The Impact of Trace Elements on Osteoarthritis

Osteoarthritis (OA) is a progressive degenerative disease characterized by cartilage degradation, synovial inflammation, subchondral sclerosis and osteophyte formation. It has a multifactorial etiology with potential contributions from heredity, endocrine function, abnormal mechanical load and nutrition. Of particular considerations are trace element status. Several trace elements, such as boron and magnesium are essential for normal development of the bone and joint in human. While cadmium correlates with the severity of OA. The present review focuses on the roles of trace elements (boron, cadmium, copper, iron, magnesium, manganese, selenium, zinc) in OA and explores the mechanisms by which they act.

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Trace element nutrition in the tropical zebu cattle type. Lessons from the Gilgel Gibe catchment, Ethiopia

Afrika Focus ◽

10.21825/af.v27i1.4916 ◽

2014 ◽

Vol 27 (1) ◽

Author(s):

Veronique Dermauw

Keyword(s):

Trace Elements ◽

Trace Element ◽

Bos Indicus ◽

Zebu Cattle ◽

Health Production ◽

Animal Products ◽

Trace Element Status ◽

Trace Element Nutrition ◽

The Tropics ◽

The Impact

In the tropics, cattle are majorly dependent on natural pastures growing on poor soils and as a result prone to trace element deficiencies. This work investigated several aspects of trace element nutrition in zebu (Bos indicus) cattle, the most widely used cattle type in the tropics. Through several trials conducted at the Gilgel Gibe catchment, Ethiopia, we aimed to study factors influencing the flow of trace elements from soil to plant and grazing zebu cattle, and to investigate the impact of trace element status on health, production and trace elements in animal products. Overall, trace element, e.g., Cu, deficiencies were widely prevalent. Environment and certain grazing strategies were intimately related and affected trace element supply whereas cattle type affected trace element status. The effect of trace element status on trace elements in animal products was obvious, whereas the impact on health and production was less clear-cut. Key words: trace elements, minerals, cattle, zebu, Bos indicus, Ethiopia, tropics

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Trace element nutrition in the tropical zebu cattle type. Lessons from the Gilgel Gibe catchment, Ethiopia

Afrika Focus ◽

10.1163/2031356x-02701006 ◽

2014 ◽

Vol 27 (1) ◽

pp. 87-95

Author(s):

Veronique Dermauw

Keyword(s):

Trace Elements ◽

Trace Element ◽

Bos Indicus ◽

Zebu Cattle ◽

Health Production ◽

Animal Products ◽

Clear Cut ◽

Trace Element Status ◽

The Tropics ◽

The Impact

In the tropics, cattle are majorly dependent on natural pastures growing on poor soils and as a result prone to trace element deficiencies. This work investigated several aspects of trace element nutri¬tion in zebu (Bos indicus) cattle, the most widely used cattle type in the tropics. Through several trials conducted at the Gilgel Gibe catchment, Ethiopia, we aimed to study factors influencing the flow of trace elements from soil to plant and grazing zebu cattle, and to investigate the impact of trace element status on health, production and trace elements in animal products. Overall, trace element, e.g., Cu, deficiencies were widely prevalent. Environment and certain grazing strategies were inti-mately related and affected trace element supply whereas cattle type affected trace element status. The effect of trace element status on trace elements in animal products was obvious, whereas the impact on health and production was less clear-cut.

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PHYSICAL ACTIVITY AND TRACE ELEMENT METABOLISM

Trace Elements in Medicine (Moscow) ◽

10.19112/2413-6174-2020-21-2-3-12 ◽

2020 ◽

Vol 21 (2) ◽

pp. 3-12

Author(s):

A.A. Skalny ◽

Keyword(s):

Physical Activity ◽

Trace Elements ◽

Trace Element ◽

The Body ◽

Cobalt Chromium ◽

Essential Trace Elements ◽

Trace Element Metabolism ◽

The Impact ◽

The Relationship ◽

Insight Into

Currently, there is no doubt about the prevailing influence of the level of physical activity of an individual on the functional state of the body. However, the available literature data on the impact of physical stress on the body's supply of trace elements and their distribution in tissues are largely contradictory. This review of available literature data provides an insight into the relationship between physical activity and microelement homeostasis. The influence of human physical activity on the exchange of toxic (lead, cadmium, Nickel, etc.) and essential trace elements, such as iron, selenium, copper, cobalt, chromium, and zinc is reviewed. Based on the analyzed works, it is concluded that in order to correct the metabolic and microelement status of a person during physical activity, the most reasonable and necessary is the modulation of homeostasis of zinc and selenium.

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Passive degassing at Nyiragongo (D.R. Congo) and Etna (Italy) volcanoes

Annals of Geophysics ◽

10.4401/ag-6637 ◽

2015 ◽

Vol 57 ◽

Author(s):

Sergio Calabrese ◽

Sarah Scaglione ◽

Silvia Milazzo ◽

Walter D'Alessandro ◽

Nicole Bobrowski ◽

...

Keyword(s):

Trace Elements ◽

Trace Element ◽

Major And Trace Elements ◽

Trace Element Composition ◽

Bulk Deposition ◽

Volcanic Plume ◽

Strong Impact ◽

Volcanic Emissions ◽

Endemic Plant ◽

The Impact

Volcanoes are well known as an impressive large natural source of trace elements into the troposphere. Etna (Italy) and Nyiragongo (D.R. Congo) are two stratovolcanoes located in different geological settings, both characterized by persistent passive degassing from their summit craters. Here, we present some results on trace element composition in volcanic plume emissions, atmospheric bulk deposition (rainwater) and their uptake by the surrounding vegetation, with the aim to compare and identify differences and similarities between these two volcanoes. Volcanic emissions were sampled by using active filter-pack for acid gases (sulfur and halogens) and specific teflon filters for particulates (major and trace elements). The impact of the volcanogenic deposition in the surrounding of the crater rims was investigated by using different sampling techniques: bulk rain collectors gauges were used to collect atmospheric bulk deposition, and biomonitoring technique was carried out to collect gases and particulates by using endemic plant species. The estimates of the trace element fluxes confirm that Etna and Nyiragongo are large sources of metals into the atmosphere, especially considering their persistent state of passive degassing. The large amount of emitted trace elements has a strong impact on the close surrounding of both volcanoes. This is clearly reflected by in the chemical composition of rainwater collected at the summit areas both for Etna and Nyiragongo. Moreover, the biomonitoring results highlight that bioaccumulation of trace elements is extremely high in the proximity of the crater rim and decreases with the distance from the active craters.

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Preface

Pure and Applied Chemistry ◽

10.1351/pac20108202iv ◽

2010 ◽

Vol 82 (2) ◽

pp. iv

Author(s):

Francesco Cubadda

Keyword(s):

Trace Elements ◽

Trace Element ◽

Food Chain ◽

Scientific Community ◽

Biological Effects ◽

Toxic Element ◽

Feed Additives ◽

Potential Health ◽

Element Species ◽

The Impact

Diet is the main source of trace elements, and exposure to dietary trace elements has a direct impact on the health of hundreds of millions worldwide. Insufficient intake of essential trace elements is a global issue. Deficiencies of iron, zinc, iodine, and selenium result in millions of people being affected by various diseases, with very serious consequences in those countries where malnutrition is widespread. On the other hand, the impact of toxic element species such as inorganic arsenic and methylmercury on entire populations has come to the fore again as a priority for both the scientific community and health authorities. The presence of trace elements in feeds, either as contaminants or as nutritional or zootechnical additives, and their transfer across the food chain to humans also raises questions within the scientific community and regulators.Different facets of trace elements, from essentiality to toxicity, were addressed throughout the 3rd International IUPAC Symposium on Trace Elements in Food (TEF-3). The meeting was organized by the Istituto Superiore di Sanità and held on 1-3 April 2009 in Rome, Italy. The objective was to gather experts with different backgrounds to discuss all aspects of trace elements in food in relation to human health, with special emphasis on biological effects of elements. The main topics included essentiality, toxicity, bioaccessibility, bioavailability, speciation, sources and transfer in the food chain, effects of processing, food and feed fortification, supplementation, international legislation and standards, analytical developments, analytical quality assurance and reference materials. In accordance with practice in previous events of this series (Warsaw, 2000, and Brussels, 2004), TEF-3 provided a forum for the exchange of new ideas and experiences in trace element research, and a basis for influencing policy, advisory practice, and risk-management tools to protect public health.Over 200 participants, representing some 40 countries, joined the event. In addition to the 15 invited lectures, delegates from Europe, Asia, Africa, North and South America enriched this edition with 20 oral and about 130 poster contributions. TEF-3 actually resulted in a lively interdisciplinary symposium on current and emerging research and development efforts.Special emphasis was placed on the following topics:- analytical techniques for element speciation studies in food and food supplements- reliability and quality control of analytical data on trace elements in foodstuffs- detection, characterization, and potential health risks of inorganic nanoparticles- arsenic speciation and toxicology- gender differences in susceptibility to toxic trace elements in food- exposure assessment of toxic element species- assessment of risks and benefits of the organic forms of trace elements as feed additives- metabolism of metal(loid)s by intestinal microorganisms- absorption and metabolism of iron, zinc, and other essential elements- use of stable isotopes to study trace mineral metabolism- selenium and iodine speciation and biological effectsAdvancements in the above-mentioned areas were discussed, and special attention was paid to the means in order to prevent adverse health effects on those individuals and populations most vulnerable to trace-element inadequacies, excesses, or imbalances.The following collection of papers based upon authoritative lectures presented at TEF-3 addresses many of the topics discussed during the symposium. Overall, it provides an excellent overview of the state of the art in the area of trace elements in food and sheds light on future challenges and subjects of research.Francesco CubaddaConference Chair

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PLASMA TRACE ELEMENT STATUS IN BETA-THALASSEMIA TRAIT PATIENTS

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2019.v12i1.28922 ◽

2019 ◽

Vol 12 (1) ◽

pp. 232

Author(s):

Prabhakaran N ◽

Sudha K ◽

Reshma K ◽

Durgarao Y

Keyword(s):

Trace Elements ◽

Trace Element ◽

High Performance ◽

Absorption Spectrometry ◽

Beta Thalassemia ◽

Plasma Zinc ◽

Trace Element Status ◽

Apparent Decrease ◽

Thalassemia Trait ◽

Student’S T

Objective: The study aims to evaluate the plasma trace element status in beta-thalassemia trait (BTT) patients and demonstrate the correlation between trace elements and hemoglobin (Hb)-A1, HbA2, and HbF.Methods: The study population consisted of 20 normal individuals and 40 patients with BTT aged between 25 and 55 years of both the sex. Hemoglobin variant analysis was performed in blood samples using cation exchange high-performance liquid chromatography. Patients were labeled as beta-thalassemia trait only if they had HbA2 >3.5% or HbF >2.0%. Plasma zinc was estimated by atomic absorption spectrometry, copper by bathocuproine disulfonate method, and iron by ferrozine method spectrophotometrically. Data were analyzed statistically by Student’s t -test and Pearson’s correlation using software SPSS version 20. p<0.05 was considered statistically significant.Results: Plasma zinc and copper decreased significantly in BTT patients compared to healthy controls. There was an apparent decrease in plasma iron in these patients. Degree of decline in zinc (p<0.001) was much greater than that of copper (p<0.04). Moreover, there was significant elevation of copper-zinc ratio and iron-zinc ratio (p<0.001) in BTT patients compared to controls. Both HbA1 and HbA2 correlated positively with both copper and iron. Interestingly, HbF showed negative correlation with all the three trace elements in BTT patients.Conclusion: The study highlights marked deficiency of plasma trace elements, hence, the need for periodic assessment and prompt administration of these micronutrients to reduce the complications in BTT patients. Further, ratios are more valuable markers in the determination of trace element status than individual elements.

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Trace elements in soils and crops

Philosophical Transactions of the Royal Society of London Series B Biological Sciences ◽

10.1098/rstb.1979.0087 ◽

1979 ◽

Vol 288 (1026) ◽

pp. 15-24 ◽

Cited By ~ 28

Keyword(s):

Trace Elements ◽

Trace Element ◽

Essential Elements ◽

Parent Material ◽

Soil Parameters ◽

Surface Soils ◽

Plant Parts ◽

Trace Element Status ◽

Element Mobilization ◽

Soil Surveys

To demonstrate the total amounts to be expected in soils, the ranges of contents of some 60 trace elements in ten representative Scottish arable surface soils are compared with ranges in soil-forming rocks and with crustal averages. It is, however, the amounts potentially available to plants rather than the total contents that are biologically significant. In temperate climates, trace element mobilization is greatest when weathering takes place under conditions of impeded pedological drainage, leading to the formation of gleyed soils. Mobilized trace elements occur in arable surface soils largely in adsorbed and chelated forms, which are available to plants to a greater or smaller extent depending on the prevailing soil parameters and on the element in question. Different species take up different amounts of trace elements: the proportions in the various plant parts vary with the element and the stage of growth. Information is required about the mobilization and uptake of many elements about which little is at present known but which may affect the functions of essential elements through inter-element interactions. Systematic soil surveys in which soils are mapped by associations related to parent material, with their series related to genetic soil types, provide a useful countrywide guide to trace element status.

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Mineral/melt partition coefficients of oceanic alkali basalts determined on natural samples using laser ablation-inductively coupled plasma-mass spectrometry (LAM-ICP-MS)

Mineralogical Magazine ◽

10.1180/002646100549148 ◽

2000 ◽

Vol 64 (1) ◽

pp. 85-94 ◽

Cited By ~ 7

Author(s):

G. M. Thompson ◽

J. Malpas

Keyword(s):

Trace Elements ◽

Trace Element ◽

Inductively Coupled Plasma ◽

Partition Coefficients ◽

Dominant Factor ◽

Alkali Basalts ◽

Compositional Evolution ◽

Icp Ms ◽

D Values ◽

The Impact

AbstractIn order to limit the range of possible differentiation mechanisms and the impact of these processes on the trace element signatures of igneous suites, it is important to be able to predict or model the compositional evolution of the primary and/or parental magmas. Part of the problem in understanding these relationships in basalts from ocean islands is the paucity of reliable trace element mineral/melt partition coefficients, particularly for undersaturated magmas. Consequently, we have measured mineral/groundmass partition coefficients for Rb, Sr, Y, Zr, Nb, Hf, Ta, Th and REE, in situ, in clinopyroxene, Fe-Ti oxides and olivine in primitive basalts from Rarotonga, Cook Islands using LAM-ICP-MS.Analyses of these mafic rocks show high concentrations of most incompatible trace elements (e.g. Sr, Th, Y, REE, etc.) in pyroxenes relative to the other phases, suggesting that fractionation of pyroxenes was the dominant factor in the distribution of these trace elements during crystal fractionation. In such cases, the highly incompatible elements (D <0.01) are Ba, Cs and Nb. Elements that could also be classified as strongly incompatible (D <0.1) are Rb, Ta and Th. The remaining trace elements have bulk partition coefficient values that range from ∼.0.1 up to ∼.0.8 (Sr, Hf, Zr, Y and REE). Magnetites incorporate greater amounts of Nb and Ta than the titanaugites, and any significant fractionation of magnetite would have affected the bulk distribution of Nb and Ta. The LREE have lower Kd values than other REE, with the HREE having Kd values close to unity. Consequently, with the separation of titanaugite an overall enrichment of REE in the residual liquid with an increase in the La/Yb ratio is produced.

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Blood and hair as non-invasive trace element biological indicators in growing rabbits

World Rabbit Science ◽

10.4995/wrs.2019.10654 ◽

2019 ◽

Vol 27 (1) ◽

pp. 21

Author(s):

George Papadomichelakis ◽

Athanasios C Pappas ◽

Evangelos Zoidis ◽

Georgios Danezis ◽

Konstantinos A Georgiou ◽

...

Keyword(s):

Trace Elements ◽

Trace Element ◽

Biological Indicators ◽

Organic Selenium ◽

Non Invasive ◽

Trace Element Status ◽

Element Profile ◽

Trace Element Contents ◽

Highly Correlated ◽

Toxic Trace Element

The suitability of blood and hair as non-invasive tools to monitor trace element contents was studied in 48 Hyla male growing rabbits. Three diets with increasing organic selenium (Se) addition (0.1, 0.5 and 2.5 mg/kg) were used to induce alterations in the concentrations of trace elements vs. an unsupplemented diet. In blood, a linear decrease in Co (P<0.001), Cu (P<0.001), Mn (P<0.05), Zn (P<0.05), Sb (P<0.001), As (P<0.001), Cr (P<0.001), Mo (P<0.001), Ni (P<0.001) and Cd (P<0.001) concentrations with increasing dietary Se was observed. In hair, a cubic effect of dietary Se on Co (P<0.01), Cu (P<0.05), Mn (P<0.001), Pb (P<0.05), Mo (P<0.05) and Cd (P<0.05) concentrations was found, while As, Cr and Ni concentrations decreased linearly (P<0.01, P<0.01 and P<0.001, respectively) with increasing dietary Se. Selenium was negatively correlated to Sb, As, Cr, Mo, Ni and Cd, (P<0.001) in blood, and to As (P<0.05), Cr, Ni (P<0.01) and Pb (P<0.05) in hair. The contents of Se, As, Cr and Ni in blood were highly correlated (P<0.001) to those in hair. Blood appeared to be more sensitive than hair in detecting small changes in the trace element profile in rabbits, as was indicated by the discriminant analysis. In conclusion, blood and hair can be suitable biological indicators of essential, toxic and potentially toxic trace element status in rabbits, particularly when used complementarily.

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Crosstalk of Nrf2 with the Trace Elements Selenium, Iron, Zinc, and Copper

Nutrients ◽

10.3390/nu11092112 ◽

2019 ◽

Vol 11 (9) ◽

pp. 2112 ◽

Cited By ~ 4

Author(s):

Maria Schwarz ◽

Kristina Lossow ◽

Johannes F. Kopp ◽

Tanja Schwerdtle ◽

Anna P. Kipp

Keyword(s):

Trace Elements ◽

Trace Element ◽

Metal Binding ◽

Target Genes ◽

Selenium Deficiency ◽

Whole Body ◽

Dependent Manner ◽

Trace Element Status ◽

Nrf2 Knockout ◽

Feeding Diets

Trace elements, like Cu, Zn, Fe, or Se, are important for the proper functioning of antioxidant enzymes. However, in excessive amounts, they can also act as pro-oxidants. Accordingly, trace elements influence redox-modulated signaling pathways, such as the Nrf2 pathway. Vice versa, Nrf2 target genes belong to the group of transport and metal binding proteins. In order to investigate whether Nrf2 directly regulates the systemic trace element status, we used mice to study the effect of a constitutive, whole-body Nrf2 knockout on the systemic status of Cu, Zn, Fe, and Se. As the loss of selenoproteins under Se-deprived conditions has been described to further enhance Nrf2 activity, we additionally analyzed the combination of Nrf2 knockout with feeding diets that provide either suboptimal, adequate, or supplemented amounts of Se. Experiments revealed that the Nrf2 knockout partially affected the trace element concentrations of Cu, Zn, Fe, or Se in the intestine, liver, and/or plasma. However, aside from Fe, the other three trace elements were only marginally modulated in an Nrf2-dependent manner. Selenium deficiency mainly resulted in increased plasma Zn levels. One putative mediator could be the metal regulatory transcription factor 1, which was up-regulated with an increasing Se supply and downregulated in Se-supplemented Nrf2 knockout mice.

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