽

The Impact

This study investigates the impact of thought suppression over a 1-week interval. In two experiments with 80 university students each, we used the think/no-think paradigm in which participants initially learn a list of word pairs (cue-target associations). Then they were presented with some of the cue words again and should either respond with the target word or avoid thinking about it. In the final test phase, their memory for the initially learned cue-target pairs was tested. In Experiment 1, type of memory test was manipulated (i.e., direct vs. indirect). In Experiment 2, type of no-think instructions was manipulated (i.e., suppress vs. substitute). Overall, our results showed poorer memory for no-think and control items compared to think items across all experiments and conditions. Critically, however, more no-think than control items were remembered after the 1-week interval in the direct, but not in the indirect test (Experiment 1) and with thought suppression, but not thought substitution instructions (Experiment 2). We suggest that during thought suppression a brief reactivation of the learned association may lead to reconsolidation of the memory trace and hence to better retrieval of suppressed than control items in the long term.

Download Full-text